AIMTo compare survival and recurrence after laparoscopic liver resection (LLR) and laparoscopic radiofrequency ablation (LRFA) for the treatment of small hepatocellular carcinoma (HCC).METHODSBetween June 1, 2005 and ...AIMTo compare survival and recurrence after laparoscopic liver resection (LLR) and laparoscopic radiofrequency ablation (LRFA) for the treatment of small hepatocellular carcinoma (HCC).METHODSBetween June 1, 2005 and November 30, 2010, 46 patients (62.26 ± 8.55 years old; female/male: 12/34) treated for small HCC were enrolled following strict criteria. Patients with better liver function and larger tumors were referred for LLR (n = 24), while those with poorer liver function and multiple tumors were referred for LRFA (n = 22), and they were then followed for similar durations (44.74 ± 21.3 mo for LLR vs 40.27 ± 30.8 mo for LRFA).RESULTSThe LLR and LRFA groups were homogeneous with regard to age, sex, etiology of liver cirrhosis, and AFP levels. The overall survival (OS) and disease-free survival (DFS) probability was 0.354 and 0.260, respectively. A significantly higher OS was observed in the LLR group (LLR: 0.442; LRFA: 0.261; P = 0.048), whereas no statistical difference was found for DFS (LLR: 0.206; LRFA: 0.286; P = 0.205). In the LRFA group was treated a greater number of nodules (LLR: 1.41 ± 0.77; LRFA: 2.72 ± 1.54; P < 0.001). Cox regression analysis found the number of intraoperative HCC nodules as the unique variable statistically significant for OS (hazard ratio: 2.225; P < 0.001). The rank-hazard plot showed a steeper increase of relative hazard for intraoperative nodules > 2.CONCLUSIONOur preliminary results confirm the superiority of hepatic resection on thermoablation in the treatment of small HCC in selected patients, when both approaches are made laparoscopically. LLR showed better results compared to LRFA in terms of OS. These data need to be confirmed by further studies on a larger number of patients.展开更多
BACKGROUND Radiofrequency ablation(RFA)is an effective treatment for early-stage hepatocellular carcinoma(HCC).Although RFA is a relatively safe technique compared with surgery,several complications have been reported...BACKGROUND Radiofrequency ablation(RFA)is an effective treatment for early-stage hepatocellular carcinoma(HCC).Although RFA is a relatively safe technique compared with surgery,several complications have been reported to be following/accompanying this treatment.Delayed diaphragmatic hernia caused by RFA is rare;however,the best surgical approach for its treatment is uncertain.We present a case of laparoscopic repair of diaphragmatic hernia due to RFA.CASE SUMMARY An 80-year-old woman with segment VIII HCC was treated twice in 5 years with RFA;28 mo after the second RFA,the patient complained of right hypochondriac pain.Computed tomography revealed that the small intestine was incarcerated in the right thorax.The patient was diagnosed with diaphragmatic hernia and underwent laparoscopic repair by non-absorbable running sutures.The patient’s postoperative course was favorable,and the patient was discharged on postoperative day 12.The diaphragmatic hernia has not recurred 24 mo after surgery.CONCLUSION Laparoscopic treatment of iatrogenic diaphragmatic hernia is effective and minimally invasive.展开更多
Objective:To investigate the effects of laparoscopic hepatectomy and laparoscopic radiofrequency ablation on immune function, pain related indexes and liver function in patients with hepatocellular carcinoma.Methods: ...Objective:To investigate the effects of laparoscopic hepatectomy and laparoscopic radiofrequency ablation on immune function, pain related indexes and liver function in patients with hepatocellular carcinoma.Methods: Ninety-six patients with hepatocellular carcinoma were randomly divided into two groups: control group and observation group. The patients in the control group were treated with laparoscopic hepatectomy, and the patients in the observation group were treated with laparoscopic radiofrequency ablation. The immune function, pain index and liver function were compared between the two groups.Results:There was no significant difference in the levels of CD3+, CD4+, CD8+, CD4+/CD8+, COR, NE, CRP, ALT and AST in two groups before treatment. After treatment, the levels of CD3+, CD4+and CD4+/CD8+ in the observation group were significantly higher than those in the control group. The levels of CD8+, COR, NE, CRP, ALT and AST in the observation group were significantly lower than those in the control group.Conclusion: Compared with laparoscopic hepatectomy, laparoscopic radiofrequency ablation for hepatocellular carcinoma can improve the immune function and liver function, reduce pain, and has certain clinical value.展开更多
Hepatocellular carcinoma (HCC) is a cancer with increasing incidence in the USA and high mortality rate. HCC is often difficult to treat due to underlying comorbidities such as cirrhosis. However, the application of l...Hepatocellular carcinoma (HCC) is a cancer with increasing incidence in the USA and high mortality rate. HCC is often difficult to treat due to underlying comorbidities such as cirrhosis. However, the application of loco-regional thermal ablation using radio frequency (RF) and trans-arterial embolization with chemotherapy (TACE) or without (TAE) has shown promising results in the treatment of patients not amenable to surgical resection or liver transplantation. Conventionally, RF and TAE are performed in two separated sessions or two steps and often RF ablation is performed percutaneously. However, no consensus has been reached regarding the ideal interval between the two treatments. In this article, we discuss the feasibility and benefits of a single-step TAE in combination with laparoscopic RF ablation in one operative session. We also present a case where this procedure has been successfully performed demonstrating its feasibility. We suggest that the use of laparoscopic RF ablation in the same surgical session as TAE is feasible and potentially offers several advantages over the two-step process that is usually performed with embolization followed by percutaneous RF with a long time interval. In this article we discuss such advantages.展开更多
Objective： Three mainstream techniques-laparoscopic hepatectomy （LH）, percutaneous radiofrequency ablation （pRFA）, and open hepatectomy （OH）--were compared in this study, in terms of their efficacies in the tre...Objective： Three mainstream techniques-laparoscopic hepatectomy （LH）, percutaneous radiofrequency ablation （pRFA）, and open hepatectomy （OH）--were compared in this study, in terms of their efficacies in the treat- ment of small hepatocellular carcinoma （HCC）. Methods： A comparative study was performed within a total of 94 patients diagnosed with small HCC in our hospital from 2005 to 2010, who underwent LH （28）, RFA （33）, or OH （33）. They had either a single tumor lesion of less than 5 cm or up to three nodules with diameters of less than 3 cm each. Outcomes were carefully evaluated throughout a 3-year follow-up interval and statistically interpreted. Results： The pRFA group had a significantly lower disease-free survival rate compared with the two surgical groups （P=0.001） and significantly shorter overall survival （P=-0.005）, while the LH group and the OH group had no difference in survival results. For patients younger than 60 years old, surgical approaches offered a better long-term overall survival prognosis （P=0.008）. There were no statistically significant differences among the three groups in overall survival for elderly patients （P=0.104）. Conclusions： Among patients with small HCC, LH may provide better curative effects than pRFA without increasing complication rates, pRFA leads to faster recurrence than surgical resections. LH has similar therapeutic effects to OH and causes less trauma. For patients younger than 60 years old, LH may be the best curative treatment. Elderly patients may choose either surgery or pRFA.展开更多
Aim:The optimal treatment for hepatocellular carcinoma(HCC)is either surgical resection or liver transplantation,but only one-third of the patients are suitable candidates for surgery.Laparoscopic radiofrequency ablat...Aim:The optimal treatment for hepatocellular carcinoma(HCC)is either surgical resection or liver transplantation,but only one-third of the patients are suitable candidates for surgery.Laparoscopic radiofrequency ablation(RFA)in selected patients is a safe,feasible technique,which has proved to be superior to the percutaneous approach in patients with severe liver disease or in lesions in which the percutaneous approach is impossible.The aim of this study is to present our experience with laparoscopic RFA and demonstrate its safety as an alternative therapeutic procedure in selected patients with HCC.Methods:This is a retrospective study of patients with HCC who underwent laparoscopic RFA between March 2009 and December 2014.Results:Thirty-two patients with 37 tumors underwent laparoscopic RFA.Median tumor size was 2.24 cm(0.7-4.45 cm).Major complications occurred in 8 patients.Initial complete ablation was achieved in 94.6%(35/37)lesions and sustained complete ablation rate was 62.85%(22/35).Overall survival rates at 1-,2-,and 3-year were 89%,67.5%,and 40%,respectively.Conclusion:Laparoscopic RFA of HCC is safe and the long-term outcomes are similar to those achieved with liver resection.Further trials combining chemoembolization and RFA are needed to improve long-term outcomes and to limit local tumor progression.展开更多
目的探讨超声引导下射频消融术与腹腔镜肝部分切除术治疗小肝癌的疗效对比。方法回顾性分析2010年1月至2016年1月台州市立医院肝胆外科收治的小肝癌(直径≤3 cm)患者,根据治疗方法分为超声引导下射频消融组(A组,47例)与腹腔镜肝部分切除...目的探讨超声引导下射频消融术与腹腔镜肝部分切除术治疗小肝癌的疗效对比。方法回顾性分析2010年1月至2016年1月台州市立医院肝胆外科收治的小肝癌(直径≤3 cm)患者,根据治疗方法分为超声引导下射频消融组(A组,47例)与腹腔镜肝部分切除组(B组,36例),比较两组的手术时间、术中出血量、术后第1天疼痛评分、下床活动时间、进食时间、术后第2天AST和CRP水平,以及住院时间、住院费用、术后并发症发生情况。结果 A组手术时间[(29.1±12.3)min vs(127.5±29.6)min,P<0.001]、术中出血量[(5.3±2.1)mL vs (138.3±37.5)mL,P<0.001]、术后第1天疼痛评分[(0.9±0.3) vs (3.1±0.7),P=0.010]、下床活动时间[(0.7±0.2)d vs (2.3±0.9)d,P=0.021]、进食时间[(1.1±0.1)d vs (2.4±0.6)d,P=0.045]、住院时间[(7.3±2.4)d vs (12.3±3.7)d,P=0.012]和住院费用[(23 872.8±2 159.5)元 vs(31 563.7±3 547.6)元,P=0.033]优于B组;且并发症中胆瘘(2.1% vs 13.8%,P=0.040)和肝功能不全发生率(4.2% vs 19.4%,P=0.027)均低于B组。A组和B组术后1、3年总体生存率分别为90.0% vs 93.7%、72.5% vs 81.3%,差异无统计学意义(P>0.05)。结论在治疗直径≤3 cm的小肝癌时,超声引导下射频消融术比腹腔镜肝部分切除术围手术期恢复更快;两者总体治疗效果相当,可根据具体情况选择性应用。展开更多
目的探讨腹腔镜下射频消融术(LRFA)在肝癌患者中的临床应用价值及其对血清血管内皮生长因子(VEGF)和基质金属蛋白酶-2(MMP-2)的影响。方法收集2012年1月-2013年12月该院收治的晚期原发性肝癌患者120例,将患者随机分为LRFA组和对照组。L...目的探讨腹腔镜下射频消融术(LRFA)在肝癌患者中的临床应用价值及其对血清血管内皮生长因子(VEGF)和基质金属蛋白酶-2(MMP-2)的影响。方法收集2012年1月-2013年12月该院收治的晚期原发性肝癌患者120例,将患者随机分为LRFA组和对照组。LRFA组患者采用LRFA治疗后,继续采用FOLFOX4方案化疗;对照组仅采用PIAF方案化疗。主要观察指标为健康相关生存质量(HRQL)、实体瘤疗效评价(RECIST)等级、无进展生存期和2年死亡率;次要观察指标为血清VEGF和MMP-2水平。结果与对照组相比,LRFA组患者病情进展率明显降低(28.33%vs 50.00%,P=0.015);无进展生存期明显延长(500 d vs 380 d,P=0.013);临床干预后6个月时HRQL明显增高[(80.33±5.84)vs(65.87±9.59),P=0.000];临床干预后7、14和28天以及6个月时VEGF明显降低(P值均为0.000);临床干预后14和28天以及6个月时MMP-2明显降低(P值分别为0.003、0.001和0.000)。结论 LRFA明显改善了肝癌患者临床预后,并显著降低患者VEGF、MMP-2水平。展开更多
文摘AIMTo compare survival and recurrence after laparoscopic liver resection (LLR) and laparoscopic radiofrequency ablation (LRFA) for the treatment of small hepatocellular carcinoma (HCC).METHODSBetween June 1, 2005 and November 30, 2010, 46 patients (62.26 ± 8.55 years old; female/male: 12/34) treated for small HCC were enrolled following strict criteria. Patients with better liver function and larger tumors were referred for LLR (n = 24), while those with poorer liver function and multiple tumors were referred for LRFA (n = 22), and they were then followed for similar durations (44.74 ± 21.3 mo for LLR vs 40.27 ± 30.8 mo for LRFA).RESULTSThe LLR and LRFA groups were homogeneous with regard to age, sex, etiology of liver cirrhosis, and AFP levels. The overall survival (OS) and disease-free survival (DFS) probability was 0.354 and 0.260, respectively. A significantly higher OS was observed in the LLR group (LLR: 0.442; LRFA: 0.261; P = 0.048), whereas no statistical difference was found for DFS (LLR: 0.206; LRFA: 0.286; P = 0.205). In the LRFA group was treated a greater number of nodules (LLR: 1.41 ± 0.77; LRFA: 2.72 ± 1.54; P < 0.001). Cox regression analysis found the number of intraoperative HCC nodules as the unique variable statistically significant for OS (hazard ratio: 2.225; P < 0.001). The rank-hazard plot showed a steeper increase of relative hazard for intraoperative nodules > 2.CONCLUSIONOur preliminary results confirm the superiority of hepatic resection on thermoablation in the treatment of small HCC in selected patients, when both approaches are made laparoscopically. LLR showed better results compared to LRFA in terms of OS. These data need to be confirmed by further studies on a larger number of patients.
文摘BACKGROUND Radiofrequency ablation(RFA)is an effective treatment for early-stage hepatocellular carcinoma(HCC).Although RFA is a relatively safe technique compared with surgery,several complications have been reported to be following/accompanying this treatment.Delayed diaphragmatic hernia caused by RFA is rare;however,the best surgical approach for its treatment is uncertain.We present a case of laparoscopic repair of diaphragmatic hernia due to RFA.CASE SUMMARY An 80-year-old woman with segment VIII HCC was treated twice in 5 years with RFA;28 mo after the second RFA,the patient complained of right hypochondriac pain.Computed tomography revealed that the small intestine was incarcerated in the right thorax.The patient was diagnosed with diaphragmatic hernia and underwent laparoscopic repair by non-absorbable running sutures.The patient’s postoperative course was favorable,and the patient was discharged on postoperative day 12.The diaphragmatic hernia has not recurred 24 mo after surgery.CONCLUSION Laparoscopic treatment of iatrogenic diaphragmatic hernia is effective and minimally invasive.
文摘Objective:To investigate the effects of laparoscopic hepatectomy and laparoscopic radiofrequency ablation on immune function, pain related indexes and liver function in patients with hepatocellular carcinoma.Methods: Ninety-six patients with hepatocellular carcinoma were randomly divided into two groups: control group and observation group. The patients in the control group were treated with laparoscopic hepatectomy, and the patients in the observation group were treated with laparoscopic radiofrequency ablation. The immune function, pain index and liver function were compared between the two groups.Results:There was no significant difference in the levels of CD3+, CD4+, CD8+, CD4+/CD8+, COR, NE, CRP, ALT and AST in two groups before treatment. After treatment, the levels of CD3+, CD4+and CD4+/CD8+ in the observation group were significantly higher than those in the control group. The levels of CD8+, COR, NE, CRP, ALT and AST in the observation group were significantly lower than those in the control group.Conclusion: Compared with laparoscopic hepatectomy, laparoscopic radiofrequency ablation for hepatocellular carcinoma can improve the immune function and liver function, reduce pain, and has certain clinical value.
文摘Hepatocellular carcinoma (HCC) is a cancer with increasing incidence in the USA and high mortality rate. HCC is often difficult to treat due to underlying comorbidities such as cirrhosis. However, the application of loco-regional thermal ablation using radio frequency (RF) and trans-arterial embolization with chemotherapy (TACE) or without (TAE) has shown promising results in the treatment of patients not amenable to surgical resection or liver transplantation. Conventionally, RF and TAE are performed in two separated sessions or two steps and often RF ablation is performed percutaneously. However, no consensus has been reached regarding the ideal interval between the two treatments. In this article, we discuss the feasibility and benefits of a single-step TAE in combination with laparoscopic RF ablation in one operative session. We also present a case where this procedure has been successfully performed demonstrating its feasibility. We suggest that the use of laparoscopic RF ablation in the same surgical session as TAE is feasible and potentially offers several advantages over the two-step process that is usually performed with embolization followed by percutaneous RF with a long time interval. In this article we discuss such advantages.
文摘Objective： Three mainstream techniques-laparoscopic hepatectomy （LH）, percutaneous radiofrequency ablation （pRFA）, and open hepatectomy （OH）--were compared in this study, in terms of their efficacies in the treat- ment of small hepatocellular carcinoma （HCC）. Methods： A comparative study was performed within a total of 94 patients diagnosed with small HCC in our hospital from 2005 to 2010, who underwent LH （28）, RFA （33）, or OH （33）. They had either a single tumor lesion of less than 5 cm or up to three nodules with diameters of less than 3 cm each. Outcomes were carefully evaluated throughout a 3-year follow-up interval and statistically interpreted. Results： The pRFA group had a significantly lower disease-free survival rate compared with the two surgical groups （P=0.001） and significantly shorter overall survival （P=-0.005）, while the LH group and the OH group had no difference in survival results. For patients younger than 60 years old, surgical approaches offered a better long-term overall survival prognosis （P=0.008）. There were no statistically significant differences among the three groups in overall survival for elderly patients （P=0.104）. Conclusions： Among patients with small HCC, LH may provide better curative effects than pRFA without increasing complication rates, pRFA leads to faster recurrence than surgical resections. LH has similar therapeutic effects to OH and causes less trauma. For patients younger than 60 years old, LH may be the best curative treatment. Elderly patients may choose either surgery or pRFA.
文摘Aim:The optimal treatment for hepatocellular carcinoma(HCC)is either surgical resection or liver transplantation,but only one-third of the patients are suitable candidates for surgery.Laparoscopic radiofrequency ablation(RFA)in selected patients is a safe,feasible technique,which has proved to be superior to the percutaneous approach in patients with severe liver disease or in lesions in which the percutaneous approach is impossible.The aim of this study is to present our experience with laparoscopic RFA and demonstrate its safety as an alternative therapeutic procedure in selected patients with HCC.Methods:This is a retrospective study of patients with HCC who underwent laparoscopic RFA between March 2009 and December 2014.Results:Thirty-two patients with 37 tumors underwent laparoscopic RFA.Median tumor size was 2.24 cm(0.7-4.45 cm).Major complications occurred in 8 patients.Initial complete ablation was achieved in 94.6%(35/37)lesions and sustained complete ablation rate was 62.85%(22/35).Overall survival rates at 1-,2-,and 3-year were 89%,67.5%,and 40%,respectively.Conclusion:Laparoscopic RFA of HCC is safe and the long-term outcomes are similar to those achieved with liver resection.Further trials combining chemoembolization and RFA are needed to improve long-term outcomes and to limit local tumor progression.
文摘目的探讨超声引导下射频消融术与腹腔镜肝部分切除术治疗小肝癌的疗效对比。方法回顾性分析2010年1月至2016年1月台州市立医院肝胆外科收治的小肝癌(直径≤3 cm)患者,根据治疗方法分为超声引导下射频消融组(A组,47例)与腹腔镜肝部分切除组(B组,36例),比较两组的手术时间、术中出血量、术后第1天疼痛评分、下床活动时间、进食时间、术后第2天AST和CRP水平,以及住院时间、住院费用、术后并发症发生情况。结果 A组手术时间[(29.1±12.3)min vs(127.5±29.6)min,P<0.001]、术中出血量[(5.3±2.1)mL vs (138.3±37.5)mL,P<0.001]、术后第1天疼痛评分[(0.9±0.3) vs (3.1±0.7),P=0.010]、下床活动时间[(0.7±0.2)d vs (2.3±0.9)d,P=0.021]、进食时间[(1.1±0.1)d vs (2.4±0.6)d,P=0.045]、住院时间[(7.3±2.4)d vs (12.3±3.7)d,P=0.012]和住院费用[(23 872.8±2 159.5)元 vs(31 563.7±3 547.6)元,P=0.033]优于B组;且并发症中胆瘘(2.1% vs 13.8%,P=0.040)和肝功能不全发生率(4.2% vs 19.4%,P=0.027)均低于B组。A组和B组术后1、3年总体生存率分别为90.0% vs 93.7%、72.5% vs 81.3%,差异无统计学意义(P>0.05)。结论在治疗直径≤3 cm的小肝癌时,超声引导下射频消融术比腹腔镜肝部分切除术围手术期恢复更快;两者总体治疗效果相当,可根据具体情况选择性应用。
文摘目的探讨腹腔镜下射频消融术(LRFA)在肝癌患者中的临床应用价值及其对血清血管内皮生长因子(VEGF)和基质金属蛋白酶-2(MMP-2)的影响。方法收集2012年1月-2013年12月该院收治的晚期原发性肝癌患者120例,将患者随机分为LRFA组和对照组。LRFA组患者采用LRFA治疗后,继续采用FOLFOX4方案化疗;对照组仅采用PIAF方案化疗。主要观察指标为健康相关生存质量(HRQL)、实体瘤疗效评价(RECIST)等级、无进展生存期和2年死亡率;次要观察指标为血清VEGF和MMP-2水平。结果与对照组相比,LRFA组患者病情进展率明显降低(28.33%vs 50.00%,P=0.015);无进展生存期明显延长(500 d vs 380 d,P=0.013);临床干预后6个月时HRQL明显增高[(80.33±5.84)vs(65.87±9.59),P=0.000];临床干预后7、14和28天以及6个月时VEGF明显降低(P值均为0.000);临床干预后14和28天以及6个月时MMP-2明显降低(P值分别为0.003、0.001和0.000)。结论 LRFA明显改善了肝癌患者临床预后,并显著降低患者VEGF、MMP-2水平。
