骨龙胶囊联合盐酸氨基葡萄糖胶囊治疗膝骨性关节炎的疗效及对Lequesne指数的影响

目的探究骨龙胶囊联合盐酸氨基葡萄糖胶囊对膝骨性关节炎(KOA)的疗效及对奎森功能演算指数(Lequesne指数)的影响。方法选取某院2022年1月~2023年8月收治的80例KOA患者,按随机数字表法分为对照组和观察组各40例。对照组采用非甾体抗炎药(NSAIDs)治疗,观察组在对照组的基础上联合骨龙胶囊和盐酸氨基葡萄糖胶囊治疗,均按标准药物用法连续治疗6周。统计两组患者临床治疗效果,记录两组KOA患者治疗前、治疗6周后膝关节功能改善情况、Lequesne指数水平变化及炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平变化,统计不良反应发生情况。结果治疗6周后,对照组总有效率为80.00%(32/40),低于观察组的95.00%(38/40)。治疗6周后,两组膝关节评分(HSS评分)较治疗前均有升高,Lequesne指数均有下降,观察组HSS评分升高更显著,Lequesne指数下降更显著(P<0.05)。治疗6周后,两组IL-6、TNF-α指标与治疗前比较均降低(P<0.05),但两组间比较差异无统计学意义(P>0.05)。两组不良反应差异无统计学意义(P>0.05)。结论在NSAIDs的基础上联合骨龙胶囊和盐酸氨基葡萄糖胶囊治疗KOA较单一NSAIDs的疗效更好,能有效降低Lequesne指数,改善膝关节功能,但与单一NSAIDs治疗对炎症因子的影响相当。

中文版Lequesne指数在膝骨关节炎评价中的评价者间信度

目的验证中文版Lequesne指数膝骨关节炎患者中的评价者间信度。方法由2名经过培训的测评人员对30例经放射影像学确诊且有临床症状的膝骨关节炎患者在24h内进行两次Lequesne指数的指导性测试评分。评价者间信度采用组内相关系数评估(ICC)和Bland&Altman分析方法。结果中文版Lequesne指数的评价者间信度ICC为0.94。Bland&Altman分析显示评价者间没有系统误差。结论中文版Lequesne指数在膝骨关节炎患者评估中具有良好的评价者间信度。

烫熨疗法改善膝骨关节炎Lequesne指数的临床研究

目的探讨运用烫熨疗法对膝骨关节炎Lequesne指数的影响。方法将120例符合条件的膝骨关节炎患者按随机原则分为烫熨疗法-有效成分组、烫熨疗法-安慰剂组、神灯组与活血止痛膏组,对比各组间的临床疗效。结果治疗4周后,各组治疗前后数据比较,差异有统计学意义(P <0. 05),说明各组疗法均有疗效;烫熨疗法-有效成分组与其他3组治疗后比较,差异有统计学意义(P <0. 05),说明烫熨疗法-有效成分组疗效优于其他3组。结论烫熨疗法对膝骨关节炎的临床疗效更明显。

Joint Detection of Serum Vitamin D,Body Mass Index,and Tumor Necrosis Factor Alpha for the Diagnosis of Crohn’s Disease

Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD patients.This study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s disease.Methods CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December 2020.The serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before treatment.The diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)curves.Results The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,respectively.The diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.

Lequesne指数和髌股骨关节功能评分对膝骨性关节炎患者的评价比较

目的比较Lequesne指数和髌股骨关节功能评分对膝骨性关节炎严重程度的评价。方法采用超声对34例患者膝关节软骨缺损进行分级,将34例患者双侧膝关节软骨缺损分级和髌股骨关节功能评分结合在一起,进行Spearman相关检验分析。选取其中18例两膝关节严重程度不同的患者较重侧和较好侧的膝关节软骨缺损分级和髌股骨关节功能评分与Lequesne指数做相关分析。结果 18例两膝关节严重程度不同的患者的Lequesne指数只和较重侧的数据有统计学的显著相关性(P<0.01),而与较好侧无统计学相关。结论髌股骨关节功能评分和膝关节软骨缺损分级存在相关性。较重侧与在统计学上存在相关性(P<0.01),而较好侧与Lequesne指数无统计学相关。对于较好侧的评估,采用髌股骨功能评分更为准确。

Association between childhood obesity and gut microbiota:16S rRNA gene sequencing-based cohort study

BACKGROUND This study aimed to identify characteristic gut genera in obese and normal-weight children(8-12 years old)using 16S rDNA sequencing.The research aimed to provide insights for mechanistic studies and prevention strategies for childhood obesity.Thirty normal-weight and thirty age-and sex-matched obese children were included.Questionnaires and body measurements were collected,and fecal samples underwent 16S rDNA sequencing.Significant differences in body mass index(BMI)and body-fat percentage were observed between the groups.Analysis of gut microbiota diversity revealed lowerα-diversity in obese children.Differences in gut microbiota composition were found between the two groups.Prevotella and Firmicutes were more abundant in the obese group,while Bacteroides and Sanguibacteroides were more prevalent in the control group.AIM To identify the characteristic gut genera in obese and normal-weight children(8-12-year-old)using 16S rDNA sequencing,and provide a basis for subsequent mechanistic studies and prevention strategies for childhood obesity.METHODS Thirty each normal-weight,1:1 matched for age and sex,and obese children,with an obese status from 2020 to 2022,were included in the control and obese groups,respectively.Basic information was collected through questionnaires and body measurements were obtained from both obese and normal-weight children.Fecal samples were collected from both groups and subjected to 16S rDNA sequencing using an Illumina MiSeq sequencing platform for gut microbiota diversity analysis.RESULTS Significant differences in BMI and body-fat percentage were observed between the two groups.The Ace and Chao1 indices were significantly lower in the obese group than those in the control group,whereas differences were not significant in the Shannon and Simpson indices.Kruskal-Wallis tests indicated significant differences in unweighted and weighted UniFrac distances between the gut microbiota of normal-weight and obese children(P<0.01),suggesting substantial disparities in both the species and quantity of gut microbiota between the two groups.Prevotella,Firmicutes,Bacteroides,and Sanguibacteroides were more abundant in the obese and control groups,respectively.Heatmap results demonstrated significant differences in the gut microbiota composition between obese and normal-weight children.CONCLUSION Obese children exhibited lowerα-diversity in their gut microbiota than did the normal-weight children.Significant differences were observed in the composition of gut microbiota between obese and normal-weight children.

Did weekly economic index and volatility index impact US food sales during the first year of the pandemic?

We explore the impacts of economic and financial dislocations caused by COVID-19 pandemic shocks on food sales in the United States from January 2020 to January 2021.We use the US weekly economic index(WEI)to measure economic dislocations and the Chicago Board Options Exchange volatility index(VIX)to capture the broader stock market dislocations.We validate the NARDL model by testing a battery of models using the autoregressive distributed lags(ARDL)methodology(ARDL,NARDL,and QARDL specifications).Our study postulates that an increase in WEI has a significant negative long-term effect on food sales,whereas a decrease in WEI has no statistically significant(long-run)effect.Thus,policy responses that ignore asymmetric effects and hidden cointegration may fail to promote food security during pandemics.

The diagnostic value of liver stiffness measurement combined with S index in the degree of hepatitis B liver fibrosis

Objective:To investigate the value of liver stiffness measurement(LSM)combined with S index in predicting the degree of liver fibrosis in hepatitis B patients.Methods:A total of 187 chronic hepatitis B patients who were admitted to the Department of Infection,the First Affiliated Hospital of Hainan Medical College from January 2019 to December 2021 were selected.General data were collected,blood routine,liver function,liver fibrosis and liver stiffness measurement were tested,and S index,APRI and FIB-4 index were calculated,and liver biopsy was performed.Results:According to the pathological results of liver puncture,The patients were divided into no significant fibrosis group(n=86),significant fibrosis group(n=71)and cirrhosis group(n=30).There were significant differences in age,PLT,GGT,ALB,S index,HA,LN and LSM levels among the three groups(P<0.05).There was a good correlation between S index and the degree of hepatic fibrosis(rs=0.738,P<0.001).The AUC of S index and LSM for the diagnosis of significant fibrosis in hepatitis B were 0.873 and 0.792,respectively.And the AUC of S index and LSM for the diagnosis of liver cirrhosis were 0.966 and 0.879,respectively.The AUC for the combined diagnosis of significant fibrosis and cirrhosis were 0.908 and 0.988,respectively.The AUROC of combined detection in the diagnosis of cirrhosis was higher than that of LSM,APRI and FIB-4(P<0.05).Conclusion:LSM combined with S index has certain application value in the diagnosis of liver fibrosis/cirrhosis in hepatitis B patients.

基于BiLSTM-Attention的F_(10.7)指数预测模型与中国自主数据集的应用

F_(10.7)指数是太阳活动的重要指标,准确预测F_(10.7)指数有助于预防和缓解太阳活动对无线电通信、导航和卫星通信等领域的影响.基于F_(10.7)射电流量的特性,在双向长短时记忆网络(Bidirectional Long Short-Term Memory Network,BiLSTM)基础上融入注意力机制(Attention),提出了一种基于BiLSTM-Attention的F_(10.7)预报模型.在加拿大DRAO数据集上其平均绝对误差(MAE)为5.38,平均绝对百分比误差(MAPE)控制在5%以内,相关系数(R)高达0.987,与其他RNN模型相比拥有优越的预测性能.针对中国廊坊L&S望远镜观测的F_(10.7)数据集,提出了一种转换平均校准(Conversion Average Calibration,CAC)方法进行数据预处理,处理后的数据与DRAO数据集具有较高的相关性.基于该数据集对比分析了RNN系列模型的预报效果,实验结果表明,BiLSTM-Attention和BiLSTM两种模型在预测F_(10.7)指数方面具有较好的优势,表现出较好的预测性能和稳定性.

New indices to balanceα-diversity against tree size inequality

The number and composition of species in a community can be quantified withα-diversity indices,including species richness(R),Simpson’s index(D),and the Shannon-Wiener index(H΄).In forest communities,there are large variations in tree size among species and individu-als of the same species,which result in differences in eco-logical processes and ecosystem functions.However,tree size inequality(TSI)has been largely neglected in studies using the available diversity indices.The TSI in the diameter at breast height(DBH)data for each of 99920 m×20 m forest census quadrats was quantified using the Gini index(GI),a measure of the inequality of size distribution.The generalized performance equation was used to describe the rotated and right-shifted Lorenz curve of the cumulative proportion of DBH and the cumulative proportion of number of trees per quadrat.We also examined the relationships ofα-diversity indices with the GI using correlation tests.The generalized performance equation effectively described the rotated and right-shifted Lorenz curve of DBH distributions,with most root-mean-square errors(990 out of 999 quadrats)being<0.0030.There were significant positive correlations between each of threeα-diversity indices(i.e.,R,D,and H’)and the GI.Nevertheless,the total abundance of trees in each quadrat did not significantly influence the GI.This means that the TSI increased with increasing spe-cies diversity.Thus,two new indices are proposed that can balanceα-diversity against the extent of TSI in the com-munity:(1−GI)×D,and(1−GI)×H’.These new indices were significantly correlated with the original D and H΄,and did not increase the extent of variation within each group of indices.This study presents a useful tool for quantifying both species diversity and the variation in tree sizes in forest communities,especially in the face of cumulative species loss under global climate change.

基于CSLE的泛第三极地区土壤侵蚀强度空间分布特征

[目的]定量评估泛第三极地区的土壤侵蚀状况,明确土壤侵蚀的分布特征,以期为土壤侵蚀的科学防治提供依据。[方法]基于分层不等概系统抽样方法,共布设31 406个调查单元。利用中国土壤流失方程CSLE计算泛第三极地区土壤侵蚀速率,并利用莫兰指数(I)探讨其分布特征。[结果](1)泛第三极地区平均土壤侵蚀速率为162.73 t/(km^(2)·a),水土流失面积比例为7.75%,土壤侵蚀速率超过500 t/(km^(2)·a)的地区主要位于西亚、东亚和南亚;(2)土壤侵蚀存在明显的空间聚集性(I=0.920 9),以高高型和低低型聚集为主,高高型聚集主要分布在西亚北部、南亚北部和西南部以及中国的东北、黄土高原和西藏南部;(3)草地、灌丛和耕地是土壤侵蚀较严重的土地利用类型,其中>1 000 m的草地、>500 m的灌丛和耕地的土壤侵蚀更严重,超过25%的土地都发生了水土流失,平均土壤侵蚀速率变化于426.85~683.72 t/(km^(2)·a)。[结论]海拔介于1 000~6 000 m的草地、500~4 000 m的灌丛以及1 000~4 000 m的耕地是泛第三极地区土壤侵蚀发生的重点区域,需特别关注。

Elevation transition of aquatic insects closely matches a thermal feature in the Yungas of Northwestern Argentina

Temperature is a key factor that shapes the distribution of organisms.Having knowledge about how species respond to temperature is relevant to devise strategies for addressing the impacts of climate change.Aquatic insects are particularly vulnerable to climate change,yet there is still much to learn about their ecology and distribution.In the Yungas ecoregion of Northwestern Argentina,cold-and warm-adapted species of the orders Ephemeroptera,Plecoptera,and Trichoptera(EPT)are segregated by elevation.We modeled the ecological niche of South American EPT species in this region using available data and projected their potential distribution in geographic space.Species were grouped based on their ecogeographic similarity,and we analyzed their replacement pattern along elevation gradients,focusing on the ecotone where opposing thermal preferences converge.Along this interface,we identified critical points where the combined incidence of cold and warm assemblages maximizes,indicating a significant transition zone.We found that the Montane Cloud Forest holds the interface,with a particularly greater suitability at its lower boundary.The main axis of the interface runs in a N-S direction and falls between 14°C-16°C mean annual isotherms.The probability of a particular location within a basin being classified as part of the interface increases as Kira’s warmth index approaches a score around 150.Understanding the interface is critical for defining the thermal limits of species distribution and designing biomonitoring programs.Changes in the location of thermal constants related to mountainous ecotones may cause vertical displacement of aquatic insects and vegetation communities.We have recognized significant temperature thresholds that serve as indicators of suitability for the interface.As global warming is anticipated to shift these indicators,we suggest using them to monitor the imprints of climate change on mountain ecosystems.

Assessment of perianal fistulizing Crohn’s disease activity with endoanal ultrasound: A retrospective cohort study

BACKGROUND Perianal fistulas pose dual challenges to Crohn's disease(CD)patients.Low patient compliance due to the complexity of existing examination methods plagues the treatment and follow-up management of perianal CD.AIM To determine the accuracy of endoanal ultrasound(EUS)and shear wave elastography(SWE)for evaluating perianal fistulizing CD(PFCD)activity.METHODS This was a retrospective cohort study.A total of 67 patients from August 2022 to December 2023 diagnosed with CD were divided into three groups:Non-anal fistula group(n=23),low-activity perianal fistulas[n=19,perianal disease activity index(PDAI)≤4],high-activity perianal fistulas(n=25,PDAI>4)based on the PDAI.All patients underwent assessments including EUS+SWE,pelvic magnetic resonance[pelvic magnetic resonance imaging(MRI)],C-reactive protein,fecal calprotectin,CD activity index,PDAI.RESULTS The percentage of fistulas indicated by pelvic MRI and EUS was consistent at 82%,and there was good consistency in the classification of perianal fistulas(Kappa=0.752,P<0.001).Significant differences were observed in the blood flow Limberg score(χ^(2)=8.903,P<0.05)and shear wave velocity(t=2.467,P<0.05)between group 2 and 3.Shear wave velocity showed a strong negative correlation with magnetic resonance novel index for fistula imaging in CD(Magnifi-CD)score(r=-0.676,P<0.001),a weak negative correlation with the PDAI score(r=-0.386,P<0.05),and a weak correlation between the Limberg score and the PDAI score(r=0.368,P<0.05).CONCLUSION EUS combined with SWE offers a superior method for detecting and quantitating the activity of perianal fistulas in CD patients.It may be the ideal tool to assess PFCD activity objectively for management strategies.

BPS对金鲫鱼中肾抗氧化指标的影响

为研究作为双酚A替代物的双酚S(BPS)对金鲫鱼中肾抗氧化指标的影响,将提前驯养适应1周的金鲫鱼随机分为5组,每组10尾鱼。在安全浓度的基础上,设置1个对照组和以等对数浓度差设置1、10、100、1 000μg/L 4个BPS质量浓度组,进行为期15 d的急性暴露。试验结束后分别从每组取3尾鱼进行采样,测定金鲫鱼中肾中总超氧化物歧化酶(T-SOD)、丙二醛(MDA)及过氧化氢酶(CAT)含量,分析不同BPS浓度对于金鲫鱼中肾抗氧化指标的影响。经试验得出,在安全浓度的基础上,随着BPS浓度的升高,金鲫鱼中肾中的CAT活力与总SOD活力显著降低;MDA含量明显增加。

阿富汗地震R/S分形特征及地震活动性分析

地震的发生具有非线性特征,分形理论能够刻画地震时空分布特征及其变化过程。本文基于R/S分析方法确定阿富汗主要地震带的分形特征,利用ARIMA模型对兴都—库什山地震带可能发生的年度最大震级进行预测。R/S分析表明,兴都—库什山地震带Hurst指数为0.9125,地震活动记忆周期为8年;苏莱曼山地震带Hurst指数为0.7281,地震活动记忆周期为9年。兴都—库什山和苏莱曼山地震带地震活动的变化趋势与历史变化一致,且兴都—库什山地震带的趋势延续性比苏莱曼山地震带更为显著。ARIMA模型预测结果显示,2022—2026年兴都—库什山地震带可能发生的年度最大震级分别为M_(b)6.2、M_(b)6.1、M_(b)5.8、M_(b)5.8和M_(b)6.1。

Existence of Monotone Positive Solution for a Fourth-Order Three-Point BVP with Sign-Changing Green’s Function

This paper is concerned with the following fourth-order three-point boundary value problem , where , we discuss the existence of positive solutions to the above problem by applying to the fixed point theory in cones and iterative technique.

基于D-S证据理论的危化品水路运输风险模糊综合评价

针对危险化学品水路运输风险因素的不确定性和模糊性,提出一种D-S证据理论与模糊综合评价法相结合的危化品水路安全运输风险评价方法。识别分析风险因素,建立危化品水路运输风险因素指标体系;引入距离函数,获取证据可信度后将可信度作为专家权重,结合D-S证据理论,融合专家信息,合理分配指标权重;构建危化品水路运输风险模糊综合评价模型,对危化品水路运输风险等级进行评价。结果表明,该案例的量化风险值为37.389,隶属于较低风险等级,人员、管理、货物因素为关键影响因素,二级指标中教育培训不足、违规操作、安全意识不足、货物敏感条件、通航环境复杂风险值相对较高,需要进行重点防控。

关节镜病灶清理术在缓解老年KDOA患者疼痛及改善Lequesne指数中的应用

目的探究关节镜病灶清理术在缓解老年KDOA患者疼痛及改善Lequesne指数中的应用效果.方法选取我院2021年5月-2023年5月期间收治的96例老年KDOA患者开展研究,按照不同治疗方式分组:接受常规保守治疗的患者为A组、接受关节镜病灶清理术治疗的患者为B组,每组各48例,对比疗效(优良率、疼痛症状及Lequesne指数)、治疗安全性.结果治疗后,B组优良率95.83%较A组的81.25%高(P<0.05);B组术后不同时间点VAS评分、Lequesne指数低于A组(P<0.05);B组不良反应发生率2.08%较A组的16.67%低(P<0.05).结论关节镜病灶清理术的临床疗效显著,且安全性高,利于减轻患者术后疼痛症状,促进关节功能的恢复,值得优选.

基于案例分析的S-CAD政策评估方法理论研究初探

为突破传统S-CAD政策评估方法的思维限制,借鉴公共政策评估标准,从价值/政策、事实相融合的维度,采用理论分析法、文献检索法尝试构建S-CAD政策评估框架的定量评估指标体系。结果表明:(1)通过公共政策评估理论的学习,尝试构建基于“二维”的S-CAD政策评估框架;(2)结合实证分析,以内蒙古鄂尔多斯市露天矿采矿用地方式改革试点政策为例,从政策评估事实维度与价值维度出发构建了包括5个指标单元、23个单项指标在内的合理、可行的采矿临时用地政策评估指标体系。在“二维”融合视角下构建的S-CAD政策评估思路可行,且具有可操作性,可为进一步完善S-CAD政策评估方法的理论及量化研究提供参考。

An entirely new approach based on remote sensing data to calculate the nitrogen nutrition index of winter wheat

The nitrogen nutrition index(NNI)is a reliable indicator for diagnosing crop nitrogen(N)status.However,there is currently no specific vegetation index for the NNI inversion across multiple growth periods.To overcome the limitations of the traditional direct NNI inversion method(NNI_(T1))of the vegetation index and traditional indirect NNI inversion method(NNI_(T2))by inverting intermediate variables including the aboveground dry biomass(AGB)and plant N concentration(PNC),this study proposed a new NNI remote sensing index(NNI_(RS)).A remote-sensing-based critical N dilution curve(Nc_(_RS))was set up directly from two vegetation indices and then used to calculate NNI_(RS).Field data including AGB,PNC,and canopy hyperspectral data were collected over four growing seasons(2012–2013(Exp.1),2013–2014(Exp.2),2014–2015(Exp.3),2015–2016(Exp.4))in Beijing,China.All experimental datasets were cross-validated to each of the NNI models(NNI_(T1),NNI_(T2)and NNI_(RS)).The results showed that:(1)the NNI_(RS)models were represented by the standardized leaf area index determining index(sLAIDI)and the red-edge chlorophyll index(CI_(red edge))in the form of NNI_(RS)=CI_(red edge)/(a×sLAIDI~b),where"a"equals 2.06,2.10,2.08 and 2.02 and"b"equals 0.66,0.73,0.67 and 0.62 when the modeling set data came from Exp.1/2/4,Exp.1/2/3,Exp.1/3/4,and Exp.2/3/4,respectively;(2)the NNI_(RS)models achieved better performance than the other two NNI revised methods,and the ranges of R2 and RMSE were 0.50–0.82 and 0.12–0.14,respectively;(3)when the remaining data were used for verification,the NNI_(RS)models also showed good stability,with RMSE values of 0.09,0.18,0.13 and 0.10,respectively.Therefore,it is concluded that the NNI_(RS)method is promising for the remote assessment of crop N status.