Objective: To analyze the distribution characteristics and clinical significance of SLCO1B1 and ApoE gene polymorphisms of the Li people in Hainan Island. Method: Selecting 502 high school students of the Li people fr...Objective: To analyze the distribution characteristics and clinical significance of SLCO1B1 and ApoE gene polymorphisms of the Li people in Hainan Island. Method: Selecting 502 high school students of the Li people from five cities and counties in Hainan Island (namely, Qiongzhong County, Dongfang City, Ledong County, Baoting County and Wuzhishan City) as research subjects in September, 2019;Applying PCR-fluorescence probe method to detect SLCO1B1 and ApoE genotypes of the Li people in Hainan Island, and statistically analyzing the distribution characteristics of gene frequency and the distribution differences in gene polymorphisms between different genders. Meanwhile, detecting the SLCO1B1 and ApoE gene of 527 people from the Han people in five regions mentioned before, so as to analyze the distribution differences of the SLCO1B1 and ApoE gene between the Han people and the Li people. Results: The frequency of each genotype of SLCO1B1 in the Li people in Hainan Island is: *1a/*1a 6.77%, *1a/*1b 27.09%, *1b/1b 41.63%, *1a/*5 0.00%, *1a/*15 4.78%, *1b/15 16.93%., *5/*5 0.00%, *5/*15 0.00%, *15/*15 2.79%;And that of ApoE is: e2/e2 0.40%, e2/e3 17.73%, e2/e4 2.39%, e3/e3 65.54%, e3/e4 12.55%, e4/e4 1.39%. There is no significant difference (P > 0.05) in other genotypes except weak metabolic genotypes (*5/*5, *5/*15 and *15/*15) between the Han and the Li peoples. Conclusion: The gene frequency of SLCO1B1 weak metabolic genotype is dramatically higher in the Li people of Hainan Island than that of the Han people in both Hainan Island and Central and South China, but there is no significant difference in ApoE gene frequency among them. Therefore, clinicians should adjust the dosage of statins and select the types of lipid-lowering drugs according to the differences in patients’ genotypes, and strengthen the management of patients with ApoE4 risk gene.展开更多
Recent research has emphasized that attitude is key to language learners’learning outcomes.More specifically,language learners’feelings about languages and language learning may affect their study behavior and willi...Recent research has emphasized that attitude is key to language learners’learning outcomes.More specifically,language learners’feelings about languages and language learning may affect their study behavior and willingness to engage with a second or foreign language.Few studies on language attitudes have been conducted with ethnic minority groups in China.As such,influencing factors(e.g.,gender,language proficiency)have not gained sufficient attention.The present study aims to explore language attitudes,especially towards multilingualism,among members of the Li minority group in Hainan,China.First,we conceptualized and validated a questionnaire on attitudes towards multilingualism.Exploratory factor analysis and confirmatory factor analysis verified the survey’s validity.Then,we examined how selected sociodemographic variables(e.g.,gender and language proficiency)influenced students’attitudes towards multilingualism.Hierarchical regression was performed to ascertain the contribution of each predictor variable to learners’attitudes towards multilingualism.Results revealed no significant relationship between gender and language attitudes but found a significant impact of students’language proficiency level on their attitudes towards multilingualism.Implications for minority students’multilingual learning were discussed based on the findings.展开更多
文摘Objective: To analyze the distribution characteristics and clinical significance of SLCO1B1 and ApoE gene polymorphisms of the Li people in Hainan Island. Method: Selecting 502 high school students of the Li people from five cities and counties in Hainan Island (namely, Qiongzhong County, Dongfang City, Ledong County, Baoting County and Wuzhishan City) as research subjects in September, 2019;Applying PCR-fluorescence probe method to detect SLCO1B1 and ApoE genotypes of the Li people in Hainan Island, and statistically analyzing the distribution characteristics of gene frequency and the distribution differences in gene polymorphisms between different genders. Meanwhile, detecting the SLCO1B1 and ApoE gene of 527 people from the Han people in five regions mentioned before, so as to analyze the distribution differences of the SLCO1B1 and ApoE gene between the Han people and the Li people. Results: The frequency of each genotype of SLCO1B1 in the Li people in Hainan Island is: *1a/*1a 6.77%, *1a/*1b 27.09%, *1b/1b 41.63%, *1a/*5 0.00%, *1a/*15 4.78%, *1b/15 16.93%., *5/*5 0.00%, *5/*15 0.00%, *15/*15 2.79%;And that of ApoE is: e2/e2 0.40%, e2/e3 17.73%, e2/e4 2.39%, e3/e3 65.54%, e3/e4 12.55%, e4/e4 1.39%. There is no significant difference (P > 0.05) in other genotypes except weak metabolic genotypes (*5/*5, *5/*15 and *15/*15) between the Han and the Li peoples. Conclusion: The gene frequency of SLCO1B1 weak metabolic genotype is dramatically higher in the Li people of Hainan Island than that of the Han people in both Hainan Island and Central and South China, but there is no significant difference in ApoE gene frequency among them. Therefore, clinicians should adjust the dosage of statins and select the types of lipid-lowering drugs according to the differences in patients’ genotypes, and strengthen the management of patients with ApoE4 risk gene.
文摘Recent research has emphasized that attitude is key to language learners’learning outcomes.More specifically,language learners’feelings about languages and language learning may affect their study behavior and willingness to engage with a second or foreign language.Few studies on language attitudes have been conducted with ethnic minority groups in China.As such,influencing factors(e.g.,gender,language proficiency)have not gained sufficient attention.The present study aims to explore language attitudes,especially towards multilingualism,among members of the Li minority group in Hainan,China.First,we conceptualized and validated a questionnaire on attitudes towards multilingualism.Exploratory factor analysis and confirmatory factor analysis verified the survey’s validity.Then,we examined how selected sociodemographic variables(e.g.,gender and language proficiency)influenced students’attitudes towards multilingualism.Hierarchical regression was performed to ascertain the contribution of each predictor variable to learners’attitudes towards multilingualism.Results revealed no significant relationship between gender and language attitudes but found a significant impact of students’language proficiency level on their attitudes towards multilingualism.Implications for minority students’multilingual learning were discussed based on the findings.
