Background： We want to establish a lobe-specific mediastinal lymphadenectomy protocol for solitary pulmonary nodules （SPNs） in non-small cell lung cancer （NSCLC）. Methods： We retrospectively analyzed 401 patient...Background： We want to establish a lobe-specific mediastinal lymphadenectomy protocol for solitary pulmonary nodules （SPNs） in non-small cell lung cancer （NSCLC）. Methods： We retrospectively analyzed 401 patients with pathological diagnoses of NSCLC who underwent lobectomy, bilobectomy, or pneumonectomy with systematic lymphadenectomy from March 2004 to June 2011 in our hospital. All of the patients enrolled had a SPN preoperatively. Information about the primary tumor location, lymph node metastasis, and other baseline data were collected. Stepwise logistic regression was used to identify the key factors indicating non-regional mediastinal lymph node metastases （NRM）. Results： Of the primary tumors, 117, 39, 74, 104, and 67 were in the right upper lung （RUL）, right middle lung （RML）, right lower lung （RLL）, left upper lung （LUL）, and left lower lung （LLL）, respectively. Stepwise regression showed that #2,4, #10,11, and #10,11 as well as #7 was the key lymph node station for RUL, LUL, and lower lobes： #2,4 [odds ratio （OR）=28.000, 95% confidence interval （CI）： 2.917-268.790, P=0.004] for RUL, #10,11 （OR=31.667, 95% CI： 2.502-400.833, P=0.008） for LUL, #10,11 （OR=19.540, 95% CI： 4.217-90.541, P〈0.001） and #7 （OR=7.395, 95% CI： 1.586-34.484, P=0.011） for lower lobes, respectively. Patients with tumors 〉2 cm rarely had NRM without primary regional mediastinal involvement. Conclusions： With rigid consideration, a lobe-specific lymphadenectomy is feasible in practice. This protocol can be used when the lobe-specific key nodes are negative in intraoperative frozen sections, especially for NSCLC diagnosed as SPN 〈2 cm preoperatively.展开更多
Background: Some studies have suggested that among all cases of lung cancer, the outcome of lung cancer located in the right middle lobe (RML) is the worst. However, with the advances in the diagnosis and treatment me...Background: Some studies have suggested that among all cases of lung cancer, the outcome of lung cancer located in the right middle lobe (RML) is the worst. However, with the advances in the diagnosis and treatment methods of lung cancer over the last couple of decades, we investigated whether the prognosis of primary lung cancer located in the RML still remains inferior to that of lung cancer arising from other lobes. Methods: Between July 2003 and December 2011, 505 consecutive patients with non-small cell lung cancer (NSCLC) underwent surgical resection at our institution. Of these, 32 patients (6.3%) had tumors arising from the RML. Results: The rate of incomplete resection was higher for cancer located in the RML than that for cancer arising from other lobes. Significant associations were noted between cancer located in the RML and the rate of lymph node metastasis and initial locoregional recurrence. Multivariate analysis identified lymph node metastasis and location in the RML as independent risk factors influencing the recurrence-free survival (p = 0.006), although location in the RML was not extracted as an independent risk factor influenceing the overall survival (p = 0.060). Conclusion: Despite the recent advances in the treatment of lung cancer, evaluation of complete resection revealed that the outcome of cancer located in the RML is still the worst among cancer of all the lobes. Further early diagnosis and adjuvant therapy are needed for improving the prognosis of cancer located in the RML.展开更多
A 49-year-old man had an abnormal shadow on chest X-ray. Enhanced chest computed tomography (CT) revealed an 8-cm diameter right lung mass invading the right chest wall, with a tumor thrombus extending from the superi...A 49-year-old man had an abnormal shadow on chest X-ray. Enhanced chest computed tomography (CT) revealed an 8-cm diameter right lung mass invading the right chest wall, with a tumor thrombus extending from the superior pulmonary vein into the left atrium. Transesophageal echocardiography confirmed that the tumor adjoined the side wall of the atrium. Endobronchial and CT-guided needle biopsy demonstrated a low-grade carcinoma or small cell carcinoma. Operative findings through left atriotomy under cardiopulmonary bypass showed no tumor invasion of the atrium wall, but protrusion through the pulmonary vein. Frozen sections revealed a non-small cell carcinoma. We performed right upper lobectomy with parietal pleura and mediastinal lymph node dissection after detachment of cardiopulmonary bypass. Pathological examination demonstrated a large-cell neuroendocrine carcinoma p-T4N0M0, stage IIIA. The patient recovered without postoperative complications and tolerated two cycles of adjuvant chemotherapy. He was doing well without symptoms of recurrence 42 months after surgery.展开更多
永存左上腔静脉(persistent left superior vena cava,PLSVC)是一种罕见的体循环血管变异,在人群中的发生率约为0.3%~0.5%[1],但是在先天性心脏病患者中,这一发生概率可达到约1.3%~11%[1-2]。PLSVC通常无血流动力学的异常,因为它多数经...永存左上腔静脉(persistent left superior vena cava,PLSVC)是一种罕见的体循环血管变异,在人群中的发生率约为0.3%~0.5%[1],但是在先天性心脏病患者中,这一发生概率可达到约1.3%~11%[1-2]。PLSVC通常无血流动力学的异常,因为它多数经由冠状静脉窦回流入右心房,但由于该血管的特殊走行及其罕见性,胸外科医师可能会将其误认为主动脉旁肿大的淋巴结,并对肺癌进行错误的分期,抑或是增加手术误伤的风险。因此我们回顾了3例于我院行左侧肺癌手术的患者,在术前或术中发现存在这一变异的血管,本文对其进行详细描述,并结合文献复习,总结其发病原因、临床特点及影像学特征,以呼吁胸外科医生应对此提高认识,避免相关的临床不良事件发生。展开更多
目的探讨老年肺癌患者上肢PICC相关性静脉血栓(peripherally inserted central catheters related thrombosis,PICC-CRT)发生的危险因素及其护理措施。方法对2017年1月至2021年1月在某三级甲等综合医院肿瘤科行PICC化疗的287例老年肺癌...目的探讨老年肺癌患者上肢PICC相关性静脉血栓(peripherally inserted central catheters related thrombosis,PICC-CRT)发生的危险因素及其护理措施。方法对2017年1月至2021年1月在某三级甲等综合医院肿瘤科行PICC化疗的287例老年肺癌患者进行一般资料和疾病资料收集,分析其发生PICC-CRT的危险因素。结果老年肺癌化疗患者上肢PICC-CRT发生率为8.7%(25/287)。Logistic回归分析显示,高龄、日常生活活动能力差、头静脉置管、存在营养风险、置管评估为疑难是老年肺癌患者发生上肢PICC-CRT危险因素(均P<0.05),共同解释其33.8%的变异。结论老年肺癌患者上肢PICC-CRT发生率高,医护人员应关注高龄、日常生活活动能力差、存在营养风险、头静脉置管的患者,同时操作者要重视置管前后评估较差的患者,并注重提升自身专业技能水平,采取积极措施预防PICC-CRT的发生。展开更多
文摘Background： We want to establish a lobe-specific mediastinal lymphadenectomy protocol for solitary pulmonary nodules （SPNs） in non-small cell lung cancer （NSCLC）. Methods： We retrospectively analyzed 401 patients with pathological diagnoses of NSCLC who underwent lobectomy, bilobectomy, or pneumonectomy with systematic lymphadenectomy from March 2004 to June 2011 in our hospital. All of the patients enrolled had a SPN preoperatively. Information about the primary tumor location, lymph node metastasis, and other baseline data were collected. Stepwise logistic regression was used to identify the key factors indicating non-regional mediastinal lymph node metastases （NRM）. Results： Of the primary tumors, 117, 39, 74, 104, and 67 were in the right upper lung （RUL）, right middle lung （RML）, right lower lung （RLL）, left upper lung （LUL）, and left lower lung （LLL）, respectively. Stepwise regression showed that #2,4, #10,11, and #10,11 as well as #7 was the key lymph node station for RUL, LUL, and lower lobes： #2,4 [odds ratio （OR）=28.000, 95% confidence interval （CI）： 2.917-268.790, P=0.004] for RUL, #10,11 （OR=31.667, 95% CI： 2.502-400.833, P=0.008） for LUL, #10,11 （OR=19.540, 95% CI： 4.217-90.541, P〈0.001） and #7 （OR=7.395, 95% CI： 1.586-34.484, P=0.011） for lower lobes, respectively. Patients with tumors 〉2 cm rarely had NRM without primary regional mediastinal involvement. Conclusions： With rigid consideration, a lobe-specific lymphadenectomy is feasible in practice. This protocol can be used when the lobe-specific key nodes are negative in intraoperative frozen sections, especially for NSCLC diagnosed as SPN 〈2 cm preoperatively.
文摘Background: Some studies have suggested that among all cases of lung cancer, the outcome of lung cancer located in the right middle lobe (RML) is the worst. However, with the advances in the diagnosis and treatment methods of lung cancer over the last couple of decades, we investigated whether the prognosis of primary lung cancer located in the RML still remains inferior to that of lung cancer arising from other lobes. Methods: Between July 2003 and December 2011, 505 consecutive patients with non-small cell lung cancer (NSCLC) underwent surgical resection at our institution. Of these, 32 patients (6.3%) had tumors arising from the RML. Results: The rate of incomplete resection was higher for cancer located in the RML than that for cancer arising from other lobes. Significant associations were noted between cancer located in the RML and the rate of lymph node metastasis and initial locoregional recurrence. Multivariate analysis identified lymph node metastasis and location in the RML as independent risk factors influencing the recurrence-free survival (p = 0.006), although location in the RML was not extracted as an independent risk factor influenceing the overall survival (p = 0.060). Conclusion: Despite the recent advances in the treatment of lung cancer, evaluation of complete resection revealed that the outcome of cancer located in the RML is still the worst among cancer of all the lobes. Further early diagnosis and adjuvant therapy are needed for improving the prognosis of cancer located in the RML.
文摘A 49-year-old man had an abnormal shadow on chest X-ray. Enhanced chest computed tomography (CT) revealed an 8-cm diameter right lung mass invading the right chest wall, with a tumor thrombus extending from the superior pulmonary vein into the left atrium. Transesophageal echocardiography confirmed that the tumor adjoined the side wall of the atrium. Endobronchial and CT-guided needle biopsy demonstrated a low-grade carcinoma or small cell carcinoma. Operative findings through left atriotomy under cardiopulmonary bypass showed no tumor invasion of the atrium wall, but protrusion through the pulmonary vein. Frozen sections revealed a non-small cell carcinoma. We performed right upper lobectomy with parietal pleura and mediastinal lymph node dissection after detachment of cardiopulmonary bypass. Pathological examination demonstrated a large-cell neuroendocrine carcinoma p-T4N0M0, stage IIIA. The patient recovered without postoperative complications and tolerated two cycles of adjuvant chemotherapy. He was doing well without symptoms of recurrence 42 months after surgery.
文摘永存左上腔静脉(persistent left superior vena cava,PLSVC)是一种罕见的体循环血管变异,在人群中的发生率约为0.3%~0.5%[1],但是在先天性心脏病患者中,这一发生概率可达到约1.3%~11%[1-2]。PLSVC通常无血流动力学的异常,因为它多数经由冠状静脉窦回流入右心房,但由于该血管的特殊走行及其罕见性,胸外科医师可能会将其误认为主动脉旁肿大的淋巴结,并对肺癌进行错误的分期,抑或是增加手术误伤的风险。因此我们回顾了3例于我院行左侧肺癌手术的患者,在术前或术中发现存在这一变异的血管,本文对其进行详细描述,并结合文献复习,总结其发病原因、临床特点及影像学特征,以呼吁胸外科医生应对此提高认识,避免相关的临床不良事件发生。
文摘目的探讨老年肺癌患者上肢PICC相关性静脉血栓(peripherally inserted central catheters related thrombosis,PICC-CRT)发生的危险因素及其护理措施。方法对2017年1月至2021年1月在某三级甲等综合医院肿瘤科行PICC化疗的287例老年肺癌患者进行一般资料和疾病资料收集,分析其发生PICC-CRT的危险因素。结果老年肺癌化疗患者上肢PICC-CRT发生率为8.7%(25/287)。Logistic回归分析显示,高龄、日常生活活动能力差、头静脉置管、存在营养风险、置管评估为疑难是老年肺癌患者发生上肢PICC-CRT危险因素(均P<0.05),共同解释其33.8%的变异。结论老年肺癌患者上肢PICC-CRT发生率高,医护人员应关注高龄、日常生活活动能力差、存在营养风险、头静脉置管的患者,同时操作者要重视置管前后评估较差的患者,并注重提升自身专业技能水平,采取积极措施预防PICC-CRT的发生。
