Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconi...Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22. 5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22. 5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation. Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine.There was significant difference between group A and B in the above two parameters, P < 0. 01 and P < 0. 05. The analgesia maintenance time of a single injection was morphine > LB > lappaconitine > bupivacaine, that of group D was significantly longer than that of group A (P < 0. 01 ). Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.展开更多
This paper studied the effect and side-effect of epidural injected Lappaconitine (LC) for post-operative analgesia. 50 patients who were operated in the upper abdomen with epidural anesthesia, wererandomly divided int...This paper studied the effect and side-effect of epidural injected Lappaconitine (LC) for post-operative analgesia. 50 patients who were operated in the upper abdomen with epidural anesthesia, wererandomly divided into 5 groups. The general condition of each group was similar. Group A, B , C was given LC4mg, 8mg, 12mg respectively for observation. Group D, E was given 0.9% NS 6ml and morphine 2mg indi-vidually as control. When the operation was finished, LC was injected into the epidural space with singleblind method. The result showed the analgesia of LC and its effective time was: group E >C > B >A > D . Theanalgesic effect of group C was satistactory. The efficacy and the maintenance time of A, B, C groups weresignificantly different from that of group D ( P < 0. 05 , P < 0 . 01 ) . Although the effect ot group C was less po-tent than that of group E ( morphine injection) , there was no side-effect like that of morphine. It suggestedthat epidural injected LC for post-operative analgesia is effective and safe.展开更多
目的观察硬膜外腔注射吗啡施行超前镇痛对硬膜外麻醉效果的影响。方法60例妇科手术病人于硬膜外麻醉后随机分为两组:Ⅰ组(n=30)于切皮前10 m in经硬膜外腔注入局麻药5 m l+吗啡3 mg+氟哌啶2 mg,以施行吗啡超前镇痛;Ⅱ组(n=30)仅注入局麻...目的观察硬膜外腔注射吗啡施行超前镇痛对硬膜外麻醉效果的影响。方法60例妇科手术病人于硬膜外麻醉后随机分为两组:Ⅰ组(n=30)于切皮前10 m in经硬膜外腔注入局麻药5 m l+吗啡3 mg+氟哌啶2 mg,以施行吗啡超前镇痛;Ⅱ组(n=30)仅注入局麻药5 m l。观察术中镇痛效果、腹壁肌松弛质量以及不良反应。结果Ⅰ组的硬膜外麻醉效果优于Ⅱ组(P<0.05),两组肌松效果和不良反应差异则无统计学意义。结论切皮前10 m in经硬膜外腔注射吗啡施行超前镇痛,可有效增强硬膜外麻醉效果。展开更多
文摘Objective:The effect and side-effect of epidural injection with lappaconitine compound for post-operative analgesia was observed. Methods: One hundred and twenty patients were randomly divided into 4 groups. Lappaconitine compound (LB) consisted of 12 mg of lappaconitine and 22. 5 mg of bupivacaine, was used for the observed group, and lappaconitine 12 mg, bupivacaine 22. 5 mg and morphine 2 mg for the control group respectively, All were given by epidural injection with single blind method during post-operative pain of incision operation. Results: It was showed that the initiating of analgesia was earlier in LB and bupivacaine group than that in group B and D, and the efficacy was morphine group > LB > bupivacaine > lappaconitine.There was significant difference between group A and B in the above two parameters, P < 0. 01 and P < 0. 05. The analgesia maintenance time of a single injection was morphine > LB > lappaconitine > bupivacaine, that of group D was significantly longer than that of group A (P < 0. 01 ). Conclusions: It indicated that the epidural injection with LB was more rapid and potent than that with lappaconitine alone in post-operative analgesia. Besides, it had no side-effect and safer than morphine.
文摘This paper studied the effect and side-effect of epidural injected Lappaconitine (LC) for post-operative analgesia. 50 patients who were operated in the upper abdomen with epidural anesthesia, wererandomly divided into 5 groups. The general condition of each group was similar. Group A, B , C was given LC4mg, 8mg, 12mg respectively for observation. Group D, E was given 0.9% NS 6ml and morphine 2mg indi-vidually as control. When the operation was finished, LC was injected into the epidural space with singleblind method. The result showed the analgesia of LC and its effective time was: group E >C > B >A > D . Theanalgesic effect of group C was satistactory. The efficacy and the maintenance time of A, B, C groups weresignificantly different from that of group D ( P < 0. 05 , P < 0 . 01 ) . Although the effect ot group C was less po-tent than that of group E ( morphine injection) , there was no side-effect like that of morphine. It suggestedthat epidural injected LC for post-operative analgesia is effective and safe.
文摘目的观察硬膜外腔注射吗啡施行超前镇痛对硬膜外麻醉效果的影响。方法60例妇科手术病人于硬膜外麻醉后随机分为两组:Ⅰ组(n=30)于切皮前10 m in经硬膜外腔注入局麻药5 m l+吗啡3 mg+氟哌啶2 mg,以施行吗啡超前镇痛;Ⅱ组(n=30)仅注入局麻药5 m l。观察术中镇痛效果、腹壁肌松弛质量以及不良反应。结果Ⅰ组的硬膜外麻醉效果优于Ⅱ组(P<0.05),两组肌松效果和不良反应差异则无统计学意义。结论切皮前10 m in经硬膜外腔注射吗啡施行超前镇痛,可有效增强硬膜外麻醉效果。
