Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease

Alzheimer disease(AD) as worldwide progressive neurodegenerative disease is prevalent disease among elderly population. Due to limitation in chemical drugs along with their adverse effects of these treatments, research for finding more effective natural drugs, is one of interesting subjects among the scientists. Melissa officinalis(M. officinalis) has a long history of use in treatment of nervous system diseases. This review article evaluates the potency of M. officinalis in treatment of AD by review of experimental and clinical documents on the efficacy, safety and its mechanisms of action in management of AD. The information is extracted from electronic resources(PubMed, Wiley, Springer and Science Direct), English and Persian scientific books. In spite of different scientific and non-scientific reports on the use of M. officinalis and its main component of rosmarinic acid in neurodegenerative diseases, there is only one clinical trial on the efficacy of M. officinalis ethanol extract in management of AD. Different mechanisms of action for M. officinalis, including inhibitory effects against amyloid beta, reactive oxygen species, and acetylcholine esterase, are involved. Larger clinical trials are recommended to confirm the efficacy and safety of M. officinalis extracts in treatment of AD patients.

香蜂花醇提物对一次性力竭运动引起的大鼠心肌损伤的保护作用及其机制

香蜂花(Melissa officinalis L.)是一种具有广泛药理活性的药用植物,含有多种对人体有益的活性化合物,香蜂花的心脏保护作用受到了广泛关注。本研究旨在探讨香蜂花醇提物(Melissa officinalis L.ethanol extract,MOEE)对一次性力竭运动(EE)引起的大鼠心肌损伤的保护作用及其潜在机制。本研究比较了对照组(C组)、EE组以及接受不同剂量MOEE处理的EE大鼠(EE+L-MOEE,EE+M-MOEE,EE+H-MOEE)的心肌损伤指标、能量代谢参数、氧化应激反应和NLRP3炎性体通路的活性。结果显示,与EE组相比,MOEE处理能显著提高心肌的能量代谢水平,降低乳酸(LA)和尿素氮(BUN)水平,提升心肌SOD和CAT活性,减少MDA积累,抑制NLRP3炎性体通路的激活,从而减轻心肌细胞焦亡。这些发现表明,香蜂花醇提物通过改善氧化应激反应和抑制NLRP3炎性体通路,对EE引起的心肌损伤具有显著的保护作用。本研究为香蜂花醇提物在预防和治疗运动相关心脏损伤中的应用提供了实验依据。