Two new homoisoflavanones were isolated from the rhizomes of Polygonatum odoratum (Mill.) Druce and their structures were elucidated as (3R)-5,7-dihydroxy-8-methoxy-3-(4-methoxybenzyl)-6-methylchrom-an-4-one (1) and (...Two new homoisoflavanones were isolated from the rhizomes of Polygonatum odoratum (Mill.) Druce and their structures were elucidated as (3R)-5,7-dihydroxy-8-methoxy-3-(4-methoxybenzyl)-6-methylchrom-an-4-one (1) and (3R)-5,7,8-trihydroxy-3-(4-hydroxybenzyl)-6-methylchroman-4-one (2), on the basis of spectral analysis.展开更多
Two new C27 steroidal glycosides, named ophiopojaponin A (1) and B (2), were isolated from the tubers of famous traditional Chinese herb(Ophiopogon japonicus. The spectroscopic and chemical evidences revealed their st...Two new C27 steroidal glycosides, named ophiopojaponin A (1) and B (2), were isolated from the tubers of famous traditional Chinese herb(Ophiopogon japonicus. The spectroscopic and chemical evidences revealed their structures to be Pennogenin 3-O-[2’-O-acetyl-(-L-rhamnopyranosyl (1?2)]-(-D-xylopyranosyl (1?3)-(-D-glucopyranoside (1) and 26-O-(-D-glucopyranosyl-(22(, 25R)-3(, 14(, 22(, 26-tetrahydroxyfurost-5-ene 3-O-(-L-rhamnopyranosyl (1?2)-(-D-glucopyranoside (2), respectively.展开更多
A new enolate derivative of furostanol glycoside, named asparagusin A, was isolated from the roots of Asparagus filicinus and established as 3 - O- 6 - D- xylopyranosyl （l →4）- β - Dglucopyranosyl （25S）-furost-2...A new enolate derivative of furostanol glycoside, named asparagusin A, was isolated from the roots of Asparagus filicinus and established as 3 - O- 6 - D- xylopyranosyl （l →4）- β - Dglucopyranosyl （25S）-furost-20（22）-ene-3β, 26-diol 26-O-0-D-glucopyranoside （l） by spectroscopic and chemical methods. Asparagusin A （l） exhibited a cytotoxic activity effect on PC12 cells.展开更多
Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their s...Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their structures were determined mainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS and UV,as well as chemical methods.Among them,compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon,which was identified as(23R,25R)-3β,16α,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one.Their induced platelet aggregation activities and cytotoxicities were evaluated.Graphical Abstract Five new cholestanol glycosides,ypsiyunnosides A–E(1–5),were isolated from the whole plants of Ypsilandra yunnanensis.Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon.Their structures were elucidated by a combination of 1D and 2D NMR,MS and chemical analysis.展开更多
Two new furostanol saponins,named macrostemonoside E(1)andF(2),were isolated from the bulbs of Allium macrostemon Bunge(Liliaceae),their structures were established oy spectroscopic analysisand chemical evidences.Both...Two new furostanol saponins,named macrostemonoside E(1)andF(2),were isolated from the bulbs of Allium macrostemon Bunge(Liliaceae),their structures were established oy spectroscopic analysisand chemical evidences.Both possessed strong inhibitory activity onhuman platelet aggregation.展开更多
The whole plants of Ypsilandra thibetica have been analyzed as part of a systematic study on saponin constituents of medicinal plants.This has resulted in the isolation of two new bisdesmosidic furostanol saponins,nam...The whole plants of Ypsilandra thibetica have been analyzed as part of a systematic study on saponin constituents of medicinal plants.This has resulted in the isolation of two new bisdesmosidic furostanol saponins,named ypsilandroside P(1)and ypsilandroside Q(2),and one new pregnane glycoside,named ypsilandroside R(3),together with nine known steroidal glycosides.Their structures were elucidated on the basis of extensive spectroscopic analysis,including that of 2D NMR data,and the results of acidic hydrolysis.Ypsilandroside P(1)was cytotoxicity against two human tumor cell lines.展开更多
Two new monosaccharide steroidal saponins,named ypsilandroside S(1)and ypsilandroside T(2),have been isolated from the whole plants of Ypsilandra thibetica.Their structures were elucidated as heloniogenin 3-O-b-D-apio...Two new monosaccharide steroidal saponins,named ypsilandroside S(1)and ypsilandroside T(2),have been isolated from the whole plants of Ypsilandra thibetica.Their structures were elucidated as heloniogenin 3-O-b-D-apiofuranoside(1)and pregna 5,16-dien-3b,12a-diol-20-one-3-O-b-D-apiofuranoside(2)by spectroscopic techniques(1D and 2D NMR,MS).Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.展开更多
Two new steroidal saponins, diuranthosides D and E, were isolated from the whole plant of Diuranthera inarticulata Wang et K. Y. Lang. By means of spectral and chemical analysis, the structure of the new compounds wer...Two new steroidal saponins, diuranthosides D and E, were isolated from the whole plant of Diuranthera inarticulata Wang et K. Y. Lang. By means of spectral and chemical analysis, the structure of the new compounds were established as neotigogenin-3-O-(-D-glucopyranosyl (1?3)-(-D-xylopyranosyl-(1?3)-[(-D-glucopyranosyl(1?2)]-(-D-glucopyranosyl(1?4)-(-D-galactopyranoside (1) and neotigogenin-3-O-(-D-glucopyranosyl(1?3)-(-D-glucopyranosyl (1?3)-(-D-xylopyranosyl(1?3)-[(-D-glucopyranosyl(1?2)]-(-D-glucopyranosyl(1?4)-(-D-galactopyranoside (2) respectively.展开更多
Phytochemical investigation of the rhizomes of Paris polyphylla var.stenophylla led to the isolation of two new highly oxygenated spirostanol saponins,named paristenosides A(1)and B(2),together with seven known compou...Phytochemical investigation of the rhizomes of Paris polyphylla var.stenophylla led to the isolation of two new highly oxygenated spirostanol saponins,named paristenosides A(1)and B(2),together with seven known compounds.Their structures were established mainly on the base of NMR spectroscopic techniques and mass spectrometry,as well as chemical methods.In addition,the cytotoxicity of the two new saponins was tested.Graphical Abstract Two new highly oxygenated spirostanol saponins,paristenosides A(1)and B(2),were isolated from the rhizomes of Paris polyphylla var.stenophylla.Their structures were established mainly based on NMR spectroscopic techniques and mass spectrometry,as well as chemical methods.展开更多
The current state of coenotic populations of rare and endangered species of Uzbekistan-Tulipa lehmanniana Merckl. is given. Within the western part of the area (Kyzylkum desert) in different ecological and phytocenoti...The current state of coenotic populations of rare and endangered species of Uzbekistan-Tulipa lehmanniana Merckl. is given. Within the western part of the area (Kyzylkum desert) in different ecological and phytocenotic conditions, 8 coenotic populations of the species were identified. Based on the number of organism and population traits, the current state of coenotic populations of the species was evaluated. It was revealed that the vast majority of coenopopulations are in pessimal state. Coenopopulation only growing on the eastern part of the mountain Kuljuktau was assessed as optimal.展开更多
萱草属Hemerocallis L.属于百合科Liliaceae,萱草族Hemerocalleae,全世界约14种,主要分布于亚洲温带至亚热带地区,欧洲有少量分布.我国11种,为萱草属的分布中心.早在1544年,威尼斯的一名医生Pietro Andrea Mattioli曾在他的著作中使用过...萱草属Hemerocallis L.属于百合科Liliaceae,萱草族Hemerocalleae,全世界约14种,主要分布于亚洲温带至亚热带地区,欧洲有少量分布.我国11种,为萱草属的分布中心.早在1544年,威尼斯的一名医生Pietro Andrea Mattioli曾在他的著作中使用过Hemerocallis,这是Hemerocallis第一次在植物文献中出现,但这里所指的并不是我们现在所知的萱草属植物,而是代表分布在地中海地区的百合属Lilium的一些种,当时Mattioli用Daylily表示萱草.后来也一直被延用.展开更多
Two new steroidal saponins, named macrostemonoside A and D. were isolated from the bhlbus of Allium macrostemon Bunge (Liliaceae), and their strurtures were established by spectroscopic analysis and chemical evidences.
A new bianthraquinone glycoside, 8-O-β-D-glucopyranosyl-2,7’-bi(1,8-dihydroxy-3- methyl-9, 10-anthraquinonyl)1 was isolated from Eremurus chinensis Fedtch. Its structure was established by spectroscopic techniques i...A new bianthraquinone glycoside, 8-O-β-D-glucopyranosyl-2,7’-bi(1,8-dihydroxy-3- methyl-9, 10-anthraquinonyl)1 was isolated from Eremurus chinensis Fedtch. Its structure was established by spectroscopic techniques including 2D-NMR and chemical methods.展开更多
Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule.They have demonstrated a wide range of biological activities,and s...Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule.They have demonstrated a wide range of biological activities,and some of them have even been developed as therapeutic drugs,such as abiraterone acetate(Zytiga®),a blockbuster drug,which has been used for the treatment of prostate cancer.Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities,which are attractive for natural product chemistry and medicinal chemistry communities.This review comprehensively covers the structural classification,isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021,with 363 references being cited.展开更多
Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis,and their structures were determined as tupistrosides J–N(1–5),together with four known furostanol saponi...Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis,and their structures were determined as tupistrosides J–N(1–5),together with four known furostanol saponins(6–9),on the basis of physico-chemical properties and spectral analysis.Among them,compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5±2.4 and 77.3±2.5μmol·L^–1,respectively.Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6±2.1μmol·L^–1.展开更多
Liriope(Liliaceae) species have been used as folk medicines in Asian countries since ancient times. From Liriope plants(8 species), a total of 132 compounds(except polysaccharides) have been isolated and identified, i...Liriope(Liliaceae) species have been used as folk medicines in Asian countries since ancient times. From Liriope plants(8 species), a total of 132 compounds(except polysaccharides) have been isolated and identified, including steroidal saponins, flavonoids, phenols, and eudesmane sesquiterpenoids. The crude extracts or monomeric compounds from this genus have been shown to exhibit anti-tumor, anti-diabetic, anti-inflammatory, and neuroprotective activities. The present review summarizes the results on phytochemical and biological studies on Liriope plants. The chemotaxonomy of this genus is also discussed.展开更多
文摘Two new homoisoflavanones were isolated from the rhizomes of Polygonatum odoratum (Mill.) Druce and their structures were elucidated as (3R)-5,7-dihydroxy-8-methoxy-3-(4-methoxybenzyl)-6-methylchrom-an-4-one (1) and (3R)-5,7,8-trihydroxy-3-(4-hydroxybenzyl)-6-methylchroman-4-one (2), on the basis of spectral analysis.
基金a key project of Chinese Academy of sciences. We are grateful to the members of Instrument Group of Phytochemistry Laboratory, K
文摘Two new C27 steroidal glycosides, named ophiopojaponin A (1) and B (2), were isolated from the tubers of famous traditional Chinese herb(Ophiopogon japonicus. The spectroscopic and chemical evidences revealed their structures to be Pennogenin 3-O-[2’-O-acetyl-(-L-rhamnopyranosyl (1?2)]-(-D-xylopyranosyl (1?3)-(-D-glucopyranoside (1) and 26-O-(-D-glucopyranosyl-(22(, 25R)-3(, 14(, 22(, 26-tetrahydroxyfurost-5-ene 3-O-(-L-rhamnopyranosyl (1?2)-(-D-glucopyranoside (2), respectively.
文摘A new enolate derivative of furostanol glycoside, named asparagusin A, was isolated from the roots of Asparagus filicinus and established as 3 - O- 6 - D- xylopyranosyl （l →4）- β - Dglucopyranosyl （25S）-furost-20（22）-ene-3β, 26-diol 26-O-0-D-glucopyranoside （l） by spectroscopic and chemical methods. Asparagusin A （l） exhibited a cytotoxic activity effect on PC12 cells.
基金This work was supported by the National Natural Science Funding of China(Grants 31170333 and 31570363).
文摘Phytochemicalinvestigation onthe whole plants of Ypsilandra yunnanensiswas carried out forthe firsttime andledtothe isolation of five new cholestanol glycosides,ypsiyunnosides A–E(1–5),and one known analogue.Their structures were determined mainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS and UV,as well as chemical methods.Among them,compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon,which was identified as(23R,25R)-3β,16α,26-triol-16,23-cyclocholest-5,17(20)-dien-22-one.Their induced platelet aggregation activities and cytotoxicities were evaluated.Graphical Abstract Five new cholestanol glycosides,ypsiyunnosides A–E(1–5),were isolated from the whole plants of Ypsilandra yunnanensis.Compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon.Their structures were elucidated by a combination of 1D and 2D NMR,MS and chemical analysis.
基金The project supported by the National Natural Science Foundation of China
文摘Two new furostanol saponins,named macrostemonoside E(1)andF(2),were isolated from the bulbs of Allium macrostemon Bunge(Liliaceae),their structures were established oy spectroscopic analysisand chemical evidences.Both possessed strong inhibitory activity onhuman platelet aggregation.
基金supported by National Natural Science Funding of China(No.31170333)the Natural Sci-ence Foundation of Yunnan Province(No.2009CC019)+1 种基金the West Light Foundation of the Chinese Academy of Sciences(No.2908025712W1)a fund(No.540806321211)of State Key Laboratory of Phytochemistry and Plant Resources in West China,Germplasm Bank of Wild Species and CAS Innovation Program of Kunming Institute of Botany.
文摘The whole plants of Ypsilandra thibetica have been analyzed as part of a systematic study on saponin constituents of medicinal plants.This has resulted in the isolation of two new bisdesmosidic furostanol saponins,named ypsilandroside P(1)and ypsilandroside Q(2),and one new pregnane glycoside,named ypsilandroside R(3),together with nine known steroidal glycosides.Their structures were elucidated on the basis of extensive spectroscopic analysis,including that of 2D NMR data,and the results of acidic hydrolysis.Ypsilandroside P(1)was cytotoxicity against two human tumor cell lines.
基金the National Natural Science Funding of China(No.31170333)the Natural Science Foundation of Yunnan Province(No.2009CC019).
文摘Two new monosaccharide steroidal saponins,named ypsilandroside S(1)and ypsilandroside T(2),have been isolated from the whole plants of Ypsilandra thibetica.Their structures were elucidated as heloniogenin 3-O-b-D-apiofuranoside(1)and pregna 5,16-dien-3b,12a-diol-20-one-3-O-b-D-apiofuranoside(2)by spectroscopic techniques(1D and 2D NMR,MS).Compounds 1 and 2 were tested for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.
基金the Special Project of Biological Science and Technology of the Chinese Academy of Sciences (STZ-97-3-08).
文摘Two new steroidal saponins, diuranthosides D and E, were isolated from the whole plant of Diuranthera inarticulata Wang et K. Y. Lang. By means of spectral and chemical analysis, the structure of the new compounds were established as neotigogenin-3-O-(-D-glucopyranosyl (1?3)-(-D-xylopyranosyl-(1?3)-[(-D-glucopyranosyl(1?2)]-(-D-glucopyranosyl(1?4)-(-D-galactopyranoside (1) and neotigogenin-3-O-(-D-glucopyranosyl(1?3)-(-D-glucopyranosyl (1?3)-(-D-xylopyranosyl(1?3)-[(-D-glucopyranosyl(1?2)]-(-D-glucopyranosyl(1?4)-(-D-galactopyranoside (2) respectively.
基金This work is funded by the National Natural Science Funding of China(Grand No.31570363)the Key Research Program of the Chinese Academy of Sciences(Grand No.KSZDEW-Z-004-03-4)the Natural Science Foundation of Yunnan Province(Grand No.2015FA031).
文摘Phytochemical investigation of the rhizomes of Paris polyphylla var.stenophylla led to the isolation of two new highly oxygenated spirostanol saponins,named paristenosides A(1)and B(2),together with seven known compounds.Their structures were established mainly on the base of NMR spectroscopic techniques and mass spectrometry,as well as chemical methods.In addition,the cytotoxicity of the two new saponins was tested.Graphical Abstract Two new highly oxygenated spirostanol saponins,paristenosides A(1)and B(2),were isolated from the rhizomes of Paris polyphylla var.stenophylla.Their structures were established mainly based on NMR spectroscopic techniques and mass spectrometry,as well as chemical methods.
文摘The current state of coenotic populations of rare and endangered species of Uzbekistan-Tulipa lehmanniana Merckl. is given. Within the western part of the area (Kyzylkum desert) in different ecological and phytocenotic conditions, 8 coenotic populations of the species were identified. Based on the number of organism and population traits, the current state of coenotic populations of the species was evaluated. It was revealed that the vast majority of coenopopulations are in pessimal state. Coenopopulation only growing on the eastern part of the mountain Kuljuktau was assessed as optimal.
文摘萱草属Hemerocallis L.属于百合科Liliaceae,萱草族Hemerocalleae,全世界约14种,主要分布于亚洲温带至亚热带地区,欧洲有少量分布.我国11种,为萱草属的分布中心.早在1544年,威尼斯的一名医生Pietro Andrea Mattioli曾在他的著作中使用过Hemerocallis,这是Hemerocallis第一次在植物文献中出现,但这里所指的并不是我们现在所知的萱草属植物,而是代表分布在地中海地区的百合属Lilium的一些种,当时Mattioli用Daylily表示萱草.后来也一直被延用.
基金The project supported by Lhe National Natural Science Foundation of China.
文摘Two new steroidal saponins, named macrostemonoside A and D. were isolated from the bhlbus of Allium macrostemon Bunge (Liliaceae), and their strurtures were established by spectroscopic analysis and chemical evidences.
文摘A new bianthraquinone glycoside, 8-O-β-D-glucopyranosyl-2,7’-bi(1,8-dihydroxy-3- methyl-9, 10-anthraquinonyl)1 was isolated from Eremurus chinensis Fedtch. Its structure was established by spectroscopic techniques including 2D-NMR and chemical methods.
基金the National Natural Science Foundation of China (32170405)Yunnan Science and Technology Project (202105AE160006,2019FY003004) for partial financial support.
文摘Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule.They have demonstrated a wide range of biological activities,and some of them have even been developed as therapeutic drugs,such as abiraterone acetate(Zytiga®),a blockbuster drug,which has been used for the treatment of prostate cancer.Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities,which are attractive for natural product chemistry and medicinal chemistry communities.This review comprehensively covers the structural classification,isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021,with 363 references being cited.
基金supported by the Open Research Fund of Key Laboratory of Basic and New Herbal Medicament Research,Shaanxi university of Chinese medicine(Nos.17JS030 and 2017KF02)Subject Innovation Team of Shaanxi University of Chinese Medicine(No.2019-YL12)+2 种基金the Special Project of Shaanxi Province Education Department(No.14JF005)the National Natural Sciences Foundation of China(No.81503237)the Key R&D Program of Shaanxi Province(Nos.2018SF-324,2017SF-360 and 2015SF073)
文摘Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis,and their structures were determined as tupistrosides J–N(1–5),together with four known furostanol saponins(6–9),on the basis of physico-chemical properties and spectral analysis.Among them,compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values of 72.5±2.4 and 77.3±2.5μmol·L^–1,respectively.Compound 4 showed cytotoxicity against human cancer cell line HepG2 with IC50 value of 88.6±2.1μmol·L^–1.
基金supported by the National Natural Science Foundation of China(Nos.81303206 and 81303189)
文摘Liriope(Liliaceae) species have been used as folk medicines in Asian countries since ancient times. From Liriope plants(8 species), a total of 132 compounds(except polysaccharides) have been isolated and identified, including steroidal saponins, flavonoids, phenols, and eudesmane sesquiterpenoids. The crude extracts or monomeric compounds from this genus have been shown to exhibit anti-tumor, anti-diabetic, anti-inflammatory, and neuroprotective activities. The present review summarizes the results on phytochemical and biological studies on Liriope plants. The chemotaxonomy of this genus is also discussed.
