Background: Platelets play an important role in hemostatic and inflammatory responses. To evaluate any potential enhancement of platelet activity in patients with inflammatory bowel disease (IBD), we measured the plat...Background: Platelets play an important role in hemostatic and inflammatory responses. To evaluate any potential enhancement of platelet activity in patients with inflammatory bowel disease (IBD), we measured the platelet aggregation responses to various stimuli. Methods: Twenty-two healthy controls, 24 patients with ulcerative colitis (UC) and 25 patients with Crohn’s Disease (CD) were studied. The aggregation responses induced by three agonists (epinephrine, collagen, and ADP)were measured by an 8- channel aggregometer. The platelet-derived microparticles (PDMP) levels were measured by an enzyme-linked immunosorbent assay. Results: Twenty-one out of the 22 healthy controls did not respond to epinephrine (0.1 μ g/ml), collagen (0.2 μ g/ml), or ADP (1.0 μ M). Eight out of the 12 active UC patients were sensitive to all agonists, and 4 patients showed increased sensitivity to epinephrine/collagen or epinephrine/ADP. Three out of the 12 inactive UC patients were normal, but 9 of these patients showed increased sensitivity, mainly to epinephrine. Ten out of the 12 active CD patients were sensitive to all agonists, and 2 active CD patients were sensitive to epinephrine/ collagen or epinephrine/ADP. Eight out of the 13 inactive CD patients were sensitive to two or all agonists. Even after remission, almost all of the UC and CD patients showed some increased sensitivity to the agonists. The platelet number and the plasma PDMP levels were significantly higher in the active IBD patients than in the control group. Conclusions: Platelet aggregation responses are enhanced in IBD, even in inactive-phase patients. This increased sensitivity of the platelets may play an important role in the pathophysiology of IBD.展开更多
百日咳是由百日咳鲍特菌引起的急性呼吸道传染病,传染性较强,是严重威胁人类健康的主要传染病之一。随着20世纪40年代全球扩大免疫规划的实施,百日咳的流行得到有效控制。但近年来,世界卫生组织（World Health Organization,WHO）疾病...百日咳是由百日咳鲍特菌引起的急性呼吸道传染病,传染性较强,是严重威胁人类健康的主要传染病之一。随着20世纪40年代全球扩大免疫规划的实施,百日咳的流行得到有效控制。但近年来,世界卫生组织（World Health Organization,WHO）疾病监测发现,长期无细胞百白破联合疫苗（DTaP）接种所带来的百日咳低发病率形势出现逆转,表现为发达国家百日咳发病率复升和发展中国家屡出现百日咳暴发，即所谓的“百日咳再现”。展开更多
文摘Background: Platelets play an important role in hemostatic and inflammatory responses. To evaluate any potential enhancement of platelet activity in patients with inflammatory bowel disease (IBD), we measured the platelet aggregation responses to various stimuli. Methods: Twenty-two healthy controls, 24 patients with ulcerative colitis (UC) and 25 patients with Crohn’s Disease (CD) were studied. The aggregation responses induced by three agonists (epinephrine, collagen, and ADP)were measured by an 8- channel aggregometer. The platelet-derived microparticles (PDMP) levels were measured by an enzyme-linked immunosorbent assay. Results: Twenty-one out of the 22 healthy controls did not respond to epinephrine (0.1 μ g/ml), collagen (0.2 μ g/ml), or ADP (1.0 μ M). Eight out of the 12 active UC patients were sensitive to all agonists, and 4 patients showed increased sensitivity to epinephrine/collagen or epinephrine/ADP. Three out of the 12 inactive UC patients were normal, but 9 of these patients showed increased sensitivity, mainly to epinephrine. Ten out of the 12 active CD patients were sensitive to all agonists, and 2 active CD patients were sensitive to epinephrine/ collagen or epinephrine/ADP. Eight out of the 13 inactive CD patients were sensitive to two or all agonists. Even after remission, almost all of the UC and CD patients showed some increased sensitivity to the agonists. The platelet number and the plasma PDMP levels were significantly higher in the active IBD patients than in the control group. Conclusions: Platelet aggregation responses are enhanced in IBD, even in inactive-phase patients. This increased sensitivity of the platelets may play an important role in the pathophysiology of IBD.
文摘百日咳是由百日咳鲍特菌引起的急性呼吸道传染病,传染性较强,是严重威胁人类健康的主要传染病之一。随着20世纪40年代全球扩大免疫规划的实施,百日咳的流行得到有效控制。但近年来,世界卫生组织（World Health Organization,WHO）疾病监测发现,长期无细胞百白破联合疫苗（DTaP）接种所带来的百日咳低发病率形势出现逆转,表现为发达国家百日咳发病率复升和发展中国家屡出现百日咳暴发，即所谓的“百日咳再现”。
