Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central server.Multiple reliable and high-quality clients m...Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central server.Multiple reliable and high-quality clients must participate in practical applications for the federated learning global model to be accurate,but because the clients are independent,the central server cannot fully control their behavior.The central server has no way of knowing the correctness of the model parameters provided by each client in this round,so clients may purposefully or unwittingly submit anomalous data,leading to abnormal behavior,such as becoming malicious attackers or defective clients.To reduce their negative consequences,it is crucial to quickly detect these abnormalities and incentivize them.In this paper,we propose a Federated Learning framework for Detecting and Incentivizing Abnormal Clients(FL-DIAC)to accomplish efficient and security federated learning.We build a detector that introduces an auto-encoder for anomaly detection and use it to perform anomaly identification and prevent the involvement of abnormal clients,in particular for the anomaly client detection problem.Among them,before the model parameters are input to the detector,we propose a Fourier transform-based anomaly data detectionmethod for dimensionality reduction in order to reduce the computational complexity.Additionally,we create a credit scorebased incentive structure to encourage clients to participate in training in order tomake clients actively participate.Three training models(CNN,MLP,and ResNet-18)and three datasets(MNIST,Fashion MNIST,and CIFAR-10)have been used in experiments.According to theoretical analysis and experimental findings,the FL-DIAC is superior to other federated learning schemes of the same type in terms of effectiveness.展开更多
The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the ...The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed.The study shows the importance of the implementation of the teaching model“promoting teaching and learning through competitions.”This model puts emphasis on the curriculum and teaching resources,while also integrating the teaching process and evaluation with competition.These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training,while also acting as a reference for similar courses.展开更多
This study investigates the learning curve of commercial banks regarding the efficiency of credit and value creation.However,current empirical methods for accessing the learning curve in organizations are not suitable...This study investigates the learning curve of commercial banks regarding the efficiency of credit and value creation.However,current empirical methods for accessing the learning curve in organizations are not suitable for use in financial institutions.Considering bank-specific characteristics,we introduce a dynamic learning curve using a cost function adjusted to capture learning-by-doing in banks.Using the model,we test several hypotheses on the impact of bank intermediary experience(learning)on the efficiency of credit and value creation in Japanese commercial banks.The findings show that bank intermediary learning significantly improves the cost efficiency gain in the gross value created,total credit created,and investment.However,bank intermediary experience has no significant effect on the efficiency of the economic value created for all the banks analyzed.These findings have practical implications for evaluating cost dynamics in bank credit and value creation,risk management,lending to the real sector,and shareholder value creation.展开更多
This study used quantitative methods to assess students'Chinese language learning attitudes and learning habits on Kahoot,a game-based learning platform.Kahoot enables teachers to transform bland Chinese vocabular...This study used quantitative methods to assess students'Chinese language learning attitudes and learning habits on Kahoot,a game-based learning platform.Kahoot enables teachers to transform bland Chinese vocabulary memorization into exciting,game-like situations.It makes Chinese language learning fun and interactive.The study aims to compare Kahoot team play mode with individual play mode.Sixty-four fifth graders participated.In the experimental group,students grouped by themselves or the teacher to compete with one another.They enjoyed working together to share what they knew and learned from each other.Students were tested prior to the course(pretest)and following the course(post-test).Observation notes,lesson plans,and surveys were also included.Analysis of the multiple types of data strengthens the conclusion that Kahoot can be an effective tool for teaching Chinese vocabulary,sentences,and culture.展开更多
The need for evidence-based practice has been recognized by physiotherapy organizations over the past decades. Earlier studies have documented facilitators and barriers that affect the use and implementation of eviden...The need for evidence-based practice has been recognized by physiotherapy organizations over the past decades. Earlier studies have documented facilitators and barriers that affect the use and implementation of evidence-based practice. Less is known about what kind of interventions might be useful to implement evidence-based practice. This study explores what physiotherapists learn through participation in a research project relevant to their professional development towards achieving a more evidence-based physiotherapy practice. To what extent this learning was transferred to colleagues for organizational learning is also examined. This study was set in Sweden, where health care is publicly funded. Patients do not need a referral from a physician to consult a physiotherapist. Eleven interviews were conducted with physiotherapists who had participated in a randomized, controlled, multicenter, physiotherapy intervention investigating neck-specific exercise for patients with whiplash disorder. Gadamer’s hermeneutics was used to analyze the data. The physiotherapists described a range of learning experiences from their project participation, including instrumental learning (the concrete application of knowledge to achieve changes in practice) and conceptual learning (changes in knowledge, understanding or attitudes). The research project enabled the physiotherapists to develop new treatment techniques for broader application and extend their competence in techniques already known (instrumental learning). The physiotherapists believed that project participation enhanced their overall competence as physiotherapists, increased their job motivation and strengthened their self-confidence and self-efficacy (conceptual learning). Physiotherapists’ participation in the research project yielded many individual learning experiences, fostered positive attitudes to research and was conducive to achieving a more research-informed physiotherapy practice. Participation was associated with a deeper understanding of the challenges involved in conducting research. The transfer from individual learning to the wider organization in terms of organizational learning was limited.展开更多
This study examined the overall effectiveness of reading proficiency especially the extensive reading in ESL.In order to investi-gate the process of acquisition more efficiently,author used reading-to-write approach t...This study examined the overall effectiveness of reading proficiency especially the extensive reading in ESL.In order to investi-gate the process of acquisition more efficiently,author used reading-to-write approach to investigate the connection between readingand foreign language learning.The research also shows that learners need to be provided with plenty of interesting and comprehensiblebooks and they are supposed to use strategies that they will acquire anyway as they read.展开更多
Magnesium(Mg)alloys have shown great prospects as both structural and biomedical materials,while poor corrosion resistance limits their further application.In this work,to avoid the time-consuming and laborious experi...Magnesium(Mg)alloys have shown great prospects as both structural and biomedical materials,while poor corrosion resistance limits their further application.In this work,to avoid the time-consuming and laborious experiment trial,a high-throughput computational strategy based on first-principles calculations is designed for screening corrosion-resistant binary Mg alloy with intermetallics,from both the thermodynamic and kinetic perspectives.The stable binary Mg intermetallics with low equilibrium potential difference with respect to the Mg matrix are firstly identified.Then,the hydrogen adsorption energies on the surfaces of these Mg intermetallics are calculated,and the corrosion exchange current density is further calculated by a hydrogen evolution reaction(HER)kinetic model.Several intermetallics,e.g.Y_(3)Mg,Y_(2)Mg and La_(5)Mg,are identified to be promising intermetallics which might effectively hinder the cathodic HER.Furthermore,machine learning(ML)models are developed to predict Mg intermetallics with proper hydrogen adsorption energy employing work function(W_(f))and weighted first ionization energy(WFIE).The generalization of the ML models is tested on five new binary Mg intermetallics with the average root mean square error(RMSE)of 0.11 eV.This study not only predicts some promising binary Mg intermetallics which may suppress the galvanic corrosion,but also provides a high-throughput screening strategy and ML models for the design of corrosion-resistant alloy,which can be extended to ternary Mg alloys or other alloy systems.展开更多
Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are...Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized training.In this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute settings.We collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the FAST.We compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and MViT.We found that the findings of our deep learning model had a higher clinical value compared with the other approaches.Moreover,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech audio.These results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.展开更多
Data security assurance is crucial due to the increasing prevalence of cloud computing and its widespread use across different industries,especially in light of the growing number of cybersecurity threats.A major and ...Data security assurance is crucial due to the increasing prevalence of cloud computing and its widespread use across different industries,especially in light of the growing number of cybersecurity threats.A major and everpresent threat is Ransomware-as-a-Service(RaaS)assaults,which enable even individuals with minimal technical knowledge to conduct ransomware operations.This study provides a new approach for RaaS attack detection which uses an ensemble of deep learning models.For this purpose,the network intrusion detection dataset“UNSWNB15”from the Intelligent Security Group of the University of New South Wales,Australia is analyzed.In the initial phase,the rectified linear unit-,scaled exponential linear unit-,and exponential linear unit-based three separate Multi-Layer Perceptron(MLP)models are developed.Later,using the combined predictive power of these three MLPs,the RansoDetect Fusion ensemble model is introduced in the suggested methodology.The proposed ensemble technique outperforms previous studieswith impressive performance metrics results,including 98.79%accuracy and recall,98.85%precision,and 98.80%F1-score.The empirical results of this study validate the ensemble model’s ability to improve cybersecurity defenses by showing that it outperforms individual MLPmodels.In expanding the field of cybersecurity strategy,this research highlights the significance of combined deep learning models in strengthening intrusion detection systems against sophisticated cyber threats.展开更多
Intrusion detection is a predominant task that monitors and protects the network infrastructure.Therefore,many datasets have been published and investigated by researchers to analyze and understand the problem of intr...Intrusion detection is a predominant task that monitors and protects the network infrastructure.Therefore,many datasets have been published and investigated by researchers to analyze and understand the problem of intrusion prediction and detection.In particular,the Network Security Laboratory-Knowledge Discovery in Databases(NSL-KDD)is an extensively used benchmark dataset for evaluating intrusion detection systems(IDSs)as it incorporates various network traffic attacks.It is worth mentioning that a large number of studies have tackled the problem of intrusion detection using machine learning models,but the performance of these models often decreases when evaluated on new attacks.This has led to the utilization of deep learning techniques,which have showcased significant potential for processing large datasets and therefore improving detection accuracy.For that reason,this paper focuses on the role of stacking deep learning models,including convolution neural network(CNN)and deep neural network(DNN)for improving the intrusion detection rate of the NSL-KDD dataset.Each base model is trained on the NSL-KDD dataset to extract significant features.Once the base models have been trained,the stacking process proceeds to the second stage,where a simple meta-model has been trained on the predictions generated from the proposed base models.The combination of the predictions allows the meta-model to distinguish different classes of attacks and increase the detection rate.Our experimental evaluations using the NSL-KDD dataset have shown the efficacy of stacking deep learning models for intrusion detection.The performance of the ensemble of base models,combined with the meta-model,exceeds the performance of individual models.Our stacking model has attained an accuracy of 99%and an average F1-score of 93%for the multi-classification scenario.Besides,the training time of the proposed ensemble model is lower than the training time of benchmark techniques,demonstrating its efficiency and robustness.展开更多
The bioinspired nacre or bone structure represents a remarkable example of tough,strong,lightweight,and multifunctional structures in biological materials that can be an inspiration to design bioinspired high-performa...The bioinspired nacre or bone structure represents a remarkable example of tough,strong,lightweight,and multifunctional structures in biological materials that can be an inspiration to design bioinspired high-performance materials.The bioinspired structure consists of hard grains and soft material interfaces.While the material interface has a very low volume percentage,its property has the ability to determine the bulk material response.Machine learning technology nowadays is widely used in material science.A machine learning model was utilized to predict the material response based on the material interface properties in a bioinspired nanocomposite.This model was trained on a comprehensive dataset of material response and interface properties,allowing it to make accurate predictions.The results of this study demonstrate the efficiency and high accuracy of the machine learning model.The successful application of machine learning into the material property prediction process has the potential to greatly enhance both the efficiency and accuracy of the material design process.展开更多
Brain tumors are a pressing public health concern, characterized by their high mortality and morbidity rates.Nevertheless, the manual segmentation of brain tumors remains a laborious and error-prone task, necessitatin...Brain tumors are a pressing public health concern, characterized by their high mortality and morbidity rates.Nevertheless, the manual segmentation of brain tumors remains a laborious and error-prone task, necessitatingthe development of more precise and efficient methodologies. To address this formidable challenge, we proposean advanced approach for segmenting brain tumorMagnetic Resonance Imaging (MRI) images that harnesses theformidable capabilities of deep learning and convolutional neural networks (CNNs). While CNN-based methodshave displayed promise in the realm of brain tumor segmentation, the intricate nature of these tumors, markedby irregular shapes, varying sizes, uneven distribution, and limited available data, poses substantial obstacles toachieving accurate semantic segmentation. In our study, we introduce a pioneering Hybrid U-Net framework thatseamlessly integrates the U-Net and CNN architectures to surmount these challenges. Our proposed approachencompasses preprocessing steps that enhance image visualization, a customized layered U-Net model tailoredfor precise segmentation, and the inclusion of dropout layers to mitigate overfitting during the training process.Additionally, we leverage the CNN mechanism to exploit contextual information within brain tumorMRI images,resulting in a substantial enhancement in segmentation accuracy.Our experimental results attest to the exceptionalperformance of our framework, with accuracy rates surpassing 97% across diverse datasets, showcasing therobustness and effectiveness of our approach. Furthermore, we conduct a comprehensive assessment of ourmethod’s capabilities by evaluating various performance measures, including the sensitivity, Jaccard-index, andspecificity. Our proposed model achieved 99% accuracy. The implications of our findings are profound. Theproposed Hybrid U-Net model emerges as a highly promising diagnostic tool, poised to revolutionize brain tumorimage segmentation for radiologists and clinicians.展开更多
Image description task is the intersection of computer vision and natural language processing,and it has important prospects,including helping computers understand images and obtaining information for the visually imp...Image description task is the intersection of computer vision and natural language processing,and it has important prospects,including helping computers understand images and obtaining information for the visually impaired.This study presents an innovative approach employing deep reinforcement learning to enhance the accuracy of natural language descriptions of images.Our method focuses on refining the reward function in deep reinforcement learning,facilitating the generation of precise descriptions by aligning visual and textual features more closely.Our approach comprises three key architectures.Firstly,it utilizes Residual Network 101(ResNet-101)and Faster Region-based Convolutional Neural Network(Faster R-CNN)to extract average and local image features,respectively,followed by the implementation of a dual attention mechanism for intricate feature fusion.Secondly,the Transformer model is engaged to derive contextual semantic features from textual data.Finally,the generation of descriptive text is executed through a two-layer long short-term memory network(LSTM),directed by the value and reward functions.Compared with the image description method that relies on deep learning,the score of Bilingual Evaluation Understudy(BLEU-1)is 0.762,which is 1.6%higher,and the score of BLEU-4 is 0.299.Consensus-based Image Description Evaluation(CIDEr)scored 0.998,Recall-Oriented Understudy for Gisting Evaluation(ROUGE)scored 0.552,the latter improved by 0.36%.These results not only attest to the viability of our approach but also highlight its superiority in the realm of image description.Future research can explore the integration of our method with other artificial intelligence(AI)domains,such as emotional AI,to create more nuanced and context-aware systems.展开更多
Thoracic diseases pose significant risks to an individual's chest health and are among the most perilous medical diseases. They can impact either one or both lungs, which leads to a severe impairment of a person’...Thoracic diseases pose significant risks to an individual's chest health and are among the most perilous medical diseases. They can impact either one or both lungs, which leads to a severe impairment of a person’s ability to breathe normally. Some notable examples of such diseases encompass pneumonia, lung cancer, coronavirus disease 2019 (COVID-19), tuberculosis, and chronic obstructive pulmonary disease (COPD). Consequently, early and precise detection of these diseases is paramount during the diagnostic process. Traditionally, the primary methods employed for the detection involve the use of X-ray imaging or computed tomography (CT) scans. Nevertheless, due to the scarcity of proficient radiologists and the inherent similarities between these diseases, the accuracy of detection can be compromised, leading to imprecise or erroneous results. To address this challenge, scientists have turned to computer-based solutions, aiming for swift and accurate diagnoses. The primary objective of this study is to develop two machine learning models, utilizing single-task and multi-task learning frameworks, to enhance classification accuracy. Within the multi-task learning architecture, two principal approaches exist soft parameter sharing and hard parameter sharing. Consequently, this research adopts a multi-task deep learning approach that leverages CNNs to achieve improved classification performance for the specified tasks. These tasks, focusing on pneumonia and COVID-19, are processed and learned simultaneously within a multi-task model. To assess the effectiveness of the trained model, it is rigorously validated using three different real-world datasets for training and testing.展开更多
The performance of the metal halide perovskite solar cells(PSCs)highly relies on the experimental parameters,including the fabrication processes and the compositions of the perovskites;tremendous experimental work has...The performance of the metal halide perovskite solar cells(PSCs)highly relies on the experimental parameters,including the fabrication processes and the compositions of the perovskites;tremendous experimental work has been done to optimize these factors.However,predicting the device performance of the PSCs from the fabrication parameters before experiments is still challenging.Herein,we bridge this gap by machine learning(ML)based on a dataset including 1072 devices from peer-reviewed publications.The optimized ML model accurately predicts the PCE from the experimental parameters with a root mean square error of 1.28%and a Pearson coefficientr of 0.768.Moreover,the factors governing the device performance are ranked by shapley additive explanations(SHAP),among which,A-site cation is crucial to getting highly efficient PSCs.Experiments and density functional theory calculations are employed to validate and help explain the predicting results by the ML model.Our work reveals the feasibility of ML in predicting the device performance from the experimental parameters before experiments,which enables the reverse experimental design toward highly efficient PSCs.展开更多
Detecting a pipeline's abnormal status,which is typically a blockage and leakage accident,is important for the continuity and safety of mine backfill.The pipeline system for gravity-transport high-density backfill...Detecting a pipeline's abnormal status,which is typically a blockage and leakage accident,is important for the continuity and safety of mine backfill.The pipeline system for gravity-transport high-density backfill(GHB)is complex.Specifically designed,efficient,and accurate abnormal pipeline detection methods for GHB are rare.This work presents a long short-term memory-based deep learning(LSTM-DL)model for GHB pipeline blockage and leakage diagnosis.First,an industrial pipeline monitoring system was introduced using pressure and flow sensors.Second,blockage and leakage field experiments were designed to solve the problem of negative sample deficiency.The pipeline's statistical characteristics with different working statuses were analyzed to show their complexity.Third,the architecture of the LSTM-DL model was elaborated on and evaluated.Finally,the LSTM-DL model was compared with state-of-the-art(SOTA)learning algorithms.The results show that the backfilling cycle comprises multiple working phases and is intermittent.Although pressure and flow signals fluctuate stably in a normal cycle,their values are diverse in different cycles.Plugging causes a sudden change in interval signal features;leakage results in long variation duration and a wide fluctuation range.Among the SOTA models,the LSTM-DL model has the highest detection accuracy of98.31%for all states and the lowest misjudgment or false positive rate of 3.21%for blockage and leakage states.The proposed model can accurately recognize various pipeline statuses of complex GHB systems.展开更多
Reinforcement Learning(RL)based control algorithms can learn the control strategies for nonlinear and uncertain environment during interacting with it.Guided by the rewards generated by environment,a RL agent can lear...Reinforcement Learning(RL)based control algorithms can learn the control strategies for nonlinear and uncertain environment during interacting with it.Guided by the rewards generated by environment,a RL agent can learn the control strategy directly in a model-free way instead of investigating the dynamic model of the environment.In the paper,we propose the sampled-data RL control strategy to reduce the computational demand.In the sampled-data control strategy,the whole control system is of a hybrid structure,in which the plant is of continuous structure while the controller(RL agent)adopts a discrete structure.Given that the continuous states of the plant will be the input of the agent,the state–action value function is approximated by the fully connected feed-forward neural networks(FCFFNN).Instead of learning the controller at every step during the interaction with the environment,the learning and acting stages are decoupled to learn the control strategy more effectively through experience replay.In the acting stage,the most effective experience obtained during the interaction with the environment will be stored and during the learning stage,the stored experience will be replayed to customized times,which helps enhance the experience replay process.The effectiveness of proposed approach will be verified by simulation examples.展开更多
Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning technique...Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine approaches.This abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke medicine.Recently introduced machine learning algorithms have been extensively employed in all the fields of stroke medicine.Machine learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient prognosis.Despite the tremendous potential of machine learning in stroke medicine,several challenges must be addressed.These include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and bias.In addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke care.Machine learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved prognostication.Continued research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of life.This review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic evaluation.At the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling disease.展开更多
Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However...Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.展开更多
BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse outcomes.Currently,there is a lack of effective pr...BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse outcomes.Currently,there is a lack of effective preventive measures.AIM To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and treatment.METHODS Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU admission.Relevant data from the initial 14 d of ICU stay,such as age,comorbidities,sedative dosage,vasopressor dosage,duration of mechanical ventilation,length of ICU stay,and rehabilitation therapy,were gathered.The relationships between these variables and ICU-AW were examined.Utilizing iterative machine learning techniques,a multilayer perceptron neural network model was developed,and its predictive performance for ICU-AW was assessed using the receiver operating characteristic curve.RESULTS Within the ICU-AW group,age,duration of mechanical ventilation,lorazepam dosage,adrenaline dosage,and length of ICU stay were significantly higher than in the non-ICU-AW group.Additionally,sepsis,multiple organ dysfunction syndrome,hypoalbuminemia,acute heart failure,respiratory failure,acute kidney injury,anemia,stress-related gastrointestinal bleeding,shock,hypertension,coronary artery disease,malignant tumors,and rehabilitation therapy ratios were significantly higher in the ICU-AW group,demonstrating statistical significance.The most influential factors contributing to ICU-AW were identified as the length of ICU stay(100.0%)and the duration of mechanical ventilation(54.9%).The neural network model predicted ICU-AW with an area under the curve of 0.941,sensitivity of 92.2%,and specificity of 82.7%.CONCLUSION The main factors influencing ICU-AW are the length of ICU stay and the duration of mechanical ventilation.A primary preventive strategy,when feasible,involves minimizing both ICU stay and mechanical ventilation duration.展开更多
基金supported by Key Research and Development Program of China (No.2022YFC3005401)Key Research and Development Program of Yunnan Province,China (Nos.202203AA080009,202202AF080003)+1 种基金Science and Technology Achievement Transformation Program of Jiangsu Province,China (BA2021002)Fundamental Research Funds for the Central Universities (Nos.B220203006,B210203024).
文摘Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central server.Multiple reliable and high-quality clients must participate in practical applications for the federated learning global model to be accurate,but because the clients are independent,the central server cannot fully control their behavior.The central server has no way of knowing the correctness of the model parameters provided by each client in this round,so clients may purposefully or unwittingly submit anomalous data,leading to abnormal behavior,such as becoming malicious attackers or defective clients.To reduce their negative consequences,it is crucial to quickly detect these abnormalities and incentivize them.In this paper,we propose a Federated Learning framework for Detecting and Incentivizing Abnormal Clients(FL-DIAC)to accomplish efficient and security federated learning.We build a detector that introduces an auto-encoder for anomaly detection and use it to perform anomaly identification and prevent the involvement of abnormal clients,in particular for the anomaly client detection problem.Among them,before the model parameters are input to the detector,we propose a Fourier transform-based anomaly data detectionmethod for dimensionality reduction in order to reduce the computational complexity.Additionally,we create a credit scorebased incentive structure to encourage clients to participate in training in order tomake clients actively participate.Three training models(CNN,MLP,and ResNet-18)and three datasets(MNIST,Fashion MNIST,and CIFAR-10)have been used in experiments.According to theoretical analysis and experimental findings,the FL-DIAC is superior to other federated learning schemes of the same type in terms of effectiveness.
文摘The inherent teaching approach can no longer meet the demands of society.In this paper,current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed.The study shows the importance of the implementation of the teaching model“promoting teaching and learning through competitions.”This model puts emphasis on the curriculum and teaching resources,while also integrating the teaching process and evaluation with competition.These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training,while also acting as a reference for similar courses.
基金supported by JSPS KAKENHI Grant Number 19J10715.
文摘This study investigates the learning curve of commercial banks regarding the efficiency of credit and value creation.However,current empirical methods for accessing the learning curve in organizations are not suitable for use in financial institutions.Considering bank-specific characteristics,we introduce a dynamic learning curve using a cost function adjusted to capture learning-by-doing in banks.Using the model,we test several hypotheses on the impact of bank intermediary experience(learning)on the efficiency of credit and value creation in Japanese commercial banks.The findings show that bank intermediary learning significantly improves the cost efficiency gain in the gross value created,total credit created,and investment.However,bank intermediary experience has no significant effect on the efficiency of the economic value created for all the banks analyzed.These findings have practical implications for evaluating cost dynamics in bank credit and value creation,risk management,lending to the real sector,and shareholder value creation.
文摘This study used quantitative methods to assess students'Chinese language learning attitudes and learning habits on Kahoot,a game-based learning platform.Kahoot enables teachers to transform bland Chinese vocabulary memorization into exciting,game-like situations.It makes Chinese language learning fun and interactive.The study aims to compare Kahoot team play mode with individual play mode.Sixty-four fifth graders participated.In the experimental group,students grouped by themselves or the teacher to compete with one another.They enjoyed working together to share what they knew and learned from each other.Students were tested prior to the course(pretest)and following the course(post-test).Observation notes,lesson plans,and surveys were also included.Analysis of the multiple types of data strengthens the conclusion that Kahoot can be an effective tool for teaching Chinese vocabulary,sentences,and culture.
文摘The need for evidence-based practice has been recognized by physiotherapy organizations over the past decades. Earlier studies have documented facilitators and barriers that affect the use and implementation of evidence-based practice. Less is known about what kind of interventions might be useful to implement evidence-based practice. This study explores what physiotherapists learn through participation in a research project relevant to their professional development towards achieving a more evidence-based physiotherapy practice. To what extent this learning was transferred to colleagues for organizational learning is also examined. This study was set in Sweden, where health care is publicly funded. Patients do not need a referral from a physician to consult a physiotherapist. Eleven interviews were conducted with physiotherapists who had participated in a randomized, controlled, multicenter, physiotherapy intervention investigating neck-specific exercise for patients with whiplash disorder. Gadamer’s hermeneutics was used to analyze the data. The physiotherapists described a range of learning experiences from their project participation, including instrumental learning (the concrete application of knowledge to achieve changes in practice) and conceptual learning (changes in knowledge, understanding or attitudes). The research project enabled the physiotherapists to develop new treatment techniques for broader application and extend their competence in techniques already known (instrumental learning). The physiotherapists believed that project participation enhanced their overall competence as physiotherapists, increased their job motivation and strengthened their self-confidence and self-efficacy (conceptual learning). Physiotherapists’ participation in the research project yielded many individual learning experiences, fostered positive attitudes to research and was conducive to achieving a more research-informed physiotherapy practice. Participation was associated with a deeper understanding of the challenges involved in conducting research. The transfer from individual learning to the wider organization in terms of organizational learning was limited.
文摘This study examined the overall effectiveness of reading proficiency especially the extensive reading in ESL.In order to investi-gate the process of acquisition more efficiently,author used reading-to-write approach to investigate the connection between readingand foreign language learning.The research also shows that learners need to be provided with plenty of interesting and comprehensiblebooks and they are supposed to use strategies that they will acquire anyway as they read.
基金financially supported by the National Key Research and Development Program of China(No.2016YFB0701202,No.2017YFB0701500 and No.2020YFB1505901)National Natural Science Foundation of China(General Program No.51474149,52072240)+3 种基金Shanghai Science and Technology Committee(No.18511109300)Science and Technology Commission of the CMC(2019JCJQZD27300)financial support from the University of Michigan and Shanghai Jiao Tong University joint funding,China(AE604401)Science and Technology Commission of Shanghai Municipality(No.18511109302).
文摘Magnesium(Mg)alloys have shown great prospects as both structural and biomedical materials,while poor corrosion resistance limits their further application.In this work,to avoid the time-consuming and laborious experiment trial,a high-throughput computational strategy based on first-principles calculations is designed for screening corrosion-resistant binary Mg alloy with intermetallics,from both the thermodynamic and kinetic perspectives.The stable binary Mg intermetallics with low equilibrium potential difference with respect to the Mg matrix are firstly identified.Then,the hydrogen adsorption energies on the surfaces of these Mg intermetallics are calculated,and the corrosion exchange current density is further calculated by a hydrogen evolution reaction(HER)kinetic model.Several intermetallics,e.g.Y_(3)Mg,Y_(2)Mg and La_(5)Mg,are identified to be promising intermetallics which might effectively hinder the cathodic HER.Furthermore,machine learning(ML)models are developed to predict Mg intermetallics with proper hydrogen adsorption energy employing work function(W_(f))and weighted first ionization energy(WFIE).The generalization of the ML models is tested on five new binary Mg intermetallics with the average root mean square error(RMSE)of 0.11 eV.This study not only predicts some promising binary Mg intermetallics which may suppress the galvanic corrosion,but also provides a high-throughput screening strategy and ML models for the design of corrosion-resistant alloy,which can be extended to ternary Mg alloys or other alloy systems.
基金supported by the Ministry of Science and Technology of China,No.2020AAA0109605(to XL)Meizhou Major Scientific and Technological Innovation PlatformsProjects of Guangdong Provincial Science & Technology Plan Projects,No.2019A0102005(to HW).
文摘Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized training.In this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute settings.We collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the FAST.We compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and MViT.We found that the findings of our deep learning model had a higher clinical value compared with the other approaches.Moreover,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech audio.These results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.
基金the Deanship of Scientific Research,Najran University,Kingdom of Saudi Arabia,for funding this work under the Research Groups Funding Program Grant Code Number(NU/RG/SERC/12/43).
文摘Data security assurance is crucial due to the increasing prevalence of cloud computing and its widespread use across different industries,especially in light of the growing number of cybersecurity threats.A major and everpresent threat is Ransomware-as-a-Service(RaaS)assaults,which enable even individuals with minimal technical knowledge to conduct ransomware operations.This study provides a new approach for RaaS attack detection which uses an ensemble of deep learning models.For this purpose,the network intrusion detection dataset“UNSWNB15”from the Intelligent Security Group of the University of New South Wales,Australia is analyzed.In the initial phase,the rectified linear unit-,scaled exponential linear unit-,and exponential linear unit-based three separate Multi-Layer Perceptron(MLP)models are developed.Later,using the combined predictive power of these three MLPs,the RansoDetect Fusion ensemble model is introduced in the suggested methodology.The proposed ensemble technique outperforms previous studieswith impressive performance metrics results,including 98.79%accuracy and recall,98.85%precision,and 98.80%F1-score.The empirical results of this study validate the ensemble model’s ability to improve cybersecurity defenses by showing that it outperforms individual MLPmodels.In expanding the field of cybersecurity strategy,this research highlights the significance of combined deep learning models in strengthening intrusion detection systems against sophisticated cyber threats.
文摘Intrusion detection is a predominant task that monitors and protects the network infrastructure.Therefore,many datasets have been published and investigated by researchers to analyze and understand the problem of intrusion prediction and detection.In particular,the Network Security Laboratory-Knowledge Discovery in Databases(NSL-KDD)is an extensively used benchmark dataset for evaluating intrusion detection systems(IDSs)as it incorporates various network traffic attacks.It is worth mentioning that a large number of studies have tackled the problem of intrusion detection using machine learning models,but the performance of these models often decreases when evaluated on new attacks.This has led to the utilization of deep learning techniques,which have showcased significant potential for processing large datasets and therefore improving detection accuracy.For that reason,this paper focuses on the role of stacking deep learning models,including convolution neural network(CNN)and deep neural network(DNN)for improving the intrusion detection rate of the NSL-KDD dataset.Each base model is trained on the NSL-KDD dataset to extract significant features.Once the base models have been trained,the stacking process proceeds to the second stage,where a simple meta-model has been trained on the predictions generated from the proposed base models.The combination of the predictions allows the meta-model to distinguish different classes of attacks and increase the detection rate.Our experimental evaluations using the NSL-KDD dataset have shown the efficacy of stacking deep learning models for intrusion detection.The performance of the ensemble of base models,combined with the meta-model,exceeds the performance of individual models.Our stacking model has attained an accuracy of 99%and an average F1-score of 93%for the multi-classification scenario.Besides,the training time of the proposed ensemble model is lower than the training time of benchmark techniques,demonstrating its efficiency and robustness.
文摘The bioinspired nacre or bone structure represents a remarkable example of tough,strong,lightweight,and multifunctional structures in biological materials that can be an inspiration to design bioinspired high-performance materials.The bioinspired structure consists of hard grains and soft material interfaces.While the material interface has a very low volume percentage,its property has the ability to determine the bulk material response.Machine learning technology nowadays is widely used in material science.A machine learning model was utilized to predict the material response based on the material interface properties in a bioinspired nanocomposite.This model was trained on a comprehensive dataset of material response and interface properties,allowing it to make accurate predictions.The results of this study demonstrate the efficiency and high accuracy of the machine learning model.The successful application of machine learning into the material property prediction process has the potential to greatly enhance both the efficiency and accuracy of the material design process.
基金Institutional Fund Projects under Grant No.(IFPIP:801-830-1443)The author gratefully acknowledges technical and financial support provided by the Ministry of Education and King Abdulaziz University,DSR,Jeddah,Saudi Arabia.
文摘Brain tumors are a pressing public health concern, characterized by their high mortality and morbidity rates.Nevertheless, the manual segmentation of brain tumors remains a laborious and error-prone task, necessitatingthe development of more precise and efficient methodologies. To address this formidable challenge, we proposean advanced approach for segmenting brain tumorMagnetic Resonance Imaging (MRI) images that harnesses theformidable capabilities of deep learning and convolutional neural networks (CNNs). While CNN-based methodshave displayed promise in the realm of brain tumor segmentation, the intricate nature of these tumors, markedby irregular shapes, varying sizes, uneven distribution, and limited available data, poses substantial obstacles toachieving accurate semantic segmentation. In our study, we introduce a pioneering Hybrid U-Net framework thatseamlessly integrates the U-Net and CNN architectures to surmount these challenges. Our proposed approachencompasses preprocessing steps that enhance image visualization, a customized layered U-Net model tailoredfor precise segmentation, and the inclusion of dropout layers to mitigate overfitting during the training process.Additionally, we leverage the CNN mechanism to exploit contextual information within brain tumorMRI images,resulting in a substantial enhancement in segmentation accuracy.Our experimental results attest to the exceptionalperformance of our framework, with accuracy rates surpassing 97% across diverse datasets, showcasing therobustness and effectiveness of our approach. Furthermore, we conduct a comprehensive assessment of ourmethod’s capabilities by evaluating various performance measures, including the sensitivity, Jaccard-index, andspecificity. Our proposed model achieved 99% accuracy. The implications of our findings are profound. Theproposed Hybrid U-Net model emerges as a highly promising diagnostic tool, poised to revolutionize brain tumorimage segmentation for radiologists and clinicians.
基金This research was funded by the Natural Science Foundation of Gansu Province with Approval Numbers 20JR10RA334 and 21JR7RA570Funding is provided for the 2021 Longyuan Youth Innovation and Entrepreneurship Talent Project with Approval Number 2021LQGR20+1 种基金the University Level Innovation Project with Approval NumbersGZF2020XZD18jbzxyb2018-01 of Gansu University of Political Science and Law.
文摘Image description task is the intersection of computer vision and natural language processing,and it has important prospects,including helping computers understand images and obtaining information for the visually impaired.This study presents an innovative approach employing deep reinforcement learning to enhance the accuracy of natural language descriptions of images.Our method focuses on refining the reward function in deep reinforcement learning,facilitating the generation of precise descriptions by aligning visual and textual features more closely.Our approach comprises three key architectures.Firstly,it utilizes Residual Network 101(ResNet-101)and Faster Region-based Convolutional Neural Network(Faster R-CNN)to extract average and local image features,respectively,followed by the implementation of a dual attention mechanism for intricate feature fusion.Secondly,the Transformer model is engaged to derive contextual semantic features from textual data.Finally,the generation of descriptive text is executed through a two-layer long short-term memory network(LSTM),directed by the value and reward functions.Compared with the image description method that relies on deep learning,the score of Bilingual Evaluation Understudy(BLEU-1)is 0.762,which is 1.6%higher,and the score of BLEU-4 is 0.299.Consensus-based Image Description Evaluation(CIDEr)scored 0.998,Recall-Oriented Understudy for Gisting Evaluation(ROUGE)scored 0.552,the latter improved by 0.36%.These results not only attest to the viability of our approach but also highlight its superiority in the realm of image description.Future research can explore the integration of our method with other artificial intelligence(AI)domains,such as emotional AI,to create more nuanced and context-aware systems.
文摘Thoracic diseases pose significant risks to an individual's chest health and are among the most perilous medical diseases. They can impact either one or both lungs, which leads to a severe impairment of a person’s ability to breathe normally. Some notable examples of such diseases encompass pneumonia, lung cancer, coronavirus disease 2019 (COVID-19), tuberculosis, and chronic obstructive pulmonary disease (COPD). Consequently, early and precise detection of these diseases is paramount during the diagnostic process. Traditionally, the primary methods employed for the detection involve the use of X-ray imaging or computed tomography (CT) scans. Nevertheless, due to the scarcity of proficient radiologists and the inherent similarities between these diseases, the accuracy of detection can be compromised, leading to imprecise or erroneous results. To address this challenge, scientists have turned to computer-based solutions, aiming for swift and accurate diagnoses. The primary objective of this study is to develop two machine learning models, utilizing single-task and multi-task learning frameworks, to enhance classification accuracy. Within the multi-task learning architecture, two principal approaches exist soft parameter sharing and hard parameter sharing. Consequently, this research adopts a multi-task deep learning approach that leverages CNNs to achieve improved classification performance for the specified tasks. These tasks, focusing on pneumonia and COVID-19, are processed and learned simultaneously within a multi-task model. To assess the effectiveness of the trained model, it is rigorously validated using three different real-world datasets for training and testing.
基金the National Natural Science Foundation of China(Grant No.62075006)the National Key Research and Development Program of China(Grant No.2021YFB3600403)the Natural Science Talents Foundation(Grant No.KSRC22001532)。
文摘The performance of the metal halide perovskite solar cells(PSCs)highly relies on the experimental parameters,including the fabrication processes and the compositions of the perovskites;tremendous experimental work has been done to optimize these factors.However,predicting the device performance of the PSCs from the fabrication parameters before experiments is still challenging.Herein,we bridge this gap by machine learning(ML)based on a dataset including 1072 devices from peer-reviewed publications.The optimized ML model accurately predicts the PCE from the experimental parameters with a root mean square error of 1.28%and a Pearson coefficientr of 0.768.Moreover,the factors governing the device performance are ranked by shapley additive explanations(SHAP),among which,A-site cation is crucial to getting highly efficient PSCs.Experiments and density functional theory calculations are employed to validate and help explain the predicting results by the ML model.Our work reveals the feasibility of ML in predicting the device performance from the experimental parameters before experiments,which enables the reverse experimental design toward highly efficient PSCs.
基金financially supported by the China Postdoctoral Science Foundation (No.2021M690362)the National Natural Science Foundation of China (Nos.51974014 and U2034206)。
文摘Detecting a pipeline's abnormal status,which is typically a blockage and leakage accident,is important for the continuity and safety of mine backfill.The pipeline system for gravity-transport high-density backfill(GHB)is complex.Specifically designed,efficient,and accurate abnormal pipeline detection methods for GHB are rare.This work presents a long short-term memory-based deep learning(LSTM-DL)model for GHB pipeline blockage and leakage diagnosis.First,an industrial pipeline monitoring system was introduced using pressure and flow sensors.Second,blockage and leakage field experiments were designed to solve the problem of negative sample deficiency.The pipeline's statistical characteristics with different working statuses were analyzed to show their complexity.Third,the architecture of the LSTM-DL model was elaborated on and evaluated.Finally,the LSTM-DL model was compared with state-of-the-art(SOTA)learning algorithms.The results show that the backfilling cycle comprises multiple working phases and is intermittent.Although pressure and flow signals fluctuate stably in a normal cycle,their values are diverse in different cycles.Plugging causes a sudden change in interval signal features;leakage results in long variation duration and a wide fluctuation range.Among the SOTA models,the LSTM-DL model has the highest detection accuracy of98.31%for all states and the lowest misjudgment or false positive rate of 3.21%for blockage and leakage states.The proposed model can accurately recognize various pipeline statuses of complex GHB systems.
基金supported by Imperial College London,UK,King’s College London,UK and Engineering and Physical Sciences Research Council(EPSRC),UK.
文摘Reinforcement Learning(RL)based control algorithms can learn the control strategies for nonlinear and uncertain environment during interacting with it.Guided by the rewards generated by environment,a RL agent can learn the control strategy directly in a model-free way instead of investigating the dynamic model of the environment.In the paper,we propose the sampled-data RL control strategy to reduce the computational demand.In the sampled-data control strategy,the whole control system is of a hybrid structure,in which the plant is of continuous structure while the controller(RL agent)adopts a discrete structure.Given that the continuous states of the plant will be the input of the agent,the state–action value function is approximated by the fully connected feed-forward neural networks(FCFFNN).Instead of learning the controller at every step during the interaction with the environment,the learning and acting stages are decoupled to learn the control strategy more effectively through experience replay.In the acting stage,the most effective experience obtained during the interaction with the environment will be stored and during the learning stage,the stored experience will be replayed to customized times,which helps enhance the experience replay process.The effectiveness of proposed approach will be verified by simulation examples.
文摘Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine approaches.This abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke medicine.Recently introduced machine learning algorithms have been extensively employed in all the fields of stroke medicine.Machine learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient prognosis.Despite the tremendous potential of machine learning in stroke medicine,several challenges must be addressed.These include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and bias.In addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke care.Machine learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved prognostication.Continued research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of life.This review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic evaluation.At the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling disease.
基金financially supported by the National Natural Science Foundation of China,No.81303115,81774042 (both to XC)the Pearl River S&T Nova Program of Guangzhou,No.201806010025 (to XC)+3 种基金the Specialty Program of Guangdong Province Hospital of Chinese Medicine of China,No.YN2018ZD07 (to XC)the Natural Science Foundatior of Guangdong Province of China,No.2023A1515012174 (to JL)the Science and Technology Program of Guangzhou of China,No.20210201 0268 (to XC),20210201 0339 (to JS)Guangdong Provincial Key Laboratory of Research on Emergency in TCM,Nos.2018-75,2019-140 (to JS)
文摘Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.
基金Supported by Science and Technology Support Program of Qiandongnan Prefecture,No.Qiandongnan Sci-Tech Support[2021]12Guizhou Province High-Level Innovative Talent Training Program,No.Qiannan Thousand Talents[2022]201701.
文摘BACKGROUND Intensive care unit-acquired weakness(ICU-AW)is a common complication that significantly impacts the patient's recovery process,even leading to adverse outcomes.Currently,there is a lack of effective preventive measures.AIM To identify significant risk factors for ICU-AW through iterative machine learning techniques and offer recommendations for its prevention and treatment.METHODS Patients were categorized into ICU-AW and non-ICU-AW groups on the 14th day post-ICU admission.Relevant data from the initial 14 d of ICU stay,such as age,comorbidities,sedative dosage,vasopressor dosage,duration of mechanical ventilation,length of ICU stay,and rehabilitation therapy,were gathered.The relationships between these variables and ICU-AW were examined.Utilizing iterative machine learning techniques,a multilayer perceptron neural network model was developed,and its predictive performance for ICU-AW was assessed using the receiver operating characteristic curve.RESULTS Within the ICU-AW group,age,duration of mechanical ventilation,lorazepam dosage,adrenaline dosage,and length of ICU stay were significantly higher than in the non-ICU-AW group.Additionally,sepsis,multiple organ dysfunction syndrome,hypoalbuminemia,acute heart failure,respiratory failure,acute kidney injury,anemia,stress-related gastrointestinal bleeding,shock,hypertension,coronary artery disease,malignant tumors,and rehabilitation therapy ratios were significantly higher in the ICU-AW group,demonstrating statistical significance.The most influential factors contributing to ICU-AW were identified as the length of ICU stay(100.0%)and the duration of mechanical ventilation(54.9%).The neural network model predicted ICU-AW with an area under the curve of 0.941,sensitivity of 92.2%,and specificity of 82.7%.CONCLUSION The main factors influencing ICU-AW are the length of ICU stay and the duration of mechanical ventilation.A primary preventive strategy,when feasible,involves minimizing both ICU stay and mechanical ventilation duration.