BACKGROUND There are many adverse reactions in the treatment of allergic rhinitis(AR)mainly with conventional drugs.Leukotriene receptor antagonists,glucocorticoids and nasal antihistamines can all be used as first-li...BACKGROUND There are many adverse reactions in the treatment of allergic rhinitis(AR)mainly with conventional drugs.Leukotriene receptor antagonists,glucocorticoids and nasal antihistamines can all be used as first-line drugs for AR,but the clinical effects of the three drugs are not clear.AIM To examine the impact of glucocorticoids,antihistamines,and leukotriene receptor antagonists on individuals diagnosed with AR,specifically focusing on their influence on serum inflammatory indexes.METHODS The present retrospective study focused on the clinical data of 80 patients diagnosed and treated for AR at our hospital between May 2019 and May 2021.The participants were categorized into the control group and the observation group.The control group received leukotriene receptor antagonists,while the observation group was administered glucocorticoids and antihistamines.Conducted an observation and comparison of the symptoms,physical sign scores,adverse reactions,and effects on serum inflammatory indexes in two distinct groups of patients,both before and after treatment.RESULTS Subsequent to treatment,the nasal itching score,sneeze score,runny nose score,nasal congestion score,and physical signs score exhibited notable discrepancies(P<0.05),with the observation group demonstrating superior outcomes compared to the control group(P<0.05).The interleukin(IL)-6,IL-10,tumor necrosis factor-alpha,Soluble Intercellular Adhesion Molecule-1,Leukotriene D4 after treatment were significantly different and the observation group It is better than the control group,which is statistically significant(P<0.05).Following the intervention,the incidence of adverse reactions in the observation group,including symptoms such as nasal dryness,discomfort in the throat,bitter taste in the mouth,and minor erosion of the nasal mucosa,was found to be 7.5%.This rate was significantly lower compared to the control group,which reported an incidence of 27.5%.The difference between the two groups was statistically significant(P<0.05).CONCLUSION Glucocorticoids and antihistamines have obvious therapeutic effects,reduce serum inflammatory index levels,relieve symptoms and signs of patients,and promote patients'recovery,which can provide a reference for clinical treatment of AR.展开更多
文摘BACKGROUND There are many adverse reactions in the treatment of allergic rhinitis(AR)mainly with conventional drugs.Leukotriene receptor antagonists,glucocorticoids and nasal antihistamines can all be used as first-line drugs for AR,but the clinical effects of the three drugs are not clear.AIM To examine the impact of glucocorticoids,antihistamines,and leukotriene receptor antagonists on individuals diagnosed with AR,specifically focusing on their influence on serum inflammatory indexes.METHODS The present retrospective study focused on the clinical data of 80 patients diagnosed and treated for AR at our hospital between May 2019 and May 2021.The participants were categorized into the control group and the observation group.The control group received leukotriene receptor antagonists,while the observation group was administered glucocorticoids and antihistamines.Conducted an observation and comparison of the symptoms,physical sign scores,adverse reactions,and effects on serum inflammatory indexes in two distinct groups of patients,both before and after treatment.RESULTS Subsequent to treatment,the nasal itching score,sneeze score,runny nose score,nasal congestion score,and physical signs score exhibited notable discrepancies(P<0.05),with the observation group demonstrating superior outcomes compared to the control group(P<0.05).The interleukin(IL)-6,IL-10,tumor necrosis factor-alpha,Soluble Intercellular Adhesion Molecule-1,Leukotriene D4 after treatment were significantly different and the observation group It is better than the control group,which is statistically significant(P<0.05).Following the intervention,the incidence of adverse reactions in the observation group,including symptoms such as nasal dryness,discomfort in the throat,bitter taste in the mouth,and minor erosion of the nasal mucosa,was found to be 7.5%.This rate was significantly lower compared to the control group,which reported an incidence of 27.5%.The difference between the two groups was statistically significant(P<0.05).CONCLUSION Glucocorticoids and antihistamines have obvious therapeutic effects,reduce serum inflammatory index levels,relieve symptoms and signs of patients,and promote patients'recovery,which can provide a reference for clinical treatment of AR.
文摘目的 探究格隆溴铵福莫特罗吸入气雾剂对慢性阻塞性肺疾病(COPD)稳定期患者血清基质金属蛋白酶抑制剂-1(TIMP-1)、白三烯B4(LTB4)及动脉血气分析指标的影响。方法 按简单随机化分组法将2021年3月至2023年9月建德市第一人民医院就诊的COPD稳定期患者分为观察组和对照组,各45例,观察组采用格隆溴铵福莫特罗吸入气雾剂治疗,对照组采用布地奈德福莫特罗吸入粉雾剂(Ⅱ),两组均持续治疗3个月。比较两组患者的临床疗效、治疗期间的不良反应发生情况和急性发作次数。比较两组患者治疗前和治疗3个月后的肺功能指标、血清TIMP-1、LTB4和动脉血气分析指标。结果 治疗3个月后,观察组的总有效率(93.33%)高于对照组(77.78%)(P<0.05)。两组的不良反应发生率差异无统计学意义(P>0.05);观察组急性发作次数[(0.98±0.12)次]低于对照组[(1.11±0.19)次](P<0.05)。治疗3个月后,两组的第1秒用力呼气容积(FEV_1)、用力肺活量(FVC)、最大呼气流量(PEF)和动脉血氧分压(Pa O_(2))均较治疗前提高,观察组FEV_1、FVC、PEF、Pa O_(2)[分别为(2.88±0.41) L、(3.21±0.33) L、(60.13±5.23) L·min^(-1)、(77.17±2.34) mm Hg(1 mm Hg≈0.133 k Pa)]高于对照组[分别为(2.62±0.43) L、(2.94±0.40) L、(57.27±5.27) L·min^(-1)、(75.51±2.20) mm Hg](P<0.05)。治疗3个月后,两组的血清TIMP-1、LTB4和动脉血二氧化碳分压(Pa CO_(2))均较治疗前降低,观察组TIMP-1、LTB4、Pa CO_(2)[分别为(58.32±4.10)μg·L^(-1)、(106.56±6.79) ng·L^(-1)、(46.58±2.42) mm Hg]低于对照组[分别为(60.97±4.36)μg·L^(-1)、(110.23±7.57) ng·L^(-1)、(48.43±2.46) mm Hg](P<0.05)。结论 格隆溴铵福莫特罗吸入气雾剂治疗COPD稳定期患者具有较好的疗效和安全性,有助于改善患者肺功能指标、血清TIMP-1、LTB4和动脉血气分析指标。
