Clinic study on silicone hydrogel contact lenses used as bandage contact lenses after LASEK surgery

AIM: To compare the clinical performance of two types of silicon hydrogel contact lenses used as bandage lenses after LASEK surgery. METHODS: A prospective, double-masked study was conducted on 42 eyes of 21 patients who received binocular LASEK surgeries. The interocular difference in spherical equivalent power was less than -1.50D. Patients were randomly assigned to wear Galyfilcon A (Lens A) bandage contact lens in one eye and Balafilcon A (Lens B) in the fellow eye after the surgery. The responses to a subjective questionnaire on comfort of wearing, corneal epithelial status, conjunctival hyperemia, limbal neovascularization, lens fitting and contact lens debris were assessed 1 and 5 days postoperatively. Corneal endothelium was assessed before and 5 days after the surgery upon bandage lens removal. RESULTS: There was no difference between the two groups in terms of conjunctival hyperemia, limbal neovascularization, contact lens fitting, corneal epithelial status, corneal endothelium cell density (CD) and endothelium cell size (CS) at any postoperative visit. Complaints of discomfort, including foreign body sensation, pain and intolerance were statistically more among Lens B wearers at any postoperative visit (P < 0.05). Lens B appeared to attract much more debris than Lens A at the 5-day post-operative follow-up visit (P < 0.01). CONCLUSION: The two types of silicon hydrogel lenses investigated in this study demonstrated similar clinical performance in terms of corneal responses and lens fitting. However, Lens A showed a better performance in terms of comfort of wearing and deposit resistance.

Comparison of efficacy of two different silicone hydrogel bandage contact lenses after T-PRK

AIM:To compare the efficacy between two different silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy(T-PRK).METHODS:In this randomized controlled trial,a total of 89 patients(178 eyes) who underwent T-PRK at the Qingdao Eye Hospital from October to December 2019 were selected.One random eye wore a Senofilcon A bandage contact lens after surgery,and the other eye a Balafilcon A bandage contact lens.Pain scores,uncorrected visual acuity(UCVA),spherical equivalent(SE),corneal epithelial healing status,epithelial thickness,bandage lenses deposits,lenses movement,and ocular surface conditions were measured and compared.RESULTS:There were no differences between the two groups in UCVA,SE,corneal epithelial healing status,corneal epithelial thickness,tear river heights and tear film rupture time at each follow-up visit.However,postoperative pain scores in the Senofilcon A group were significantly lower than those of the Balafilcon A group(F_(intergroups)=67.833,P<0.001;F_(time)=383.773,P<0.001;F_(interaction)=57.344,P<0.001).The duration of pain in eyes in the Senofilcon A group was shorter than that of the Balafilcon A group(t=-3.326,P=0.001).The surface deposition scores and movement scores of Senofilcon A bandage lenses on the first and fourth days after surgery were lower than those of Balafilcon A bandage lenses(Z=-5.385,-6.782,P<0.001;Z=-8.336,-8.906,P<0.001).CONCLUSION:Both Senofilcon A and Balafilcon A bandage lenses have good efficacy after T-PRK.Senofilcon A lenses are associated with less pain and more comfort compared to Balafilcon A.

Curative effect assessment of bandage contact lens in neurogenic keratitis

AIM: To observe the curative effect of bandage contact lens in neurogenic keratitis.METHODS: Twenty cases of neurogenic keratitis were studied at the Department of Ophthalmology, the First Affiliated Hospital of China Medical University, between October 2012 and June 2013. These included 13 males and 7 females, aged from 35 to 88 y. Patients were voluntarily divided into an experimental group(lens wearing group, n =10) and control group(drug therapy,n =10). In experimental group patients wore silicone hydrogel bandage soft contact lens. Both groups used the following eyedrops: 0.5% levofloxacin TID; 0.5%Sodium carboxymethyl cellulose QID; fibroblast growth factor BID; ganciclovir BID [cases complicated with herpes simplex virus(HSV)]; compound tropicamide BID(cases concurrent hypopyon). The healing time of corneal ulcer and complication rates were observed in the two groups.RESULTS: The healing time of corneal ulcer in the experimental group was 10.80±4.44 d versus 46.70±13.88 d in the control group(P 【0.05). No complications occurred in the experimental group, except for the lens falling off twice in one case, the patient recovered eight days after rewearing the lens. While in the control group, all cases vascularized, 2 cases were complicated with descemetocele that recovered with amniotic membrane transplantation and 1 case was complicated with corneal perforation that recovered by autologous conjunctival flap covering.CONCLUSION: Bandage contact lens is a safe and effective method of treating neurogenic keratitis andsignificantly shortened the healing time of corneal ulcer.

Evaluation of the safety and efficacy of therapeutic bandage contact lenses on post-cataract surgery patients

AIM： To evaluate the safety of therapeutic bandage contact lens for post-cataract surgery patients and to illustrate its efficacy on post-operative comfort and tear-film stability. METHODS： A total of 40 participants were recruited and randomly divided into two groups. Group one was instructed to wear bandage contact lenses for a week and use antibiotic eye drops for a month since the first day after surgery. Group two received sub-conjunctival injection of tobramycin and was asked to wear eye pads on the first day after surgery and then were instructed to use antibiotic eye drops as the first group did. Ocular surface disease index（OSDI） questionnaire, slit-lamp microscope examination of tear break-up time（TBUT）, corneal fluorescein score（CFS）, tear meniscus height（TMH） together with anterior segment optical coherence tomography（AS-OCT） and corneal topography were evaluated preoperatively and postoperatively. RESULTS： The subjective feeling（P=0.004）, TBUT（P〈0.001） and TMH（P=0.02） post-surgery had improved in patients who used bandage contact lenses compared with those who did not at 1wk post-surgery. Until three month postoperatively, the comfort degree（P=0.004） and TMH（P=0.01） of group two were still worse than group one. Moreover, TBUT（P〈0.001） and CFS（P=0.004） of the group with eye pads got worse than the results before, whereas the group with bandage contact lenses recovered to normal. None of these patients had infections or other complications. CONCLUSION： Wearing therapeutic bandage contact lens after cataract surgery, compared with traditional eye-pads, is a safe method to improve tear-film stability and reduce post-operative discomfort without hindering corneal incision recovery.

A survey of corneal changes caused by daily wear silicone hydrogel contact lenses

The examination of the effects of second generation lotra filcon B silicone hydrogel(SiH)lenses on the cornea when worn for three years of daily wear.Material and Methods:55 healthy patients were divided into two groups:current hydrogel contact lens wearers refitted with lotrafilcon B lenses(Group 1;28 patients)and neophyte contact lens wearers(Group 2;27 patients).Each patient's subjective eye comfort was measured with a self-administered questionnaire.The corneas were analyzed using contact specular microscope to measure corneal thickness and the endothelium before the SiH lenses werefitted after four weeks,one month,six months,one year,two years,and three years of lens wear.Results:Subjective complaints of patients in Group 1 were reduced;however patients in Group 2 experienced discomfort during the first two to four weeks of use.In Group 1,objective examinations identified a decrease in endothelial cell density.In Group 2,the endothelial cell density increased slightly in the first two years but decreased after three years.The results indicate that lotra filcon B slows down the deleterious effects of contact lenses.The coe±cient of variation significantly decreased after six months in Group 1(0.47 vs 0.44;p?0:049),whereas,in Group 2,the hexagonal cells improved significantly after one month(27.78 vs 28.25;p=0.025).Conclusion:Based on the subjects involved and the period of time under examination,it can be concluded that high-Dk SiH lenses support the physiological metabolism and functions of the cornea by improving oxygen provision.

Cytotoxicity of Contact Lens Care Solution to Human Corneal Epithelium in Vitro

Purpose: To investigate the cytotoxicity of soft contact lens multi-purpose care solutions which are now in common use in China.Methods: The cell culture method was used. Cytotoxicity was indicated by significant increases in the number of dead cells relative to controls.Results: Cells were exposed to soft contact lens care solutions for 15 min. They were irregular in shape and variable in size. The intercellular space increased and variable in size.The in-tercelluar space increased and the cells became scrunken. With the time of exposure elongated , damage of cells became more severe.Conclusions: Four kinds of soft contact lens multi-purpose care solutions may have harmful effects on the culture of human corneal epithelial cells. Soaked lenses should be rinsed with saline before being placed in the eyes in order to reduce the potential toxicity of contact lens care solutions. Eye science 1998; 14 :45 - 47.

Effects of rigid gas permeable contact lens on morphological parameters and vision-related quality of life in keratoconus patients

AIM: To evaluate the effect of rigid gas permeable contact lens(RGP-CL) on corneal morphological parameters and vision-related quality of life in keratoconus(KC) patients.METHODS: Totally 57 eyes of 30 KC patients who were followed-up for more than two years, including 17 RGP wearers(32 eyes) and 13 non-wearers(25 eyes) were retrospectively analyzed. Initial medical history and corneal topography were collected at baseline. Corneal topography, corneal aberration, optical coherence tomography, and vision-related quality of life questionnaires were performed at the last follow-up.RESULTS: According to corneal topography, increase of the flattest keratometric values was higher in RGP wearers than in non-wearers(P=0.038). The morphological parameters, including symmetry index of front corneal curvature(P=0.004) and Baiocchi-Calossi-Versaci index front(P=0.047), were lower in RGP wearers than in nonwearers. Vertical coma was smaller in RGP wearers than non-wearers in 3.0, 5.0, 6.0, and 7.0 mm pupil diameters, respectively(P<0.05). The environmental triggering domain of ocular surface disease index was worse in RGP wearers as compared to non-wearers(P=0.003). At the last followup, there were no significant differences in constituent ratios of KC progression, corneal thickness topography, epithelial thickness topography, morphological parameters of corneal topography, and other questionnaire scores between the two groups(all P>0.05).CONCLUSION: Long-term use of RGP does not worsen KC but may cause corneal epithelial remodeling to increase symmetry of corneal anterior surface, reduce corneal vertical coma and improve visual quality. However, RGP wearing causes a slight decrease in vision-related quality of life. The occurrence of ocular surface symptoms is mainly associated with environmental triggering factors.

Continuous Wear of Hydrogel Contact Lenses for Therapeutic Use

Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one week of continuous therapeutic wear during 10 years. The reason for prescription of CLs, the primary disease, the duration of CL wear and the complications were assessed retrospectively. Results: The predominant reason for prescription of CLs was relief of pain or a foreign-body sensation (62.3%) and protection of the corneal epithelium (20.6%). The primary disease was post-penetrating keratoplasty (36.8%), followed by corneal epithelial erosion (14.5%), post-lamellar keratoplasty (14.0%) and bullous keratopathy (12.2%). The average duration of wearing single lens was 6.5 ± 3.2 days. The average duration of wearing CLs in total was 9.2 ± 10.7 months. The most frequent problem associated with continuous wear of CLs was their dropping out of CLs (12.3%). The complications associated with CLs included conjunctivitis with papillary hyperplasia, corneal erosion and superficial punctate keratitis, but corneal ulcer and corneal infiltrates were not found. Conclusion: Serious complications were not shown changing the lenses every week to keep to the prescribed time limit for continuous therapeutic wear, even if corneal epithelial barrier function is impaired.

EFFECT OF SHORT-TERM SOFT CONTACT LENS WEAR ON HUMAN OCULAR ABERRATIONS

Objective To evaluate the effect of short-term soft contact lens （SCLs） wearing on human ocular aberrations （ HOA ）. Methods This prospective study included 50 eyes of 50 young volunteers wearing SCLs for 1 month. The ocular aberrations were measured by Allegretto Wavefront Analyzer. The root-mean-square （RMS） values of the general （RMSG） , higher-order （RMSH） , first to sixth order （ RMS1 to RMS6） and aberration coefficients were analyzed. Results There were no significant differences in the mean values of RMSG, RMSH, RMS1 to RMS6 （ P 〉 0. 05 ） and changes of absolute values of aberration coefficients between baseline and various visits after SCLs discontinuation. However, at d I after the discontinuation of SCLs, changes in coefficient values of the third-order aberrations （ C6 to C9 ） were slightly higher than others, and C7 was the highest. The increase factors of RMS values were higher at 1 week and lower at the 2 week visit after SCLs discontinuation. The uniformity of dominating type in HOA and the corneal topography form was both about 60% after discontinuation of SCLs. The corneal thickness increased after SCLs wear and gradually decreased to baseline until 1 month discontinuation of SCLs. Conclusion The effect of short-term SCLs wear on human ocular aberrations is slight but profound. A month or more wait should be allowed before the short-term SCLs wearers are scheduled for wavefronted-guided LASIK.

Reversible grafting of antibiotics onto contact lens mediated by labile chemical bonds for smart prevention and treatment of corneal bacterial infections

Eye trauma, decreased immunity, and contact lens wear often cause serious bacterial infections and irreversible corneal damage. To realize the responsive release of antibiotics such as gentamicin sulfate(GS), a novel antibacterial contact lens was constructed through self-assembly of antibiotics loaded ADAGS/PEI(polyethyleneimine) multilayer films on the surface. Both in vitro and in vivo antibacterial tests demonstrated high efficient and fast antibacterial property based on the smart responsive to bacterial infections and reversible drug loading and release.

Effects of Contact Lens Wear on the Corneal Endotnelium and Sensitivity

The corneal endothelium of 38 contact lens wearers(74 eyes) and 74 normal eyes for control was photographed and analyzed with specular microscopy and the graphic processing system.The central corneal sensitivity and thickness were also measured.The results showed that the frequency

Influence of overnight orthokeratology lens fitting decentration on corneal topography reshaping

Background:This retrospective study was designed to investigate the sole influence of orthokeratology(OK)lens fitting decentration on the Zernike coefficients of the reshaped anterior corneal surface.Methods:This study comprised a review of 106 right eyes and measurements of corneal topography both before OK and at 1-month follow-up visit.A routine was designed to calculate local corneal surface astigmatism and assist the determination of OK lens fitting decentration from pupil center.The pupil-centered corneal Zernike coefficients of baseline(PCCB)and post-treatment(PCCP)were calculated.Meanwhile,the OK-lens-centered corneal Zernike coefficients of post-treatment(OCCP)were also calculated and considered as the presumptive ideal fitting group without decentration.Relationships between lens fitting decentration and the change of Zernike coefficients including(PCCP−PCCB)and(PCCP−OCCP)were analyzed.Results:Patients with a mean age of 11±2.36 years old had an average spherical equivalent refractive error of−3.52±1.06 D before OK.One month after treatment,OK lens fitting decentration from pupil center was 0.68±0.35 mm.RMS of 3rd-order(P<0.05),RMS of 4th-order(P<0.001)and RMS of total high order(P<0.001)corneal Zernike coefficients were increased in PCCP by comparing with OCCP,which was solely caused by lens fitting decentration.Nevertheless,no significant difference was observed in C^(0)_(2)(P>0.05).For the high order corneal Zernike coefficients in(PCCP–OCCP),radial distance of decentration was correlated with C^(−1)_(3)(r=−0.296,P<0.05),C^(1)_(3)(r=−0.396,P<0.001),and C^(0)_(4)(r=0.449,P<0.001),horizontal decentration was significantly correlated with C^(1)_(3)(r=0.901,P<0.001)and C^(1)_(5)(r=0.340,P<0.001),and vertical decentration was significantly correlated with C^(−1)_(3)(r=0.904,P<0.001).Conclusions:OK lens fitting decentration within 1.5 mm hardly influenced the change of corneal spherical power for myopia correction,but significantly induced additional corneal high order Zernike coefficients including C^(−1)_(3),C^(1)_(3),C^(0)_(4),and C^(1)_(5).

Management of corneal ulceration with a moisture chamber due to temporary lagophthalmos in a brain injury patient:A case report

BACKGROUND This study describes the use of a moisture chamber to treat corneal ulceration due to temporary lagophthalmos in a critically ill patient.CASE SUMMARY A 46-year-old woman was admitted to the intensive care unit after a car accident.She suffered multiple injuries that included brain injury and presented with moderately decreased consciousness and lagophthalmos in her right eye.Within 6 d,her consciousness improved considerably;at which time,exposure keratopathy occurred and worsened to corneal ulceration.Lubricating gel,antibiotic ointment,and bandage contact lens were all ineffective in preventing or treating the exposure keratopathy.Instead of tarsorrhaphy,a moisture chamber was applied which successfully controlled the corneal ulceration.The moisture chamber was discontinued when complete eyelid closure recovered a week later.CONCLUSION A moisture chamber may be an effective,noninvasive alternative to tarsorrhaphy for treating severe exposure keratopathy due to temporary lagophthalmos.

Orthokeratology lens related infections

Orthokeratology is a reversible technique that temporarily changes the curvature of the cornea with the aim of addressing refractive errors. The United States Food and Drug Administration(FDA) granted approval for using reverse geometry contact lenses to correct myopia without any age restriction. Information from the pre-market applications to the FDA was rated as level Ⅱ evidence. Another unapproved use of overnight orthokeratology is for the prevention of myopic progression. Although orthokeratology is advocated to reduce myopic progression, there are limited long-term studies with substantial evidence of its benefits. Much of this evidence comes from non-robust experimental studies using historical or self-selected controls with relative high dropout rates. Although some positive results have been published in temporarily reducing the myopic refractive error and its progression, the use of these lenses can be associated with serious complications such as microbial keratitis. Microbial keratitis is a potentially vision-threatening adverse response associated with contact lens wear. In fact, contact lens wearhas been shown to be the predominant risk factor of microbial keratitis in some developed countries. Most of the published cases on overnight orthokeratology related microbial keratitis occurred in children or adolescents. Parents considering orthokeratology must make an informed decision about its temporary benefit and its potential for permanent loss of vision. The ophthalmic community should be reminded of the potential complications of orthokeratology.

巩膜镜矫正屈光不正的安全性

目的 探讨硬性巩膜接触镜在矫正屈光不正方面的安全性。方法 前瞻性研究,选取96例(192眼)近视患者(度数-20.00~0 D,散光度数0~3.50 D)为研究对象,分为试验组(配戴硬性巩膜接触镜)和对照组[配戴硬性角膜接触镜(RGP)],每组48例,分别于戴镜前、戴镜当天、戴镜后1周、戴镜后1个月及戴镜后3个月时检测并比较两组患者眼部相关参数指标[最佳矫正视力、角膜内皮细胞密度、六角形细胞比率、泪膜破裂时间(BUT)、眼压、角膜荧光素染色评分、结膜充血及睫状充血评分],观察是否出现眼部异常改变。结果 戴镜前至戴镜3个月期间,两组患者最佳矫正视力均≥1.00;戴镜后3个月时,与戴镜前比较,试验组患者角膜内皮细胞密度轻微下降,六角形细胞比率轻微上升,但差异均无统计学意义(均为P>0.05);戴镜前及戴镜后3个月时,试验组角膜内皮细胞密度及六角形比率均较对照组稍高,但差异均无统计学意义(均为P>0.05)。戴镜前、戴镜当天、戴镜后1周、戴镜后1个月及戴镜后3个月时,试验组与对照组患者BUT比较,差异均无统计学意义(均为P>0.05)。戴镜前、戴镜当天、戴镜后1周、戴镜后1个月及戴镜后3个月试验组与对照组患者眼压比较,差异均无统计学意义(均为P>0.05)。戴镜前及戴镜后3个月时,两组患者角膜荧光染色评级、结膜充血及睫状充血评级比较,差异均无统计学意义(均为P>0.05)。戴镜后3个月时,试验组患者均未出现结膜及角膜水肿等异常改变。结论 硬性巩膜接触镜与RGP具有一致的安全性与矫正屈光不正的有效性,值得推广及应用。

接触镜在圆锥角膜中的临床应用及并发症研究进展

圆锥角膜是一种不断进展的致盲性眼病,其特征是角膜变薄和突起,伴有不规则散光和视力下降。早期圆锥角膜的不规则散光可通过框架眼镜矫正,对于中重度圆锥角膜的不规则散光,框架眼镜不再适用,接触镜成为患者矫正视力的最佳选择。接触镜种类繁多,在接触镜的选择上难以抉择,如长时间试戴镜片会增加患者的不适,影响整体感受,也大大增加了医生的工作量。因此,本文对接触镜的分类、接触镜在不同圆锥角膜类型中的应用、接触镜配戴中的并发症及其未来展望等方面予以汇总和讨论,以期了解接触镜在圆锥角膜中的临床应用与管理,有助于进一步发挥接触镜在圆锥角膜中的应用价值。

生物羊膜和角膜绷带镜对翼状胬肉手术后角膜创面修复的作用

背景:有文献报道,生物羊膜与角膜绷带镜应用于翼状胬肉术中均可明显减轻翼状胬肉切除术后疼痛反应、促进角膜创面愈合。目的:对比生物羊膜与角膜绷带镜对翼状胬肉术后角膜创面修复与神经性疼痛的影响。方法:选择南阳市第二人民医院2020年8月至2022年5月收治的原发性翼状胬肉患者121例(142眼),均接受翼状胬肉切除联合自体游离结膜瓣移植手术,其中63例(68眼)采用生物羊膜修复角膜创面(生物羊膜组),58例(74眼)采用硬性透氧性角膜接触镜修复角膜创面(绷带镜组)。术后随访,观察患者术后2周内的角膜创面修复情况;术后当天及术后1 d、2周,采用Wong-Baker脸评估神经性疼痛情况;术前、术后1个月、术后3个月,检测患者角膜地形图表面不对称指数、最佳矫正视力、角膜散光度及表面规则指数。结果与结论:①绷带镜组患者术后2周的角膜创面愈合率高于生物羊膜组(P<0.05),创面愈合时间短于生物羊膜组(P<0.01);②绷带镜组患者术后当天及术后1 d的神经性疼痛程度低于生物羊膜组(P<0.001),两组术后2周的神经性疼痛比较差异无显著性意义(P>0.05);③两组患者术后1,3个月的角膜地形图表面不对称指数、最佳矫正视力、角膜散光度及表面规则指数均较术前明显改善(P<0.05),绷带镜组患者术后1,3个月的角膜散光度、角膜地形图表面不对称指数及表面规则指数均低于生物羊膜组(P<0.05);④术后3个月内,生物羊膜组复发1眼(1.47%),绷带镜组复发3眼(4.05%),组间比较差异无显著性意义(P>0.05);⑤结果表明,与生物羊膜相比,角膜绷带镜修复翼状胬肉手术后角膜创面的效果更佳。

翼状胬肉切除术联合角膜缘干细胞移植术后应用角膜绷带镜的效果

目的:分析翼状胬肉切除术联合角膜缘干细胞移植术后应用角膜绷带镜的效果。方法:选取2017年1月—2022年12月于双桥医院眼整形科行翼状胬肉切除术联合角膜缘干细胞移植术患者80例(80眼)作为研究对象,随机分为对照组和观察组,各40例。对照组术后应用妥布霉素地塞米松滴眼液、玻璃酸钠滴眼液,观察组在对照组基础上应用角膜绷带镜。比较两组恢复效果。结果:观察组复发率低于对照组,角膜上皮修复时间短于对照组,差异有统计学意义(P<0.05)。术后1 d,两组疼痛评分比较,差异无统计学意义(P>0.05);术后3 d,两组疼痛评分均低于术后1 d,观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组症状评分比较,差异无统计学意义(P>0.05);治疗后,观察组畏光、异物感、流泪、眼部充血评分低于对照组,差异均有统计学意义(P<0.05)。结论:角膜绷带镜有利于减轻患者术后疼痛,缓解术后症状,降低复发率。

不同方法及术后干预对翼状胬肉患者舒适度及疗效的影响

目的:探讨不同球结膜移植术及术后干预对翼状胬肉患者舒适度及疗效的影响。方法:选取2017年1月—2019年12月样本医院收治的200例(200眼)翼状胬肉患者作为研究对象,按随机数表法分为A、B、C、D 4组,每组50例(50眼)。A、B组采用切除术联合自体游离结膜瓣移植术,C、D组采用切除术联合角膜缘干细胞移植,B、D组术后佩戴角膜绷带镜。观察对比4组患者术后眼部不适、视力、角膜上皮愈合时间、治愈率及复发率情况。结果:4组患者术后均出现不同程度的眼部不适,3 d后缓解,2周后基本消失。术后1 d、3 d、7 d B组患者眼部不适较A组轻,D组患者眼部不适较C组轻,而A组与C组、B组与D组之间比较,差异无统计学意义(F=0.083,P>0.05);术后1 d、3 d 4组患者的裸眼视力均有不同程度的下降。术后1 d、3 d B组患者视力较A组高,D组患者视力较C组高,差异有统计学意义(F=3.026、3.088,P<0.05);4组患者术后角膜上皮愈合约需4~6 d,B组角膜上皮愈合时间较A组短,D组较C组短,差异有统计学意义(F=35.800,P<0.05);4组患者术后治愈率和术后翼状胬肉复发情况比较,差异无统计学意义(χ^(2)=0.632、1.031,P>0.05)。结论:切除术联合角膜缘干细胞移植对翼状胬肉患者治疗效果显著,复发率较低。佩戴角膜绷带镜可减轻术后眼部不适,有利于角膜上皮愈合和早期视力的稳定,对翼状胬肉的治疗具有积极意义。

ICL植入术治疗高度近视术后早期眼前节形态的变化分析

目的探讨有晶体状眼后房型人工晶状体(ICL)植入术治疗高度近视术后早期眼前节形态的变化情况。方法选取60例(113眼)高度近视患者,均接受ICL植入术治疗。对比患者治疗前后裸眼视力、最佳矫正视力变化情况,眼前节形态变化情况[角膜厚度(CCT)、角膜曲率(K值)、中央前房深度(ACD)],角膜像差变化情况[角膜高阶像差(CHOA)、角膜低阶像差(CLOA)、角膜总像差(CTA)]。结果治疗后30 d、90 d、半年的裸眼视力、最佳矫正视力均优于治疗前(P<0.05)。治疗前及治疗后30 d、90 d、半年,角膜厚度分别为(532.50±25.40)、(532.54±23.17)、(534.64±22.55)、(532.97±24.10)μm,角膜曲率分别为(43.80±0.89)、(43.55±0.92)、(43.55±0.97)、(43.43±1.03)D,中央前房深度分别为(3.22±0.14)、(3.06±0.17)、(3.06±0.14)、(3.09±0.11)mm。与治疗前对比,治疗后30 d、90 d、半年的角膜曲率、中央前房深度均有所减小(P<0.05);治疗前后各个阶段,角膜厚度对比均无明显差异(P>0.05)。治疗后30 d、90 d、半年的CHOA均大于治疗前(P<0.05);治疗后30 d、90 d、半年的CLOA、CTA与治疗前对比均无明显差异(P>0.05)。结论高度近视患者应用ICL植入术治疗,患者的最佳矫正视力、裸眼视力均有所改善,角膜曲率变小、中央前房深度变浅、前房角变窄,患者术后早期眼前节形态良好,且较小影响角膜,安全性较高,可促进患者术后早日康复。