MiR-107-3p/Atp6v0e1 contributes to protective effects of two selenium-containing peptides,TSeMMM and SeMDPGQQ on lead-induced neurotoxicity

Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced cytotoxicity.However,the crosstalk between mRNA and microRNAs(miRNA)involved in the neuroprotection mechanism remains to be elucidated.In this study,RNA-sequencing and miRNA-sequencing were used to independently identify differentially expressed mRNAs and small RNAs profiles in Pb^(2+)-treated primary fetal rat cortical neurons and then the correlated miRNA-mRNA target pairs were obtained.It was found that 34 mRNAs related to oxidative phosphorylation could be reversed by pretreatment of TSeMMM and SeMDPGQQ.The protective effect of TSeMMM and SeMDPGQQ was mediated by upregulation of miR-107-3p,which downregulates the ATPase H+transporting V0 subunit e1(Atp6v0e1)mRNA level.A zebrafish model was applied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative PCR.The results indicated that miR-107-3p was a potential therapeutic target to achieve neuroprotection of Se-containing peptides via stimulation of Atp6v0e1.

A short overview of the lead iodide residue impact and regulation strategies in perovskite solar cells

Lead iodide(PbI2) is a vital raw material for preparing perovskite solar cells(PSCs),and it not only takes part in forming the light absorption layer but also remains in the grain boundary as a passivator.In other words,the PbI2 content in the precursor and as formed film will affect the efficiency and stability of the PSCs.With moderate residual PbI2,it passivates the bulk/surface defects of perovskite,reduces the interfacial recombination,promotes the perovskite stability,minimizes the device hysteresis,and so on.Deficient PbI2 residue will reduce the interfacial passivation effect and device performance.In addition to facilitating the non-radiative recombination,over PbI2 residue can also lead to electronic insulation in the grain boundary and deteriorate the device performance.However,the impact and regulation of PbI2 residue on the device performance and stability is still not fully understood.Herein,a comprehensive and detailed review is presented by discussing the PbI2 residue impact and its regulation strategies(i.e., elimination,facilitation and conversion of the residue PbI2) to manipulate the PbI2 content,distribution and forms.Finally,we also show future outlooks in this field,with an aim to help further the progression of high-efficiency and stable PSCs.

Epicatechin attenuates lead(Pb)-induced cognitive impairment in mice:regulation on Nrf2 signaling pathway,and interference on the interaction between Pb with albumin

Epicatechin(EC)was used in this study to antagonize the cognitive dysfunction caused by lead(Pb)exposure in mice.Eight-week-old male Kunming mice were treated with PbCl_(2)(20 mg/kg)and/or EC(50 mg/kg)by gavage administration for 4 weeks.Morris water maze test showed that EC could improve memory dysfunction induced by Pb.EC antagonized Ca^(2+)overload,activated Nrf2 signaling pathway and reduced the accumulation of Pb in the brain and serum,which suggested that EC might alter Pb distribution in mice.In vitro,spectroscopic analysis,potentiometric titration and docking studies were applied to inquiry into the interaction between bovine serum albumin(BSA)and Pb^(2+)in presence or absence of EC.EC was proved to chelate Pb^(2+)and reduced the interaction between BSA and Pb^(2+).In summary,EC might protect Pb-induced cognitive impairment by activating Nrf2 signaling pathway,and suppressing Pb accumulation via interference on the binding of Pb to albumin.

Conformity Assessment of Lead Aprons Used in Conventional Radiology: A Multi-Centre Survey in Togo

Aim: Lead aprons are used to protect against scattered radiation from the patient during interventional procedures and certain special conventional radiological examinations. Given the importance of the role lead aprons are supposed to play in radiation protection, we propose to assess their conformity in medical imaging departments in public and religious hospitals in Togo. Materials and method: A multi-centre survey conducted from 26 November to 06 December 2021 in the radiology departments of public and religious health facilities in Togo. All aprons in use were included. The evaluation criteria were physical (visual), quantitative (radiographic) and qualitative (dosimetric). Results: We had registred 43 aprons among wich 27 (62.79%) leaded aprons were labelled non-compliant and 16 (37.21%) were labelled compliant. Of the aprons judged to be non-compliant, 70.37% were more than 10 years old and 96.30% showed defects on the radiographic images. The most common defects were vampire marks (18.64%), multiple folds (16.96%), cracks (16.96%), multiple cracks (15.25%), tears (8.47%), absence of lead (5.08%), holes (3.39%) and lead corrosion (1.69%). Defective aprons (62.96%) had at least two defects. The defects were of thoraco-abdomino-pelvic (74.07%), thoracic (14.82%) and abdomino-pelvic (11.11%) topography. For indirect exposure at 50 and 70 kilovolts, all the aprons had an attenuation factor greater than 90%. After dosimetric measurement, 13.95% of aprons had attenuation factors below 90% for indirect exposure at 100 kilovolts. Conclusion: The compliance of the leaded decks is trifactorial (physical, radiographic and dosimetric). However, there is no significant difference in X-ray attenuation capacity between defective and normal decks.

Management of a patient with an unusual trajectory of a temporary trans-venous pacing lead

Perforation of the right ventricle during placement of pacing wires is a welldocumented complication and can be potentially fatal.Use of temporary pacemaker,helical screw leads and steroids use prior to implant are recognised as risk factors for development of post-permanent pacemaker effusion.We reported an unusual case of pacing wire perforating interventricular septum into the left ventricle that occurred during the implant procedure performed in another institution.After the preoperative work-up and transfer to our tertiary cardiothoracic centre,the patient underwent successful surgical management.In conclusion,early recognition and timely diagnosis using advanced multimodality imaging can guide surgical intervention and prevent unfavourable consequences of device-related complications.

Leading Pattern of Spring Drought Variability over East Asia and Associated Drivers

Drought events have become more frequent and intense over East Asia in recent decades,leading to huge socioeconomic impacts.Although the droughts have been studied extensively by cases or for individual regions,their leading variability and associated causes remain unclear.Based on the Standardized Precipitation Evapotranspiration Index(SPEI)and ERA5 reanalysis product from 1979 to 2020,this study evealuates the severity of spring droughts in East Asia and investigates their variations and associated drivers.The results indicate that North China and Mongolia have experienced remarkable trends toward dryness during spring in recent decades,while southwestern China has witnessed an opposite trend toward wetness.The first Empirical Orthogonal Function mode of SPEI variability reveals a similar seesawing pattern,with more severe dryness in northwestern China,Mongolia,North China,South Korea,and Japan but increased wetness in Southwestern China and southeast Asia.Further investigation reveals that the anomalously dry(wet)surface in North(Southwestern)China is significantly associated with anomalously high(low)temperature,less(more)precipitation,and reduced(increased)soil moisture during the previous winter and early spring,regulated by an anomalous anticyclone(cyclone)and thus reduced(increased)water vapor convergence.The spring dry-wet pattern in East Asia is also linked to cold sea surface temperature anomalies in the central-eastern Pacific.The findings of this study have important implications for improving the prediction of spring drought events in East Asia.

Seasonal Characteristics of Forecasting Uncertainties in Surface PM_(2.5)Concentration Associated with Forecast Lead Time over the Beijing-Tianjin-Hebei Region

Forecasting uncertainties among meteorological fields have long been recognized as the main limitation on the accuracy and predictability of air quality forecasts.However,the particular impact of meteorological forecasting uncertainties on air quality forecasts specific to different seasons is still not well known.In this study,a series of forecasts with different forecast lead times for January,April,July,and October of 2018 are conducted over the Beijing-Tianjin-Hebei(BTH)region and the impacts of meteorological forecasting uncertainties on surface PM_(2.5)concentration forecasts with each lead time are investigated.With increased lead time,the forecasted PM_(2.5)concentrations significantly change and demonstrate obvious seasonal variations.In general,the forecasting uncertainties in monthly mean surface PM_(2.5)concentrations in the BTH region due to lead time are the largest(80%)in spring,followed by autumn(~50%),summer(~40%),and winter(20%).In winter,the forecasting uncertainties in total surface PM_(2.5)mass due to lead time are mainly due to the uncertainties in PBL heights and hence the PBL mixing of anthropogenic primary particles.In spring,the forecasting uncertainties are mainly from the impacts of lead time on lower-tropospheric northwesterly winds,thereby further enhancing the condensation production of anthropogenic secondary particles by the long-range transport of natural dust.In summer,the forecasting uncertainties result mainly from the decrease in dry and wet deposition rates,which are associated with the reduction of near-surface wind speed and precipitation rate.In autumn,the forecasting uncertainties arise mainly from the change in the transport of remote natural dust and anthropogenic particles,which is associated with changes in the large-scale circulation.

Exploring the Path of Party Building Leading League Construction in Colleges and Universities under the Pattern of Great Ideological and Political Education

In accordance with the pattern of"great ideology and politics",the Party and youth League organizations assume the role of vanguard in the organization of colleges and universities.Simultaneously,they serve as a pivotal force in ideological and political education.In order to construct a comprehensive ideological and political framework encompassing the entire educational process,it is of paramount importance to identify an efficacious methodology for Party building leading League construction.This paper employs a comprehensive analysis to elucidate the pivotal role of Party building leading League construction in facilitating ideological and political education.It also illuminates the practical challenges encountered in the implementation of Party building leading League construction initiatives within colleges and universities.The article proposes a specific path for Party building leading League construction in colleges and universities based on three key aspects:cohesion of the consensus of Party building leading League building,establishment of the institutional system of Party building leading League construction,and creation of the model brand of Party building leading League construction.The aim is to promote in-depth development of Party building in colleges and universities and enhance the quality and effect of ideological and political education.

Analysis of Oxygen Consumption in Lead and Zinc Metallurgy

This article analyzes the role of oxygen in lead zinc metallurgy,including shortening the metallurgical process,promoting energy conservation and environmental protection,improving metallurgical strength,enhancing raw material adaptability,and enhancing comprehensive recovery efficiency.This article introduces different lead zinc metallurgical processes and their oxygen consumption characteristics,including oxygen enriched side blowing lead smelting,oxygen bottom blowing lead smelting,oxygen enriched top blowing lead smelting,flash smelting lead,oxygen pressure leaching zinc smelting,and atmospheric pressure oxygen leaching zinc smelting.It is pointed out that oxygen enhanced metallurgy is the direction for the transformation and upgrading of lead zinc metallurgy.

MER联合Lead-DBS在帕金森病患者术后程控中的应用研究

目的探讨微电极记录(MER)联合多模态影像融合技术(Lead-DBS)多模态影像融合技术在帕金森病患者术后程控中的应用效果。方法选取中国人民解放军联勤保障部队第九八八医院2018年10月至2023年8月期间收治的60例帕金森病患者,随机将其分为对照组和观察组。对照组患者根据脑深部电刺激术(DBS)专家程控共识逐个触点程控,观察组患者根据MER联合术后Lead-DBS多模态影像融合技术进行程控。比较两组术中操作时间、术后症状改善情况、生活质量评分、不良情绪及并发症发生率。结果观察组术中操作时间少于对照组,差异具有统计学意义(P<0.05);干预前两组帕金森症状评分、帕金森病生活质量评分、不良情绪评分、并发症发生率差异均无统计学意义(P>0.05),干预后观察组帕金森症状评分、帕金森病生活质量评分、不良情绪评分、并发症发生率均低于对照组,差异均有统计学意义(P<0.05)。结论术中MER联合术后Lead-DBS多模态影像融合技术,结合患者症状针对性选择开机触点方法具有较高的可行性,可提高手术效率、改善患者预后,安全性良好。

Mechanical and Electrical Properties of Some Sn-Zn Based Lead-Free Quinary Alloys

Although there are many lead-free soldering alloys on the market, none of them have ideal qualities. The researchers are combining binary alloys with a variety of additional materials to create the soldering alloys’ features. The eutectic Sn-9Zn alloy is among them. This paper investigated the mechanical and electrical properties of Sn-9Zn-x (Ag, Cu, Sb);{x = 0.2, 0.4, and 0.6} lead-free solder alloys. The mechanical properties such as elastic modulus, ultimate tensile strength (UTS), yield strength (YS), and ductility were examined at the strain rates in a range from 4.17 10−3 s−1 to 208.5 10−3 s−1 at room temperature. It is found that increasing the content of the alloying elements and strain rate increases the elastic modulus, ultimate tensile strength, and yield strength while the ductility decreases. The electrical conductivity of the alloys is found to be a little smaller than that of the Sn-9Zn eutectic alloy.

COTTON LEADS^(TM) 认证计划引发行业负责任生产的共鸣

COTTON LEADS^TM 认证计划由澳大利亚和美国棉花行业携手创立,并且是棉花基金会旗下的一个项目。其创始成员包括澳洲棉花协会、美国国家棉花总会、美国国际棉花协会和美国棉花公司。该计划旨在提高人们对负责任的棉花种植的认知度,并让人们了解其成员国的棉花种植者一直致力于持续改进。五大理念引领负责任生产截至目前,全球已经有超过232家机构和企业加入了该国际认证计划,其中,中国有63家企业加入该计划,

Numerical simulation of soldered joints and reliability analysis of PLCC components with J-shape leads

This paper deals with a study on SnPb and lead-free soldered joint reliability of PLCC devices with different lead counts under three kinds of temperature cycle profiles, which is based on non-linear finite element method. By analyzing the stress of soldered joints, it is found that the largest stress is at the area between the soldered joints and the leads, and analysis results indicate that the yon Mises stress at the location slightly increases with the increase of lead counts. For PLCC with 84 leads the soldered joints was modeled for three typical loading （273 -398 K, 218 -398 K and 198 -398 K） in order to study the influence of acceleration factors on the reliability of soldered joints. And the estimation of equivalent plastic strain of three different lead-free solder alloys （ Sn3.8AG0. 7Cu, Sn3.5Ag and Sn37Pb ） was also carried out.

Analysis of system trustworthiness based on information flow noninterference theory

The trustworthiness analysis and evaluation are the bases of the trust chain transfer. In this paper the formal method of trustworthiness analysis of a system based on the noninterfer- ence （NI） theory of the information flow is studied. Firstly, existing methods cannot analyze the impact of the system states on the trustworthiness of software during the process of trust chain trans- fer. To solve this problem, the impact of the system state on trust- worthiness of software is investigated, the run-time mutual interfer- ence behavior of software entitles is described and an interference model of the access control automaton of a system is established. Secondly, based on the intransitive noninterference （INI） theory, a formal analytic method of trustworthiness for trust chain transfer is proposed, providing a theoretical basis for the analysis of dynamic trustworthiness of software during the trust chain transfer process. Thirdly, a prototype system with dynamic trustworthiness on a plat- form with dual core architecture is constructed and a verification algorithm of the system trustworthiness is provided. Finally, the monitor hypothesis is extended to the dynamic monitor hypothe- sis, a theorem of static judgment rule of system trustworthiness is provided, which is useful to prove dynamic trustworthiness of a system at the beginning of system construction. Compared with previous work in this field, this research proposes not only a formal analytic method for the determination of system trustworthiness, but also a modeling method and an analysis algorithm that are feasible for practical implementation.

Access Request Trustworthiness in Weighted Access Control Framework

Weighted factor is given to access eontrol policies to express the importanceof policy and its effect on access control decision. According to this weighted access controlframework, a trustworthiness model for aceess request is also given. In this model, we give themeasure of trustworthiness factor to access request- by using some idea of uncertainty reasoning ofexpert system, present and prove the parallel propagation formula of request trustworthiness factoramong multiple policies, and get thefinal trustworthiness factor to decide whether authorizing. Inthis model, authorization decision is given according to the calculation of request trustworthinessfactor, which is more understandable, more suitable for real requirement and more powerfulforsecurity enhancement than traditional methods. Meanwhile the finer access control granularity isanother advantage.

Novel Metal-organic Framework Compound Pb(C_5H_4NCOO)_2 Showing One-dimensional Channel Defined as Four Leads and Four Nicotinic Acids

A novel metal-organic framework（MOF） compound of Pb（C5H4NCOO）2 was hydrothermally synthesized and structurally determined by X-ray single-crystal diffraction. The data of unit cell： orthorhombic space group Pccn, a=1.0325（2） nm, b=1.3597（3） nm, c=0.8499（2） nm, V=1.1931（4） nm^3, Z=4, Dc=2.513 g/cm^3, R1=0.047 were obtained on the basis of 1365 reflections with Fo〉2σ（Fo）. PbN2O6 polyhedron adopts the distorted cubic configuration which is assigned to the holodirected geometry. These PbN2O6 polyhedra can form the zigzag chain by edge-sharing mode along（001） direction. Pb atom is connected by six nicotinic acid molecules, leading neutral 3D metal-organic framework with a channel defined by four Pb atoms and four nicotinic acid molecules.

Exploring of drug leads from diversity-oriented Michael-acceptor library derived from natural products

A potential strategy for drug lead identification and in-active natural products re-discovery is elaborated.Starting from fifteen structurally diverse natural products,a focused library featured by Michael acceptors is constructed with IBX mediated oxidation.Biological assay on five tumor cell lines indicates that four Michael acceptors,8a,11a,12a,14a,are with improved cytotoxicity(3-10 folds more potent than the parent compounds),which merit further investigations.Further thiol-sensitive assay of the active hit 8a revealed that it was an irreversible Michael acceptor.The results suggest that the strategy is not only effective and relatively high discovery rate(28%),but also resource saving.

Component-Based Software Trustworthiness Fuzzy Analytic Hierarchy Process Model

For a more accurate and comprehensive assessment of the trustworthiness of component-based soft- ware system, the fuzzy analytic hierarchy process is introduced to establish the analysis model. Combine qualitative and quantitative analyses, the impacts to overall trustworthiness by the different types of components are distinguished. Considering the coupling relationship between components, dividing the system into several layers from target layer to scheme layer, evaluating the scheme advantages disadvantages by group decision-making, the trustworthiness of a typical J2EE structured component-based software is assessed. The trustworthiness asses model of the software components provides an effective methods of operation.

Multi-targeting cytotoxic drug leads from mushrooms

Due to genetic and epigenetic mechanisms, cancer have become a resistant disease and there is a need for new molecules having multiple targeting action that promotes apoptosis. Phytomolecules having multiple targeting anticancer activity are in high demand and there is less documentation or information available on these metabolites. It is evident that mushrooms are became the store houses of new anticancer molecules and mushrooms like Agaricus blazei, Antrodia camphorate, Albatrellus confluens, Bolteus badius, Cordyceps militaris, Clitocybe maxima, Funalia trogii, Grifola frondosa, and Inocybe umbrinella, are some of the medicinal mushrooms reported for their cytotoxic activity. Cytotoxic molecules like lentinan, grifolin, illudin-S, psilocybin, ganoderic acid, theanine, and hispolon, have been isolated from various mushroom species. However, studies have been limited only to in vitro cytotoxic mechanisms and very few trials have been conducted to prove the clinical efficacy of these drug leads. Hence, the current review focuses on new anticancer metabolites isolated from various mushrooms having multiple targeting mechanisms in cancer. However, an extensive research is needed to define the biosynthesis and clinical mechanism of these multiple acting metabolites. This review provides a platform for researchers new anticancer drugs and to bring out potent multiple acting anticancer newer drugs.

Pretreatment of caffeine leads to partial neuroprotection in MPTP model of Parkinson＇s disease

Parkinson＇s disease （PD） is disorder affecting more than a common neurodegenerative 1% people above 60 years of age worldwide, manifesting as the impaired motor function such as tremors, rigidity, akinesia/bradykinesia and postural inefficiency with a reduced life expectancy （Dorsey et al., 2007）. PD is believed to be the end result of the progressive death of dopaminergic neurons in the substantia nigra pars compacta （SNc）.