Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional ...Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional attention schemes have not considered the impact of lesion type differences on grading,resulting in unreasonable extraction of important lesion features.Therefore,this paper proposes a DR diagnosis scheme that integrates a multi-level patch attention generator(MPAG)and a lesion localization module(LLM).Firstly,MPAGis used to predict patches of different sizes and generate a weighted attention map based on the prediction score and the types of lesions contained in the patches,fully considering the impact of lesion type differences on grading,solving the problem that the attention maps of lesions cannot be further refined and then adapted to the final DR diagnosis task.Secondly,the LLM generates a global attention map based on localization.Finally,the weighted attention map and global attention map are weighted with the fundus map to fully explore effective DR lesion information and increase the attention of the classification network to lesion details.This paper demonstrates the effectiveness of the proposed method through extensive experiments on the public DDR dataset,obtaining an accuracy of 0.8064.展开更多
In this work,we propose a new,fully automated system for multiclass skin lesion localization and classification using deep learning.The main challenge is to address the problem of imbalanced data classes,found in HAM1...In this work,we propose a new,fully automated system for multiclass skin lesion localization and classification using deep learning.The main challenge is to address the problem of imbalanced data classes,found in HAM10000,ISBI2018,and ISBI2019 datasets.Initially,we consider a pretrained deep neural network model,DarkeNet19,and fine-tune the parameters of third convolutional layer to generate the image gradients.All the visualized images are fused using a High-Frequency approach along with Multilayered Feed-Forward Neural Network(HFaFFNN).The resultant image is further enhanced by employing a log-opening based activation function to generate a localized binary image.Later,two pre-trained deep models,Darknet-53 and NasNet-mobile,are employed and fine-tuned according to the selected datasets.The concept of transfer learning is later explored to train both models,where the input feed is the generated localized lesion images.In the subsequent step,the extracted features are fused using parallel max entropy correlation(PMEC)technique.To avoid the problem of overfitting and to select the most discriminant feature information,we implement a hybrid optimization algorithm called entropy-kurtosis controlled whale optimization(EKWO)algorithm.The selected features are finally passed to the softmax classifier for the final classification.Three datasets are used for the experimental process,such as HAM10000,ISBI2018,and ISBI2019 to achieve an accuracy of 95.8%,97.1%,and 85.35%,respectively.展开更多
A high throughput rice DNA mini-preparation method was developed. The method is suitable for large-scale mutant bank screening as well as large mapping populations with characteristics of maintaining relatively high l...A high throughput rice DNA mini-preparation method was developed. The method is suitable for large-scale mutant bank screening as well as large mapping populations with characteristics of maintaining relatively high level of DNA purity and concentration. The extracted DNA was tested and suitable for regular PCR amplification （SSR） and for Targeting Induced Local Lesion in Genome （TILLING） analysis.展开更多
基金supported in part by the Research on the Application of Multimodal Artificial Intelligence in Diagnosis and Treatment of Type 2 Diabetes under Grant No.2020SK50910in part by the Hunan Provincial Natural Science Foundation of China under Grant 2023JJ60020.
文摘Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional attention schemes have not considered the impact of lesion type differences on grading,resulting in unreasonable extraction of important lesion features.Therefore,this paper proposes a DR diagnosis scheme that integrates a multi-level patch attention generator(MPAG)and a lesion localization module(LLM).Firstly,MPAGis used to predict patches of different sizes and generate a weighted attention map based on the prediction score and the types of lesions contained in the patches,fully considering the impact of lesion type differences on grading,solving the problem that the attention maps of lesions cannot be further refined and then adapted to the final DR diagnosis task.Secondly,the LLM generates a global attention map based on localization.Finally,the weighted attention map and global attention map are weighted with the fundus map to fully explore effective DR lesion information and increase the attention of the classification network to lesion details.This paper demonstrates the effectiveness of the proposed method through extensive experiments on the public DDR dataset,obtaining an accuracy of 0.8064.
基金supported by Korea Institute for Advancement of Technology(KIAT)grant funded by the Korea Government(MOTIE)(P0012724,The Competency Development Program for Industry Specialist)the Soonchunhyang University Research Fund.
文摘In this work,we propose a new,fully automated system for multiclass skin lesion localization and classification using deep learning.The main challenge is to address the problem of imbalanced data classes,found in HAM10000,ISBI2018,and ISBI2019 datasets.Initially,we consider a pretrained deep neural network model,DarkeNet19,and fine-tune the parameters of third convolutional layer to generate the image gradients.All the visualized images are fused using a High-Frequency approach along with Multilayered Feed-Forward Neural Network(HFaFFNN).The resultant image is further enhanced by employing a log-opening based activation function to generate a localized binary image.Later,two pre-trained deep models,Darknet-53 and NasNet-mobile,are employed and fine-tuned according to the selected datasets.The concept of transfer learning is later explored to train both models,where the input feed is the generated localized lesion images.In the subsequent step,the extracted features are fused using parallel max entropy correlation(PMEC)technique.To avoid the problem of overfitting and to select the most discriminant feature information,we implement a hybrid optimization algorithm called entropy-kurtosis controlled whale optimization(EKWO)algorithm.The selected features are finally passed to the softmax classifier for the final classification.Three datasets are used for the experimental process,such as HAM10000,ISBI2018,and ISBI2019 to achieve an accuracy of 95.8%,97.1%,and 85.35%,respectively.
文摘A high throughput rice DNA mini-preparation method was developed. The method is suitable for large-scale mutant bank screening as well as large mapping populations with characteristics of maintaining relatively high level of DNA purity and concentration. The extracted DNA was tested and suitable for regular PCR amplification （SSR） and for Targeting Induced Local Lesion in Genome （TILLING） analysis.
