Early Cenozoic paleontological assemblages and provenance evolution of the Lishui Sag,East China Sea

The East China Sea Shelf Basin generated a series of back-arc basins with thick successions of marine-and terrestrial-facies sediments during Cenozoic.It is enriched with abundant oil and gas resources and is of great significance to the petroleum exploration undertakings.Therein,the Lishui Sag formed fan delta,fluvial delta and littoral-to-neritic facies sediments during Paleocene–Eocene,and the research on its sedimentary environment and sediment source was controversial.This study analyzed the paleontological combination characteristics,and conducted a source-to-sink comparative analysis to restore the sedimentary environment and provenance evolution of the Lishui Sag during Paleocene–Eocene based on the integration of detrital zircon U-Pb age spectra patterns with paleontological assemblages.The results indicated that Lishui Sag was dominated by littoral and neritic-facies environment during time corroborated by large abundance of foraminifera,calcareous nannofossils and dinoflagellates.Chronological analysis of detrital zircon U-Pb revealed that there were significant differences in sediment sources between the east and west area of the Lishui Sag.The western area was featured by deeper water depths in the Paleocene–Eocene,and the sediment was characterized by a single Yanshanian peak of zircon U-Pb age spectra,and mainly influenced from Yanshanian magmatic rocks of South China Coast and the surrounding paleo-uplifts.However,its eastern area partly showed Indosinian populations.In particular,the upper Eocene Wenzhou sediments were featured by increasingly plentiful Precambrian zircons in addition to the large Indosinian-Yanshanian peaks,indicating a possible impact from the Yushan Low Uplift to the east.Therefore,it is likely that the eastern Lishui Sag generated large river systems as well as deltas during time.Due to the Yuquan Movement,the Lishui Sag experienced uplifting and exhumation in the late stage of the late Eocene and was not deposited with sediments until Miocene.Featured by transitional-facies depositions of Paleocene–Eocene,the Lishui Sag thus beared significant potential for source rock and oil-gas reservoir accumulation.

Optimization Analysis of Campus Topic Space in Colleges and Universities——A Case Study of the Colleges and Universities in Lishui, Zhejiang Province

University campus is the most important place for life, study, activity and experience of contemporary college students. It is helpful for students to survive and develop to create the topic space of campus. Taking the topic space of college campuses in Lishui City of Zhejiang Province as an example, the current situations are analyzed through questionnaire survey and field visit. The results show that uni- versity campus space needs a clear topic; the demands are generally large for the topics of exchange and communication, learning and thinking, sports and leisure in all kinds of space; the creation of these types of topic spaces should focus on the peaceful environment, beautiful scenery, privacy of the space and WlFI coverage.

Study on Forming and Strengthening of Lishui Tourist Transport Center

The current development of Lishui tourist transport center is introduced,its forming reason and current problems are analyzed,finally its strengthening strategy is proposed.

New Nodosaurid Dinosaur from the Late Cretaceous of Lishui, Zhejiang Province, China

A new genus and species of nodosaurid dinosaur： Zhejiangosaurus lishuiensis gen. et sp. nov. is erected herein. It is characterized by the sacrum consisting of at least three true sacral vertebrae, 5 caudal dorsal vertebrae fused to form the presacral rod, wide divergence of long slender preacetabular process of the ilium from the middle line of the body, and the fourth trochanter located at the femoral mid-length.

Geochemistry of the Paleocene Clastic Rocks in Lishui Sag, East China Sea Shelf Basin： Implications for Tectonic Background and Provenance

The Lishui Sag, in the East China Sea Shelf Basin, is rich in hydrocarbons, with the major hydrocarbon-bearing layers being the Paleocene Mingyuefeng clastic rocks. Analysis of the implicit geologic background information of these Paleocene clastic rocks using petrological and geochemical methods has significant practical importance. These Paleocene sandstones are mainly lithic arenite, lithic arkose and greywacke, composed of K-feldspar, plagioclase, authigenic clays, silica and carbonates. As continental deposits, Yueguifeng clastic rocks have high aluminosilicate and mafic detritus contents, while the Lingfeng and Mingyuefeng Formations are rich in silica due to an oscillating coastal marine depositional environment. The major element contents of these Paleocene sandstones are low and have a concentrated distribution, indicating that the geochemical composition is non-epigenetic, transformed by sedimentary processes and diagenesis. The Yueguifeng detritus comprises recycled sediments, controlled by moderate weathering and erosion, while the Lingfeng and Mingyuefeng detritus is interpreted as primarily first-cycle materials due to low chemical weathering. In the Late Cretaceous to Early Paleocene, the Pacific Plate began subducting under the Eurasian Plate, causing an orogeny by plate collision and magma eruption due to the melting of subducted oceanic crust. This resulted in the dual tectonic settings of ＂active margin＂ and ＂continental island arc＂ in the East China Sea Shelf Basin. During the Late Paleocene, the Pacific Plate margin migrated eastward along with development of the Philippine Ocean Plate, and the tectonic setting of the Lishui Sag gradually turned into a passive continental margin. Detrital sources included both orogenic continental blocks and continental island arcs, and the parent rocks are primarily felsic volcanic rocks and granites.

Recovery of the Erosion Thickness and Characterization of the Paleogeomorphology in the Southern Lishui Sag, East China Sea Shelf Basin

The restoration of the denudation thickness is the basis for quantitatively analyzing the basin burial history,thermal evolution history and hydrocarbon accumulation conditions.The well data is not sufficient to do this in the southern Lishui Sag with only 5 wells,so the new,high-quality three-dimensional(3D)seismic data is essential.The methods employed to determine the eroded thicknesses of key unconformities in the study area are the mudstone acoustic time difference(AC)method,vitrinite reflectance(Ro%)method and stratigraphic trend comparison method.On the basis of the structural evolution,the restoration of the paleogeomorphology is carried out.The results show that the Wenzhou formation(E2 w)in the entire study area has been all denuded.The denudation thickness is in the range of 0–550 m,and decreases gradually from west,thicker than 200 m,to east.The erosion of the upper Lingfeng formation(E1l)are mainly occurred in the N-P-1 structural trap(N-P-1),the N-P-2 structural trap(N-P-2)and the N-P-3 structural trap(N-P-3).Among them,the eroded area in N-P-1(near well S-1)and N-P-2 is 200–230 km^2,and the denudation thickness is 0–600 m,which increases from south to north,even up to 200–400 m in the region around well S-1.In N-P-3,the extent of denudation is 30–50 km^2,and the denudation thickness is 0–400 m.In the early stage of the upper E1 l,one north-south strike slip fault began to develop in the southern study area.Affected by this fault,the southern Lingfeng bulge was offset,forming a gorge,and the eastern and western sides of the concave belt connected to each other.On the basis of the paleo-geomorphological characteristics,it is shown that the sedimentary center of the west subsag began to migrate to the south.

Comparison of the Pore Structure of Ultralow-Permeability Reservoirs Between the East and West Subsags of the Lishui Sag Using Constant-Rate Mercury Injection

In this study, the differences in reservoir parameters, such as pore radius, throat radius, and pore-throat ratio, between the east and west subsags of the Lishui Sag are analyzed by using data obtained from a constant-rate mercury injection experiment. Furthermore, the quality of the reservoirs in the two subsags is systematically evaluated. Results show that the throat radius of the Lishui west subsag is larger than that of the east subsag, and this parameter has a positive correlation with reservoir quality. However, the pore-throat ratio of the east subsag is larger than that of the west subsag, which has an inverse relationship with reservoir quality. The main reasons for this reservoir difference can be attributed to sedimentation and diagenesis. The sedimentary facies types of the Lishui east subsag are the fan delta, shore lake, shallow lake, and shore shallow lake;their sandstone composition maturity is low;the clay mineral content is high;and the rock has undergone strong diagenesis. Therefore, the physical conditions of the reservoir are poor. However, the sandstones in the Lishui west subsag have weak cementation and compaction, mainly with an intergranular pore structure type, which leads to good connectivity between pores. Therefore, the storage performance and seepage capacity of the Lishui west subsag are better than those of the east subsag;the west subsag is the main area of oil and gas accumulation, as confirmed in the process of exploration and development.

Base level changes based on Basin Filling Modelling:a case study from the Paleocene Lishui Sag,East China Sea Basin

Estimation of base level changes in geological records is an important topic for petroleum geologists.Taking the Paleocene Upper Lingfeng Member of Lishui Sag as an example,this paper conducted a base level reconstruction based on Basin Filling Modelling(BFM).The reconstruction was processed on the ground of a previously interpreted seismic stratigraphic framework with several assumptions and simplification.The BFM is implemented with a nonlinear diffusion equation solver written in R coding that excels in shallow marine stratigraphic simulation.The modeled results fit the original stratigraphy very well.The BFM is a powerful tool for reconstructing the base level,and is an effective way to check the reasonableness of previous interpretations.Although simulation solutions may not be unique,the BFM still provides us a chance to gain some insights into the mechanism and dynamic details of the stratigraphy of sedimentary basins.

Effect of Jianshen Lishui Decoction on C-reactive protein and procalcitonin in patients with acute cerebral hemorrhage

Objective:To investigate the effect of Jianshen Lishui decoction on C-reactive protein and Procalcitonin in patients with acute Cerebral Hemorrhage.Methods:120 patients with acute spontaneous Cerebral Hemorrhage were randomly divided into two groups:Control Group and the Observation Group.The Control Group was treated with routine Western medicine.The Observation Group was treated with Jianshen Lishui decoction on the basis of the Control Group.The observation period was 4 weeks,the changes of nerve function,C-reactive protein and Procalcitonin were observed before treatment and 3d,7d,14d and 4w after treatment.Results:After treatment,the scores of neurologic impairment,C-reactive protein and Procalcitonin decreased gradually with the time of treatment(3d-4w),and the scores of neurologic impairment,C-reactive protein and Procalcitonin decreased gradually,there was no difference in the score of nerve function,C-reactive protein and Procalcitonin between the two groups(P>0.05),the score of nerve function,C-reactive protein and Procalcitonin in the Observation Group were lower than those in the Control Group(P<0.05).Conclusion:Jianshen Lishui decoction can improve the neurological function of patients with acute Cerebral Hemorrhage,reduce the expression of C-reactive protein,Procalcitonin.

Effect of Huoxue Huayu Lishui Decoction on P65 and TAK1 of acute soft tissue injury in rats

Objective:To explore the mechanism of the action of Huoxue Huayu Lishui prescription on acute ankle joint injury.Methods:Forty-eight SPF rats were randomly divided into blank group,model group,Shujin Huoluo capsule group,low,medium and high dose groups for promoting blood circulation and removing blood stasis.The blank group was not modeled,and the other groups were modeled.Each group of 8 animals,the Shujin Huoluo capsule group was given 0.2g/ml mixed liquid by gavage,and the low,medium and high blood circulation and blood stasis Lishui prescription group was given 1.03g/ml,2.06g/ml,4.12g/ml decoction For the stomach,the normal group was given 1.5ml/100g,once a day for 1 week.The expression of NF-κB P65 and transforming growth factor kinase 1(TAK1)protein in the soft tissue around the ankle joint of rats was detected by sports protein immunoblotting method,and the mRNA expression of NF-κB P65 and TAK1 was detected by PCR technology.Results:One day after modeling,the expressions of P65 and TAK1 mRNA and protein in the model group,the positive drug group,and low,medium and high doses of Huoxue Huayu Lishui Recipe were significantly different from those of the blank control group(P<0.05).After taking the medicine for 7 days,compared with the model group,the expressions of P65 and TAK1 mRNA and protein in the Shujin Huoluo capsule group and the low,medium and high dose Huoxue Huayu Lishui Recipe group were all decreased(P<0.05).After 7 days of taking the medicine,compared with the Shujin Huoxue Capsule group,there was no difference in P65 protein in the low-dose Huoxue Huayu Lishui Recipe group.The expression of P65 protein in the middle and high groups and the Shujin Huoxue Capsule group were all decreased(P<0.05).Compared with the Shujin Huoxue Capsule group,the expressions of TAK1 protein,P65 and TAK1 mRNA in the low,medium,and high groups and the Shujin Huoxue Capsule group were all decreased(P<0.05).The results suggest that Huoxue Huayu Lishui Recipe can inhibit the expression of NF-κB P65 and TAK1 protein in ankle joint injury.Conclusion:Huoxue Huayu Lishui prescription may regulate the expression of NF-κB P65 and TAK1 in ankle joint injury of NF-κB rats,so as to improve the clinical symptoms of local swelling and pain in the ankle joint.

Analysis of the Clinical Value of Baogan Lishui Decoction and Conventional Western Medicine in Treating Hepatitis B Cirrhosis Refractory Ascites

The objective of this study was to investigate the clinical effect of combination treatment of Chinese medicine Baogan Lishui decoction and western medicine on hepatitis B(Hep B)cirrhosis-related refractory ascites.The control group was given conventional western medicine therapy while the observation group was given same conventional western medicine therapy with additional of Chinese medicine Baogan Lishui decoction.The total effective of clinical treatment on Hep B cirrhosis-related refractory ascites in observation group was higher than that of the control group which was 88.89%compared to 71.11%,respectively,and it was significant different(P<0.05).The combination treatment of Chinese medicine Baogan Lishui decoction and conventional western medicine can significantly increase the treatment effect on Hep B cirrhosis refractory ascites,and thus increases the quality and safety of life.

2019—2023年丽水市老年肺结核患者就诊延迟情况及影响因素分析

目的:了解2019—2023年丽水市老年肺结核患者就诊延迟现状及其影响因素,为制定和调整结核病防治措施提供依据。方法:通过“中国疾病预防控制信息系统”子系统“结核病信息管理系统”收集2019—2023年登记的现住址为丽水市≥60岁肺结核患者的病案信息,共2436例,包括个人基本信息和诊疗情况等,分析患者的就诊延迟时间和就诊延迟率分布情况和变化趋势,采用多因素logistic回归模型分析其影响因素。结果:老年肺结核患者就诊延迟时间的中位数(四分位数)为30(12,77)d,总体就诊延迟率为70.11%(1708/2436)。2019—2023年老年肺结核患者就诊延迟率分别为65.02%(290/446)、62.75%(288/459)、67.39%(310/460)、74.00%(353/477)、78.62%(467/594),总体呈上升趋势,差异有统计学意义(χ^(2)_(趋势)=42.993,P<0.001)。多因素logistic回归分析显示,登记年份为2022年(OR=1.538,95%CI:1.149~2.059)和2023年(OR=2.108,95%CI:1.584~2.805)、首诊地区为本市(OR=3.931,95%CI:1.602~9.650)、现住址为松阳县(OR=1.569,95%CI:1.045~2.357)是就诊延迟的危险因素,现住址为云和县(OR=0.433,95%CI:0.269~0.700)、景宁县(OR=0.412,95%CI:0.254~0.667)、龙泉市(OR=0.402,95%CI:0.260~0.621)是就诊延迟的保护因素。结论:丽水市老年肺结核患者就诊延迟率高,且呈上升趋势,需重点关注本市就诊者及松阳县患者,并采取有效措施,降低老年肺结核患者就诊延迟率。

基于miR-153/TREM1探讨健神利水方对脑出血大鼠神经细胞凋亡的作用机制

目的探究健神利水方对脑出血大鼠神经细胞凋亡的作用机制。方法通过miRNA微阵列芯片和RT-PCR分析出脑出血中miR-153的表达,观察并分析miR-153与脑出血神经细胞凋亡关系;预测miR-153的靶基因,采用双荧光素酶报告基因实验观察其与靶基因的结合情况,观察过表达和抑制miR-153对靶基因的影响,随后,明确靶基因与脑出血神经细胞凋亡关系,最后观察健神利水方对miR-153、靶基因的影响,最终探究健神利水方对脑出血大鼠神经细胞凋亡的相关机制。结果微阵列芯片和RT-PCR检测表明miR-153在脑出血中是低表达的(P<0.05),miR-153与神经细胞凋亡呈负相关(R:-0.875,P=0.0002)。在线数据库TargetScan和miRDB显示miR-153与TREM1具有结合区域,双荧光素酶报告基因实验证明两者具有结合关系,当miR-153过表达时,TREM1表达量会下调,相反,当miR-153抑制时,TREM1表达量会上调,TREM1与神经细胞凋亡呈正相关(R:0.857,P<0.001)。健神利水方组的TREM1表达量、神经细胞凋亡数量、神经功能缺损评分均低于模型组(P<0.05),miR-153表达量高于模型组(P<0.05)。健神利水方+miR-153抑制组的TREM1表达量、神经细胞凋亡数量、神经功能缺损评分均高于健神利水方组(P<0.05)。结论健神利水方通过促进miR-153表达,抑制TREM1表达来达到抑制脑出血大鼠神经细胞凋亡,保护神经功能。

益气养阴活血利水法联合康柏西普治疗糖尿病性黄斑水肿的临床研究

目的评估益气养阴活血利水法联合康柏西普治疗糖尿病性黄斑水肿(DME)的安全性和有效性,为中西医结合治疗DME提供更多的临床手段和思路。方法选取2019年6月至2022年6月在萍乡市人民医院眼科住院的70例DME患者作为研究对象,每治疗周期中行单眼药物注射,均为单眼入组。随访脱失6例,共64例患者计入统计。按入院先后分为治疗组(29例)与对照组(35例),治疗组采用玻璃体腔注射康柏西普1次联合口服益气养阴活血利水中药组方3个月;对照组采用单纯玻璃体腔注射康柏西普1次。比较两组治疗前及治疗后1、3、6个月的最佳矫正视力(BCVA)、中心视网膜厚度(CRT)、中医证候评分、需要重复眼内药物注射次数的差异。结果两组患者治疗前后的BCVA、CRT及中医证候评分的时点比较,差异有统计学意义(P<0.05),两组患者治疗前后的BCVA、CRT及中医证候评分的组间、交互作用比较,差异无统计学意义(P>0.05),治疗组治疗后1、3个月以及对照组治疗后1个月的BCVA、CRT及中医证候评分均高于治疗前,差异有统计学意义(P<0.05)。对照组治疗后3个月及两组治疗后6个月的BCVA、CRT及中医证候评分治疗前后比较,差异无统计学意义(P>0.05)。治疗后3月检查CRT较治疗后1个月反弹,其中治疗组有5例需要再次注射康柏西普,少于对照组的15例(χ^(2)=4.844,P=0.033),差异有统计学意义;两组治疗后的BCVA、CRT及中医证候评分与治疗前的平均变化比较,治疗组BCVA、CRT及中医证候评分的改善始终优于对照组。此外,治疗期间两组均没有发生重大的安全问题。结论益气养阴活血利水中药组方联合康柏西普治疗DME,有助于提高BCVA,延缓黄斑水肿复发,疗效优于单独康柏西普治疗。

三子利水颗粒对心衰肺水肿大鼠肺组织液体转运相关蛋白表达的影响

目的通过观察三子利水颗粒对心衰肺水肿大鼠肺组织病理组织学、AQP1、AQP5、ENaC蛋白及mRNA表达的影响探讨其治疗心衰肺水肿的机制。方法选择雄性SD大鼠,通过结扎腹主动脉、腹腔注射氯化铵造成心衰急性肺水肿模型,随机分为模型组、西药组、中药低剂量组、中药高剂量组、中药低剂量+西药组、中药高剂量+西药组。给药1周后观察各组大鼠肺组织含水率、病理组织学及AQP1、AQP5、ENaC蛋白及mRNA表达水平。结果与模型组比较,各给药组肺含水量均减少(P<0.05);组织细胞间的炎性浸润和肺泡间的充血症状均改善。AQP1、AQP5蛋白表达均不同程度地升高,中药低剂量组AQP1差异有统计学意义(P<0.05),AQP5差异无统计学意义(P>0.05),其余给药组差异有统计学意义(P<0.01)。ENaC蛋白表达均不同程度地升高,空白对照组、中药低剂量组+西药组、中药高剂量组+西药组差异有统计学意义(P<0.05),其余各组差异无统计学意义(P>0.05)。AQP1、AQP5mRNA表达均不同程度地升高,中药低剂量组+西药组、中药高剂量组+西药组差异有统计学意义(P<0.01)。ENaC mRNA表达均不同程度地升高,中药低剂量组+西药组差异有统计学意义(P<0.05),西药组、中药高剂量组+西药组差异有统计学意义(P<0.01)。中药低、高剂量组差异无统计学意义(P>0.05)。结论三子利水颗粒可通过升高AQP1、AQP5、ENaC蛋白表达及mRNA表达含量来改善上皮细胞病理组织形态,达到清上焦肺水,缓解心衰肺水肿体征的目的。

健神利水方治疗急性脑出血的临床观察

目的观察健神利水方对急性(自发性)脑出血患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响及临床疗效。方法90例患者随机分为观察组与对照组,两组均采取西医常规治疗,观察组加予健神利水方治疗,治疗观察期为4周,观察两组入院24 h和治疗7、14、28 d的格拉斯哥昏迷指数(GCS)评分、神经功能缺损量表(NIHSS)评分及TNF-α、IL-6的变化,同时评估两组的临床疗效。结果观察组总有效率为81.39%,高于对照组的72.09%(P<0.05);随着治疗时间的延长,两组NIHSS评分、血清TNF-α、IL-6水平均逐步下降(P<0.05),GCS评分逐步上升,观察组的NIHSS及血清IL-1、IL-6水平低于对照组(P<0.05),观察组的GCS评分高于对照组(P<0.05)。结论健神利水方可改善急性脑出血患者意识障碍程度和神经功能缺损,有助于提高临床疗效。

和营利水方治疗视网膜静脉阻塞继发黄斑水肿的疗效观察

目的观察和营利水方治疗视网膜静脉阻塞继发黄斑水肿(RVO-ME)的临床疗效。方法纳入2021年1月—2023年6月上海中医药大学附属龙华医院诊治的RVO-ME患者110例(110只眼)。随机分为治疗组和对照组,最终纳入治疗组54例(54只眼)、对照组49例(49只眼)。对照组予阿柏西普眼内注射液玻璃体腔内注射治疗。治疗组在对照组的基础上联合和营利水方口服。分别于治疗前、治疗后1、3、6、12个月检测2组受试者的最佳矫正视力(BCVA),采用光学相干断层扫描血管成像(OCTA)检测黄斑中心凹厚度(CMT)、视网膜浅层毛细血管丛血流密度(SCP)、视网膜深层毛细血管丛血流密度(DCP)、中心凹无血管区(FAZ)面积、非圆度指数(AI)和FAZ范围300μm宽度内的血流密度(FD-300),记录数据并做统计分析。结果(1)BCVA:治疗组治疗后各时间点的BCVA均较治疗前提高,差异均有统计学意义(t_(1个月)=34.093、t_(3个月)=57.481、t_(6个月)=59.741、t_(12个月)=46.442,均P=0.000)。对照组治疗后各时间点BCVA均较治疗前提高,差异均有统计学意义(t_(1个月)=29.606、t_(3个月)=49.027、t_(6个月)=48.711、t_(12个月)=30.826,均P=0.000)。治疗后2组间比较,治疗组治疗后各时间点的BCVA均优于对照组,差异均有统计学意义(t_(1个月)=3.646、t_(3个月)=5.068、t_(6个月)=6.758、t_(12个月)=11.549,均P=0.000)。(2)CMT:治疗组治疗后各时间点的CMT均较治疗前降低,差异均有统计学意义(t_(1个月)=34.702、t_(3个月)=52.204、t_(6个月)=51.470、t_(12个月)=41.842,均P=0.000)。对照组治疗后各时间点的CMT均较治疗前降低,差异均有统计学意义(t_(1个月)=34.950、t_(3个月)=42.529、t_(6个月)=46.152、t_(12个月)=43.355,均P=0.000)。治疗后2组间比较,治疗组治疗后各时间点的CMT均低于对照组,差异均有统计学意义(t_(1个月)=2.438,P=0.017;t_(3个月)=6.649、t_(6个月)=3.776、t_(12个月)=6.138,均P=0.000)。(3)SCP:治疗组治疗后1个月与治疗前比较,差异无统计学意义(P>0.05),治疗后3、6、12个月的SCP均提高,差异均有统计学意义(t_(3个月)=17.613、t_(6个月)=13.095、t_(12个月)=4.640,均P=0.000)。对照组治疗后1个月的SCP较治疗前下降,差异有统计学意义(t=12.963,P=0.000),其余各时间点的SCP均无明显变化,差异均无统计学意义(P>0.05)。治疗后2组间比较,治疗组治疗后各时间点的SCP均高于对照组,差异均有统计学意义(t_(1个月)=16.639、t_(3个月)=16.125、t_(6个月)=11.443,均P=0.000;t_(12个月)=2.975,P=0.004)。(4)DCP:治疗组治疗后1个月与治疗前比较,差异无统计学意义(P>0.05),治疗后3、6、12个月的DCP均升高,差异均有统计学意义(t_(3个月)=9.261、t_(6个月)=6.833、t_(12个月)=4.749,均P=0.000)。对照组治疗后1、3、6个月的DCP均较治疗前下降,差异均有统计学意义(t_(1个月)=26.876、t_(3个月)=10.916,均P=0.000;t_(6个月)=3.486,P=0.001),治疗后12个月的DCP无明显变化,差异无统计学意义(P>0.05)。治疗后2组间比较,治疗组治疗后各时间点的DCP均高于对照组,差异均有统计学意义(t_(1个月)=23.077、t_(3个月)=17.558、t_(6个月)=10.694、t_(12个月)=7.299,均P=0.000)。(5)FAZ面积:治疗组治疗后1个月与治疗前比较,差异无统计学意义(P>0.05),其余各时间点的FAZ均下降,差异均有统计学意义(t_(3个月)=20.915、t_(6个月)=16.959、t_(12个月)=9.167,均P=0.000)。对照组治疗后1个月的FAZ较治疗前升高,差异有统计学意义(t=22.974,P=0.000),其余各时间点的FAZ均无明显变化,差异均无统计学意义(P>0.05)。治疗后2组间比较,治疗组治疗后各时间点的FAZ面积均小于对照组,差异均有统计学意义(t_(1个月)=21.963、t_(3个月)=16.895、t_(6个月)=12.043、t_(12个月)=6.758,均P=0.000)。(6)AI:治疗组治疗后3、6个月的AI均较治疗前下降,差异均有统计学意义(t_(3个月)=5.654、t_(6个月)=3.934,均P=0.000),其余时间点的AI均无明显变化,差异均无统计学意义(P>0.05)。对照组治疗后1个月的AI较治疗前升高,差异有统计学意义(t=7.797,P=0.000),其余时间点的AI均无明显变化,差异均无统计学意义(P>0.05)。治疗后2组间比较,治疗组治疗后1、3、12个月的AI均低于对照组,差异均有统计学意义(t_(1个月)=8.029,P=0.000;t_(3个月)=3.379,P=0.001;t_(12个月)=2.305,P=0.023)。而2组治疗后6个月的AI比较,差异无统计学意义(P>0.05)。(7)FD-300:治疗组治疗后3、6个月的FD-300较治疗前升高,差异有统计学意义(t_(3个月)=6.022、t_(6个月)=5.020,均P=0.000),其余各时间点均无明显变化,差异无统计学意义(P>0.05)。对照组治疗后1、3个月的FD-300较治疗前降低,差异有统计学意义(t_(1个月)=12.729、t_(3个月)=4.391,均P=0.000),其余各时间点的FD-300均无明显变化,差异均无统计学意义(P>0.05)。治疗后2组间比较,治疗组治疗后1、3、6个月的FD-300均高于对照组,差异均有统计学意义(t_(1个月)=7.324、t_(3个月)=8.912、t_(6个月)=5.158,均P=0.000)。而2组治疗后12个月的FD-300比较,差异无统计学意义(P>0.05)。(8)注射次数:治疗组平均注射(4.83±0.38)次,低于对照组的(5.17±0.46)次,差异有统计学意义(t=4.104,P=0.000)。结论和营利水方可改善RVO-ME患者视网膜血流,减少注射次数,值得临床推广。

参芪利水颗粒配合脐灸治疗慢性阻塞性肺疾病急性加重期临床研究

目的探讨参芪利水颗粒配合脐灸治疗慢性阻塞性肺疾病急性加重期(Acute exacerbation of chronic obstructivepulmonary disease,AECOPD)患者的临床疗效。方法选取2022年8月—2023年8月自河北省保定市第一中医院收治的60例AECOPD患者,按照随机数字表法分为对照组和观察组,每组各30例。对照组采用常规西医治疗方法,观察组在对照组基础上脐灸联合参芪利水颗粒治疗,治疗2周后,观察比较两组患者临床疗效、治疗安全性,治疗前后改良版英国医学研究委员会呼吸问卷(modified British medical research council,mMRC)评分、慢阻肺患者自我评估测试(COPD Assessment test,CAT)评分、血气分析指标及血清炎性因子[降钙素原(Procalcitonin,PCT)、肿瘤坏死因子-α(Tumor necrosis factor alpha-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)]水平。结果治疗后观察组临床总有效率93.33%(28/30)明显高于对照组66.67%(20/30),差异有统计学意义(P<0.05)。治疗后两组患者mMRC、CAT评分均较治疗前降低,差异有统计学意义(P<0.05);且观察组mMRC、CAT评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者PaCO_(2)指标均较治疗前降低,PaO_(2)和SaO_(2)指标均较治疗前升高,差异有统计学意义(P<0.05);且观察组PaCO_(2)指标较对照组明显降低,PaO_(2)和SaO 2指标均较对照组明显升高,差异有统计学意义(P<0.05)。治疗后两组患者PCT、TNF-α、IL-6水平均较治疗前降低,差异有统计学意义(P<0.05),且观察组PCT、TNF-α、IL-6水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗期间,两组患者均未见与治疗药物相关的不良反应情况发生。结论参芪利水颗粒配合脐灸能够抑制AECOPD炎症反应,改善患者血气分析指标,缓解临床症状。

丽水南酸枣果实表型性状分析评价

以丽水南酸枣为研究材料,测定分析单果质量、纵径、横径、果肉鲜质量等果实表型性状指标。结果表明:南酸枣单果质量为10.38~14.14 g,果形指数为1.14~1.25,变异系数小,果形均匀。果实可食率最高可达63.85%,平均57.36%,可食率53%~62%占比95%,明显高于江西、湖北、贵州、福建等地17%~30%可食率。相关性分析结果表明,可食率与果肉鲜质量呈显著正相关(r=0.53,P<0.05),与其他指标无相关性,说明果肉鲜质量是评价果实可食率高低的关键因素。以可食率为指标可以筛选优良果用南酸枣。主成分分析结果表明,前4个主成分累积贡献率为96.32%。第1主成分主要反映果实、果核大小;第2主成分主要反映果核形态;第3主成分主要反映果实形态特征;第4主成分反映果皮质量。丽水南酸枣果实属中型果,未来人工培育大果型优质品种是提升南酸枣开发利用水平的有效途径。

长效型花境植物配置分析——以丽水市处州公园为例

长效型花境是今后花境发展的主要方向,主要体现在可持续发展的理念和科学合理的植物配置。提出了长效型花境植物配置要以种类丰富、群落稳定、观赏期长、季相丰富、养护简便、经济低碳为原则。以丽水市处州公园西侧入口处花境改造方案为例,从主题设计、季相设计、植物群落设计3个方面进行了分析,指出了植物配置中存在的地域特色不够明显、乡土植物使用不多的问题,并且要进一步优化植物种类选择、进一步创新植物配置手法的建议,以期为今后的长效型花境植物配置提供一定的参考。