Vulnerable brain regions in adolescent major depressive disorder:A resting-state functional magnetic resonance imaging activation likelihood estimation meta-analysis

BACKGROUND Adolescent major depressive disorder(MDD)is a significant mental health concern that often leads to recurrent depression in adulthood.Resting-state functional magnetic resonance imaging(rs-fMRI)offers unique insights into the neural mechanisms underlying this condition.However,despite previous research,the specific vulnerable brain regions affected in adolescent MDD patients have not been fully elucidated.AIM To identify consistent vulnerable brain regions in adolescent MDD patients using rs-fMRI and activation likelihood estimation(ALE)meta-analysis.METHODS We performed a comprehensive literature search through July 12,2023,for studies investigating brain functional changes in adolescent MDD patients.We utilized regional homogeneity(ReHo),amplitude of low-frequency fluctuations(ALFF)and fractional ALFF(fALFF)analyses.We compared the regions of aberrant spontaneous neural activity in adolescents with MDD vs healthy controls(HCs)using ALE.RESULTS Ten studies(369 adolescent MDD patients and 313 HCs)were included.Combining the ReHo and ALFF/fALFF data,the results revealed that the activity in the right cuneus and left precuneus was lower in the adolescent MDD patients than in the HCs(voxel size:648 mm3,P<0.05),and no brain region exhibited increased activity.Based on the ALFF data,we found decreased activity in the right cuneus and left precuneus in adolescent MDD patients(voxel size:736 mm3,P<0.05),with no regions exhibiting increased activity.CONCLUSION Through ALE meta-analysis,we consistently identified the right cuneus and left precuneus as vulnerable brain regions in adolescent MDD patients,increasing our understanding of the neuropathology of affected adolescents.

Maximum Likelihood Estimation of the Identification Parameters and Its Correction

By taking the subsequence out of the input-output sequence of a system polluted by white noise, an independent observation sequence and its probability density are obtained and then a maximum likelihood estimation of the identification parameters is given. In order to decrease the asymptotic error, a corrector of maximum likelihood (CML) estimation with its recursive algorithm is given. It has been proved that the corrector has smaller asymptotic error than the least square methods. A simulation example shows that the corrector of maximum likelihood estimation is of higher approximating precision to the true parameters than the least square methods.

Convergence Diagnostics for Gibbs Sampler via Maximum Likelihood Estimation

A diagnostic procedure based on maximum likelihood estimation, to study the convergence of the Markov chain produced by Gibbs sampler, is presented. The unbiasedness, consistent and asymptotic normality are considered for the estimation of the parameters produced by the procedure. An example is provided to illustrate the procedure, and the numerical result is consistent with the theoretical one.

Immune Clone Maximum Likelihood Estimation of Improved Non-homogeneous Poisson Process Model Parameters

Aiming at the solving problem of improved nonhomogeneous Poisson process( NHPP) model in engineering application,the immune clone maximum likelihood estimation( MLE)method for solving model parameters was proposed. The minimum negative log-likelihood function was used as the objective function to optimize instead of using iterative method to solve complex system of equations,and the problem of parameter estimation of improved NHPP model was solved by immune clone algorithm. And the interval estimation of reliability indices was given by using fisher information matrix method and delta method. An example of failure truncated data from multiple numerical control( NC) machine tools was taken to prove the method. and the results show that the algorithm has a higher convergence rate and computational accuracy, which demonstrates the feasibility of the method.

Weighted Likelihood Estimation Method Based on the Multidimensional Nominal Response Model

The Monte Carlo study evaluates the relative accuracy of Warm＇s （1989） weighted likelihood estimate （WLE） compared to the maximum likelihood estimate （MLE） using the nominal response model. And the results indicate that WLE was more accurate than MLE.

Multimodal abnormalities of brain structures in adolescents and young adults with major depressive disorder:An activation likelihood estimation meta-analysis

BACKGROUND Major depressive disorder(MDD)in adolescents and young adults contributes significantly to global morbidity,with inconsistent findings on brain structural changes from structural magnetic resonance imaging studies.Activation likeli-hood estimation(ALE)offers a method to synthesize these diverse findings and identify consistent brain anomalies.METHODS We performed a comprehensive literature search in PubMed,Web of Science,Embase,and Chinese National Knowledge Infrastructure databases for neuroi-maging studies on MDD among adolescents and young adults published up to November 19,2023.Two independent researchers performed the study selection,quality assessment,and data extraction.The ALE technique was employed to synthesize findings on localized brain function anomalies in MDD patients,which was supplemented by sensitivity analyses.RESULTS Twenty-two studies comprising fourteen diffusion tensor imaging(DTI)studies and eight voxel-based morphome-try(VBM)studies,and involving 451 MDD patients and 465 healthy controls(HCs)for DTI and 664 MDD patients and 946 HCs for VBM,were included.DTI-based ALE demonstrated significant reductions in fractional anisotropy(FA)values in the right caudate head,right insula,and right lentiform nucleus putamen in adolescents and young adults with MDD compared to HCs,with no regions exhibiting increased FA values.VBM-based ALE did not demonstrate significant alterations in gray matter volume.Sensitivity analyses highlighted consistent findings in the right caudate head(11 of 14 analyses),right insula(10 of 14 analyses),and right lentiform nucleus putamen(11 of 14 analyses).CONCLUSION Structural alterations in the right caudate head,right insula,and right lentiform nucleus putamen in young MDD patients may contribute to its recurrent nature,offering insights for targeted therapies.

Joint polarization and DOA estimation based on improved maximum likelihood estimator and performance analysis for conformal array

The conformal array can make full use of the aperture,save space,meet the requirements of aerodynamics,and is sensitive to polarization information.It has broad application prospects in military,aerospace,and communication fields.The joint polarization and direction-of-arrival(DOA)estimation based on the conformal array and the theoretical analysis of its parameter estimation performance are the key factors to promote the engineering application of the conformal array.To solve these problems,this paper establishes the wave field signal model of the conformal array.Then,for the case of a single target,the cost function of the maximum likelihood(ML)estimator is rewritten with Rayleigh quotient from a problem of maximizing the ratio of quadratic forms into those of minimizing quadratic forms.On this basis,rapid parameter estimation is achieved with the idea of manifold separation technology(MST).Compared with the modified variable projection(MVP)algorithm,it reduces the computational complexity and improves the parameter estimation performance.Meanwhile,the MST is used to solve the partial derivative of the steering vector.Then,the theoretical performance of ML,the multiple signal classification(MUSIC)estimator and Cramer-Rao bound(CRB)based on the conformal array are derived respectively,which provides theoretical foundation for the engineering application of the conformal array.Finally,the simulation experiment verifies the effectiveness of the proposed method.

Correlation Between Brain Activation Changes and Cognitive Improvement Following Cognitive Remediation Therapy in Schizophrenia： An Activation Likelihood Estimation Meta-analysis

Background：Several studies using functional magnetic resonance imaging （fMRI） and positron emission tomography （PET） have indicated that cognitive remediation therapy （CRT） might improve cognitive function by changing brain activations in patients with schizophrenia.However,the results were not consistent in these changed brain areas in different studies.The present activation likelihood estimation （ALE） meta-analysis was conducted to investigate whether cognitive function change was accompanied by the brain activation changes,and where the main areas most related to these changes were in schizophrenia patients after CRT.Analyses of whole-brain studies and whole-brain ＋ region of interest （ROI） studies were compared to explore the effect of the different methodologies on the results.Methods：A computerized systematic search was conducted to collect fMRI and PET studies on brain activation changes in schizophrenia patients from pre-to post-CRT.Nine studies using fMRI techniques were included in the meta-analysis.Ginger ALE 2.3.1 was used to perform meta-analysis across these imaging studies.Results：The main areas with increased brain activation were in frontal and parietal lobe,including left medial frontal gyrus,left inferior frontal gyrus,right middle frontal gyrus,right postcentral gyrus,and inferior parietal lobule in patients after CRT,yet no decreased brain activation was found.Although similar increased activation brain areas were identified in ALE with or without ROI studies,analysis including ROI studies had a higher ALE value.Conclusions：The current findings suggest that CRT might improve the cognition of schizophrenia patients by increasing activations of the frontal and parietal lobe.In addition,it might provide more evidence to confirm results by including ROI studies in ALE meta-analysis.

Collaborative target tracking in WSNs using the combination of maximum likelihood estimation and Kalman filtering

Target tracking using wireless sensor networks requires efficient collaboration among sensors to tradeoff between energy consumption and tracking accuracy. This paper presents a collaborative target tracking approach in wire- less sensor networks using the combination of maximum likelihood estimation and the Kalman filter. The cluster leader converts the received nonlinear distance measurements into linear observation model and approximates the covariance of the converted measurement noise using maximum likelihood estimation, then applies Kalman filter to recursively update the target state estimate using the converted measurements. Finally, a measure based on the Fisher information matrix of maximum likelihood estimation is used by the leader to select the most informative sensors as a new tracking cluster for further tracking. The advantages of the proposed collaborative tracking approach are demonstrated via simulation results.

Frame synchronization for underwater acoustic communication based on maximum likelihood estimation

Traditional frame synchronization methods for underwater acoustic communication(UWAC) merely depend on correlation coefficient when synchronization signal detection is concerned and,hence,false triggering and missed synchronization can hardly be avoided in complex UWAC channels.In order to solve this problem,firstly,we analyze the effects of interference from noise,multipath and Doppler on frame synchronization;then we propose a new frame synchronization scheme based on parameter estimation.By exploiting the parameter estimation technique,we detect the synchronization signal according to the estimated parameters,thus the false triggering rate and missed synchronization rate can be reduced.We also simplify the maximum likelihood estimation to reduce computational cost.Simulation results indicate that this new scheme outperforms the traditional method in terms of delay resolution and correlation coefficient.Both static and mobile communication experimental results show that the correlation coefficient of the new scheme is higher than that of the traditional one.Moreover,the detection ability of the receiver is improved,which helps to avoid false triggering and missed synchronization.

Maximum Likelihood Estimation via Duality for Cell Probabilities Subject to Convex and Log-convex Constraints

This article proposes a method for fitting models subject to a convex and log-convex constraint on the probability vector of a product multinomial （binomial） distribution. We present an iterative algorithm for finding the restricted maximum likelihood estimates （MLEs） of the probability vector and show that the algorithm converges to the true solution. Some examples are discussed to illustrate the method.

Adaptive speckle reduction of ultrasound images based on maximum likelihood estimation

A method has been developed in this paper to gain effective speckle reduction in medical ultrasound images. To exploit full knowledge of the speckle distribution, here maximum likelihood was used to estimate speckle parameters corresponding to its statistical mode. Then the results were incorporated into the nonlinear anisotropic diffusion to achieve adaptive speckle reduction. Verified with simulated and ultrasound images, we show that this algorithm is capable of enhancing features of clinical interest and reduces speckle noise more efficiently than just applying classical filters. To avoid edge contribution, changes of contrast-to-noise ratio of different regions are also compared to investigate the performance of this approach.

Scenario Generations for Renewable Energy Sources and Loads Based on Implicit Maximum Likelihood Estimations

Scenario generations for renewable energy sources and loads play an important role in the stable operation and risk assessment of integrated energy systems.This paper proposes a deep generative network based method to model time-series curves,e.g.,power generation curves and load curves,of renewable energy sources and loads based on implicit maximum likelihood estimations(IMLEs),which can generate realistic scenarios with similar patterns as real ones.After training the model,any number of new scenarios can be obtained by simply inputting Gaussian noises into the data generator of IMLEs.The proposed approach does not require any model assumptions or prior knowledge of the form in the likelihood function being made during the training process,which leads to stronger applicability than explicit density model based methods.The extensive experiments show that the IMLEs accurately capture the complex shapes,frequency-domain characteristics,probability distributions,and correlations of renewable energy sources and loads.Moreover,the proposed approach can be easily generalized to scenario generation tasks of various renewable energy sources and loads by fine-tuning parameters and structures.

Heuristic techniques for maximum likelihood localization of radioactive sources via a sensor network

Maximum likelihood estimation(MLE)is an effective method for localizing radioactive sources in a given area.However,it requires an exhaustive search for parameter estimation,which is time-consuming.In this study,heuristic techniques were employed to search for radiation source parameters that provide the maximum likelihood by using a network of sensors.Hence,the time consumption of MLE would be effectively reduced.First,the radiation source was detected using the k-sigma method.Subsequently,the MLE was applied for parameter estimation using the readings and positions of the detectors that have detected the radiation source.A comparative study was performed in which the estimation accuracy and time consump-tion of the MLE were evaluated for traditional methods and heuristic techniques.The traditional MLE was performed via a grid search method using fixed and multiple resolutions.Additionally,four commonly used heuristic algorithms were applied:the firefly algorithm(FFA),particle swarm optimization(PSO),ant colony optimization(ACO),and artificial bee colony(ABC).The experiment was conducted using real data collected by the Low Scatter Irradiator facility at the Savannah River National Laboratory as part of the Intelligent Radiation Sensing System program.The comparative study showed that the estimation time was 3.27 s using fixed resolution MLE and 0.59 s using multi-resolution MLE.The time consumption for the heuristic-based MLE was 0.75,0.03,0.02,and 0.059 s for FFA,PSO,ACO,and ABC,respectively.The location estimation error was approximately 0.4 m using either the grid search-based MLE or the heuristic-based MLE.Hence,heuristic-based MLE can provide comparable estimation accuracy through a less time-consuming process than traditional MLE.

Data-Based Filters for Non-Gaussian Dynamic Systems With Unknown Output Noise Covariance

This paper proposes linear and nonlinear filters for a non-Gaussian dynamic system with an unknown nominal covariance of the output noise.The challenge of designing a suitable filter in the presence of an unknown covariance matrix is addressed by focusing on the output data set of the system.Considering that data generated from a Gaussian distribution exhibit ellipsoidal scattering,we first propose the weighted sum of norms(SON)clustering method that prioritizes nearby points,reduces distant point influence,and lowers computational cost.Then,by introducing the weighted maximum likelihood,we propose a semi-definite program(SDP)to detect outliers and reduce their impacts on each cluster.Detecting these weights paves the way to obtain an appropriate covariance of the output noise.Next,two filtering approaches are presented:a cluster-based robust linear filter using the maximum a posterior(MAP)estimation and a clusterbased robust nonlinear filter assuming that output noise distribution stems from some Gaussian noise resources according to the ellipsoidal clusters.At last,simulation results demonstrate the effectiveness of our proposed filtering approaches.

Maximum likelihood spectrum estimation method and its application in seismo－magnet－icrelation

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Blind Joint Maximum Likelihood Channel Estimation and Data Detection for SIMO Systems

A blind adaptive scheme is proposed for joint maximum likelihood （ML） channel estimation and data detection of singleinput multiple-output （SIMO） systems. The joint ML optimisation over channel and data is decomposed into an iterative optimisation loop. An efficient global optimisation algorithm called the repeated weighted boosting search is employed at the upper level to optimally identify the unknown SIMO channel model, and the Viterbi algorithm is used at the lower level to produce the maximum likelihood sequence estimation of the unknown data sequence. A simulation example is used to demonstrate the effectiveness of this joint ML optimisation scheme for blind adaptive SIMO systems.

A Study of EM Algorithm as an Imputation Method: A Model-Based Simulation Study with Application to a Synthetic Compositional Data

Compositional data, such as relative information, is a crucial aspect of machine learning and other related fields. It is typically recorded as closed data or sums to a constant, like 100%. The statistical linear model is the most used technique for identifying hidden relationships between underlying random variables of interest. However, data quality is a significant challenge in machine learning, especially when missing data is present. The linear regression model is a commonly used statistical modeling technique used in various applications to find relationships between variables of interest. When estimating linear regression parameters which are useful for things like future prediction and partial effects analysis of independent variables, maximum likelihood estimation (MLE) is the method of choice. However, many datasets contain missing observations, which can lead to costly and time-consuming data recovery. To address this issue, the expectation-maximization (EM) algorithm has been suggested as a solution for situations including missing data. The EM algorithm repeatedly finds the best estimates of parameters in statistical models that depend on variables or data that have not been observed. This is called maximum likelihood or maximum a posteriori (MAP). Using the present estimate as input, the expectation (E) step constructs a log-likelihood function. Finding the parameters that maximize the anticipated log-likelihood, as determined in the E step, is the job of the maximization (M) phase. This study looked at how well the EM algorithm worked on a made-up compositional dataset with missing observations. It used both the robust least square version and ordinary least square regression techniques. The efficacy of the EM algorithm was compared with two alternative imputation techniques, k-Nearest Neighbor (k-NN) and mean imputation (), in terms of Aitchison distances and covariance.

Estimation for constant-stress accelerated life test from generalized half-normal distribution

In the constant-stress accelerated life test, estimation issues are discussed for a generalized half-normal distribution under a log-linear life-stress model. The maximum likelihood estimates with the corresponding fixed point type iterative algorithm for unknown parameters are presented, and the least square estimates of the parameters are also proposed. Meanwhile, confidence intervals of model parameters are constructed by using the asymptotic theory and bootstrap technique. Numerical illustration is given to investigate the performance of our methods.

Elevation estimation for low-angle target based on reffection paths suppression

In the signal processing for metrewave radar, the reflection paths of target echoes can cause severe error in the elevation estimation for the low-angle target tracking. The exact angles of the reflection paths are unknown beforehand, and therefore, the reflection paths can not be suppressed easily. Therefore, in this article, an improved reflection paths suppression approach is presented. A block matrix aggregate is constructed based on the possible angles of the reflection paths. Combined with the beamforming-like processing, a generalized maximum likelihood estimation is derived to optimize the estimation. Moreover, the noise reduction method based on the Toeplitz covariance matrix is used for better performance. This approach is applied to the real data collected by the low-angle tracking radar with 8-channel vertical array. The experiment results show that the reflection effects are reduced and the accuracy of the elevation estimate is improved.