2024年9月15日,浙江大学生命科学学院易文/朱强研究员团队与美国科学院院士Linda C. Hsieh-Wilson团队合作在《美国化学会志》(Journal of the American Chemical Society)在线发表了题为“Chemoenzymatic labeling,detection and profi...2024年9月15日,浙江大学生命科学学院易文/朱强研究员团队与美国科学院院士Linda C. Hsieh-Wilson团队合作在《美国化学会志》(Journal of the American Chemical Society)在线发表了题为“Chemoenzymatic labeling,detection and profiling of core fucosylation in live cells”的研究论文(DOI:10.1021/jacs.4c09303)。该研究利用糖基转移酶1(GALT-1)的高度特异性以及对改造底物UDP-Gal-6-N3的适配性,实现了对核心岩藻糖基化修饰的高选择性和高灵敏度标记、荧光成像和富集等多功能检测。研究人员使用线虫来源的GALT-1作为酶标记方法的工具酶,设计并合成了带有叠氮基团的底物UDP-Gal-6-N3,并结合点击化学反应将荧光基团或生物素连接到核心岩藻糖基化修饰的蛋白上。展开更多
Hi! I'm Linda.I'm 12 years old.I'm a student.I'm in No.1 middle school~(1).Here is a nice photo of my family.These are my parents,Tom and Mary.My mother is a~(2) English teacher.My father is a doctor.T...Hi! I'm Linda.I'm 12 years old.I'm a student.I'm in No.1 middle school~(1).Here is a nice photo of my family.These are my parents,Tom and Mary.My mother is a~(2) English teacher.My father is a doctor.Those are my brother and sister.My sister~(3)name is Helen.She is 6 years old.My brother is Eric.He is 4 years old.And those are my grandparents.They are old.Coco is my cat.It is my good friend.I have a happy family.I like my family very much.展开更多
Q:Thanksgiving is this month.How do you spend the holiday withfamily?A:My family and I usually invite family and friends over to celebrate Thanksgiving together.This year,we plan on doing the same.During the night,we ...Q:Thanksgiving is this month.How do you spend the holiday withfamily?A:My family and I usually invite family and friends over to celebrate Thanksgiving together.This year,we plan on doing the same.During the night,we usually go around and share what we are thankful for.This year,I am extremely thankful for our home,loved ones and the time to spend with them.展开更多
文摘2024年9月15日,浙江大学生命科学学院易文/朱强研究员团队与美国科学院院士Linda C. Hsieh-Wilson团队合作在《美国化学会志》(Journal of the American Chemical Society)在线发表了题为“Chemoenzymatic labeling,detection and profiling of core fucosylation in live cells”的研究论文(DOI:10.1021/jacs.4c09303)。该研究利用糖基转移酶1(GALT-1)的高度特异性以及对改造底物UDP-Gal-6-N3的适配性,实现了对核心岩藻糖基化修饰的高选择性和高灵敏度标记、荧光成像和富集等多功能检测。研究人员使用线虫来源的GALT-1作为酶标记方法的工具酶,设计并合成了带有叠氮基团的底物UDP-Gal-6-N3,并结合点击化学反应将荧光基团或生物素连接到核心岩藻糖基化修饰的蛋白上。
文摘Hi! I'm Linda.I'm 12 years old.I'm a student.I'm in No.1 middle school~(1).Here is a nice photo of my family.These are my parents,Tom and Mary.My mother is a~(2) English teacher.My father is a doctor.Those are my brother and sister.My sister~(3)name is Helen.She is 6 years old.My brother is Eric.He is 4 years old.And those are my grandparents.They are old.Coco is my cat.It is my good friend.I have a happy family.I like my family very much.
文摘Q:Thanksgiving is this month.How do you spend the holiday withfamily?A:My family and I usually invite family and friends over to celebrate Thanksgiving together.This year,we plan on doing the same.During the night,we usually go around and share what we are thankful for.This year,I am extremely thankful for our home,loved ones and the time to spend with them.
