With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredi...With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredients, could provide multiple therapeutic effects. Professor Tong Xiaolin has accumulated abundant experience during many years of clinical practice and applies Rhizoma Coptidis(RC) well with the treatment of diabetes and its complications. Rhizoma coptidis is a classical natural herb which is used frequently by professor Tong Xiaolin. In this review, we summarize Tong Xiaolin's clinical experience of applying Rhizoma Coptidis(Huang Lian) in the treatment of disease from two aspects as well as introducing some traditional Chinese medical theory and clinical experience, with a prospect of guiding clinician to use RC more suitably and reasonably.展开更多
OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mi...OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mice with a western diet.The mice were orally administered with differ.ent doses of DYL or vehicle daily for 28 d.The anti-atherosclerotic effect was evaluated by measuring the aortic atherosclerotic lesion area and media thickness with ultrasound imaging and histological sec.tions staining method.The effect on blood lipid was investigated by determining TC,TG,LDL,HDL,Apo-A1,Apo-B,etc.The anti-oxidative activity as assessed by determining the level of SOD,CAT,GSH,GSH-Px and MDA.Western blot analysis was used to determine the effect on ICAM-1,VCAM-1,MMP-2 and TNF-α.RESULTS In Dan-yi-lian administered ApoE(-/-) mice,the plaque area and media thickness were significantly reduced.Meanwhile,serum TC,TG,LDL and Apo-B were decreased,in contrast to the increased level of HDL and Apo-A1.On the other hand,SOD,CAT,GSH and GSH-Px were increased,while MDA was reduced in liver homogenate.In addition,the expression of ICAM-1,VCAM-1,MMP-2 and TNF-α was obviously inhibited by Dan-yi-lian.CONCLUSION Dan-yi-lian exhibit.ed potent anti-athero-sclerotic efficacy,in which the lipid-regulating,anti-oxidative and anti-inflammato.ry mechanism might be involved.展开更多
文摘With the advantages of less toxicity and side effects, traditional Chinese medicine(TCM) is showing a bright future with a good clinical practice. Chinese herbal medicine, which usually contains various active ingredients, could provide multiple therapeutic effects. Professor Tong Xiaolin has accumulated abundant experience during many years of clinical practice and applies Rhizoma Coptidis(RC) well with the treatment of diabetes and its complications. Rhizoma coptidis is a classical natural herb which is used frequently by professor Tong Xiaolin. In this review, we summarize Tong Xiaolin's clinical experience of applying Rhizoma Coptidis(Huang Lian) in the treatment of disease from two aspects as well as introducing some traditional Chinese medical theory and clinical experience, with a prospect of guiding clinician to use RC more suitably and reasonably.
基金supported by National Natural Science Foundation of China(8137344181673464)
文摘OBJECTIVE To explore the anti-atherosclerotic effect of the extract of traditional Chinese medicine formula Dan-yi-lian(DYL) and the related mechanism.METHODS Atherosclerosis(AS) mod.el was established in ApoE(-/-) mice with a western diet.The mice were orally administered with differ.ent doses of DYL or vehicle daily for 28 d.The anti-atherosclerotic effect was evaluated by measuring the aortic atherosclerotic lesion area and media thickness with ultrasound imaging and histological sec.tions staining method.The effect on blood lipid was investigated by determining TC,TG,LDL,HDL,Apo-A1,Apo-B,etc.The anti-oxidative activity as assessed by determining the level of SOD,CAT,GSH,GSH-Px and MDA.Western blot analysis was used to determine the effect on ICAM-1,VCAM-1,MMP-2 and TNF-α.RESULTS In Dan-yi-lian administered ApoE(-/-) mice,the plaque area and media thickness were significantly reduced.Meanwhile,serum TC,TG,LDL and Apo-B were decreased,in contrast to the increased level of HDL and Apo-A1.On the other hand,SOD,CAT,GSH and GSH-Px were increased,while MDA was reduced in liver homogenate.In addition,the expression of ICAM-1,VCAM-1,MMP-2 and TNF-α was obviously inhibited by Dan-yi-lian.CONCLUSION Dan-yi-lian exhibit.ed potent anti-athero-sclerotic efficacy,in which the lipid-regulating,anti-oxidative and anti-inflammato.ry mechanism might be involved.
