Differential diagnoses and treatment of lipedema

Lipedema is a frequently unrecognized and misdiagnosed disorder of the fatty tissue of extremities and hips,which affects almost purely women.The beginning of the disease usually occurs with hormonal changes,such as puberty,pregnancy,or menopause.Women suffer from pain,easy bruising,and disfigurement,which may lead to early immobility and social stress.Accurate diagnosis and treatment are essential.The differentiation between obesity and lipedema is difficult,as these two different entities often occur together.Other differential diagnoses are lymphedema,benign lipohypertrophy,and Dercum's disease.A therapy targeting the underlying cause of lipedema is not available because the exact etiology of the disorder is not clarified yet.Decongestive physical therapy is the basic conservative treatment,which is usually necessary lifelong.However,liposuction has led to a paradigm shift in the treatment of lipedema.The purposes of this article are to describe the symptoms and treatment options of the still fairly unknown disease Lipedema and to show the distinctions to its differential diagnoses.

脂肪水肿研究现状

脂肪水肿是以局部脂肪沉积为主要临床表现的疾病,常表现为四肢、臀部及髋关节皮下脂肪组织不成比例地增加,临床上常将其误诊为肥胖症或淋巴水肿。其发病机制不明确,临床治疗方法没有统一标准。该文对脂肪水肿发病机制的研究情况进行了阐述,并从临床表现及分类、诊断与鉴别诊断、治疗方法等方面进行了总结,以提高对脂肪水肿的认识。

罕见原发性双下肢巨大脂肪水肿一例及文献回顾

脂肪水肿是继发于局部脂肪沉积，以下肢对称性增粗为特征的一种疼痛性疾病，或称痛性脂肪综合征（painful fat syndrome）。多发生于女性，青春期和妊娠期增粗明显，表现为疼痛、针刺样不适感。本病并不罕见，但由于临床医师对此病的认知不足，故常易与肥胖、原发性或继发性淋巴水肿相混淆。由于脂肪水肿常伴发慢性下肢静脉病变、淋巴功能不全及早期关节退行性变等并发症，因此，对其作出及时、正确的诊断和治疗是至关重要的。通过检索中国期刊全文数据库的相关文章，并查阅相关的专著，未见有关报道。现就脂肪水肿的病因、症状、体征、组织病理改变、诊断和鉴别诊断以及并发症结合文献总结，以期为临床医师提供有益的参考。

原发性双侧下肢脂肪水肿的相关研究与进展

脂肪水肿是继发于局部脂肪异常沉积，以下肢对称性增粗为特征的一种疾病，多发生于女性，尤以青春期和妊娠期为主，在其早期阶段易与淋巴水肿相混淆。通过广泛查阅近年来关于原发性脂肪水肿的相关文献，就脂肪水肿的临床症状体征、诊断治疗进行总结，以期为临床医师提供有益的参考。