Actinomycetes are the main sources of antibiotics.The onset and level of production of each antibiotic is subject to complex control by multi-level regulators.These regulators exert their functions at hierarchical lev...Actinomycetes are the main sources of antibiotics.The onset and level of production of each antibiotic is subject to complex control by multi-level regulators.These regulators exert their functions at hierarchical levels.At the lower level,cluster-situated regulators(CSRs)directly control the transcription of neighboring genes within the gene cluster.Higher-level pleiotropic and global regulators exert their functions mainly through modulating the transcription of CSRs.Advances in understanding of the regulation of antibiotic biosynthesis in actinomycetes have inspired us to engineer these regulators for strain improvement and antibiotic discovery.展开更多
Lignin with important biological functions is the second abundant natural product, its content is only less than cellulose in plant. But the lignin must be extracted from the cellulose fraction in making paper pulp pr...Lignin with important biological functions is the second abundant natural product, its content is only less than cellulose in plant. But the lignin must be extracted from the cellulose fraction in making paper pulp process leading energy_requiring, cost_increasing and pollution. Also, the lignin has negative effect on the digestibility of silage grass. So it is of considerable interest to reduce the lignin content in resource plants. The paper reviews the progress of lignin biosynthesis and regulation. The feasibility of reducing the lignin content and altering its composition for improving paper pulp production and decreasing pollution are discussed.展开更多
基金the National Natural Science Foundation of China(31470206 and 31870061)a start-up grant from Southwest University(SWU117015)+1 种基金grants from Chongqing Science and Technology Commission(cstc2017jcyjAX0467 and cstc2018jcyjAX0066)the Fundamental Research Funds for the Central Universities(XDJK2018B029)to G.N.
文摘Actinomycetes are the main sources of antibiotics.The onset and level of production of each antibiotic is subject to complex control by multi-level regulators.These regulators exert their functions at hierarchical levels.At the lower level,cluster-situated regulators(CSRs)directly control the transcription of neighboring genes within the gene cluster.Higher-level pleiotropic and global regulators exert their functions mainly through modulating the transcription of CSRs.Advances in understanding of the regulation of antibiotic biosynthesis in actinomycetes have inspired us to engineer these regulators for strain improvement and antibiotic discovery.
文摘Lignin with important biological functions is the second abundant natural product, its content is only less than cellulose in plant. But the lignin must be extracted from the cellulose fraction in making paper pulp process leading energy_requiring, cost_increasing and pollution. Also, the lignin has negative effect on the digestibility of silage grass. So it is of considerable interest to reduce the lignin content in resource plants. The paper reviews the progress of lignin biosynthesis and regulation. The feasibility of reducing the lignin content and altering its composition for improving paper pulp production and decreasing pollution are discussed.
