From the alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala,three novel eremophilane sesquiterpene lactones, 6α, 10α-dihydroxy-1-oxoeremophila- 7(11),8(9)-dien-8, 12-olide, 6β, 10α-dihyd...From the alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala,three novel eremophilane sesquiterpene lactones, 6α, 10α-dihydroxy-1-oxoeremophila- 7(11),8(9)-dien-8, 12-olide, 6β, 10α-dihydroxy-1-oxoeremophila-7 (11), 8 (9)-dien-8, 12-olide and10α-diydroxy-1-oxoeremophila-7(11), 8 (9)-dien-8, 12 olide were isolated. Their structure s wereelucidated by various, spectroscopic methods including intensive 2D NMR techniques (COSY,HMQC, HMBC and ~1H-~1H NOESY) and HR-MS.展开更多
Chemical investigation of L. fischeri afforded two new eremophilenolides. which were identified as 6 beta-methoxy-8 beta-hpdroxy-eremophil-7(11)-en-12,8 alpha-olide 1; 6-oxo-8 beta-hydroxy-eremophil-7(11)-en- 12.8 alp...Chemical investigation of L. fischeri afforded two new eremophilenolides. which were identified as 6 beta-methoxy-8 beta-hpdroxy-eremophil-7(11)-en-12,8 alpha-olide 1; 6-oxo-8 beta-hydroxy-eremophil-7(11)-en- 12.8 alpha-olide 2.展开更多
Chemical investigation of L. tongolensis afforded two new eremophilenolides, which were identified as 3β-（2＇-methylbutanoyloxy）-8βH-eremophil-7（11）-en-12, 8α（14, 6α）-diolide （1）and 8βH-eremophil-3, 7（11...Chemical investigation of L. tongolensis afforded two new eremophilenolides, which were identified as 3β-（2＇-methylbutanoyloxy）-8βH-eremophil-7（11）-en-12, 8α（14, 6α）-diolide （1）and 8βH-eremophil-3, 7（11）-dien-12, 8α （14, 6α）-diolide （2）. Their structures were established by spectroscopic methods including 2D NMR experiments.展开更多
From Ligularia atroviolacea, four new eremophilendiolides, 81$-hydroxy-eremophil-3,7 （11）-dien-12,8α（14,6α）-diolide （1）, 8β-methoxy-eremophil-3,7（11）-dien-12,8α（14,6α）-diolide （2）, 8α-hydroxy-eremoph...From Ligularia atroviolacea, four new eremophilendiolides, 81$-hydroxy-eremophil-3,7 （11）-dien-12,8α（14,6α）-diolide （1）, 8β-methoxy-eremophil-3,7（11）-dien-12,8α（14,6α）-diolide （2）, 8α-hydroxy-eremophil-3,7（11）-dien-12,8lβ（14,6α）-diolide （3） and eremophil-3,7（11）,8-trien-12,8 （14,6α）-diolide （4）, as well as a known diolide （5） were isolated. Their structures were elucidated on the basis of 1D and 2D NMR as well as ESI-MS spectral data.展开更多
A new furanoeremophilane and a new eudesmane were isolated from the roots of Ligularia veitchiana. Their structures were elucidated as 1b, 10b-epoxy-6b-isobutyryloxy-9-oxo-furanoeremophilane and 8a-hydroxy-4 (15), 11...A new furanoeremophilane and a new eudesmane were isolated from the roots of Ligularia veitchiana. Their structures were elucidated as 1b, 10b-epoxy-6b-isobutyryloxy-9-oxo-furanoeremophilane and 8a-hydroxy-4 (15), 11-eudesmadiene by spectroscopic methods.展开更多
From the roots of Ligularia macrophylla, a bisesquiterpene, ligumacrophyllal was isolated and its structure was elucidated on the basis of spectroscopic methods.
A new stigmasterol 3, 7, 22-trihydoxystigmast-5-ene (1) and a new eremophilen- olide 8-methoxy-6-angeloyloxyeremophil-7(11)-en-8, 12-olide-14-oic acid (2) were isolated from Ligularia dolichobotrys Diels. Their struc...A new stigmasterol 3, 7, 22-trihydoxystigmast-5-ene (1) and a new eremophilen- olide 8-methoxy-6-angeloyloxyeremophil-7(11)-en-8, 12-olide-14-oic acid (2) were isolated from Ligularia dolichobotrys Diels. Their structures were deduced on the basis of spectral data.展开更多
A new bisabolane sesquiterpene, 5 beta-acetoxy-4 beta, 8-diangeloyloxy-2 beta,3 beta, :10,11-diepoxy-bisabola-7 (14)-ene, was isolated from the roots of Ligularia songarica and its structure was elucidated on the basi...A new bisabolane sesquiterpene, 5 beta-acetoxy-4 beta, 8-diangeloyloxy-2 beta,3 beta, :10,11-diepoxy-bisabola-7 (14)-ene, was isolated from the roots of Ligularia songarica and its structure was elucidated on the basis of spectroscopic methods, especially 2D-NMR techniques.展开更多
A new isopropenyl benzofuran-type tetramer was isolated from the roots of ligularia stenocephala and its structure was established by spectroscopic methods.
Natural hybridization has been regarded as a crucial pathway of speciation and provides the raw materials for the evolution of biodiversity. The interspecific natural hybridization of the genus Ligularia Cass.is unive...Natural hybridization has been regarded as a crucial pathway of speciation and provides the raw materials for the evolution of biodiversity. The interspecific natural hybridization of the genus Ligularia Cass.is universal and has been considered to be an important factor driving the high diversity of Ligularia species in the Hengduan Mountains, China. Although the natural hybridization between L. vellerea and L. subspicata was reported previously, the direction of hybridization was uncertain due to the limitation of sampling. Thus, in this study, we sampled more individuals and increased two fragments of chloroplast DNA on the basis of the previous study to further verify the natural hybridization between L. vellerea and L. subspicata and confirm the direction of hybridization. Based on DNA sequences(atpBrbcL, trnL-rpl32, trnQ-5'rps16, and nuclear ribosomal internal transcribed spacer region) data, we concluded that putative hybrids were primary products of hybridization between L. vellerea and L. subspicata and the hybridization was bidirectional. Moreover, sympatric L. tongolensis was not apparently involved in the hybridization. Surprisingly, some pure L. subspicata individuals showed the disaccordance between morphology and DNA data, which might indicate that introgression occurs between L. vellerea and L. subspicata.展开更多
Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the under...Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the underground parts of Ligularia intermedia. Their structures were elucidated by spectroscopic methods.展开更多
Tow new oplopanol esters were isolated from the roots of Ligularia narynensis. Their structures were eluc idated by spectroscopic methods, especially 2D-NMR techniques.
A novel eremophilane dimer,named fischelactone（1）,was isolated from the roots of Ligularia fischeri.Complete structural elucidation of this compound was performed by HRESIMS,IR,1D NMR and 2D NMR（;H-;H COSY,HMBC,HMQ...A novel eremophilane dimer,named fischelactone（1）,was isolated from the roots of Ligularia fischeri.Complete structural elucidation of this compound was performed by HRESIMS,IR,1D NMR and 2D NMR（;H-;H COSY,HMBC,HMQC and NOESY） data.展开更多
Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane （1） and 6α, 15β-epoxy eremophila-7（11）-en-8α, 12-olide （2） were isolation from the roots of Ligularia macrophylla. Their structu...Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane （1） and 6α, 15β-epoxy eremophila-7（11）-en-8α, 12-olide （2） were isolation from the roots of Ligularia macrophylla. Their structures were deduced from spectroscopic methods and 2D NMR experiments.展开更多
文摘From the alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala,three novel eremophilane sesquiterpene lactones, 6α, 10α-dihydroxy-1-oxoeremophila- 7(11),8(9)-dien-8, 12-olide, 6β, 10α-dihydroxy-1-oxoeremophila-7 (11), 8 (9)-dien-8, 12-olide and10α-diydroxy-1-oxoeremophila-7(11), 8 (9)-dien-8, 12 olide were isolated. Their structure s wereelucidated by various, spectroscopic methods including intensive 2D NMR techniques (COSY,HMQC, HMBC and ~1H-~1H NOESY) and HR-MS.
文摘Chemical investigation of L. fischeri afforded two new eremophilenolides. which were identified as 6 beta-methoxy-8 beta-hpdroxy-eremophil-7(11)-en-12,8 alpha-olide 1; 6-oxo-8 beta-hydroxy-eremophil-7(11)-en- 12.8 alpha-olide 2.
基金This work was supported by the NNSFC(No.20372029 and No,20021001)by the Key Project of Chinese Ministry of Education(No.104178).
文摘Chemical investigation of L. tongolensis afforded two new eremophilenolides, which were identified as 3β-（2＇-methylbutanoyloxy）-8βH-eremophil-7（11）-en-12, 8α（14, 6α）-diolide （1）and 8βH-eremophil-3, 7（11）-dien-12, 8α （14, 6α）-diolide （2）. Their structures were established by spectroscopic methods including 2D NMR experiments.
文摘From Ligularia atroviolacea, four new eremophilendiolides, 81$-hydroxy-eremophil-3,7 （11）-dien-12,8α（14,6α）-diolide （1）, 8β-methoxy-eremophil-3,7（11）-dien-12,8α（14,6α）-diolide （2）, 8α-hydroxy-eremophil-3,7（11）-dien-12,8lβ（14,6α）-diolide （3） and eremophil-3,7（11）,8-trien-12,8 （14,6α）-diolide （4）, as well as a known diolide （5） were isolated. Their structures were elucidated on the basis of 1D and 2D NMR as well as ESI-MS spectral data.
基金supported by the National Natural Science Foundation of China(No.29972017)
文摘A new furanoeremophilane and a new eudesmane were isolated from the roots of Ligularia veitchiana. Their structures were elucidated as 1b, 10b-epoxy-6b-isobutyryloxy-9-oxo-furanoeremophilane and 8a-hydroxy-4 (15), 11-eudesmadiene by spectroscopic methods.
基金This work was supported by the NNSFC (No. 29972017).
文摘From the roots of Ligularia macrophylla, a bisesquiterpene, ligumacrophyllal was isolated and its structure was elucidated on the basis of spectroscopic methods.
文摘A new stigmasterol 3, 7, 22-trihydoxystigmast-5-ene (1) and a new eremophilen- olide 8-methoxy-6-angeloyloxyeremophil-7(11)-en-8, 12-olide-14-oic acid (2) were isolated from Ligularia dolichobotrys Diels. Their structures were deduced on the basis of spectral data.
文摘A new bisabolane sesquiterpene, 5 beta-acetoxy-4 beta, 8-diangeloyloxy-2 beta,3 beta, :10,11-diepoxy-bisabola-7 (14)-ene, was isolated from the roots of Ligularia songarica and its structure was elucidated on the basis of spectroscopic methods, especially 2D-NMR techniques.
基金supoaed by the National Natural Science Foundation of China(No.29972017)
文摘A new isopropenyl benzofuran-type tetramer was isolated from the roots of ligularia stenocephala and its structure was established by spectroscopic methods.
基金supported by the National Science Foundation of China (31470336 to XG)
文摘Natural hybridization has been regarded as a crucial pathway of speciation and provides the raw materials for the evolution of biodiversity. The interspecific natural hybridization of the genus Ligularia Cass.is universal and has been considered to be an important factor driving the high diversity of Ligularia species in the Hengduan Mountains, China. Although the natural hybridization between L. vellerea and L. subspicata was reported previously, the direction of hybridization was uncertain due to the limitation of sampling. Thus, in this study, we sampled more individuals and increased two fragments of chloroplast DNA on the basis of the previous study to further verify the natural hybridization between L. vellerea and L. subspicata and confirm the direction of hybridization. Based on DNA sequences(atpBrbcL, trnL-rpl32, trnQ-5'rps16, and nuclear ribosomal internal transcribed spacer region) data, we concluded that putative hybrids were primary products of hybridization between L. vellerea and L. subspicata and the hybridization was bidirectional. Moreover, sympatric L. tongolensis was not apparently involved in the hybridization. Surprisingly, some pure L. subspicata individuals showed the disaccordance between morphology and DNA data, which might indicate that introgression occurs between L. vellerea and L. subspicata.
基金This work was financially supported by the National Natural Science Foundation of China for outstanding young scientists to Z. T. Wang (No. 39825129).
文摘Two new dibenzofurans, 7,8-dimethoxy-4-methyldibenzofuran-1-carboxaldehyde, named ligumedial (1) and 7,8-dimethoxy-4-methyldibenzofuran-1-carboxylic acid, named ligumediaoic acid (2), have been isolated from the underground parts of Ligularia intermedia. Their structures were elucidated by spectroscopic methods.
文摘Tow new oplopanol esters were isolated from the roots of Ligularia narynensis. Their structures were eluc idated by spectroscopic methods, especially 2D-NMR techniques.
基金financially supported by State Key Laboratory of Applied Organic Chemistry,Lanzhou University, China and Natural Science Foundation of Shandong Province,China(No.Y2008D23).
文摘A novel eremophilane dimer,named fischelactone（1）,was isolated from the roots of Ligularia fischeri.Complete structural elucidation of this compound was performed by HRESIMS,IR,1D NMR and 2D NMR（;H-;H COSY,HMBC,HMQC and NOESY） data.
基金This work was supported by the National Natural Science Foundation of China(No.29972017).
文摘Two new eremophilane sesquiterpenes, 15β-formic ether-6-oxo-furanoeremophilane （1） and 6α, 15β-epoxy eremophila-7（11）-en-8α, 12-olide （2） were isolation from the roots of Ligularia macrophylla. Their structures were deduced from spectroscopic methods and 2D NMR experiments.
