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China-Latin America Green Cooperation under the Global Development Initiative
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作者 Cao Ting 《China International Studies》 2024年第3期73-99,共27页
The international development environment is entering a chaotic and volatile period.The world economy remains sluggish,while geopolitical conflicts,climate change,food crisis and a multitude of other challenges become... The international development environment is entering a chaotic and volatile period.The world economy remains sluggish,while geopolitical conflicts,climate change,food crisis and a multitude of other challenges become more closely intertwined and mutually reinforcing.In this context,countries across the world have been prompted to look for healthy,feasible and sustainable solutions to keep their socioeconomic development momentum on track. 展开更多
关键词 latin mutually PROMPT
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Sociodemographic determinants associated with breastfeeding in term infants with low birth weight in Latin American countries
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作者 Carlos Javier Avendaño-Vásquez Magda Liliana Villamizar-Osorio +2 位作者 Claudia Jazmin Niño-Peñaranda Judith Medellín-Olaya Nadia Carolina Reina-Gamba 《World Journal of Clinical Pediatrics》 2024年第1期141-149,共9页
BACKGROUND A progressive decrease in exclusive breastfeeding(BF)is observed in Latin America and the Caribbean compared with global results.The possibility of being breastfed and continuing BF for>6 months is lower... BACKGROUND A progressive decrease in exclusive breastfeeding(BF)is observed in Latin America and the Caribbean compared with global results.The possibility of being breastfed and continuing BF for>6 months is lower in low birth weight than in healthy-weight infants.AIM To identify factors associated with BF maintenance and promotion,with particular attention to low-and middle-income countries,by studying geographic,socioeconomic,and individual or neonatal health factors.METHODS A scoping review was conducted in 2018 using the conceptual model of social determinants of health published by the Commission on Equity and Health Inequalities in the United States.The extracted data with common characteristics were synthesized and categorized into two main themes:(1)Sociodemographic factors and proximal determinants involved in the initiation and maintenance of BF in low-birth-weight term infants in Latin America;and(2)individual characteristics related to the self-efficacy capacity for BF maintenance and adherence in low-birth-weight term infants.RESULTS This study identified maternal age,educational level,maternal economic capacity,social stratum,exposure to BF substitutes,access to BF information,and quality of health services as mediators for maintaining BF.CONCLUSION Individual self-efficacy factors that enable BF adherence in at-risk populations should be analyzed for better health outcomes. 展开更多
关键词 BREASTFEEDING Low birth weight latin America SELF-EFFICACY Social determinants of health
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Dissemination of Traditional Chinese Medicine in Latin America and the Caribbean: the Cases of Peru, Chile, and Cuba 被引量:2
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作者 Patricia Palma 《Chinese Medicine and Culture》 2023年第4期330-338,共9页
Traditional Chinese medicine(TCM) arrived from China to Latin America and the Caribbean in the 1840s due to the massive migration of Chinese people to the region. In a few years, the press noticed the presence of Chin... Traditional Chinese medicine(TCM) arrived from China to Latin America and the Caribbean in the 1840s due to the massive migration of Chinese people to the region. In a few years, the press noticed the presence of Chinese herbalists practicing in different cities and countries regardless of the demographic weight of the Chinese community. The fascination with Chinese doctors implicated not only the press but also the literature, a phenomenon particularly observed in Cuba. In the first decades of the 20th century, the reactivation of Chinese immigration to the region fostered an anti-Chinese climate that materialized in more significant migratory restrictions and control of their businesses, such as what happened with Chinese herbalists. These herbalists who practiced inside and outside the Chinese community started to object to criticism and persecution by the conservative press and professional doctors. Despite this, Chinese doctors will continue to maintain their support of a significant number of ill persons. This work seeks to illuminate the historical relevance of TCM in Latin America and the Caribbean, focusing on the cases of Peru, Chile, and Cuba. This last country was far from China culturally and geographically, but as in many other small towns in the region, Chinese medicine presented an alternative to the treatment of illnesses. 展开更多
关键词 Caribbean Chile Chinese migration CUBA History of medicine latin America Peru Traditional Chinese medicine
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Latin方阵和二维量子漫步相结合的图像加密
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作者 蒋建伟 张田 +1 位作者 陈祯羽 马鸿洋 《电子科技大学学报》 EI CAS CSCD 北大核心 2023年第5期649-658,共10页
针对数字图像在网络传输过程中容易受到攻击导致信息泄漏的问题,在Arnold置乱变换的基础上引入量子漫步和Latin方阵,设计了一种新型的彩色图像加密方案。首先把彩色图像的三通道分离,用Arnold变换来对图像像素点置乱,量子漫步和Latin方... 针对数字图像在网络传输过程中容易受到攻击导致信息泄漏的问题,在Arnold置乱变换的基础上引入量子漫步和Latin方阵,设计了一种新型的彩色图像加密方案。首先把彩色图像的三通道分离,用Arnold变换来对图像像素点置乱,量子漫步和Latin方阵被用来处理置乱后图像的像素值,然后对处理之后的图像使用加取模扩散算法进一步改变图像的像素值,最后合并三通道加密图像得到彩色加密图像。量子漫步的作用是为该文的加密算法提供随机序列。该文对加密算法进行了实验仿真,在直方图、相关性、信息熵、噪声攻击、裁剪攻击等多个方面对实验结果进行了性能分析。仿真结果显示:加密图像的直方图均匀分布,像素点之间的相关性趋近于0,信息熵为7.9993,接近于8,说明该算法具有较不错的抵抗统计分析的能力;经过噪声攻击和裁剪攻击之后的加密图像经过解密之后,仍然可以看到原图像信息,表明该算法的鲁棒性是良好的;该加密算法的密钥空间足够大为1060且密钥敏感性良好,NPCR值接近于99.61%,UACI值接近于33.45%,证明该算法拥有抵抗差分攻击的能力。 展开更多
关键词 ARNOLD变换 图像加密 latin方阵 量子漫步
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The Effect of Latinization on Reading Time and Understanding: Greeklish in Communication and Social Media
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作者 Evangelos Kehris George Karavasilis +1 位作者 Vasiliki Vrana Dimitrios Kydros 《Social Networking》 2023年第3期67-91,共25页
The increasing prevalence of technology in society has an impact on young people’s language use and development. Greeklish is the writing of Greek texts using the Latin instead of the Greek alphabet, a practice known... The increasing prevalence of technology in society has an impact on young people’s language use and development. Greeklish is the writing of Greek texts using the Latin instead of the Greek alphabet, a practice known as Latinization, also employed for many non-latin alphabet languages. The primary aim of this research is to evaluate the effect of Greeklish on reading time. A sample of 732 young Greeks were asked about their habits when communicating through e-mail and social media with their friends and they then participated in an experiment in which they were asked to read and understand two short texts, one written in Greek and the other in Greeklish. The findings of the research show that nearly one third of the participants use Greeklish. The results of the experiment conducted reveal that understanding is not affected by the alphabet used but reading Greeklish is significantly more time consuming than reading Greek independently of the sex and the familiarity of the participants with Greeklish. The findings suggest that amending social and communication media with software utilities related to Latinization such as language identifiers and converters may reduce reading time and thus facilitate written communication among the users. 展开更多
关键词 Social Media Digital Communication latinization Reading Speed Text Understanding Greeklish
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某乘用车型Latin NCAP评价中儿童座椅安装不便利问题的改进
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作者 周晓玲 刘灵祥 +2 位作者 华鑫维 周鸿滔 杨灿 《汽车与驾驶维修》 2023年第5期33-36,共4页
本文针对某车型在拉丁美洲安全评价机构(Latin NCAP)评价中儿童座椅安装便利性不满足要求问题,通过对儿童座椅与座椅坐垫及车身的固定结构进行分析,提出ISOFIX固定系统及后排坐垫的优化更改方案。经过CAE模拟分析、手工制作样件装配儿... 本文针对某车型在拉丁美洲安全评价机构(Latin NCAP)评价中儿童座椅安装便利性不满足要求问题,通过对儿童座椅与座椅坐垫及车身的固定结构进行分析,提出ISOFIX固定系统及后排坐垫的优化更改方案。经过CAE模拟分析、手工制作样件装配儿童座椅验证,装配效果满足Latin NCAP评价中对儿童座椅安装便利性的要求。 展开更多
关键词 latin NCAP 儿童座椅安装便利性 ISOFIX固定系统 后排座椅坐垫
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基于Latin方抽样和修正的Latin方抽样的可靠性灵敏度估计及其方差分析 被引量:14
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作者 万越 吕震宙 袁修开 《机械强度》 EI CAS CSCD 北大核心 2008年第6期927-934,共8页
运用Latin方抽样(Latin hypercube sampling)方法和经统计相关减小方程修正后的Latin方抽样(updated Latin hypercube sampling)方法对结构进行可靠性灵敏度估计及其方差分析。单模式和多模式的数值及工程算例说明,可靠性灵敏度分析的La... 运用Latin方抽样(Latin hypercube sampling)方法和经统计相关减小方程修正后的Latin方抽样(updated Latin hypercube sampling)方法对结构进行可靠性灵敏度估计及其方差分析。单模式和多模式的数值及工程算例说明,可靠性灵敏度分析的Latin方抽样和修正的Latin方抽样在样本容量较小时都可以得到比Monte Carlo抽样方法更稳定的估计结果。采用Latin方抽样可以得到可靠性灵敏度的无偏估计,而修正的Latin方抽样方法在样本容量较小的情况下得到的可靠性灵敏度估计值的方差的分散性较Latin方抽样有进一步的减小。Latin方抽样和修正的Latin方抽样方法对基本变量的分布形式和相关性等均无限定,是适用于结构可靠性灵敏度分析的一种有效而实用的小样本抽样方法。 展开更多
关键词 latin方抽样 修正的latin方抽样 统计相关减小方程 方差 MONTE Carlo
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Book review “Wattles: Australian Acacia species around the world” by David M. Richardson, Johannes J. Le Roux and Elizabete Marchante
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作者 Klaus von Gadow 《Forest Ecosystems》 SCIE CSCD 2024年第2期140-141,共2页
In a world of Google and AI, developing an encyclopedic coverage of a theme that is of great interest to biologists, social scientists, politicians and environmental managers, is a daunting challenge. Wattles is a boo... In a world of Google and AI, developing an encyclopedic coverage of a theme that is of great interest to biologists, social scientists, politicians and environmental managers, is a daunting challenge. Wattles is a book that presents new knowledge, makes interesting reading, and has the potential to stimulate research in a variety of disciplines. We learn that Acacia, commonly known as the wattles or acacias, is a genus of shrubs and trees comprising 1,083 species of which 417 are known to have been introduced to areas outside their native range. We are surprised to read that Australian acacias are found almost everywhere, in virtually all terrestrial habitats, including woodlands, grasslands, alpine settings,rainforests, coastal dunes and deserts, causing major environmental and socio-economic changes in the invaded regions. Until recently, Acacia comprised a group of plant species native to Africa, South America and Australasia, but the name is now reserved for species predominantly from Australia, including some from Southeast Asia. The genus name Acacia is Neo-Latin, and refers to a preparation extracted from the leaves and fruit pods of Vachellia nilotica, the original type of the genus. 展开更多
关键词 RICHARDSON OUTSIDE latin
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Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration
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作者 JoséM.Izquierdo 《Neural Regeneration Research》 SCIE CAS 2025年第3期805-807,共3页
The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of previously replication-competent cells. 展开更多
关键词 latin POTENTIAL lasting
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Efficient slope reliability analysis under soil spatial variability using maximum entropy distribution with fractional moments
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作者 Chengxin Feng Marcos A.Valdebenito +3 位作者 Marcin Chwała Kang Liao Matteo Broggi Michael Beer 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1140-1152,共13页
Spatial variability of soil properties imposes a challenge for practical analysis and design in geotechnical engineering.The latter is particularly true for slope stability assessment,where the effects of uncertainty ... Spatial variability of soil properties imposes a challenge for practical analysis and design in geotechnical engineering.The latter is particularly true for slope stability assessment,where the effects of uncertainty are synthesized in the so-called probability of failure.This probability quantifies the reliability of a slope and its numerical calculation is usually quite involved from a numerical viewpoint.In view of this issue,this paper proposes an approach for failure probability assessment based on Latinized partially stratified sampling and maximum entropy distribution with fractional moments.The spatial variability of geotechnical properties is represented by means of random fields and the Karhunen-Loève expansion.Then,failure probabilities are estimated employing maximum entropy distribution with fractional moments.The application of the proposed approach is examined with two examples:a case study of an undrained slope and a case study of a slope with cross-correlated random fields of strength parameters under a drained slope.The results show that the proposed approach has excellent accuracy and high efficiency,and it can be applied straightforwardly to similar geotechnical engineering problems. 展开更多
关键词 SLOPE Random field Reliability analysis Maximum entropy distribution latinized partial stratified sampling
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拉美亟待破解转型困局
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作者 杨首国 严谨 吕洋 《Contemporary International Relations》 2024年第1期109-117,共9页
In 2023, Latin America was confronted with increased domestic and international challenges, resulting in a stronger public desire for change. New social ideologies are continuing to emerge, and transformation through ... In 2023, Latin America was confronted with increased domestic and international challenges, resulting in a stronger public desire for change. New social ideologies are continuing to emerge, and transformation through reform has become a broad consensus. However, during the complicated reshaping of Latin America's political ecology, the swing of the political pendulum and the change of regimes are accelerating. 展开更多
关键词 latin POLITICAL desire
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拉美新一轮经济改革及其前景
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作者 王飞 吕洋 《Contemporary International Relations》 2024年第3期79-95,共17页
Currently,a new round of economic reform is catching up pace in Latin American and the Caribbean countries.This round of reform coincides with a new wave of leftist governments in this region.Driven by the severe econ... Currently,a new round of economic reform is catching up pace in Latin American and the Caribbean countries.This round of reform coincides with a new wave of leftist governments in this region.Driven by the severe economic dilemma and social conflicts,Latin American and Caribbean countries have initiated a new round of economic reform by strengthening the state's role in the economy,transforming production modes,improving fiscal and monetary functions,and emphasizing income distribution and social equality,which achieved both economic and social effects.This round of reform has had a certain impact at both the regional and global levels,not only activating the sluggish integration of this region,but also reflecting the development demands of the Global South for transformation and independence.The adjustment of interests brought about by the new round of economic reform in Latin America and the Caribbean will also bring new development opportunities for Sino–Latin American relations. 展开更多
关键词 economic reform Global South latin America and the Caribbean world economy
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Confucius and American Democracy
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作者 ALFRED HORNUNG 《China Today》 2024年第6期48-50,共3页
UPON the establishment of European universities in the Middle Ages,the educational system in Western countries became characterized by an essentially Eurocentric worldview.This was reflected in the study of Latin and ... UPON the establishment of European universities in the Middle Ages,the educational system in Western countries became characterized by an essentially Eurocentric worldview.This was reflected in the study of Latin and Greek in high school,and in basing public life and political systems on philosophies of classical antiquity.The work of the influential Chinese philosopher Confucius(551-479 B.C.),a near-contemporary of the major Greek philosophers Socrates(469-399 B.C.),Plato(428-348 B.C.)and Aristotle(384-322 B.C.),whose ethical and political ideas entered into the constitutions of European states,remained unknown. 展开更多
关键词 latin MIDDLE CONFUCIUS
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不同的时间观
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作者 Manya Cramer 《空中英语教室(初级版.大家说英语)》 2024年第1期24-26,53,共4页
Time is an important part of life.Different cultures view time in different ways.In places such as the U.S.,Germanyand Japan,peoplevaluetime very much.They begin and end activities ontime.ForpeoplefromLatinAmericaand ... Time is an important part of life.Different cultures view time in different ways.In places such as the U.S.,Germanyand Japan,peoplevaluetime very much.They begin and end activities ontime.ForpeoplefromLatinAmericaand Africa,that is not important.They are often late.But that is fine.They focus on activities.That's usualforthem. 展开更多
关键词 AMERICA SUCH latin
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Latin抽样法在导弹结构裂纹概率仿真中的应用
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作者 汤建湘 陈玉波 关正西 《上海航天》 1999年第4期23-26,共4页
提出了Latin抽样与分层抽样相结合的复合抽样方法,对于提高抽样精度和效率都有较为明显的作用,特别适用于结构裂纹概率的仿真和其它应用工程仿真计算。在复合抽样仿真计算示例中,对某型导弹的燃汽发生器进行了抽样仿真计算,所... 提出了Latin抽样与分层抽样相结合的复合抽样方法,对于提高抽样精度和效率都有较为明显的作用,特别适用于结构裂纹概率的仿真和其它应用工程仿真计算。在复合抽样仿真计算示例中,对某型导弹的燃汽发生器进行了抽样仿真计算,所得的抽样结果的精度和相关差都达到了令人满意的预期效果,与实验结果吻合。 展开更多
关键词 latin抽样法 导弹结构 裂纹概率 仿真
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Application of the optimal Latin hypercube design and radial basis function network to collaborative optimization 被引量:16
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作者 ZHAO Min CUI Wei-cheng 《Journal of Marine Science and Application》 2007年第3期24-32,共9页
Improving the efficiency of ship optimization is crucial for modem ship design. Compared with traditional methods, multidisciplinary design optimization (MDO) is a more promising approach. For this reason, Collabora... Improving the efficiency of ship optimization is crucial for modem ship design. Compared with traditional methods, multidisciplinary design optimization (MDO) is a more promising approach. For this reason, Collaborative Optimization (CO) is discussed and analyzed in this paper. As one of the most frequently applied MDO methods, CO promotes autonomy of disciplines while providing a coordinating mechanism guaranteeing progress toward an optimum and maintaining interdisciplinary compatibility. However, there are some difficulties in applying the conventional CO method, such as difficulties in choosing an initial point and tremendous computational requirements. For the purpose of overcoming these problems, optimal Latin hypercube design and Radial basis function network were applied to CO. Optimal Latin hypercube design is a modified Latin Hypercube design. Radial basis function network approximates the optimization model, and is updated during the optimization process to improve accuracy. It is shown by examples that the computing efficiency and robustness of this CO method are higher than with the conventional CO method. 展开更多
关键词 multidisciplinary design optimization (MDO) collaborative optimization (CO) optimal latin hypercube design radial basis function network APPROXIMATION
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Role of gene polymorphisms in gastric cancer and its precursor lesions:Current knowledge and perspectives in Latin American countries 被引量:6
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作者 Miguel Angel Chiurillo 《World Journal of Gastroenterology》 SCIE CAS 2014年第16期4503-4515,共13页
Latin America shows one of the highest incidence rates of gastric cancer in the world,with variations in mortality rates among nations or even within countries belonging to this region.Gastric cancer is the result of ... Latin America shows one of the highest incidence rates of gastric cancer in the world,with variations in mortality rates among nations or even within countries belonging to this region.Gastric cancer is the result of a multifactorial complex process,for which a multistep model of carcinogenesis is currently accepted.Additionally to the infection with Helicobacter pylori,that plays a major role,environmental factors as well as genetic susceptibility factors are significant players at different stages in the gastric cancer process.The differences in population origin,demographic structure,socio-economic development,and the impact of globalization lifestyles experienced in Latin America in the last decades,all together offer opportunities for studying in this context the influence of genetic polymorphisms in the susceptibility to gastric cancer.The aim of this article is to discuss current trends on gastric cancer in Latin American countries and to review the available published information about studies of association of gene polymorphisms involved in gastric cancer susceptibility from this region of the world.A total of 40 genes or genomic regions and69 genetic variants,58%representing markers involved in inflammatory response,have been used in a number of studies in which predominates a low number of individuals(cases and controls)included.Polymorphisms of IL-1B(-511 C/T,14 studies;-31 T/C,10 studies)and IL-1RN(variable number of tandem repeats,17 studies)are the most represented ones in the reviewed studies.Other genetic variants recently evaluated in large metaanalyses and associated with gastric cancer risk were also analyzed in a few studies[e.g.,prostate stem cell antigen(PSCA),CDH1,Survivin].Further and better analysis centered in gene polymorphisms linked to other covariates,epidemiological studies and the information provided by meta-analyses and genome-wide association studies should help to improve our understanding of gastric cancer etiology in order to develop appropriate health programs in Latin America. 展开更多
关键词 latin America Gastric cancer Precancerous lesions Gene polymorphisms Single nucleotide polymorphisms
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Helicobacter pylori recurrence after eradication in Latin America:Implications for gastric cancer prevention 被引量:5
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作者 Juan E Corral Robertino Mera +1 位作者 Corey W Dye Douglas R Morgan 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2017年第4期184-193,共10页
To estimate Helicobacter pylori (H. pylori) recurrence rate in Latin America, a region with a significant H. pylori prevalence and gastric cancer burden. METHODSPubMed, LILACS, SciELO, Cochrane databases and abstracts... To estimate Helicobacter pylori (H. pylori) recurrence rate in Latin America, a region with a significant H. pylori prevalence and gastric cancer burden. METHODSPubMed, LILACS, SciELO, Cochrane databases and abstracts from relevant meetings were reviewed. Information collected included: Participants’ characteristics, recruitment strategy, diagnostic modality, treatment arms, follow-up and recurrence rates. Recurrence was calculated using 100-patients-year rates, and data were pooled using a random effects model. The I<sup>2</sup> statistic assessed between study heterogeneity. Meta-regression analyses evaluated for effect modifying variables. RESULTSLiterature search yielded 163 articles. Twelve studies involving 4848 patients from 9 countries met inclusion criteria. Four hundred and thirty-two reinfections were recorded in 5487 person-years of follow-up. Pooled analysis showed a recurrence rate of 7.9 cases per 100 person-years (95%CI: 5.3-10.5). Meta-regression revealed that neither the antibiotic schema, a second antibiotic course, nor the diagnostic modality had an impact on the observed risk of recurrence. The recurrence rate in the first year after treatment, predominantly recrudescence, was 11.2 (6.1-16.4) per 100 patient years. Recurrence in subsequent years, was only 6.2 (3.8-8.7). CONCLUSIONH. pylori recurrence rates in Latin America are significant, and with geographic variability, yet are acceptable based upon the current literature for consideration of large scale intervention trials. Further research in Latin America is warranted to evaluate the efficacy, cost-effectiveness, and potential adverse outcomes of proposed eradication programs. 展开更多
关键词 Gastric cancer REINFECTION Hispanic Helicobacter pylori latin America
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Hepatocellular carcinoma in Latin America: Diagnosis and treatment challenges 被引量:4
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作者 Federico Pinro Jaime Poniachik +1 位作者 Ezequiel Ridruejo Marcelo Silva 《World Journal of Gastroenterology》 SCIE CAS 2018年第37期4224-4229,共6页
Latin America, a region with a population greater than 600000000 individuals, is well known due to its wide geographic, socio-cultural and economic heterogeneity. Access to health care remains as the main barrier that... Latin America, a region with a population greater than 600000000 individuals, is well known due to its wide geographic, socio-cultural and economic heterogeneity. Access to health care remains as the main barrier that challenges routine screening, early diagnosis and proper treatment of hepatocellular carcinoma(HCC). Therefore, identification of population at risk, implementation of surveillance programs and access to curative treatments has been poorly obtained in the region. Different retrospective cohort studies from the region have shown flaws in the implementation process of routine surveillance and early HCC diagnosis. Furthermore, adherence to clinical practice guidelines recommendations assessed in two studies from Brazil and Argentina demonstrated that there is also room for improvement in this field, similarly than the one observed in Europe and the United States. In summary, Latin America shares difficulties in HCC decision-making processes similar to those from developed countries. However, a transversal limitation in the region is the poor access to health care with the consequent limitation to standard treatments for overall population. Specifically, universal health care access to the different World Health Organization levels is crucial, including improvement in research, education and continuous medical training in order to expand knowledge and generation of data promoting a continuous improvement in the care of HCC patients. 展开更多
关键词 latin AMERICA Liver cancer LIMITATIONS CHALLENGE
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Hepatitis B virus infection in Latin America:A genomic medicine approach 被引量:5
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作者 Sonia Roman Alexis Jose-Abrego +4 位作者 Nora Alma Fierro Griselda Escobedo-Melendez Claudia Ojeda-Granados Erika Martinez-Lopez Arturo Puro 《World Journal of Gastroenterology》 SCIE CAS 2014年第23期7181-7196,共16页
Hepatitis B virus(HBV)infection is the leading cause of severe chronic liver disease.This article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes... Hepatitis B virus(HBV)infection is the leading cause of severe chronic liver disease.This article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes in Latin America.Three levels of evolutionary adaptation may correlate with the clinical outcomes of HBV infection.Infections in Latin America are predominantly of genotype H in Mexico and genotype F in Central and South America;these strains have historically circulated among the indigenous population.Both genotypes appear to be linked to a benign course of disease among the native and mestizo Mexicans and native South Americans.In contrast,genotypes F,A and D are common in acute and chronic infections among mestizos with Caucasian ancestry.Hepatocellular carcinoma is rare in Mexicans,but it has been associated with genotype F1b among Argentineans.This observation illustrates the significance of ascertaining the genetic and environmental factors involved in the development of HBV-related liver disease in Latin America,which contrast with those reported in other regions of the world. 展开更多
关键词 Genomic medicine Hepatitis B virus Hepatitis B virus genotypes latin America Mexico Central America South America
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