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Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology 被引量:17
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作者 Bram Smarius Charlotte Loozen +3 位作者 Wendy Manten Mireille Bekker Lou Pistorius Corstiaan Breugem 《World Journal of Methodology》 2017年第3期93-100,共8页
Cleft lip with or without cleft palate(CP) is one of the most common congenital malformations. Ultrasonographers involved in the routine 20-wk ultrasound screening could encounter these malformations. The face and pal... Cleft lip with or without cleft palate(CP) is one of the most common congenital malformations. Ultrasonographers involved in the routine 20-wk ultrasound screening could encounter these malformations. The face and palate develop in a very characteristic way. For ultrasonographers involved in screening these patients it is crucial to have a thorough understanding of the embryology of the face. This could help them to make a more accurate diagnosis and save time during the ultrasound. Subsequently, the current postnatal classification will be discussed to facilitate the communication with the CP teams. 展开更多
关键词 Cleft lip Cleft palate Embryology face Orofacial clefts ULTRASOUND
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Obstructive Tumor of the Palate in the Old Person: A Case Report
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作者 Silly Toure Mouhamadou Makhtar Ndiaye +3 位作者 Abibou Ndiaye Mamadou Coume Mame Sanou Diouf Baye Karim Diallo 《Open Journal of Stomatology》 2024年第5期199-205,共7页
Introduction: Pleomorphic adenoma or mixed salivary gland tumor is a heterogeneous benign tumor of the salivary glands. The most common site is the parotid gland. Its extra-parotid locations, particularly in the acces... Introduction: Pleomorphic adenoma or mixed salivary gland tumor is a heterogeneous benign tumor of the salivary glands. The most common site is the parotid gland. Its extra-parotid locations, particularly in the accessory salivary glands, are rarer. We report a case of a pleomorphic adenoma of the posterior palate which posed management problems. Observation: This is an 85-year-old patient who consulted for a tumor of the posterior palate that had been evolving for 3 years. The examination revealed a globular tumor of the posterior palate extending beyond the midline by approximately 7 cm in long axis, shooting towards the oropharynx and hindering breathing, speech and eating, indicating a life-saving tracheotomy. A CT scan of the facial area revealed a well-circumscribed tumor at the expense of the soft palate, with multiple sites of bone lysis. The biopsy performed was in favor of a pleomorphic adenoma. The patient underwent total surgical excision of a huge tumor on the palate. The aftermath of the operation was marked by a loosening of the sutures with an oronasal fistula requiring the creation of an obturator plate due to the patient’s refusal to have another operation. Conclusion: Large pleomorphic adenoma of the posterior palate is a rare entity that can cause respiratory problems and surgical difficulties. His prognosis is generally good. 展开更多
关键词 Pleomorphic Adenoma Posterior palate Respiratory Disorders Prognosis Obturator Plaque
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Assessment of Two Years of Free Surgical Treatment of Cleft Lip, Palate and Alveolar (CLPA) in the Maxillofacial Surgery and Stomatology Department of the Hospital University of Treichville-Abidjan
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作者 Anoumon Marguerite Reine Evelyne Anzouan-Kacou Romaric Evrard Assi Yapo +3 位作者 Jean Francois Regis Koffi Behibro Beatrice Tehoua Ettien Franck-Olivier Manoussa Seguy Emmanuel Kouadio Konan 《Open Journal of Stomatology》 2023年第8期223-232,共10页
Introduction: Cleft lip, palate and alveolar (CLPA) are congenital malformations of the face due to a defect in the fusion of embryonic buds during the first weeks of embryogenesis. These malformations affect the uppe... Introduction: Cleft lip, palate and alveolar (CLPA) are congenital malformations of the face due to a defect in the fusion of embryonic buds during the first weeks of embryogenesis. These malformations affect the upper lip, the alveolar bone and the palate. The incidence in Africa ranges from 1/2000 to 1/500 births. Their multidisciplinary management is long and costly. Thus, the help provided by humanitarian organisations during free care campaigns is welcome. Materials and Methods: This is a retrospective descriptive study conducted from August 2014 to July 2016 in the Maxillofacial Surgery and Stomatology Department of the Treichville University Hospital in Abidjan, Côte d’Ivoire. The objective was to describe the epidemiological, clinical and therapeutic aspects of CLPA during a humanitarian campaign for free care. Results: 51 cases of CLPA were operated on. Males were involved in 54.9% of the cases, i.e. a sex ratio of 1.2. The average age of the patients at the time of the operation was 3.44 years with extremes of 3 months and 52 years. Patients with low socioeconomic status represented 84.3% of the cases. Cleft lips (31.4%) and cleft palates (33.33%) predominated. For cleft lips, unilateral forms were the most frequent (73.5%) and the left side was most often affected (59.2%). The most common surgical techniques used were MILLARD cheiloplasty for cleft lips (79.36%) and Dorrance pushback for cleft palates (78.05%). The postoperative course was simple in the majority of cases (80.47%). Patients and/or parents were satisfied with the postoperative results in over 90% of cases. Discussion: Cleft lip and palate are common. Their management by humanitarian missions through mass campaigns allows us to receive a large number of patients affected by this pathology who are treated with a high satisfaction rate. Conclusion: The characteristics of cleft lip and palate in this study are in many respects identical to those described in the literature, but with some differences specific to Africa, notably the absence of antenatal diagnosis and the advanced age at the time of treatment. 展开更多
关键词 Cleft lip and palate Free Care Humanitarian Surgery
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Rhinoplasty in Cleft Lip and Palate
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作者 Enrique Hernandez Vidal Enrique Hernandez Del Moral +4 位作者 Omar Hernandez Del Moral Erick Daniel Hernandez Del Moral Juan Daniel Madera Brito Erik Ramos Garcia Crystell Guadalupe Guzmán-Priego 《Case Reports in Clinical Medicine》 2023年第11期439-446,共8页
Various surgical techniques and approaches have been described to repair cleft nose deformities. It is necessary to consider that since it is a congenital deformity, surgical management must consider the patient’s gr... Various surgical techniques and approaches have been described to repair cleft nose deformities. It is necessary to consider that since it is a congenital deformity, surgical management must consider the patient’s growth process, as well as the healing itself from the surgery. The present study aims to evaluate an alternative solution to secondary rhinology, aesthetic, and functional alterations to unilateral or bilateral cleft lift palate to minimize deformities and ensure good results. 11 patients were studied between 1995 to 2002, ten male and one female. In 8 cases, the patients had a history of cleft lip and palate on the left side, 2 patients with cleft lift palate on the right, and 1 patient with bilateral cleft lip and palate. 100% of the patients increased their naso-labial angle. This improved their appearance and structure, starting from a preoperative arithmetic mean of 39 degrees to a postoperative arithmetic mean of 96 degrees. Such intervention increased the naso-labial angle by 57 degrees. At the base of the nose, it was possible to improve the inclination of the alar line (line B) in 10 of the cases with a variation of 2 to 3 mm in relation to the perpendicular line A and only one case remained with the same inclination. 展开更多
关键词 Cleft lip and palate Naso-Labial Angle INCLINATION APPEARANCE
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The common MTHFR C677T and A1298C variants are not associated with the risk of non-syndromic cleft lip/palate in northern Venezuela 被引量:7
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作者 Mehmet A.Szen Marie M.Tolarova Richard A.Spritz 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2009年第5期283-288,共6页
Non-syndromic cleft lip with or without cleft palate (nsCL/P) is among the most common major birth defects, with complex inheritance involving multiple genes and environmental factors. Numerous studies of MTHFR, enc... Non-syndromic cleft lip with or without cleft palate (nsCL/P) is among the most common major birth defects, with complex inheritance involving multiple genes and environmental factors. Numerous studies of MTHFR, encoding methylenetetrahydrofolate reductase, which catalyzes the rate-limiting step of folic acid biosynthesis, have shown inconsistent association of two common hypomorphic allelic variants, C677T and A1298C, in nsCL/P patients and, in some cases, their mothers. We have studied the MTHFR C677T and A1298C polymorphisms in nsCL/P patients, their mothers, and population-matched controls from northern Venezuela. We found no evidence for contribution of the MTHFR C677T and A1298C variants to the risk of nsCL/P in northern Venezuela. Overall, our findings fail to support a causal role of either the MTHFR C677T or A 1298C variants in the pathogenesis of nsCL/P in northern Venezuela. 展开更多
关键词 cleft lip cleft palate methylenetetrahydrofolate reductase folic acid MTHFR polymorphisms
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BHMT Gene Polymorphisms as Risk Factors for Cleft Lip and Cleft Palate in a Chinese Population 被引量:3
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作者 HU Ying CHEN ErJun +2 位作者 MU Yue LI JinLu CHEN RenJi 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2011年第2期89-93,共5页
Objective Convincing evidence suggests a link between increased risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and low intake of folic acid by the mother during pregnancy. The present study was... Objective Convincing evidence suggests a link between increased risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) and low intake of folic acid by the mother during pregnancy. The present study was designed to explore if genetic variation in the betaine‐homocysteine methyltransferase (BHMT) gene contributes to NSCL/P. Methods DNA was obtained from 166 individuals with NSCL/P and 285 healthy subjects. Three known single nucleotide polymorphisms (SNPs) present in the BHMT gene (rs651852, rs3797546, and rs3733890) were investigated by real‐time PCR‐based TaqMan genotyping. Results Neither allelic nor genotypic association was found between NSCL/P and SNPs rs651852 and rs3733890. SNP rs3797546 did not show allelic association with NSCL/P; however, a higher proportion of NSCL/P patients carry the CC genotype compared with the TT+CT genotype (P=0.020, OR=2.10, 95% CI=1.11‐3.95). Conclusion Our study suggests that polymorphism rs3797546 in the BHMT gene may confer genetic risk of NSCL/P in a recessive manner. 展开更多
关键词 Nonsyndromic cleft lip with or without palate HOMOCYSTEINE Folate POLYMORPHISMS
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Genome-wide and Interaction Linkage Scan for Nonsyndromic Cleft Lip with or without Cleft Palate in Two Multiplex Families in Shenyang,China 被引量:2
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作者 YUN WANG XIN LI +4 位作者 WEN-LI ZHU JIN-ZHEN GUO XIAO-MING SONG SHU-QIN LI YONG LI 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2010年第5期363-370,共8页
Objectives To identify the loci involved in nonsyndromic cleft lip with or without cleft palate (NSCL/P) in Northern Chinese people in Shenyang by using genomewide and interaction linkage scan.Methods Two multiplex ... Objectives To identify the loci involved in nonsyndromic cleft lip with or without cleft palate (NSCL/P) in Northern Chinese people in Shenyang by using genomewide and interaction linkage scan.Methods Two multiplex families in Shenyang from North China were ascertained through probands with NSCL/P.Blood of every member was drawn for DNA extraction and analysis.Genotypes were available for 382 autosomal short tandem repeat (STR) markers from the ABI Prism Linkage Mapping Set version 2.5.Linkage between markers and NSCL/P was assessed by 2-point parametric LOD scores,multipoint heterogeneity parametric LOD scores (HLODs),and multipoint nonparametric linkage score (NPL).Results The initial scan suggested linkage on Chromosomes 1,2,and 15.In subsequent fine mapping,1q32-q42 showed a maximum multipoint LOD score of 1.9(empirical P=0.013) and an NPL score of 2.35 (empirical P=0.053).For 2p24-p25,the multipoint NPL increased to 2.94 (empirical P=0.007).2-locus interaction analysis obtained a maximum NPL score of 3.73 (P=0.00078) and a maximum LOD score of 3 for Chromosome 1 (at 221 cM) and Chromosome 2 (at 29 cM).Conclusion Both parametric and nonparametric linkage scores greatly increased over the initial linkage scores on 1q32-q42,suggesting a susceptibility locus in this region.Nonparametric linkage gave a strong evidence for a candidate region on chromosome 2p24-p25.The superiority of 2-locus linkage scores compared to single-locus scores gave additional evidence for linkage on 1q32-q42 and 2p24-p25,and suggested that certain genes in the two regions may contribute to NCSL/P risks with interaction. 展开更多
关键词 Nonsyndromic cleft lip with or without cleft palate Parametric linkage Nonparametric linkage INTERACTION
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Penetrating soft palate injury by lollypop candy stick
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作者 Shalendra Singh Sushrut Avinash Kulkarni +1 位作者 Nitesh Agrawal Abhishek Mishra 《Journal of Acute Disease》 2023年第5期213-214,共2页
Incidents of soft palate injury or laceration caused by unintended movement when holding a sharp object in the mouth in the pediatric population are usually rarely reported.Here we report a case of soft palate lacerat... Incidents of soft palate injury or laceration caused by unintended movement when holding a sharp object in the mouth in the pediatric population are usually rarely reported.Here we report a case of soft palate laceration in a child due to a lollypop stick tip. 展开更多
关键词 INJURY SHARP palate
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A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou,China 被引量:2
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作者 XU Li Fang ZHOU Xiao Long +12 位作者 WANG Qi ZHOU Ji Long LIU Ya Peng JU Qiang WANG Hui ZHANG Jin Peng WU Qing Rong LI Yi Qun XIA Yu Juan PENG Xiu ZHANG Mei Rong YU Hong Min XU Li Chun 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第7期535-538,共4页
In this study, we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate (NSCLP) to understand the etiology of the disease. A total of 200 NSCLP cases and 3... In this study, we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate (NSCLP) to understand the etiology of the disease. A total of 200 NSCLP cases and 327 controls were recruited at the Maternal and Child Health Hospital of Xuzhou City. We conducted face-to-face interviews with the mothers of both cases and controls. The factors increasing the risk of NSCLP were a positive family history [odds ratio (OR)=56.74], pesticide exposure (OR=8.90), and indoor decoration pollution (OR= 4.32). On the other hand, the factors decreasing the risk of NSCLP were a high education level (OR=0.22) and supplementation of folic acid (OR=0.23) and multivitamins (OR=0.16). Positive family history, pesticide exposure, and indoor decoration pollution are associated with the risk of NSCLP. In contrast, high education level and folic acid and multivitamin supplementation are protective factors against NSCLP. 展开更多
关键词 A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the lip and/or palate in Xuzhou China CLP
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Comparison of Congenital Tooth Deficiencies Seen in Permanent Teeth in Individuals with Unilateral Cleft Lip and Palate to Those without Cleft Lip and Palate 被引量:1
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作者 Ege Dogan 《Open Journal of Stomatology》 2021年第5期188-196,共9页
<strong>Objective:</strong> To compare the congenital tooth deficiencies seen in permanent dentition in individuals with unilateral cleft lip and palate (UCLP) to non-cleft individuals with Angle Class I m... <strong>Objective:</strong> To compare the congenital tooth deficiencies seen in permanent dentition in individuals with unilateral cleft lip and palate (UCLP) to non-cleft individuals with Angle Class I malocclusion. <strong>Method:</strong> The study was performed on orthopantomograph films of 50 individuals with UCLP aged between 12 - 16 years and 50 individuals with Angle Class I malocclusion individuals aged between 13 - 15 years. Individuals with UCLP;32 clefts were on the left side and 18 clefts were on the right side. Permanent third molar teeth deficiency was excluded from the study. <strong>Results: </strong>In 50 individuals with UCLP;35 (70%) upper lateral incisors were congenitally deficient in the cleft area, while 15 (30%) missing lateral teeth were found in the non-cleft side. In control group, 12 (24%) of 50 patients had congenital lateral incisor deficiency. Congenital deficiency of upper lateral incisor in UCLP;the cleft area was higher than the non-cleft side (p < 0.01). The difference was statistically important when compared with the control group (p < 0.001). In 50 individuals with UCLP;while 27 (54%) of second premolar teeth were congenitally deficient in cleft side, 23 (46%) were missing in non-cleft side. In control group, 18 (36%) congenital second premolar deficiency was detected. However, second premolar congenital deficiency was higher in UCLP group when compared to control group (p < 0.01). <strong>Conclusion:</strong> The deficiency of the lateral incisors in the cleft side is more often congenitally deficient than upper second premolar teeth and this should be considered in the treatment planning from an early age. 展开更多
关键词 Congenital Teeth Deficiency Unilateral Cleft lip and palate
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Effect of Cleft Lip and Palate Repair on Craniofacial Morphology in Patients with Unilateral Complete Cleft Lip and Palate. 被引量:2
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作者 YUShi-bin LIZu-bing 《口腔医学纵横》 CSCD 2001年第3期225-228,共4页
目的 :通过对替牙期正常儿童及单侧完全唇腭裂 (UCLP)患者X线头影测量侧位片进行比较研究 ,了解唇腭裂及其手术对颌骨发育的影响 ,探索继发畸形的发病机制。方法 :将替牙期的正常儿童及UCLP患者分为四组 :①正常对照组 (Normal) ,本组包... 目的 :通过对替牙期正常儿童及单侧完全唇腭裂 (UCLP)患者X线头影测量侧位片进行比较研究 ,了解唇腭裂及其手术对颌骨发育的影响 ,探索继发畸形的发病机制。方法 :将替牙期的正常儿童及UCLP患者分为四组 :①正常对照组 (Normal) ,本组包括 48名替牙期正常湖北地区儿童 ;②未手术组 (NO) ,本组 10名UCLP患者未经任何手术治疗 ;③唇裂修复组 (OL) ,34名UCLP患者已行唇裂修复 ,腭裂暂未手术 ;④唇腭裂修复组 (OLP) ,16名UCLP患者已行唇、腭裂修复。各受试对象拍摄X线头影测量侧位片 ,测量描述颌骨的形态特征及生长方向 ,对各组之间测量结果进行统计学分析。结果 :未行手术治疗的U CLP患者颌骨形态除腭部先天性发育不足外 ,颌骨侧位头影测量与正常无显著性差异 ;OL和OLP组较正常存在严重的颌骨畸形 ,主要表现为上颌后缩、位置后移 ,同时下颌骨向后下旋转移位 ;OL和OLP组上颌后缩的程度无显著性差异。结论 :UCLP患者颌骨具有趋于发育正常的生长能力 ;手术是导致颌骨继发畸形的主要因素 ;对于单侧完全唇腭裂患者 。 展开更多
关键词 单侧完全唇腭裂 颌骨形态 头影测量 修复术 唇裂 腭裂
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改进Wav2Lip的文本音频驱动人脸动画生成
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作者 孙瑜 朱欣娟 《计算机系统应用》 2024年第2期276-283,共8页
为了提高中文唇音同步人脸动画视频的真实性,本文提出一种基于改进Wav2Lip模型的文本音频驱动人脸动画生成技术.首先,构建了一个中文唇音同步数据集,使用该数据集来预训练唇部判别器,使其判别中文唇音同步人脸动画更加准确.然后,在Wav2... 为了提高中文唇音同步人脸动画视频的真实性,本文提出一种基于改进Wav2Lip模型的文本音频驱动人脸动画生成技术.首先,构建了一个中文唇音同步数据集,使用该数据集来预训练唇部判别器,使其判别中文唇音同步人脸动画更加准确.然后,在Wav2Lip模型中,引入文本特征,提升唇音时间同步性从而提高人脸动画视频的真实性.本文模型综合提取到的文本信息、音频信息和说话人面部信息,在预训练的唇部判别器和视频质量判别器的监督下,生成高真实感的唇音同步人脸动画视频.与ATVGnet模型和Wav2Lip模型的对比实验表明,本文模型生成的唇音同步人脸动画视频提升了唇形和音频之间的同步性,提高了人脸动画视频整体的真实感.本文成果为当前人脸动画生成需求提供一种解决方案. 展开更多
关键词 文本音频驱动 人脸动画 Wav2lip模型 动画生成
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Updating Genetics Polymorphisms of Non-Syndromic Clefts Lip-Palates
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作者 Amine Rafik Sellama Nadifi 《American Journal of Molecular Biology》 2018年第3期178-185,共8页
Introduction: Non-Syndromic Clefts Lip-Palates (NSCLP/CP) are most common congenital malformation in the world, with very important psychic and social impact. Formation of NSCLP/CP arises from the interaction of envir... Introduction: Non-Syndromic Clefts Lip-Palates (NSCLP/CP) are most common congenital malformation in the world, with very important psychic and social impact. Formation of NSCLP/CP arises from the interaction of environmental and genetic factors. This paper provides a review of recent progress in defining the genetic causes of NSCLP. Methods: A literature review was conducted on the Medline data by searching for the following keywords: genes, non-syndromic cleft lip-palate, and genetics of clefts lip-palates, until January 2018. Results: Various genes are identified in different population and country, with the study using case parent’s trio. The aim of this study contributes to review relative gene which has been identify in non-syndromic cleft lip and palate, and to help to have a better understanding of the inheritance pattern of this pathology and the prevention of genetic disease. Conclusion: Although three major genes have been confirmed, the genetic research is necessary to provide an understanding of the pathophysiology of the clefts lip-palates. 展开更多
关键词 CLEFT lip CLEFT palate CLEFT lip and/or CLEFT palate NON-SYNDROMIC Genetics
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Evaluation of Maxillary Dental Arch Widths in Individuals Having Unilateral and Bilateral Cleft Lip and Palate Using Three-Dimensional Digital Models
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作者 Ege Dogan Abdü +2 位作者 lkadir Iş ik Servet Dogan 《Open Journal of Stomatology》 2019年第7期159-167,共9页
Aim: Maxillary dental arch widths were evaluated in individuals having unilateral (UCLP) and bilateral (BCLP) cleft lip and palate (CLP) using three-dimensional (3D) digital models. Material and Method: The study had ... Aim: Maxillary dental arch widths were evaluated in individuals having unilateral (UCLP) and bilateral (BCLP) cleft lip and palate (CLP) using three-dimensional (3D) digital models. Material and Method: The study had been conducted on 80 individuals aged between 14 - 17 years having UCLP and BCLP. 40 of the individuals had UCLP, whereas 40 had BCLP. The maxillary dental models taken from patients before the treatment were scanned using Orthomodel Programme (v.1.01, Orthomodel Inc., Istanbul, Turkey) to obtain 3D imagery. Student’s t-test was used in order to assess the data obtained by using SPSS software version 22.0. Results: In BCLP, the average inter-canine distance was 17.44 ± 1.31 mm, the average inter-molar distance was 36.57 ± 1.12 mm, while inter-canine/inter-molar ratio was 0.47. Whereas in UCLP, it was 25.10 ± 0.63 mm, 42.20 ± 0.53 mm and 0.59. The inter-canine distance in UCLP was found to be large enough to be statistically significant (p 0.05), even though there were differences in inter-molar widths. Conclusion: For the stable orthodontic treatment results, one of the most important points is arch form and widths to be coherent with each other. In our study, the increase of inter-canine distance seen in UCLP indicates that in the cleft region, the maxillary arch is inclined over to the back, while the same situation in BCLP suggests that the maxillary segments are collapsed inside. The difference in the arch is highly affected by the primary surgical treatment. 展开更多
关键词 UNILATERAL CLEFT lip and palate Bilateral CLEFT lip and palate THREE-DIMENSIONAL Digital Models
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Gastroschisis Associated with Cleft Lip and Palate: Report of Three Cases
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作者 Kouamé Soroboua Agbara Martial Olivier Moulot +10 位作者 Adjoba Manuela Ehua Jean Marie Konan Ibrahim Traoré Franck Grah Anon Ghislain Anon Josaphat Konvolbo Robert Boulleys Idalia Ajoumissi Alphamoyé Haidara Paule-Christine Ekobo Sanni Roumanatou Bankolé 《Open Journal of Pediatrics》 2019年第1期1-6,共6页
Gastroschisis is a malformation of the abdominal wall like omphalocele. In most cases, gastroschisis is isolated. But in some cases, we find malformations, essentially minor and concern gastrointestinal or genitourina... Gastroschisis is a malformation of the abdominal wall like omphalocele. In most cases, gastroschisis is isolated. But in some cases, we find malformations, essentially minor and concern gastrointestinal or genitourinary systems. Association with craniofacial congenital midline defects is uncommon. We report 3 cases of association between gastroschisis and cleft lip and palate for the benefit of the scientific community. Two 0-day-old and a 1-day newborns were admitted in our institution for malformation of face and abdominal wall. The physical examination confirmed the association of gastroschisis and cleft lip and palate. The patients underwent primary closure. Other malformations could not be sought until all patients died. 展开更多
关键词 GASTROSCHISIS CLEFT lip and palate Primary CLOSURE
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Post-Traumatic Palatine Odontogenic Abscess: About 2 Cases
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作者 Aké Lucien Jonathan Yapo Bakary Ouattara +6 位作者 Koffi Laurent Boka Konan René Kouakou Ahi Morel Mounin Chapo Affoué Linda Marie Pierre Koffi Kahder Morel Diarra Rokiatou Koné-Kamaté Konan Marc Koffi 《Open Journal of Stomatology》 2024年第7期336-340,共5页
Introduction: Palatal abscess or cellulitis of dental origin is a rare clinical form of circumscribed cellulitis that can sometimes pose a diagnostic problem. It is the consequence of poor or non-treatment of dental c... Introduction: Palatal abscess or cellulitis of dental origin is a rare clinical form of circumscribed cellulitis that can sometimes pose a diagnostic problem. It is the consequence of poor or non-treatment of dental caries or trauma. The aim of this study is to describe the clinical and therapeutic aspects of these two cases of palatal cellulitis of post-traumatic dental origin. Observation: The patients consulted for painful palatal swelling secondary to untreated dental trauma of the 21s. The diagnosis of palatal cellulitis was based on the inflammatory and fluctuating nature of the swelling. A probabilistic bi-antibiotic treatment and an incision and drainage associated with treatment of the portal of entry were carried out. Progression was favourable in both cases. Conclusion: Palatal cellulitis is a rare condition and can be prevented by systematic stomatological consultation after dental trauma. Diagnosis is clinical. However, CT scans are sometimes useful. The course is generally favorable with appropriate treatment. 展开更多
关键词 ABSCESS palate DENTAL TRAUMA
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Stability of maxillary advancement using external rigid distractors in cleft lip and palate patients
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作者 Sondos Abuzinada Ahmed Alyamani 《Open Journal of Stomatology》 2012年第4期383-387,共5页
Purpose: To evaluate the skeletal changes associated with maxillary advancement using the external rigid distractor in cleft lip and palate patients after distraction and to assess the stability of these changes. Pati... Purpose: To evaluate the skeletal changes associated with maxillary advancement using the external rigid distractor in cleft lip and palate patients after distraction and to assess the stability of these changes. Patients and Methods: Eight cleft lip and palate patients with maxillary hypoplasia underwent maxillary distraction osteogenesis using external rigid devise. Lateral cephalometric records were obtained before distraction T1 and after completing active distraction T2. After a three month follow up period a final lateral cephalometric record was evaluated T3. Results: The maxilla was significantly advanced as indicated by the increase in maxillary depth angle and effective maxillary length (median difference, 10 mm). The palatal plane angle showed a significant increase (median difference, 5o), showing clockwise rotation. At T3 there was a slight decrease in maxillary depth angle (median difference, 3o). Effective maxillary length decreased significantly at T3 (median difference, 2 mm). The palatal plane angle decreased (median difference, 3o) and almost returned to its original position, showing a counterclockwise rotation. Conclusion: Maxillary advancement using external rigid distractor resulted in clockwise rotation of maxilla with increase in palatal plane angle and slight increase in mandibular plane angle. The amount of maxillary advancement was slightly reduced during follow up and the palatal plane almost returned to its original position. These changes showed good stable clinical results. 展开更多
关键词 MAXILLARY HYPOPLASIA CLEFT lip palate MAXILLARY DISTRACTION OSTEOGENESIS
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A protocol used to manage maxillary hypoplasia in cleft lip and palate patients
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作者 Ahmed Alyamani Sondos Abuzinada 《Open Journal of Stomatology》 2012年第2期130-135,共6页
Objectives: We report our experience and the protocol we used in managing maxillary hypoplasia in cleft lip and palate patients. Patients and methods: 14 adult cleft lip and palate patients with maxillary hypoplasia w... Objectives: We report our experience and the protocol we used in managing maxillary hypoplasia in cleft lip and palate patients. Patients and methods: 14 adult cleft lip and palate patients with maxillary hypoplasia were evaluated clinically. Dental models and radiographs including (lateral cephalograms and orthopantographs) were obtained at the initial visit and upon completion of the presurgical orthodontic treatment. Patients with occlusal discrepancies larger than 6 mm and severe palatal scaring underwent Distraction osteogenesis (DO) to advance the maxilla. Patients with an occlusal discrepancy of 6 mm or less, underwent traditional orthognathic surgery including le fort I advancement and Bilateral sagittal split osteotomy (BSSO) to seat the mandible in occlusion. Results: Five patients underwent orthognathic surgery. Two of them underwent double jaw surgery. Three underwent single jaw conventional le fort l advancement. Four patients required bone grafting to repair the residual alveolar defect and to augment the midface deficiency. Nine patients with severe maxillary hypoplasia underwent maxillary advancement using distraction osteogenesis. Conclusion: Patients with a severe maxillary hypoplasia of 6 mm or more and excessive palatal scaring are successfully treated with DO. Conventional le fort I is reserved for patients with less severe maxillary hypoplasia. Both techniques gave promising results providing having followed the proper selection criteria. 展开更多
关键词 CLEFT lip and palate HYPOPLASIA MAXILLA MIDFACE Class III RED DISTRACTION Osteogenesis
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Epidemiology, Clinical Aspects and Management of Cleft Lip and/or Palate in Burkina Faso: A Humanitarian Pediatric Surgery-Based Study
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作者 Kisito Nagalo Isso Ouédraogo +2 位作者 Jean-Martin Laberge Louise Caouette-Laberge Jean Turgeon 《Open Journal of Pediatrics》 2015年第2期113-120,共8页
Background: Cleft lip and/or palate are the most common orofacial malformations. Many studies, especially in developed countries have been conducted on this malformation, but in Burkina Faso, data are scarce and they ... Background: Cleft lip and/or palate are the most common orofacial malformations. Many studies, especially in developed countries have been conducted on this malformation, but in Burkina Faso, data are scarce and they are not specific to children. The aim of this study was to report the epidemiological, clinical and therapeutic aspects of cleft lip and/or palate in children in a low-income country. Materials and Method: The authors conducted a retrospective descriptive study based on data of three humanitarian missions of pediatric reconstructive facial surgery which took place in 2007, 2010 and 2014 at Clinique El Fateh-Suka in Ouagadougou, Burkina Faso. All children of 0 - 14 years of age, presenting with cleft lip and/or palate, were included in the study. Results: A total of 185 cases of cleft lip and/or palate were seen during these three humanitarian surgery missions. There were 100 boys and 85 girls. The average age of the children was 2.4 ± 3.2 years [0 - 12 years];there were 8.7% newborns. The commonest type of cleft was cleft lip and palate (49.7%) followed by isolated cleft lip (48.7%) and isolated cleft palate (1.6%). The left side was the most affected (49.2%). In 21.1% of cases, clefts were associated with other congenital malformations. In total, 150 of 185 (81.1%) children underwent surgery and there were no postoperative complications reported. Conclusions: Epidemiological and clinical characteristics of cleft lip and/or palate observed in this study are not very different from those described elsewhere in Africa. However, in our conditions, there are circumstances and structural factors which hinder the diagnosis and constitute challenges that must be addressed for adequate management of this congenital, highly disfiguring malformation. 展开更多
关键词 OROFACIAL CLEFTS CLEFT lip and/or palate Congenital MALFORMATIONS HUMANITARIAN Surgery International Cooperation
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Malonylcarnitine in Newborns with Non-syndromic Cleft Lip with or without Cleft Palate
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作者 Kamil Konrad Hozyasz Mariusz Oltarzewski Zofia Dudkiewicz 《International Journal of Oral Science》 SCIE CAS CSCD 2010年第3期136-141,共6页
Aim Malonyl-CoA is regarded as a key signaling molecule in mammalian ceils. It is converted to acetyl-CoA, and to a lesser extent, to malonyl acid and malonylcamitine (C3DC). Availability of carnitine has been repor... Aim Malonyl-CoA is regarded as a key signaling molecule in mammalian ceils. It is converted to acetyl-CoA, and to a lesser extent, to malonyl acid and malonylcamitine (C3DC). Availability of carnitine has been reported to be essential for the developing fetus. The objectives of the present study were to analyze associations of malonylcarnitine, acetylcarnitine (C2), and free carnitine (CO) in subjects with orofacial clefts. Methodology We performed a retrospective analysis of carnitine concentration obtained from a newborn screening program carried out in our institution. Concentrations of whole blood malonylcarnitine, acetylcarnitine, and free carnitine were measured using tandem mass spectrometry. The study group consisted of 51 children with nonsyndromic cleft lip with or without cleft palate. In total, 106 healthy children without congenital anomalies served as controls. Cut-off points were established using likeli-hood ratio values. Results The mean concentration of malonylcarnitine in the cleft group was lower than that of the control group, 0.048 μmol.L^1 vs. 0.058 μmol.L^-1, respectively (P=-0.009). In patients with orofacial cleft, low malonylcarnitine levels (〈0.047 μmol.L-1) were 1.7 times more predominant than in healthy individuals (P=-0.03). The mean concentration of acetylcarnitine was also lower in affected newborns in comparison to controls, 33.8 μol.L^-1 vs. 37.8 μmol·L^-1, respectively (P=-0.026). After analysis of acetylearnitine and free carnitine concentrations, the likelihood ratio test did not indicate valuable cut-offpoints. Conclusion The study provides initial data indicating a potential association between decreased malonylcarnitine and abnormal palatogenesis. 展开更多
关键词 cleft palate MALONYL-COA carnitines fatty acids BIOTIN
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