Long-term outcomes of laser dacryoplasty combined with intubation using a new silicon tube in patients with lacrimal duct obstruction

AIM:To determine the 15-year outcomes of laser dacryoplasty(LDP)in patients with lacrimal duct obstruction;and to evaluate LDP combined with intubation using a new silicone tube to treat complicated cases.METHODS:Patients with lacrimal duct obstruction and treated with LDP between April 2000 and April 2005 were investigated retrospectively.Totally 116 eyes with completed 15-year follow-up records were included in this study.For complicated cases(52 eyes of 52 patients),both LDP and intubation using a self-made silicon tube were performed.For patients with uncomplicated obstruction(64 eyes of 61 patients),only LDP was performed.Outcomes were assessed based on results of lacrimal irrigation and degree of symptoms during follow-up.RESULTS:At the follow-up time of 15y,81 eyes achieved full success(69.8%);21 eyes got improved(18.1%);and 14 eyes were considered failure(12.1%).The success rate was 71.2%(37/52 eyes)for complicated cases;and 68.8%(44/64 eyes)for uncomplicated cases.No statistically significant difference between two groups was observed(P=0.961).No postoperative complication was observed.CONCLUSION:LDP is a well-tolerated,simple,and effective procedure with satisfactory long-term outcomes in selected patients,which make it a good alternative to conventional dacryocystorhinostomy.In addition,intubation with the self-made mono-canalicular silicone tube facilitates the management of complicated cases with few complications.

Diagnosis and Treatment of Lacrimal Passage Obstruction by Lacrimal Endoscope

The diagnosis and treatment of the lacrimal passage obstruction with lacrimal endoscope was investigated and its subsidiary surgical procedures were evaluated. Ninety-three patients （109 eyes） with lacrimal passage obstruction, including presaccal canalicular obstruction （PSCO） and nasolacrimal duct obstruction （NLDO）, were examined under a lacrimal endoscope, and the obstruc- tions were treated with laser or micro-drill. All patients were followed up after the operation for 3--6 months. The difference between the laser and the micro-drill treatment was observed. During the period of follow-up, the curative rate was 82.57%. The healing rate in PSCO group and NLDO was 80.36% and 84.91% respectively （P〉0.05）. Alter treatment with the laser, the healing rate was 93.33% in the PSCO group and 66.67% in the NLDO group respectively （P〈0.05）. After treatment with the micro-drill, the healing rate in PSCO and NLDO groups was 65.39% and 94.28% respec- tively （P〈0.01）. The lacrimal passage obstruction can be observed and treated directly through the lacrimal endoscope. Choosing different surgical procedures in operation according to the locations of the obstruction is helpful to improve the effectiveness.

Effect of mitomycin combined with Nd-YAG laser on cell proliferation and invasion as well as MEK/ERK signaling pathway in obstructive lacrimal duct model

Objective: To study the effect of mitomycin (MMC) combined with Nd-YAG laser on cell proliferation and invasion as well as MEK/ERK signaling pathway in obstructive lacrimal duct model. Methods: New Zealand rabbits were selected as experimental animals and divided into model group, laser group and MMC + laser group;obstructive lacrimal duct model was established, then laser group were given Nd-YAG laser intervention, and MMC + laser group were given Nd-YAG laser combined with mitomycin intervention. 2 months after intervention, the expression of proliferation molecules, invasion molecules and MEK-ERK signaling molecules in lacrimal duct tissue were measured. Results: TGF-β, CTGF, PCNA, Ki-67, Col-I, Col-III, MEK, ERK1/2, MMP2 and MMP9 protein levels in lacrimal duct tissue of laser group were significantly higher than those of model group while TSG-6, Cthrc1 and TIMP1 protein levels were significantly lower than those of model group;TGF-β, CTGF, PCNA, Ki-67, Col-I, Col-III, MEK, ERK1/2, MMP2 and MMP9 protein levels in lacrimal duct tissue of MMC + laser group were significantly lower than those of laser group while TSG-6, Cthrc1 and TIMP1 protein levels were significantly higher than those of laser group. Conclusion:Mitomycin can inhibit cell proliferation and invasion as well as MEK/ERK signaling pathway activation in obstructive lacrimal duct model after Nd-YAG laser treatment.

Effects of medication methods after simple and effective probing of lacrimal passage

AIM:To evaluate the effect of reducing the use of antibiotics in the treatment of infant bacterial dacryocystitis after probing of the lacrimal duct.METHODS:A total of 542 cases of children under one year old and accepting nasolacrimal duct probing treatment were divided into two groups, which were treated with topical and oral antibiotics, respectively.Conjunctival sac secretions were used as a control index of bacterial infection, whereas the disappearance of epiphora symptoms and lacrimal passage patency were used as cure indexes. The χ2test was used to compare enumeration and measurement data, and a statistical significance was set at P 【0.05. The therapeutic effect on the two groups of postoperative patients was investigated.RESULTS:In the two study groups, no significant differences in gender, age and postoperative control of lacrimal sac infection were observed. The cure rates after three probing operations also showed no significant difference.CONCLUSION:After probing of the lacrimal passage,results of this study confirmed that postoperative medication without oral antibiotics but an ophthalmic dosage of antibiotics was a simple and effective treatment method.

A proteomics analysis for certain signature proteins of rabbit lacrimal passages after ^(125)I seeds brachytherapy

To search for certain signature proteins and the expression profiles in lacrimal passage stenosis,rabbit models of lacrimal passage stenosis were treated by 125I seed brachytherapy.All the signature proteins were separated by two-dimensional electrophoresis,and identified by mass spectrometry.The results show that the up-regulated proteins are peptidyl-prolyl cis-trans isomerase A(PPIase A),and epidermal fatty acid-binding protein(E-FABP),while the down-regulated proteins are myosin light chain 1(isomer of skeletal muscle),myosin light polypeptide 6(isomer 1 of smooth muscle and non-muscle),myosin light chain 1(isomer of slow-twitch muscle A),isomer 2 of ERC protein 2,and α-crystallin family protein.The proteins may play a role in healing the wound and regulating synaptic active zone of neurons due to correlation to cell apoptosis,proliferation and migration of smooth muscle cell.These provide molecular mechanism for preventing stenosis and restenosis of lacrimal passage.

Laser cooling with adiabatic passage for type-Ⅱ transitions

We extend the idea of laser cooling with adiabatic passage to multi-level type-Ⅱ transitions.We find the cooling force can be significantly enhanced when a proper magnetic field is applied.That is because the magnetic field decomposes the multi-level system into several two-level sub-systems,hence the stimulated absorption and stimulated emission can occur in order,allowing for the multiple photon momentum transfer.We show that this scheme also works on the laser-coolable molecules with a better cooling effect compared to the conventional Doppler cooling.A reduced dependence on spontaneous emission based on our scheme is observed as well.Our results suggest this scheme is very feasible for laser cooling of polar molecules.

正常泪囊在计算机断层扫描图像中的形态观察

目的探讨正常泪囊在计算机断层扫描图像中的形态及变化的原因。方法回顾性分析2020年9月至2021年1月安徽医科大学第一附属医院放射科提供的50例(100眼)来检人员头颅CT扫描图像资料,分别在软组织窗和肺窗观察其计算机断层扫描图像中泪囊的影像,根据泪囊类型和形态分为4组:泪囊空气充盈组(31眼)、泪囊空气半充盈组(20眼)、泪囊半封闭组(16眼)、泪囊全封闭组(33眼),比较各组泪囊形态的变化。结果泪囊空气充盈组软组织窗冠状位泪囊为空气密度影,肺窗轴位泪囊腔形状为椭圆形。泪囊空气半充盈组软组织窗冠状位泪囊为空气密度影,轴位上部泪囊形状为椭圆形,下部为弧形;肺窗轴位上部泪囊腔形状为椭圆形,下部为裂隙形。泪囊半封闭组软组织窗冠状位上部泪囊为空气密度影,下部为软组织密度影;肺窗轴位上部泪囊腔形状为椭圆形,下部泪囊腔消失。泪囊全封闭组软组织窗为软组织密度影,肺窗轴位泪囊腔消失。下部泪囊腔横截面由椭圆形变为裂隙形或消失可能原因是下部泪囊外侧壁向鼻侧移位;泪囊软组织密度影范围扩大,而空气密度影范围减少或消失可能原因是眶内软组织向鼻侧移位,正常泪囊CT图像中软组织密度影的来源是眶内软组织。结论正常泪囊的形态可能不是固定不变,而是在不停变化的过程中;眶内软组织压力可向鼻侧推动,进而改变下部泪囊形态。

Population transfer via adiabatic passage in the Rydberg potassium atom

Using the time-dependent multilevel approach, we have calculated the coherent population transfer between the quantum states of potassium atom by a single frequency-chirped laser pulse. The result shows that a pair of sequential ＇broadband＇ frequency-chirped laser pulses can efficiently transfer population from the initial state of the ladder system to the target state. It is also found that the population can be efficiently transferred to a target state and trapped there by using an ＇intuitive＇ or a ＇counterintuitive＇ frequency sweep laser pulse in the case of ＇narrowband＇ frequency-chirped laser pulse. Our research shows that the complete population transfer is related to the pulse duration, chirp rate, and amplitude of the laser pulse.

Nd:YAG泪道激光联合泪道引流管置入对泪道阻塞患者疗效及并发症的影响

目的:探讨Nd:YAG泪道激光联合泪道引流管置入对泪道阻塞患者疗效及并发症的影响。方法:选取2018年2月—2023年2月海安市中医院收治的102例泪道阻塞患者作为研究对象,采用随机数字表法分为对照组与观察组,各51例。对照组采用传统泪道重建手术治疗,观察组采用Nd:YAG泪道激光联合泪道引流管置入治疗,比较两组治疗总有效率、并发症发生率及眼表状态。结果:术后1个月,观察组治疗总效率显著高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率显著低于对照组,差异有统计学意义(P<0.05)。两组术前及术后2个月的泪液分泌量、泪膜破裂时间比较,差异均无统计学意义(P>0.05)。结论:对泪道阻塞患者行Nd:YAG泪道激光联合泪道引流管置入治疗,能够显著提高患者的治疗有效率,降低并发症的发生率,并且不影响眼表状态。

婴幼儿泪道阻塞实施泪道探通术的年龄段和并发症的关系分析

目的 分析婴幼儿泪道阻塞实施泪道探通术的年龄段和并发症的关系,探讨婴幼儿泪道探通术的合适时机。方法 回顾性分析诊断为泪道阻塞并在门诊表面麻醉下实施了泪道探通术的389例患儿(589只眼)的临床资料。记录患儿冲洗及探通术中及术后有无并发症发生,以及患儿发生的并发症类型和年龄。结果 本组实施了泪道探通术的389例患儿中发生并发症有54例,并发症发生率为13.88%。未发生窒息和吸入性肺炎等严重并发症。结论 婴幼儿泪道阻塞实施泪道探通术的并发症与年龄有关,其中5~7月龄患儿并发症较少,所以婴幼儿泪道探通术以5~7月龄进行为佳。由于小月龄患儿(≤3月龄)患儿神经系统、呼吸系统及吞咽功能没有发育完全,尤其是早产儿,对这个时期患儿尽可能采取保守治疗,因为泪道冲洗及探通时如果患儿吞咽不及时,可能发生呼吸道阻塞、吸入性肺炎,严重者可能引起患儿窒息、死亡等风险;对于大龄患儿(≥8月龄),患儿理解能力及身体素质变强壮,表面麻醉下患儿不容易制动并且更容易恐惧,行泪道冲洗时更加容易出现泪道的损伤,而且随着患儿年龄增大,泪道阻塞及粘连程度逐渐加重,泪道探通的成功率随着年龄增长逐渐下降。由于不同年龄段发生并发症的风险各不相同,在行泪道冲洗和泪道探通时要根据不同年龄段采取相应的预防措施,尽可能避免并发症的出现。

缝线吻合技术在鼻内镜下泪囊鼻腔吻合术中的应用

目的探讨鼻内镜下泪囊鼻腔吻合术(En-DCR)中应用缝线吻合技术治疗慢性泪囊炎的效果。方法回顾性分析该院79例(79眼)慢性泪囊炎患者的临床资料,分为缝合组和无缝合组。无缝合组给予En-DCR瓣膜单纯明胶海绵固定技术,缝合组给予En-DCR瓣膜缝线吻合技术。比较两组患者的临床总有效率、术后并发症发生率、吻合口修复时间和肉芽增生等情况。结果术后两组患者总有效率比较,差异无统计学意义(χ^(2)=4.36,P=0.137),并发症总发生率比较,差异无统计学意义(P=0.705)。缝合组造口黏膜上皮愈合时间短于无缝合组,差异有统计学意义(t=0.57,P=0.032),造口肉芽增生少于无缝合组,差异有统计学意义(P=0.037)。结论瓣膜缝线吻合并未改善其临床有效性和安全性,但可缩短造口黏膜上皮愈合时间,减少组织肉芽增生。

静吸复合麻醉与表面麻醉用于小儿泪道探通术中的对比研究

目的对比分析静吸复合麻醉与表面麻醉用于小儿泪道探通术中的麻醉效果及安全性。方法选取抚顺市眼病医院2020年1月至2020年12月收治的患有先天性泪道阻塞疾病并开展泪道探通术的患儿96例(105眼)为研究对象,根据选择使用麻醉的方式不同而将这些患儿分为对照组(n=52,57眼)与观察组(n=44,48眼),对照组采用表面麻醉,观察组采用静吸复合麻醉。比较两组血流动力学指标、治愈率及并发症发生情况。结果两组MAP和HR组间、时间、交互效应比较差异有统计学意义(P<0.05),两组SpO2组间、时间和交互效应比较差异无统计学意义。在麻醉诱导前(T0)、意识消失(T1)、手术开始后1min(T3)、手术开始后5min(T4)时,两组MAP、HR比较差异无统计学意义;在手术开始时(T2),观察组MAP和HR均低于对照组,差异有统计学意义(P<0.05)。两组治愈率比较差异无统计学意义。观察组术后溢泪、形成假道发生率均低于对照组差异有统计学意义(P<0.05);两组呛咳、眼眶蜂窝织炎发生率比较差异无统计学意义。结论静吸复合麻醉应用于小儿泪道探通术中,可维持患儿血流动力学稳定,减少术后溢泪、形成假道等并发症发生,在安全方面更有保障。

Re-canalized stenostic rabbit nasolacrimal duct by the ^(125)I radioactive probing:Affecting Bcl-2 and Bax protein expression

To evaluate the ^(125)I radioactive probing re-canalizing stenostic nasolacrimal duct,the nasolacrimal duct stenosis models in epithelium and connective tissues are experimentally structured by inbred white rabbits(New Zealand),including the nasolacrimal duct stenosis,the mechanical probing with outer layer of thermoplastic tube,and the ^(125)I radioactive probing with the ^(125)I seeds sealing into the thermoplastic tube.After re-canalized for four weeks, tissue specimens from bilateral nasolacrimal ducts are obtained,and the Bcl-2 and Bax protein expression levels are evaluated by immunohistochemical staining analysis.Comparing with the blank control,the expression levels of the Bcl-2 and Bax in the nasolacrimal duct stenosis and the mechanical probing are significantly up-/down-regulated(p<0.05),but in the ^(125)I radioactive probing are down-/up-regulated(p<0.05) and can be used to re-canalize the stenostic lacrimal passage.The results show that the ^(125)I radioactive probing is a therapeutical mechanism for radioactive probing strategy for treating nasolacrimal duct stenosis to induce cell apoptosis.

计算机断层扫描(CT)研究正常泪道内空气的分布和作用

目的观察泪道内空气的存在和分布并探讨空气在泪道引流中的作用。方法在计算机断层扫描(CT)工作站(Advantage Workstation 4.7)对50例(100只眼)的头部CT扫描图像进行分析。研究对象年龄25~44岁,男性35例,女性15例,排除泪道系统、眼眶、鼻窦、鼻腔等相关疾病以确保泪道引流系统正常。CT扫描采用256层单源双能螺旋CT扫描系统。CT扫描范围包括眶上缘至鼻底并采用仰卧位扫描。结果空气是正常泪道内容物的一个组成部分并改变泪囊和鼻泪管的CT值,泪囊和鼻泪管的整体和内部结构包括Hasner瓣和泪道鼻开口的开放或关闭可以在含气的泪道CT图像中清晰显示。结论Hasner瓣为鼻泪管下壁,瓣膜移动使泪道鼻开口开放或闭合,空气在泪道引流过程中可能有压力传导的作用。

抗生素联合泪囊抽脓冲洗及泪道探通术治疗新生儿急性泪囊炎的效果观察

目的:观察抗生素联合泪囊抽脓冲洗及泪道探通术治疗新生儿急性泪囊炎的临床效果。方法:回顾性分析2016年1月—2022年7月在浙江大学医学院附属儿童医院眼科进行治疗的60例新生儿急性泪囊炎患儿的病例资料。患儿均在全身及局部应用抗生素控制感染的基础上行泪囊抽脓冲洗并行泪道探通术治疗,并取患儿泪囊脓液做一般细菌培养及药物敏感性检测。结果:一次手术治愈率89.39%,两次手术治愈率96.97%,多次手术治愈率100.00%。一般细菌培养阳性率64.29%,金黄色葡萄球菌、凝固酶阴性葡萄球菌及缓症链球菌占培养出菌种的67.50%。药敏结果显示多数病原体对头孢三代、左氧氟沙星及妥布霉素敏感。结论:抗生素联合泪囊抽脓冲洗并同次行泪道探通术是治疗新生儿急性泪囊炎的可行方案,临床经验性抗感染治疗首选头孢三代静滴,左氧氟沙星滴眼液或妥布霉素滴眼液滴眼治疗。

鼻内镜下泪囊鼻腔吻合术治疗泪道阻塞性疾病的疗效及安全性分析

目的探讨鼻内镜下泪囊鼻腔吻合术治疗泪道阻塞性疾病的疗效及安全性。方法选取2019年3月至2022年6月湖州市第一人民医院收治的泪道阻塞患者50例,采用随机数字表法分为观察组和对照组,每组25例。观察组采用鼻内镜泪囊鼻腔吻合术(endoscopic dacryocystorhinostomy,En-DCR)治疗,对照组采用传统的经内眦外路泪囊鼻腔吻合术(externaldacryocystorhinostomy,Ex-DCR)治疗,所有患者均随访6个月,比较两组的手术相关指标、临床疗效、术后并发症发生情况及复发率。结果观察组手术时间和住院时间短于对照组,术中出血量少于对照组,术后疼痛视觉模拟量表(visual analogue scale,VAS)评分低于对照组,差异均有显著性(P<0.05)。术后1个月时观察组的治疗总有效率(100%)与对照组(92%)比较差异无显著性(P>0.05),而术后6个月时观察组的治疗总有效率(100%)明显高于对照组(84%),差异有显著性(P<0.05)。观察组术后并发症发生率(4%)明显低于对照组(24%),差异有显著性(P<0.05),而两组复发率比较差异无显著性(P>0.05)。结论与传统的Ex-DCR相比,En-DCR治疗泪道阻塞性疾病具有创伤小、疗效佳、术后并发症少的优点,患者更容易耐受。

RS泪道再通硅胶软管体留置支撑物在泪小管断裂吻合术中的应用

目的:探讨RS泪道再通硅胶软管在泪小管断裂吻合术后留置作支撑物的临床效果。方法:选取2017年1月-2020年12月笔者科室收治的223例泪小管断裂患者作为研究对象,均予以RS泪道再通硅胶软管作为支撑物行泪小管断裂吻合术,于显微镜直视下寻找鼻侧泪小管断端,将RS泪道再通硅胶软管置入上下泪小管,采用8-0可吸收缝线间断缝合断端3针,术后10 d拆线,RS泪道再通硅胶软管留置3个月后取出,术后随访1年。观察术中泪小管断裂吻合情况,术后3个月临床疗效及随访期间并发症发生情况。结果:术中泪小管断裂100.00%吻合。术后3个月,治愈215例(96.41%),好转8例(3.59%),无效0例(0.00%)。随访期间,出现泪小点及泪小管部分撕裂3例,下睑轻度外翻,导致术后轻度流泪2例,泪小管断端瘢痕2例,泪小点增生及息肉1例,并发症发生率为3.59%。结论:泪小管断裂吻合术中应用RS泪道再通硅胶软管作支撑物手术治疗效果较佳,术后并发症较少,安全性较高。

气压弹道碎石术与经皮肾通道输尿管软镜钬激光碎石术治疗复杂性肾结石的临床疗效比较

目的对比观察气压弹道碎石(PL)术与经皮肾通道输尿管软镜钬激光碎石(PNHLL)术治疗复杂性肾结石的临床疗效。方法回顾性分析2017年5月至2021年12月宿迁市第一人民医院收治的92例复杂性肾结石患者资料,根据不同术式分为研究组(n=46)与对照组(n=46)。研究组行PL治疗,对照组行PNHLL治疗。比较两组患者手术前后肾损伤指标[肾损伤分子-1(KIM-1)、血清胱抑素-C(Cys-C)、尿素、肾小球滤过率(GFR)、血清肌酐]水平与术中出血量、手术时间、碎石时间、住院时间、清石成功率及并发症发生率。结果术后,两组患者的KIM-1、Cys-C、尿素、GFR、血清肌酐水平均较术前明显下降,差异均有统计学意义(P<0.05);研究组术后KIM-1、Cys-C、尿素、GFR、血清肌酐水平分别为(0.59±0.26)pg/mL、(0.82±0.15)μmol/L、(4.38±0.64)μmol/L、(87.13±9.28)μmol/L、(74.15±10.19)μmol/L,均明显低于对照组[(0.78±0.35)pg/mL、(0.96±0.17)μmol/L、(5.11±1.14)μmol/L、(94.11±10.27)μmol/L、(80.58±11.52)μmol/L],清石成功率为95.65%,明显高于对照组(76.09%),差异均有统计学意义(P<0.05)。两组患者术中出血量、手术时间、碎石时间、住院时间与肾周血肿、发热、创面感染、血尿发生率比较,差异均无统计学意义(P>0.05)。结论复杂性肾结石治疗中PL与PNHLL均具有良好疗效,但PL可进一步提高患者的结石清除率,还可减轻其肾损伤,促使肾功能快速恢复。

泪道探通术联合典必殊眼膏治疗泪道阻塞的临床效果

目的探讨泪道探通术联合典必殊眼膏治疗泪道阻塞患者的临床效果。方法选取2019年9月至2021年9月德州市陵城区人民医院收治的80例泪道阻塞患者(80眼)作为研究对象,按照随机数字表法分为对照组与观察组,每组40例(40眼),对照组行泪道探通术治疗,观察组行泪道探通术联合典必殊眼膏治疗,比较两组眼表疾病指数量表(OSDI)评分、降钙素原(PCT)水平、超敏C反应蛋白(hs-CRP)水平、临床疗效、不良反应发生率。结果治疗后1个月,观察组不良环境下眼部不适发生频率、眼部不适对日常活动的影响、眼部不适频率评分均低于对照组,差异有统计学意义(P<0.05)。治疗后1个月,观察组PCT、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);治疗后3个月,观察组治疗有效率为92.50%,高于对照组的72.50%,差异有统计学意义(P<0.05);观察组不良反应发生率为5.00%,对照组为10.00%,两组比较差异无统计学意义,且不良反应程度均轻微。结论泪道探通术联合典必殊眼膏治疗泪道阻塞效果确切,可减轻眼部不适感及炎症反应,且不良反应少,值得临床推广应用。

经鼻内镜下鼻腔泪囊吻合术在泪道阻塞患者中的应用效果

目的分析经鼻内镜下鼻腔泪囊吻合术在泪道阻塞患者中的应用效果。方法选取2020年8月至2022年3月余姚市人民医院眼科接诊的72例泪道阻塞患者作为研究对象,采用随机数字表法将其分为对照组和研究组(各36例)。对照组采用常规鼻腔泪囊吻合术,研究组采用改良经鼻内镜下鼻腔泪囊吻合术。比较两组的临床效率、泪腺分泌功能、溢泪程度评分及泪道通畅率及复发率。结果研究组的临床总有效率高于对照组,差异有统计学意义(P<0.05)。术前,两组的SchirmerⅠ、破裂时间(BUT)比较,差异无统计学意义(P>0.05)。两组术后8周的SchirmerⅠ、BUT短于本组术前,差异有统计学意义(P<0.05)。术后8周,研究组的SchirmerⅠ短于对照组,BUT短于对照组,差异有统计学意义(P<0.05)。术前,两组的溢泪程度评分比较,差异无统计学意义(P>0.05)。两组术后8周的溢泪程度评分低于本组术前,差异有统计学意义(P<0.05)。术后8周,研究组的溢泪程度评分低于对照组,差异有统计学意义(P<0.05)。研究组术后6个月的复发率低于对照组,差异有统计学意义(P<0.05)。结论经鼻内镜下鼻腔泪囊吻合术在泪道阻塞患者中应用可提高有效率,促进泪腺分泌功能恢复,降低复发率。