Hair Mercury Levels and Their Relationship with Seafood Consumption among Preschool Children in Shanghai

Mercury is a global pollutant. Children are vulnerable to environmental toxicants. Seafood consumption is a major source of methylmercury exposure. In order to ascertain children’s mercury exposure levels and study their relationship with seafood consumption, we conducted a cross-sectional study among preschool children in Shanghai.

Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausal Chinese women

Growth differentiation factor 11 （GDF11） is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density （BMD） were determined in 169 postmenopausal Chinese women （47-78 years old）. GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index （BMI）, the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase （BAP） was identified and remained significant after adjusting for age and BMI. No significant correlation was noted between cross-linked N-telopeptides of type I collagen （NTX） and GDF11. In conclusion, GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation, BAP, in postmenopausal Chinese women. GDF11 potentially exerts a negative effect on bone mass by regulating bone formation.

Relationship between glutathione and malonaldehyde levels in erythrocytes and the deformation index of erythrocyte in patients at various periods following acute cerebral infarction

BACKGROUND： Glutathione, as an in vivo free radical scavenger, plays an important role in the anti-oxidation defense mechanism in patients with acute cerebral infarction. OBJECTIVE： To observe the relationship between the levels of glutathione （GSH） and malonaldehyde （MDA）, the metabolite of lipid peroxidation, in erythrocyte and deformation index of erythrocyte in patients at various periods following acute cerebral infarction. DESIGN： Controlled observation.SETTING： Qilu Hospital of Shandong University and Institute of Cerebrovascular Disease of Qingdao Medical College. PARTICIPANTS： We chose 98 inpatients with acute cerebral infarction from Department of Neurology, Qilu Hospital of Shandong University from January to December 2000 , serving as cerebral infarction group, including 50 male and 48 female, with mean age of （62±7）years. There were 23 cases found on the 1^st day after onset; 25 cases on the 3^rd day after onset; 25 cases on the 7^th day after onset; 25 cases on the 14th days after onset, and they were all confirmed by craniocerebral CT or MRI. Another 30 homeochronous inpatients with neurosis, cervical syndrome, lumbar intervertebral disc herniation and motor neuron disease were chosen as control group, including 20 male and 10 female, with mean age of （52±8）years . There was no significant difference in age and gender distribution between two groups （P 〉 0.05）. Patients in the two groups were informed of detected index.METHODS：①Ulnar venous blood was chosen from the patients who were fasted on the 1^st, 3^rd,7^th and 14^th days after onset. Deformation index of erythrocyte was measured with BL88-CKX laser diffraction erythrocyte deformeter and photographing was performed. GSH level in erythrocyte was measured with DTNB assay introduced by Beu-tler. MDA level in erythrocyte was measured with modified thiobarbituric acid colorimetric method.②At each sample collecting , according to the criteria accepted by the Fourth National Conference of Cerebrovascular Disease, intergrant of neurologic impairment 〈 15 points was regarded as mild （n=46）, 15 to 30 points as moderate （n=40）and, 〉 30 points as severe （n=12）. ③ t test was used to compare data between two groups , and linear correlation analysis was used in relationship analysis among indexes. MAIN OUTCOME MEASURES ：① Comparison of erythrocyte GSH and MDA levels and deformation index of erythrocyte at various periods between patients with acute cerebral infarction and controls. ②Correlation of erythrocyte GSH level with erythrocyte MDA level and with deformation index of erythrocyte in patients with cerebral infarction . ③ Relationship between erythrocyte GSH level and severity of disease in patients with acute cerebral infarction. RESULTS： Totally 98 patients with acute cerebral infarction and 30 controls all entered the stage of result analysis. ① Erythrocyte GSH level and deformation index of erythrocyte were lower on the 1^st, 3^rd, 7^th and 14^th days after onset in cerebral infarction group than in control group （P 〈 0.05-0.01）, and erythrocyte MDA level was significantly higher in cerebral infarction group than in control group （P 〈 0.05-0.01）. The three indexes changed most significantly on day 3 after onset in patients, and began to recover or decrease on day 7 after onset and inclined to be normal on day 14 after onset. ② Erythrocyte GSH level was significantly negatively correlated with erythrocyte MDA level in patients with acute cerebral infarction on the 1^st, 3^rd, 7^th and 14^th days after onset （r=-0.534, -0.713, -0.645, -0.656, respectively, P 〈 0.05-0.01 ） ,and significantly positively correlated with erythrocyte deformation index （t-=0.502, 0.560, 0.455, 0.504, respectively, P 〈 0.05）. ③Erythrocyte GSH level was significantly lower in moderate or severe patients with acute cerebral infarction than in mild patients[（0.215±0.088）,（0.192±0.102）, （0.281±0.090） g/L, P〈 0.05]. CONCLUSION：①Erythrocyte GSH and MDA levels and deformation index of erythrocyte change significantly on the 3^rd day following acute cerebral infarction. Index detection results gradually tended to be normal on from the 7^th day to 14^th days day after onset. ② Change of erythrocyte GSH level can reflect the severity of disease of patients with acute cerebral infarction.③Decrease of erythrocyte GSH level in patients with acute cerebral infarction is one of reasons that result in the decrease of deformation ability of erythrocyte.

A PRELIMINARY STUDY ON THE RELATIONSHIP BETWEEN MURINE IgE LEVEL AND 3-METHYL-CHOLANTHRENE INDUCED FIBROSARCOMA

The relationship between murine IgE, IgG, and IgG1 level and birosarcoma induced by 3-Methyl-cholanthrene in NIH mice was studied. The results showed that IgE, IgG or IgGl had no significant effect on tumor incidence; the high IgE level could extend the survival time of 3-Methylcholanthrene injected mice (P<0.05) and survival time of tumor bearing mice (P<0.01), while IgG or IgGl could not. The data from this study did not show that IgE, IgG or IgGl had any significant effect on the tumor size and the tumor growth rate. The probable mechanism involved was discussed.

Relationship between changes of endogenous ABA level and resistance in hybrid rice under temperature stress

We studied the relationship between endogenous ABA and resistance to temperature stress in seedlings of hybrid rice. The hybrid rice Combinations Shanyou 63, Shanyou 287, Weiyou 63, and Weiyou 287 were treated under 2℃ and 42℃ respectively for 48 h. Endogenous ABA concentrations were obtained by gas chromatography with electron capture detector (GC-ECD) and a nickel labelled external standard. Leakage of electrolytes were determined. At optimal temperature (27℃), there was difference between the level of endogenous ABA and the leakage of electrolytes in hybrid rice combinations, which attributed to genetic difference. ABA level in Weiyou system was higher than that in Shanyou, and there were distinctions between Shanyou system itself (see table). At 2℃, the ABA content of rice seedling was increased. ABA level of Weiyou system maintained higher than Shanyou system at 27℃. The leakage quantities of

THE RELATIONSHIP BETWEEN THE ERYTHROCYTE POLYAMINE LEVELS AND THE DIFFERENT TYPES OF LEUKEMIA

In a study on erythrocyte polyamine levels in 20 leukemia patients and 18 healthy individuals, following results were obtained. Putrescine(Pu) in ery-throcytes was nearly undetectable but in 2 AMoL patients; Spermidine(Spd) level in ALL was higher than the control volue (P<0.05), in AML (M1, M2) and APL the Spd level was in the range of control group (P>0.1), while that in AMoL and AMMoL was considerably lower as compared to control (P< 0.001); Spermine (Spm) level in all types of leukemia was increased (P<0.001); Spd/Spm ratio was significantly decreased, showing 1.525 in control group, 0.938 in ALL (P<0.025), 0.779 in AML (M1, M2) P< 0.01), 0.319 in APL (P<0.001) and 0.296 in AMoL & AMMoL (P<0.001), and the differences between the Spd/Spm ratio in AMoL and AMMoL and in ALL were noted (P<0.05). These results suggested that determination of erythrocyte polyamines in leukemia patients may be helpful in diagnosis, differential diagnosis and prognosis.

A Study on the Dose-Response Relationship between Asbestos Exposure Level and Asbestosis among Workers in a Chinese Chrysotile Product Factory

The dose-response relationship for asbestos exposure in a chrysotile product factory was studied. The past gravimetric dust concentration values, obtained from different worksites, were converted into fiber concentration values according to conversion factors that were worked out by simultaneous sampling in this study. The conversions were made so that exposure could be expressed in fiber-years (f-yr). Asbestosis was diagnosed on the basis of chest radiographs and occupational histories. Cumulative dust exposure (f-yr) was calculated up to the date of diagnosis for asbestosis patients, and up to September 1982 for the remaining workers. A dose-response relationship expressed as fiber-years exposed vs cumulative prevalence of asbestosis was established by the life table method on the basis of these data. Predicted 3 and 1% prevalence of asbestosis corresponded to 43 and 22 f-yr exposure, respectively. Considering that a worker can work for 35 years, these doses are commensurate with dust concentrations of 1.22 and 0.63 f/ml, respectively. It is recommended that 1 f/ml be taken as the maximum allowable concentration of airborne asbestos dust for the workplace with an anticipated prevalence of about 2% asbestosis after 35 years of exposure. 1990 Academic Press, Inc.

我国本科职业教育治理的批判性思考:场域理论的视角

基于场域理论的视角,分析我国本科层次职业教育各场域及其组织间的互动情境,以此探寻不同场域与组织间的关系。立足科层管理、育人定位、职业技能和社会空间四个主要关系场域,思考如何突破科层权力失衡、育人资本缺失、职业惯习固化、社会资源协同不足等困局,进而结合组织与场域理论的适切性,分析路径过程为“入场准备”“中场适应”“出场联动”三个阶段。为应对关系场域形成的困局,提出应从以下三个场域阶段进行治理路径探究:首先是入场的环境建构,考虑权力与文化资本的完善;其次是控场的惯习重塑,重在加深职业行动能力;最后是出场的社会资本联动,关注治理的社会化发展,以期丰富我国本科职业教育治理思路,促进治理多样化发展。

融合交互注意力网络的实体和关系联合抽取模型

实体关系三元组的抽取效果直接影响后期知识图谱构建的质量,而传统流水线式和联合式抽取的模型,并没有对句子级别和关系级别的语义特征进行有效建模,从而导致模型性能的缺失。为此,提出一种融合句子级别和关系级别的交互注意力网络的实体和关系联合抽取模型RSIAN,该模型通过交互注意力网络来学习句子级别和关系级别的高阶语义关联,增强句子和关系之间的交互,辅助模型进行抽取决策。在构建的中文旅游数据集(TDDS)的Precision、Recall和F1值分别为0.872、0.760和0.812,其性能均优于其他对比模型;为了进一步验证该模型在英文联合抽取上的性能,在公开英文数据集NYT和Webnlg上进行实验,该模型的F1值相比基线模型RSAN模型分别提高了0.014和0.013,并且该模型在重叠三元组的分析实验也均取得了优于基线模型的性能且更稳定。

PGE2、COX-2表达与牙槽骨成骨活性、内氧水平的关系

目的:探讨前列腺素E2(prostaglandin E2,PGE2)、环氧合酶2(cyclooxygenase-2,COX-2)表达与牙槽骨成骨活性、内氧水平的关系。方法:选择2021年3月—2023年3月收治的56例慢性牙周炎且牙槽骨感染的患者为试验(牙周炎)组,同一时段53例健康牙槽骨为对照组。采用组织块培养法进行成骨细胞培养,采用改良Kaplow碱性磷酸酶(alkaline phosphatase,ALP)染色鉴定细胞,利用ELISA试剂盒检测COX-2、PGE2、破骨细胞抑制因子(osteoclastogenesis inhibitory factor,OPG)和核因子κB受体活化因子配体(receptor activator of nuclear factor-κb ligand,RANKL)等的表达,比较2组患者PGE2、COX-2、OPG、内氧水平、ALP和RANKL的表达水平,并分析其相关性。采用SPSS 27.0软件包对数据进行统计学分析。结果:牙周炎组的PGE2、COX-2、RANKL显著高于对照组,而OPG、内氧水平、ALP显著低于对照组(P<0.05)。PGE2、COX2呈高度正相关,与OPG、内氧水平和ALP呈高度负相关,但与RANKL呈高度正相关(P<0.05)。结论:PGE2、COX-2表达与ALP、内氧水平呈高度负相关,可考虑通过增加内氧水平,加大氧分压,并通过药物调节ALP水平,改变牙周炎或其他类似疾病的炎症状况。

文档级关系抽取中的小波变换特征增强方法

传统的文档级关系抽取方法在特征表示的有效性和噪声消除方面存在局限,不能准确地找出证据句子和实体对的关系。为了进一步提升文档级关系抽取和证据句子抽取的准确性,该文提出了一种使用小波变换对预训练语言模型生成的文本向量进行特征提取、清洗和去噪处理的方法。首先利用预训练语言模型对文档进行编码,将得到的初始文本向量应用小波变换出更精确的特征,其次引入多头注意力机制对小波变换的数据进行加权处理,以凸显与实体对关系相关的重要特征。为了充分利用原始数据和清洗后的数据,采用残差连接的方式将它们进行融合。在DocRED数据集上对模型进行了实验,结果表明,该文所提模型能够更好地抽取实体对的关系。

维持性血液透析患者希望水平与生存质量的现况及其相互关系调查

目的调查分析维持性血液透析患者希望水平与生存质量的现况及其相互关系。方法应用便利抽样法选取2021年12月至2023年12月中山市人民医院收治的220例维持性血液透析患者进行研究,采用本院自制的一般情况调查表、简明健康状况调查表以及Herth希望量表进行问卷调查,采用单因素χ^(2)检验、多因素Logistic回归分析法分析患者希望水平与生存质量的相关影响因素,并采用Pearson相关分析法分析两者之间的相关性。结果Herth希望量表评分为(25.68±7.50)分,简明健康状况调查表中的生理职能评分为(63.14±5.11)分、情感职能评分为(65.16±4.98)分、生理功能评分为(60.19±5.11)分、社会功能评分为(64.42±5.31)分、精力评分为(63.37±4.75)分、躯体疼痛评分为(62.37±4.62)分、精神健康评分为(62.15±4.71)分、总体健康评分为(61.63±4.58)分。影响维持性血液透析患者希望水平与生存质量的单因素中,家庭月收入>10000元、受教育水平为大学、透析时间为3~24个月患者的希望水平和生存质量均明显更高,差异有统计学意义(P<0.05)。经Logistic回归模型筛查,结果显示,家庭月收入、受教育水平、透析时间是影响维持性血液透析患者希望水平与生存质量的独立危险因素(P<0.05)。经Pearson相关分析结果显示,维持性血液透析患者希望相关维度、总体水平与生存质量各维度均呈正相关(P<0.05)。结论维持性血液透析患者希望水平较低、生存质量较差,家庭收入、受教育程度、透析时间均是影响患者希望水平与生存质量的独立危险因素,且患者希望相关维度、总体水平与生存质量各维度呈正相关,因此临床可对希望水平进行充分评估并给予个体化、针对性护理措施,以提高生存质量。

甲状腺功能水平与肌少症相关特征表型的关联

背景:多项观察性研究发现甲状腺功能水平与肌少症之间存在密切关系,但是甲状腺功能水平与肌少症发病之间的因果关系尚不明确。目的:采用两样本孟德尔随机化方法研究甲状腺功能水平与肌少症的因果关系。方法:利用促甲状腺激素、游离三碘甲状腺原氨酸、游离四碘甲状腺原氨酸、亚临床甲状腺功能亢进症、亚临床甲状腺功能减退症和肌少症的4种相关表型——左手握力、右手握力、四肢瘦体质量、步速的全基因组关联研究汇总数据进行两样本孟德尔随机化分析,分别采用逆方差加权法、加权中位数法、简单模式法、加权中值方法和MR-Egger回归法作为分析方法,同时采用异质性检验、多效性检验、MR-PRESSO、留一法、漏斗图等方法进行敏感性分析。结果与结论:促甲状腺激素的增高会增加左手握力(β=0.02,SE=0.01,P=0.01)、右手握力(β=0.02,SE=0.01,P=0.01),游离三碘甲状腺原氨酸的增高会降低左手握力(β=-0.06,SE=0.02,P=9.5×10^(-5))、右手握力(β=-0.07,SE=0.02,P=9.3×10^(-5)),亚临床甲状腺功能亢进症会降低步速(β=-4.4×10^(-3),SE=1.7×10^(-3),P=0.01)。敏感性分析结果与主要分析基本一致。结果表明:促甲状腺激素上升是肌少症保护因素,游离三碘甲状腺原氨酸上升和亚临床甲状腺功能亢进症可能导致肌少症发生风险增加。

制造业企业数字化转型对出口绩效的影响研究

随着新一代信息技术快速发展,数字经济已成为我国制造业高质量发展的新动力。选取2012—2019年133家制造业上市企业为研究对象,构建制造业企业数字化转型水平测度体系,研究数字化转型水平对制造业企业出口绩效的影响,对加快提升我国制造业企业出口竞争优势具有重要意义。研究结果表明:制造业企业数字化转型水平对其出口绩效具有促进作用,并且数字化转型水平越高,促进作用越显著。制造业企业数字化转型水平与其出口绩效间不存在U形或倒U形关系。企业创新水平可以正向调节数字化转型对出口绩效的促进作用,从政府和企业两个层面提出了针对性的对策建议。

长江中游干流河段洲滩民垸行蓄洪能力研究

长江中下游洲滩民垸具有巨大行蓄洪能力,对保障重点地区防洪安全起重要作用。但是,洲滩民垸点多面广,地形数据缺乏,无法充分利用并有效构建数学模型分析行蓄洪作用。基于长江中下游高分辨率遥感影像数据,构建长江中游干流河段洲滩民垸数字高程模型,以生产水位-面积-容积关系成果,分区分类研究洲滩民垸的行蓄洪能力。结果表明:长江中游干流洲滩民垸行蓄洪能力强,但空间分布差异大,其中,荆江河段洲滩民垸面积及蓄洪容积占比最高,在面临大洪水时调度运用多。研究成果能够直观有效呈现长江中游干流洲滩民垸的行蓄洪能力,为洲滩民垸的调度运用打牢数据基础,为科学准确制定防洪决策提供有力支持。

基层治理现代化转型中党群互信关系建构的创新路径——以安徽省X县为例

构建党群互信关系,是党贯彻以人民为中心的发展思想,坚定不移走中国式现代化之关键路径。研究表明,基层治理现代化转型中党群互信关系建构的内在逻辑在于践行人民至上理念,坚持民生问题导向,完善党群双向沟通机制,实现党群联通制度化,健全民意督办机制。有效化解党群互信关系建构的重点与难点问题,应当持续增强基层党组织创新服务能力,不断提高党员干部民生问题回应能力,积极完善党群双向互信沟通机制,健全完善党群互联互通制度与机制,清晰界定民意督办机构的职责权限,扎实推动基层治理现代化转型,着力增强基层治理现代化能力。

稳定期慢性阻塞性肺疾病患者体力活动水平的影响因素分析

目的探究稳定期慢性阻塞性肺疾病患者体力活动水平与其血气分析、肺功能的关系。方法回顾性选取2021年1月至2022年4月于福建中医药大学附属第三人民医院肺病科就诊的103例慢性阻塞性肺疾病患者为研究对象,按患者体力活动水平进行分组,分为高体力组、中体力组和低体力组。比较三组患者的一般临床资料、血气分析及肺功能情况。结果103例慢性阻塞性肺疾病患者中高体力活动水平28例、中度体力活动水平59例、低体力活动水平16例。经过单因素分析,三组患者年龄、动脉血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、血氧饱和度(SaO_(2))、第1秒用力呼气容积(FEV_(1))、最大呼气流速(PEF)、一秒率[FEV_(1)/用力肺活量(FVC)]、6 min步行试验(6MWD)、核转录因子(NF-κB)及细胞黏附分子-1(ICAM-1)比较,差异有统计学意义(P<0.05)。PaO_(2)、Sa O_(2)、FEV_(1)、PEF、FEV_(1)/FVC、6MWD与体力活动水平呈正相关,PaCO_(2)、NF-κB、ICAM-1与体力活动水平呈负相关(P<0.05)。进行多元线性回归分析,患者PaCO_(2)、NF-κB、ICAM-1是体力活动水平的独立危险因素,PaO_(2)、SaO_(2)、FEV_(1)、PEF、FEV_(1)/FVC、6MWD是体力活动水平的保护因素(P<0.05)。结论PaO_(2)、SaO_(2)、FEV_(1)、PEF、FEV_(1)/FVC、6MWD指标高水平表达是体力活动水平的保护因素,PaCO_(2)、NF-κB、ICAM-1高水平表达是体力活动水平的独立危险因素,反映了体力活动水平越高,肺功能恢复越好。临床上可根据患者上述指标因素制订个性化康复活动。

南营水库(渠)流量间测分析

随着水文现代化的推进,加强对水文监测方式的转变显得意义重大和刻不容缓,不仅能更好地完成水文监测任务,而且提高了工作效率。依据《水文巡测规范》对各项指标的要求,对南营水库(渠)进行流量间测分析论证,为下一步开展水文巡测探索途径和积累经验。选用2010年至2022年13年的资料成果进行分析。通过对各年高、中、低各级水位级的频率计算分析南营水库(渠)可实行流量间测。

手机成瘾对正念水平与人际关系的中介作用——以高职护理专业学生为例

为了探讨正念水平对高职护理专业学生人际关系的影响以及手机成瘾在正念水平和人际关系之间的中介效应,采用便利抽样的方法选取923名高职护理专业学生,应用五因素正念量表、人际关系综合诊断量表、大学生手机成瘾倾向性量表对学生进行了调查。从而得出结论,手机成瘾在高职护理专业学生正念水平和人际关系之间起部分中介效应的作用,提高学生的正念水平有助于减少学生手机成瘾情况,解决人际关系困扰问题。

共同富裕背景下教育水平对城乡收入差距的影响研究

以新时代推进共同富裕这一历史使命为出发点,在理论回顾的基础上提出问题,利用31个省(区、市)2000-2021年的省际面板数据,就教育水平如何影响城乡收入差距展开实证分析。结果发现,教育水平显著影响城乡收入差距,方向为正,伴随着城乡收入差距水平的提高,教育水平的影响作用更为明显;教育水平和城乡收入差距存在倒U型关系。同时经济开放水平越高,城乡收入差距越大;经济发展和城镇化有助于缩小城乡收入差距;城乡收入差距具有较强的惯性,需采取有效举措控制,以防失控。异质性分析发现东部、中部、西部和东北地区的教育水平对城乡收入差距的作用程度有明显差异,中部最大,西部次之,再次是东部,东北最小;处于不同收入差距分布上的地区对教育水平的依赖程度存在显著差异,教育水平对不同收入差距的地区存在不同的影响作用;不同教育层次对城乡收入差距的影响有明显差异,高中及以下层次的教育对城乡收入差距非常小也不显著,大学及以上教育层次影响较大且显著。