Isoperistaltic vs antiperistaltic anastomosis after right hemicolectomy:A comprehensive review

To optimize the efficiency of ileocolic anastomosis following right hemicolectomy,several variations of the surgical technique have been tested.These include performing the anastomosis intra-or extracorporeally or performing a stapled or hand-sewn anastomosis.Among the least studied is the configuration of the two stumps(i.e.,isoperistaltic or antiperistaltic)in the case of a side-to-side anastomosis.The purpose of the present study is to compare the isoperistaltic and antiperistaltic side-to-side anastomotic configuration after right hemicolectomy by reviewing the relevant literature.High-quality literature is scarce,with only three studies directly comparing the two alternatives,and no study has revealed any significant differences in the incidence of anastomosis-related complications such as leakage,stenosis,or bleeding.However,there may be a trend towards an earlier recovery of intestinal function following antiperistaltic anastomosis.Finally,existing data do not identify a certain anastomotic configuration(i.e.,isoperistaltic or antiperistaltic)as superior over the other.Thus,the most appropriate approach is to master both anastomotic techniques and select between the two configurations based on each individual case scenario.

Causes of epigastric pain and vomiting after laparoscopic-assisted radical right hemicolectomy-superior mesenteric artery syndrome

BACKGROUND Superior mesenteric artery syndrome(SMAS)is a rare condition causing functional obstruction of the third portion of the duodenum.Postoperative SMAS following laparoscopic-assisted radical right hemicolectomy is even less prevalent and can often be unrecognized by radiologists and clinicians.AIM To analyze the clinical features,risk factors,and prevention of SMAS after laparoscopic-assisted radical right hemicolectomy.METHODS We retrospectively analyzed clinical data of 256 patients undergoing laparoscopicassisted radical right hemicolectomy in the Affiliated Hospital of Southwest Medical University from January 2019 to May 2022.The occurrence of SMAS and its countermeasures were evaluated.Among the 256 patients,SMAS was confirmed in six patients(2.3%)by postoperative clinical presentation and imaging features.All six patients were examined by enhanced computed tomography(CT)before and after surgery.Patients who developed SMAS after surgery were used as the experimental group.A simple random sampling method was used to select 20 patients who underwent surgery at the same time but did not develop SMAS and received preoperative abdominal enhanced CT as the control group.The angle and distance between the superior mesenteric artery and abdominal aorta were measured before and after surgery in the experimental group and before surgery in the control group.The preoperative body mass index(BMI)of the experimental group and the control group was calculated.The type of lymphadenectomy and surgical approach in the experimental and control groups were recorded.The differences in angle and distance were compared preoperatively and postoperatively in the experimental group compared.The differences in angle,distance,BMI,type of lymphadenectomy and surgical approach between the experimental and control groups were compared,and the diagnostic efficacy of the significant parameters was assessed using receiver operating characteristic curves.RESULTS In the experimental group,the aortomesenteric angle and distance after surgery were significantly decreased than those before surgery(P<0.05).The aortomesenteric angle,distance and BMI were significantly higher in the control group than in the experimental(P<0.05).There was no significant difference in the type of lymphadenectomy and surgical approach between the two groups(P>0.05).CONCLUSION The small preoperative aortomesenteric angle and distance and low BMI may be important factors for the complication.Over-cleaning of lymph fatty tissues may also be associated with this complication.

Single port laparoscopic right hemicolectomy for ileocolic intussusception

A 36-year-old male was admitted with right lower abdominal pain and diarrhea for more than 3 mo. Colonoscopy and a barium enema study revealed a submucosal tumor over the cecum, but computed tomography showed an ileal lipoma. There was no definitive diagnosis preoperatively, but ileocolic intussusception was noted during surgery. Single port laparoscopic radical right hemicolectomy was performed because intra-operative reduction failed. The histological diagnosis of the resected tumor was lipoma. Single port laparoscopic surgery has recently been proven to be safe and feasible. There are advantages compared with conventional laparoscopic surgery, such as smaller incision wounds, fewer port site complications, and easier conversion. However, there are some drawbacks which need to be overcome, such as difficulties in triangulation and instrument clashing. If there are no contraindications to laparoscopy, single port laparoscopic surgery can be performed safely and should be considered for diagnosis and treatment of intussusception in adults. Here, we report the first case of ileocolic intussusception successfully treated by single port laparoscopic surgery.

Laparoscopic versus open right hemicolectomy with curative intent for colon carcinoma

AIM: Laparoscopic surgery, especially laparoscopic rectal surgery, for colorectal cancer has been developed considerably. However, due to relatively complicated anatomy and high requirements for surgery techniques,laparoscopic right colectomy develops relatively slowly. This study was designed to compare the outcomes of laparoscopic right hemicolectomy (LRH) with open right hemicolectomy (ORH) in the treatment of colon carcinoma.METHODS: Between September 2000 and February 2003,30 patients with colon cancer who underwent LRH were compared with 34 controls treated by ORH in the same period. All patients were evaluated with respect to surgeryrelated complications, postoperative recovery, recurrence and metastasis rate, cost-effectiveness and survival.RESULTS: Among 30 LRH, 2 (6.7%) were converted to open procedure. No significant differences were observed in terms of mean operation time, blood loss, post-operative complications, and hospital cost between LRH and ORH groups. Mean time for bowel movement, hospital stay,and time to resume early activity in the LRH group were significantly shorter than those in the ORH group (2.24±0.56vs 3.25±1.29 d, 13.94±6.5 vs 18.25±5.96 d, 3.94±1.64 vs 5.45±1.82 d respectively, P＜0.05). As to the lymph node yield, the specimen length and total cost for operation and drugs, there was no significant difference between the two groups. Local recurrence rate and metachronous metastasis rate had no marked difference between the two groups.Cumulative survival probability at 40 mo in LRH group (76.50%) was not obviously different compared to the ORH group (74.04%).CONCLUSION: LRH in patients with colon cancer has statistically and clinically significant advantages over ORH.Thus, LRH can be regarded as a safe and effective procedure.

En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer

AIM To assess the usefulness of en bloc right hemicolectomy with pancreaticoduodenectomy(RHCPD) for locally advanced right-sided colon cancer(LARCC).METHODS We retrospectively reviewed the database of Saitama Medical Center, Jichi Medical University, between January 2009 and December 2016. During this time, 299 patients underwent radical right hemicolectomy for right-sided colon cancer. Among them, 5 underwent RHCPD for LARCC with tumor infiltration to adjacent organs. Preoperative computed tomography(CT) was routinely performed to evaluate local tumor infiltration into adjacent organs. During the operation, we evaluated the resectability and the amount of infiltration into the adjacent organs without dissecting the adherent organs from the cancer. When we confirmed that radical resection was feasible and could lead to R0 resection, we performed RHCPD. The clinical data were carefully reviewed, and the demographic variables, intraoperative data, and postoperative parameters were recorded.RESULTS The median age of the 5 patients who underwent RHCPD for LARCC was 70 years. The tumors were located in the ascending colon(three patients) and transverse colon(two patients). Preoperative CT revealed infiltration of the tumor into the duodenum in all patients, the pancreas in four patients, the superior mesenteric vein(SMV) in two patients, and tumor thrombosis in the SMV in one patient. We performed RHCPD plus SMV resection in three patients. Major postoperative complications occurred in 3 patients(60%) as pancreatic fistula(grade B and grade C, according to International Study Group on Pancreatic Fistula Definition) and delayed gastric empty. None of the patients died during their hospital stay. A histological examination confirmed malignant infiltration into the duodenum and/or pancreas in 4 patients(80%), and no patients showed any malignant infiltration into the SMV. Two patients were histologically confirmed to have tumor thrombosis in the SMV. All of the tumors had clear resection margins(R0). The median follow-up time was 77 mo. During this period, two patients with tumor thrombosis died from liver metastasis. The overall survival rates were 80% at 1 year and 60% at 5 years. All patients with node-negative status(n = 2) survived for more than seven years.CONCLUSION This study showed that the long-term survival is possible for patients with LARCC if RHCPD is performed successfully, particularly in those with node-negative status.

Laparoscopic vs open extended right hemicolectomy for colon cancer

AIM:To evaluate the feasibility,safety,and oncologic outcomes of laparoscopic extended right hemicolectomy(LERH)for colon cancer.METHODS:Since its establishment in 2009,the Southern Chinese Laparoscopic Colorectal Surgical Study(SCLCSS)group has been dedicated to promoting patients’quality of life through minimally invasive surgery.The multicenter database was launched by combining existing datasets from members of the SCLCSS group.The study enrolled 220 consecutive patients who were recorded in the multicenter retrospective database and underwent either LERH(n=119)or open extended right hemicolectomy(OERH)(n=101)for colon cancer.Clinical characteristics,surgical outcomes,and oncologic outcomes were compared between the two groups.RESULTS:There were no significant differences in terms of age,gender,body mass index(BMI),history of previous abdominal surgery,tumor location,and tumor stage between the two groups.The blood loss was lower in the LERH group than in the OERH group[100(100-200)mL vs 150(100-200)mL,P<0.0001].The LERH group was associated with earlier first flatus(2.7±1.0 d vs 3.2±0.9 d,P<0.0001)and resumption of liquid diet(3.6±1.0 d vs 4.2±1.0 d,P<0.0001)compared to the OERH group.The postoperative hospital stay was significantly shorter in the LERH group(11.4±4.7 d vs 12.8±5.6 d,P=0.009)than in the OERH group.The complication rate was 11.8%and17.6%in the LERH and OERH groups,respectively(P=0.215).Both 3-year overall survival[LERH(92.0%)vs OERH(84.4%),P=0.209]and 3-year disease-free survival[LERH(84.6%)vs OERH(76.6%),P=0.191]were comparable between the two groups.CONCLUSION:LERH with D3 lymphadenectomy for colon cancer is a technically feasible and safe procedure,yielding comparable short-term oncologic outcomes to those of open surgery.

Pure transvaginal natural orifice transluminal endoscopic surgery right hemicolectomy for colon cancer:A case report

BACKGROUND Pure natural orifice transluminal endoscopic surgery(NOTES)for colorectal cancer is a complex procedure and rarely used in clinical practice because of the ethical concerns and technical challenges,including loss of triangulation,in-line orientation,and instrument collision.Transvaginal(v)NOTES,however,can overcome these technical challenges.We report a case of pure vNOTES right hemicolectomy for colon cancer,attached with surgical video.CASE SUMMARY A 65-year-old woman with a 2-year history of intermittent diarrhea was diagnosed with ascending colon adenocarcinoma by colonoscopy and biopsy.Pure vNOTES right hemicolectomy was performed with complete mesocolic excision by well-experienced surgeons.The operative time was 200 min and the estimated blood loss was 30 mL.No intraoperative or postoperative complications occurred within 30 d after the surgery.The visual analog scale pain score on postoperative day 1 was 1 and dropped to 0 on postoperative days 2 and 3.The patient was discharged at postoperative day 6.The pathologic specimen had sufficient clear resection margins and 14 negative harvested lymph nodes.CONCLUSION vNOTES right hemicolectomy,performed by well-experienced surgeons,overcomes the technical challenges of pure NOTES and may be feasible for colon cancer.

Does cranial-medial mixed dominant approach have a unique advantage for laparoscopic right hemicolectomy with complete mesocolic excision?

BACKGROUND Complete mesocolic excision(CME)with central vascular ligation(CVL)was proposed by Hohenberger in 2009.The CME principle has gradually become the technical standard for colon cancer surgery.How to achieve CME with CVL in laparoscopic right hemicolectomy(LRH)is controversial,and a unified standard approach is not yet available.In recent years,the authors’team has integrated the theory of membrane anatomy,tried to combine the cephalic approach with the classic medial approach(MA)for technical optimization,and proposed a cranialmedial mixed dominant approach(CMA).AIM To explore the feasibility of operational approaches for LRH with CME.METHODS In this retrospective cohort study,the clinical data of 57 patients with right-sided colon cancer(TNM stage I,II,or III)who underwent LRH with CME from January 2016 to June 2020 were collected and summarized.There were 31 patients in the traditional MA group and 26 in the CMA group.RESULTS There were no significant differences in baseline data between the two groups.The operation was shorter and the number of lymph nodes dissected was higher in the CMA group than in the MA group,but there was no significant difference in the number of positive lymph nodes,intraoperative blood loss,postoperative exhaust time,feeding time,postoperative hospital stay or postoperative complication incidence.CONCLUSION Our study shows that the CMA is a safe and feasible procedure for LRH with CME and has a unique advantage.

Open versus laparoscopic right hemicolectomy in the elderly population

AIM:To compare short term outcomes of elective laparoscopic and open right hemicolectomy(RH) in an elderly population.METHODS:All patients over the age of 70 undergoing elective RH at Ninewells Hospital and Perth Royal Infirmary between January 2006 and May 2011 were included in our analysis.Operative details,hospital length of stay,morbidity and mortality was collected by way of proforma from a dedicated prospective database.An extracorporeal anastomosis was performed routinely in the laparoscopic group.The primary endpoints for analysis were morbidity and mortality.Our secondary endpoints were operative duration,length of hospital stay and discharge destination.RESULTS:Two hundred and six patients were included in our analysis.One hundred and twenty-five patients underwent an open resection and 81 patients had a laparoscopic resection.The mean operating time was significantly longer in the laparoscopic group(139 ± 36 min vs 197 ± 53 min,P = 0.001).The mean length of hospital stay was similar in both groups(11.2 ± 7.8 d vs 9.6 ± 10.7 d,P = 0.28).The incidence of postoperative morbidities was 27% in the open group and 38% in the laparoscopic group(P = 0.12).Overall inhospital mortality was 0.8% in open procedures vs 1% in laparoscopic.CONCLUSION:Laparoscopic RH was associated with a significantly longer operative time compared to open RH.In our study,laparoscopic RH was not associated with reduced post-operative morbidity or significantly shorter length of hospital stay.

Comparison Study between Extracorporeal and Intracorporeal Anastomosis for Laparoscopic Right Hemicolectomy

Background: Nowadays, laparoscopic colectomy is considered a safe and effective surgical technique regarding short- and long-term outcomes, as well as specific oncologic outcomes. The anastomosis can be created intra- or extracorporeally. The goal of our study was to evaluate and compare short term outcomes of extra- and intra-corporeal anastomosis after laparoscopic right hemi colectomies. Aim of the Study: The goal of our study was to evaluate and compare short term outcomes of extra- and intra-corporeal anastomosis after laparoscopic right hemi colectomies. Methods: In the period from December 2014 to January 2019, all patients underwent laparoscopic right hemicolectomy for cancer colon who presented to surgical oncology department—south Egypt cancer institute and general surgery department—Assiut University was analyzed. Data like age, sex, body mass index (BMI), operative technique, operative times, blood loss, intra- and post-operative complications, pathology and hospital stay were reported and analyzed. Results: Twenty three (69.7%) patients underwent extracorporeal anastomosis while intracorporeal anastomosis was performed in ten (30.3%) patients. There was no significant difference in patient characteristics and demographic data in both groups (P > 0.05). There was no statistically significant difference in operative (operative time, blood loss or length of hospital stay) and postoperative (ileus, anastomotic leak, wound infection, incisional hernia, readmission, reoperation or deaths) details in the 2 groups except in length of the incision which was significantly shorter in the IA group (5.500 ± 1.269) vs. (6.565 ± 1.308) for EA (P = 0.015). Conclusion: No significant difference in short term outcomes of laparoscopic-assisted and total laparoscopic right colectomy. Intracorporeal anastomosis had shorter incision which may decrease wound-related complications.

腹腔镜右半结肠切除同期行肝方叶转移癌切除1例

目的分析腹腔镜下同期治疗结肠癌及其肝转移的过程,探讨腹腔镜同期手术在治疗结肠癌肝转移中的作用。方法回顾性分析2023年3月安徽医科大学第一附属医院1例结肠癌伴肝方叶转移患者的临床资料,同期行混合入路腹腔镜右半结肠切除、Glisson蒂横断法肝方叶转移癌切除。结果RO切除右半结肠及肝转移癌,术中出血量约50 mL,第4天拔引流管,无并发症,顺利出院。病理结果:结肠溃疡型低分化腺癌,肠周(12/21)个淋巴结有癌转移,低分化肝转移癌。结论腹腔镜同期行右半结肠切除和肝转移癌切除的治疗安全可行,采用新的手术路径和操作模式可保证手术安全,值得推广。

Risk factors for the prognosis of colon cancer

A study on clinical outcomes and prognostic factors in T4N0M0 colon cancer patients after R0 resection revealed that ileostomy,T stage,right hemicolectomy,irregular follow-up,and CA199 level were independent risk factors affecting overall survival.T4-stage cancer invades the entire thickness of the intestinal tract,increasing the difficulty of treatment and the risk of recurrence,and requires a combination of chemotherapy,immunotherapy,and targeted therapy to control the spread of cancer cells.The prognosis of right hemicolectomy is significantly worse than that of left hemicolectomy,and right hemicolectomy is an independent risk factor for a poor prognosis.Advanced age,histopathological type,and lymph node metastasis are also risk factors for colon cancer.

Laparoscopic right radical hemicolectomy: Central vascular ligation and complete mesocolon excision vs D3 lymphadenectomy - How I do it?

In colon cancer surgery,ensuring the complete removal of the primary tumor and draining lymph nodes is crucial.Lymphatic drainage in the colon follows the vascular supply,typically progressing from pericolic to paraaortic lymph nodes.While NCCN guidelines recommend the removal of 10-12 lymph nodes for ade-quate oncological resection,achieving complete oncological resection involves more than just meeting these numerical targets.Various techniques have been developed and studied over time to attain optimal oncological outcomes.A key technique central to this goal is identifying the ileocolic vessels at their origin from the superior mesenteric vessels.Complete excision of the visceral and parietal mesocolon ensures the intact removal of the specimen,while D3 lymphade-nectomy targets all draining regional lymph nodes.Although these principles emphasize different aspects,they ultimately converge to achieve the same goal of complete oncological resection.This article aims to simplify the surgical steps that align with the principle of central vascular ligation and mesocolon mobilization while ensuring adequate D3 dissection.

Robotic vs laparoscopic right colectomy—the burden of age and comorbidity in perioperative outcomes: An observational study

BACKGROUND Several studies have shown the safety,feasibility and oncologic adequacy of robotic right hemicolectomy(RRH).Laparoscopic right hemicolectomy(LRH)is considered technically challenging.Robotic surgery has been introduced to overcome this technical limitation,but it is related to high costs.To maximize the benefits of such surgery,only selected patients are candidates for this technique.In addition,due to progressive aging of the population,an increasing number of minimally invasive procedures are performed on elderly patients with severe comorbidities,who are usually more prone to post-operative complications.AIM To investigate the outcomes of RRH vs LRH with regard to age and comorbidities.METHODS We retrospectively analyzed 123 minimally invasive procedures(68 LRHs vs 55 RRHs)for right colon cancer or endoscopically unresectable adenoma performed in our Center from January 2014 until September 2019.The surgical procedures were performed according to standardized techniques.The primary clinical outcome of the study was the length of hospital stay(LOS)measured in days.Secondary outcomes were time to first flatus(TFF)and time to first stool evacuation.The robotic technique was considered the exposure and the laparoscopic technique was considered the control.Routine demographic variables were obtained,including age at time of surgery and gender.Body mass index and American Society of Anesthesiologists physical status were registered.The age-adjusted Charlson Comorbidity Index(ACCI)was calculated;the tumornode-metastasis system,intra-operative variables and post-operative complications were recorded.Post-operative follow-up was 180 d.RESULTS LOS,TFF,and time to first stool were significantly shorter in the robotic group:Median 6[interquartile range(IQR)5-8]vs 7(IQR 6-10.5)d,P=0.028;median 2(IQR 1-3)vs 3(IQR 2-4)d,P<0.001;median 4(IQR 3-5)vs 5(IQR 4-6.5)d,P=0.005,respectively.Following multivariable analysis,the robotic technique was confirmed to be predictive of significantly shorter hospitalization and faster restoration of bowel function;in addition the dichotomous variables of age over75 years and ACCI more than 7 were significant predictors of hospital stay.No outcomes were significantly associated with Clavien-Dindo grading.Sub-group analysis demonstrated that patients aged over 75 years had a longer LOS(median6-IQR 5-8-vs 7-IQR 6-12-d,P=0.013)and later TFF(median 2-IQR 1-3-vs 3-IQR 2-4-d,P=0.008),while patients with ACCI more than 7 were only associated with a prolonged hospital stay(median 7-IQR 5-8-vs 7-IQR 6-14.5-d,P=0.036).CONCLUSION RRH is related to shorter LOS when compared with the laparoscopic approach,but older age and several comorbidities tend to reduce its benefits.

腹腔镜下右半结肠根治性切除术对结肠癌患者胃肠功能、复发转移及生存情况的影响

目的 探讨腹腔镜下右半结肠根治性切除术对结肠癌患者胃肠功能、复发转移及生存情况的影响。方法 根据手术方式的不同将107例右半结肠癌患者分为研究组(n=55)和对照组(n=52),研究组患者接受腹腔镜下右半结肠根治性切除术,对照组患者接受常规开腹手术。比较两组患者的手术相关指标、胃肠功能恢复指标、复发转移情况、生存情况及并发症发生情况。结果 研究组患者的手术时间明显长于对照组,术中出血量明显少于对照组,住院时间明显短于对照组,差异均有统计学意义(P﹤0.01)。研究组患者肠鸣音恢复时间、首次排气时间、恢复进食时间均明显短于对照组,差异均有统计学意义(P﹤0.01)。两组患者1、3、5年复发转移率及生存率比较,差异均无统计学意义(P﹥0.05)。研究组患者的并发症总发生率低于对照组(P﹤0.05)。结论 腹腔镜下右半结肠根治性切除术治疗结肠癌疗效显著,能够有效促进患者胃肠功能恢复,且安全性较高,值得临床推广应用。

完全腹腔镜右半结肠切除术联合腹腔热灌注化疗后延迟性肠麻痹危险因素分析与风险预测模型构建

目的 探讨结肠癌患者行完全腹腔镜右半结肠切除术联合腹腔热灌注化疗后延迟性术后肠麻痹(Prolonged postoperative ileus, PPOI)的危险因素并建立风险预测模型。方法 回顾性分析2018年1月—2022年1月在解放军总医院第一医学中心普通外科医学部行完全腹腔镜右半结肠切除术联合腹腔热灌注化疗的83例结肠癌患者的病例资料,统计PPOI的发生情况,分析其危险因素,并构建列线图风险预测模型及进行效能验证。结果 83例患者中有26例(31.3%)发生PPOI。多因素logistic回归分析结果显示,合并糖尿病(OR=14.820,95%CI:2.819~77.918)、既往腹部手术史(OR=6.514,95%CI:1.433~29.604)、术前血红蛋白<9 g/L(OR=5.338,95%CI:1.197~23.809)、术中出血超过200 mL(OR=4.869,95%CI:1.213~19.544)以及未关闭系膜裂孔(OR=5.462,95%CI:1.408~21.186)为PPOI发生的独立危险因素。依据多因素分析结果构建ROC曲线及PPOI列线图风险预测模型,内部验证一致性指数(C-index)为0.85(95%CI:0.735~0.957)。结论 合并糖尿病、既往腹部手术史、术前血红蛋白<9 g/L、术中出血超过200 mL以及未关闭系膜裂孔是完全腹腔镜右半结肠切除术联合腹腔热灌注化疗后发生PPOI的危险因素。构建的完全腹腔镜右半结肠切除术后发生PPOI的列线图风险预测模型具有良好的评价效果和临床应用价值。

腹腔镜CME手术与开腹CME手术在根治性右半结肠癌中的近期和远期疗效比较

目的探讨腹腔镜全结肠系膜切除(CME)手术与开腹CME手术在根治性右半结肠癌中的近期和远期疗效差异。方法选取本院2017年1月—2018年8月收治的右半结肠癌患者84例,采用随机数字表法分为微创组(42例)和开腹组(42例)。微创组给予腹腔镜CME手术治疗,开腹组给予开腹CME手术治疗,比较2组患者手术相关指标(术中出血量、手术时间、淋巴结清扫数量、术后进食时间、术后排气时间)、应激反应相关指标[促肾上腺皮质激素(ACTH)、皮质醇(COR)、肾上腺素(E)]、术后并发症、术后生存率及复发率、术后生活质量。结果微创组术后进食时间、术后排气时间短于开腹组,术中出血量均少于开腹组,差异有统计学意义(P<0.05)。术后,2组患者ACTH、COR、E水平升高,但微创组低于开腹组,差异均有统计学意义(P<0.05)。微创组术后并发症发生率为4.76%,低于开腹组的23.81%,差异有统计学意义(P<0.05)。微创组术后1年生存率、3年生存率及3年复发率分别为97.62%、83.33%、19.05%,开腹组1年生存率、3年生存率及3年复发率分别为95.24%、80.95%、21.43%,组间差异无统计学意义(P>0.05)。术后6个月及术后12个月,2组患者生活质量评分升高,且微创组高于开腹组,差异均有统计学意义(P<0.05)。结论腹腔镜下CME手术与开腹CME手术远期预后均较好,但腹腔镜下CME术后应激反应轻,恢复快,且并发症少,可优先选择。

主刀中间站位改良五孔法在腹腔镜下右半结肠切除术的效果

目的研究主刀中间站位改良五孔法对比常规五孔法在腹腔镜下右半结肠切除术的临床疗效。方法回顾性分析2018年11月至2021年11月于南昌大学第二附属医院72例接受腹腔镜辅助右半结肠癌根治术患者的临床资料。其中观察组(33例)采用主刀中间站位改良五孔法腹腔镜手术,对照组(39例)采用常规五孔法腹腔镜手术,均为同一主刀医师手术。比较2组患者围手术期相关指标(手术时间、术中出血量、清扫淋巴结数、术后首次通气时间、住院时间)和2组术后并发症(切口感染、吻合口瘘、肠梗阻、肺部感染)及术后1年复发或转移情况。结果72例患者手术均顺利完成,无中转开腹,术后均痊愈出院。观察组手术时间、术中出血量少于对照组,清扫淋巴结数多于对照组(P<0.05);2组首次排气时间、住院时间比较差异无统计学意义(P>0.05)。2组患者术后切口感染、吻合口瘘、肠梗阻发生率比较差异无统计学意义(P>0.05);观察组肺部感染和并发症总发生率低于对照组(P<0.05)。排外术后病理分期为Ⅳ期患者后,观察组病例数29例,对照组32例。术后随访1年,观察组出现肝转移1例[3.45%(1/29)],对照组出现转移3例[9.38%(3/32),其中肝转移2例,网膜/腹壁种植转移1例],2组比较差异无统计学意义(P>0.05)。结论在腹腔镜辅助右半结肠癌根治性切除术中,相比常规五孔法,改良五孔法临床疗效及安全性均更优。

尾内侧入路联合中间翻页式淋巴结清扫在腹腔镜右半结肠癌根治术中的临床应用

目的探讨尾内侧入路联合中间翻页式淋巴结清扫在腹腔镜右半结肠癌根治术中的应用价值。方法2019年5月~2020年5月我院收治的右半结肠癌病人86例,以随机抽签法的方式将其分为观察组(43例)和对照组(43例),对照组采用中间入路法,观察组采用尾内侧入路联合中间翻页式清扫。比较两组病人的手术恢复指标、并发症发生率、血清肿瘤标志物水平、生存指标,以评估临床疗效及安全性。结果两组淋巴结清扫数量、切除肠管长度、拔管进流食及住院时间、术后并发症方面比较,差异无统计学意义(P>0.05),观察组手术时间和术中出血量明显较低,且术后排气时间较短,差异有统计学意义(P<0.05),1年后两组的血清糖类抗原19⁃9、癌胚抗原水平均有所下降,且观察组血清糖类抗原19⁃9、癌胚抗原水平低于对照组,差异有统计学意义(P<0.05);观察组的无疾病进展期延长(P<0.05),生存期比较,差异无统计学意义(P>0.05)。结论尾内侧入路联合中间翻页式淋巴结清扫在腹腔镜右半结肠癌根治术中,有利于缩短手术时间和术后排气时间,降低术中出血量和术后血清糖类抗原19⁃9、癌胚抗原水平,同时也提高了无疾病进展期,具有较高的安全性。

阑尾腺癌5例临床诊疗分析

目的 探讨阑尾腺癌的临床特点及诊治原则。方法 回顾性分析2010年1月至2020年12月华中科技大学同济医学院附属协和医院收治的5例阑尾腺癌病人的临床资料。结果 5例病人中有3例初诊为急性阑尾炎,一期行阑尾切除术,二期行右半结肠根治术;2例术前诊断为回盲部占位性病变,肠镜取活检确诊为阑尾腺癌,一期行右半结肠根治术。5例病人中结肠型腺癌2例(中分化),黏液腺癌2例(中分化),杯状细胞腺癌1例(中分化)。结论 阑尾腺癌在临床上极为少见,缺乏特异性症状,术前诊断困难,术前CT和肠镜检查有助于确诊,右半结肠根治术是常规手术方式,对侵犯浆膜的肿瘤术中、术后可行腹腔热灌注化疗,术后应根据分期辅以化疗。