Objective: To compare a new device (Innocor) for non-invasive measurement of cardiac output (CO) by foreign gas rebreathing method with conventional techniques used in the measurements of cardiac function. Methods: Ca...Objective: To compare a new device (Innocor) for non-invasive measurement of cardiac output (CO) by foreign gas rebreathing method with conventional techniques used in the measurements of cardiac function. Methods: Cardiac outputs measured by Innocor (CORB) were compared with CO obtained by echocardiography (COEC), Swan-Ganz thermodilution (COTD), and left ventricle radiography (COLVR) in 34 patients subjected to cardiac catheterization. Values obtained from the four methods were analyzed by linear regression and paired values were compared by the method of Bland and Altman in SPSS. Results: There was strong positive correlation (r=0.94) between Innocor cardiac output values and the corresponding values obtained by ther-modilution and between COEC and COLVR values. Thermodilution appears to overestimate cardiac output when compared to the values obtained with Innocor by (0.66±0.22) L/min (P<0.0001). There was no correlation between data obtained by Innocor and the corresponding COEC and COLVR values. Conclusion: Innocor CORB is an easy, safe and well established method for non-invasive measurement of cardiac output with good prospects for clinical application in heart disease patients.展开更多
左冠状动脉异常起源于肺动脉(anomalous left coronary artery origin from pulmonary artery,ALCAPA)是一种发病率低、预后较差的先天性心脏畸形,常在婴儿期需要外科手术矫治。低心排血量综合征是指各种原因导致心排出量降低的一种病...左冠状动脉异常起源于肺动脉(anomalous left coronary artery origin from pulmonary artery,ALCAPA)是一种发病率低、预后较差的先天性心脏畸形,常在婴儿期需要外科手术矫治。低心排血量综合征是指各种原因导致心排出量降低的一种病理异常表现,是心脏术后导致患者死亡的主要原因之一。体外膜氧合(extracorporeal membrane oxygenation,ECMO)是一种可以临时替代心肺功能的装置,在重症及急救领域应用广泛,但在ALCAPA术中及术后应用相关经验报道较少,本文分享一例ECMO成功救治ALCAPA术后低心排血量综合征的案例。展开更多
Almost 50 years ago,we published detailed hemodynamic findings in a patient with heart failure and intermittent left bundle branch block.Delayed intraventricular conduction was consistently accompanied by an increased...Almost 50 years ago,we published detailed hemodynamic findings in a patient with heart failure and intermittent left bundle branch block.Delayed intraventricular conduction was consistently accompanied by an increased duration of left ventricular(LV)isometric contraction,a drop in systolic blood pressure,a rise in heart rate,and a drop in cardiac output.To our knowledge,this observation provided the first ever evidence that delayed mechanical LV contraction was associated with deterioration,and return to a normal pre-ejection phase with improvement in LV function.展开更多
目的探讨应用无创心排量监测系统(USCOM)动态监测新生儿外周动静脉同步换血左心功能的临床意义。方法方便选取该院2017年10月—2019年1月收治的因“新生儿高胆红素血症”需行外周动静脉同步换血的新生儿共20例,随机化入组“USCOM监测组...目的探讨应用无创心排量监测系统(USCOM)动态监测新生儿外周动静脉同步换血左心功能的临床意义。方法方便选取该院2017年10月—2019年1月收治的因“新生儿高胆红素血症”需行外周动静脉同步换血的新生儿共20例,随机化入组“USCOM监测组(研究组)”及“无USCOM监测组(对照组)”,每组10例,应用USCOM动态监测研究组新生儿换血前、中、后左心功能,记录并分析研究组USCOM左心功能相关参数,比较两组换血速度、时长及效果等相关情况。结果研究组“换血中”“换血后”速度峰值(Vpk)[(“换血中”“换血后”0.92(0.73,0.95)、0.81(0.69,0.89)m/s vs“换血前”1.01(0.97,1.30)m/s]差异有统计学意义(Z=10.958,P<0.05)、每搏输出量指数(SVI)[17.00(14.00,18.33)、16.00(14.10,19.00)mL/m^(2) vs 19.00(19.00,25.00)mL/m^(2)]差异有统计学意义(Z=8.314,P<0.05)、心输出量(CO)[(0.49±0.09)、(0.41±0.10)L/min vs(0.65±0.18)L/min]差异有统计学意义(F=5.743,P<0.05)、心脏指数(CI)[(2.56±0.44)、(2.10±0.42)L/(min·m^(2))vs(3.32±0.88)L/(min·m^(2))],差异有统计学意义(F=6.345,P<0.05),“换血后”肌力指数(INO)[0.48(0.41,0.54)W/m^(2) vs 0.67(0.64,1.03)W/m^(2)]、单位体重心输出量(CO/kg)[(0.15±0.03)L/(min·kg)vs(0.24±0.07)L/(min·kg)]均较“换血前”明显下降,差异有统计学意义(P<0.05);“换血后”外周血管阻力指数(SVRI)较“换血前”明显上升,差异有统计学意义(P<0.05);“换血中”“换血后”势动能比(PKR)均较“换血前”明显上升[37.67(34.00,68.00)、48.00(40.25,83.50)vs 29.00(20.67,36.00)],差异有统计学意义(P<0.05);“换血中”“换血后”USCOM参数差异无统计学意义(P>0.05);研究组平均换血速度明显低于对照组[(45.59±5.95)mL/(kg·h)vs(56.94±6.12)mL/(kg·h)]、换血时长较对照组长[3.50(3.13,4.00)h vs 3.09(3.00,3.34)h],差异有统计学意义(P<0.05);两组换血效果差异无统计学意义(P>0.05)。结论新生儿外周动静脉同步换血过程中存在血流动力学的不稳定性,USCOM动态监测显示换血可能导致左心输出功能下降、外周阻力升高,应用USCOM动态监测换血可以使换血过程更为平稳、安全。展开更多
【目的】探讨左心室射血分数（LVEF）正常的原发性高血压患者晨峰血压对早期肾功能损害的影响以及与同型半胱氨酸（Hcy）、尿微量白蛋白（UmAlb）的相关性。【方法】应用24 h动态血压监测仪器将197例原发性高血压且LVEF正常的患者依据...【目的】探讨左心室射血分数（LVEF）正常的原发性高血压患者晨峰血压对早期肾功能损害的影响以及与同型半胱氨酸（Hcy）、尿微量白蛋白（UmAlb）的相关性。【方法】应用24 h动态血压监测仪器将197例原发性高血压且LVEF正常的患者依据晨峰血压水平分为两组：A组（晨峰血压正常组），共90例；B组（晨峰血压增高组）共107例。检测患者血尿素氮（BUN）、血清肌酐（SCr）、血尿酸（UA）、Hcy、UmAlb及血脂水平等指标。应用Pearson相关分析法和多元线性逐步回归法分析晨峰血压与肾功能、Hcy、UmAlb等指标的相关性。【结果】A组与B组患者在24 h、日间、夜间收缩压（SBP）和舒张压（DBP）的血压平均值，24 h平均动脉压（MAP）等方面均无显著性意义。B组在BUN、SCr、UA、Hcy和UmAlb水平方面均明显高于A组，差异有显著性意义（ P ＜0．05）。晨峰血压水平与BUN、SCr、UA、Hcy和UmAlb均显著相关（ P ＜0．05），其中晨峰血压与UmAlb相关性最强。【结论】晨峰血压在LVEF正常的原发性高血压患者所致早期肾功能损害方面有重要的意义，患者晨峰血压水平越高所致肾功能损害越重，且与Hcy、UmAlb密切相关，提示控制晨峰血压可降低患者早期肾功能损害程度。展开更多
文摘Objective: To compare a new device (Innocor) for non-invasive measurement of cardiac output (CO) by foreign gas rebreathing method with conventional techniques used in the measurements of cardiac function. Methods: Cardiac outputs measured by Innocor (CORB) were compared with CO obtained by echocardiography (COEC), Swan-Ganz thermodilution (COTD), and left ventricle radiography (COLVR) in 34 patients subjected to cardiac catheterization. Values obtained from the four methods were analyzed by linear regression and paired values were compared by the method of Bland and Altman in SPSS. Results: There was strong positive correlation (r=0.94) between Innocor cardiac output values and the corresponding values obtained by ther-modilution and between COEC and COLVR values. Thermodilution appears to overestimate cardiac output when compared to the values obtained with Innocor by (0.66±0.22) L/min (P<0.0001). There was no correlation between data obtained by Innocor and the corresponding COEC and COLVR values. Conclusion: Innocor CORB is an easy, safe and well established method for non-invasive measurement of cardiac output with good prospects for clinical application in heart disease patients.
文摘左冠状动脉异常起源于肺动脉(anomalous left coronary artery origin from pulmonary artery,ALCAPA)是一种发病率低、预后较差的先天性心脏畸形,常在婴儿期需要外科手术矫治。低心排血量综合征是指各种原因导致心排出量降低的一种病理异常表现,是心脏术后导致患者死亡的主要原因之一。体外膜氧合(extracorporeal membrane oxygenation,ECMO)是一种可以临时替代心肺功能的装置,在重症及急救领域应用广泛,但在ALCAPA术中及术后应用相关经验报道较少,本文分享一例ECMO成功救治ALCAPA术后低心排血量综合征的案例。
文摘Almost 50 years ago,we published detailed hemodynamic findings in a patient with heart failure and intermittent left bundle branch block.Delayed intraventricular conduction was consistently accompanied by an increased duration of left ventricular(LV)isometric contraction,a drop in systolic blood pressure,a rise in heart rate,and a drop in cardiac output.To our knowledge,this observation provided the first ever evidence that delayed mechanical LV contraction was associated with deterioration,and return to a normal pre-ejection phase with improvement in LV function.
文摘目的探讨应用无创心排量监测系统(USCOM)动态监测新生儿外周动静脉同步换血左心功能的临床意义。方法方便选取该院2017年10月—2019年1月收治的因“新生儿高胆红素血症”需行外周动静脉同步换血的新生儿共20例,随机化入组“USCOM监测组(研究组)”及“无USCOM监测组(对照组)”,每组10例,应用USCOM动态监测研究组新生儿换血前、中、后左心功能,记录并分析研究组USCOM左心功能相关参数,比较两组换血速度、时长及效果等相关情况。结果研究组“换血中”“换血后”速度峰值(Vpk)[(“换血中”“换血后”0.92(0.73,0.95)、0.81(0.69,0.89)m/s vs“换血前”1.01(0.97,1.30)m/s]差异有统计学意义(Z=10.958,P<0.05)、每搏输出量指数(SVI)[17.00(14.00,18.33)、16.00(14.10,19.00)mL/m^(2) vs 19.00(19.00,25.00)mL/m^(2)]差异有统计学意义(Z=8.314,P<0.05)、心输出量(CO)[(0.49±0.09)、(0.41±0.10)L/min vs(0.65±0.18)L/min]差异有统计学意义(F=5.743,P<0.05)、心脏指数(CI)[(2.56±0.44)、(2.10±0.42)L/(min·m^(2))vs(3.32±0.88)L/(min·m^(2))],差异有统计学意义(F=6.345,P<0.05),“换血后”肌力指数(INO)[0.48(0.41,0.54)W/m^(2) vs 0.67(0.64,1.03)W/m^(2)]、单位体重心输出量(CO/kg)[(0.15±0.03)L/(min·kg)vs(0.24±0.07)L/(min·kg)]均较“换血前”明显下降,差异有统计学意义(P<0.05);“换血后”外周血管阻力指数(SVRI)较“换血前”明显上升,差异有统计学意义(P<0.05);“换血中”“换血后”势动能比(PKR)均较“换血前”明显上升[37.67(34.00,68.00)、48.00(40.25,83.50)vs 29.00(20.67,36.00)],差异有统计学意义(P<0.05);“换血中”“换血后”USCOM参数差异无统计学意义(P>0.05);研究组平均换血速度明显低于对照组[(45.59±5.95)mL/(kg·h)vs(56.94±6.12)mL/(kg·h)]、换血时长较对照组长[3.50(3.13,4.00)h vs 3.09(3.00,3.34)h],差异有统计学意义(P<0.05);两组换血效果差异无统计学意义(P>0.05)。结论新生儿外周动静脉同步换血过程中存在血流动力学的不稳定性,USCOM动态监测显示换血可能导致左心输出功能下降、外周阻力升高,应用USCOM动态监测换血可以使换血过程更为平稳、安全。
文摘【目的】探讨左心室射血分数（LVEF）正常的原发性高血压患者晨峰血压对早期肾功能损害的影响以及与同型半胱氨酸（Hcy）、尿微量白蛋白（UmAlb）的相关性。【方法】应用24 h动态血压监测仪器将197例原发性高血压且LVEF正常的患者依据晨峰血压水平分为两组：A组（晨峰血压正常组），共90例；B组（晨峰血压增高组）共107例。检测患者血尿素氮（BUN）、血清肌酐（SCr）、血尿酸（UA）、Hcy、UmAlb及血脂水平等指标。应用Pearson相关分析法和多元线性逐步回归法分析晨峰血压与肾功能、Hcy、UmAlb等指标的相关性。【结果】A组与B组患者在24 h、日间、夜间收缩压（SBP）和舒张压（DBP）的血压平均值，24 h平均动脉压（MAP）等方面均无显著性意义。B组在BUN、SCr、UA、Hcy和UmAlb水平方面均明显高于A组，差异有显著性意义（ P ＜0．05）。晨峰血压水平与BUN、SCr、UA、Hcy和UmAlb均显著相关（ P ＜0．05），其中晨峰血压与UmAlb相关性最强。【结论】晨峰血压在LVEF正常的原发性高血压患者所致早期肾功能损害方面有重要的意义，患者晨峰血压水平越高所致肾功能损害越重，且与Hcy、UmAlb密切相关，提示控制晨峰血压可降低患者早期肾功能损害程度。
