Aim: To find out whether the response of testicular oxidative stress parameters to hexachlorocyclohexane (HCH) is species specific. Methods: In rats and mice (n=5 in each group), HCH was administered at a dose of 20 m...Aim: To find out whether the response of testicular oxidative stress parameters to hexachlorocyclohexane (HCH) is species specific. Methods: In rats and mice (n=5 in each group), HCH was administered at a dose of 20 mg/kg/day intraperitoneally for 30 days in 0.1 ml of refined groundnut oil. The control groups received equal volume of the vehicle. Animals were sacrificed 24 hours after the last injection and various oxidative stress parameters were measured immediately. Results: The level of both endogenous as well as FeSO_4 and ascorbic acid-stimulated lipid peroxidation was increased significantly in the HCH-treated rats, whereas the pattern was just the reverse in case of mice. Although the level of H_2O_2 content increased in response to HCH in both groups, a totally different trend was observed for the activity of the principal H_2O_2-metabolising enzyme, catalase. In case of rats, a significant decline in the activity of catalase was recorded in response to HCH whereas a sharp augmentation in the enzyme activity was noticed in mice. Similarly, the decreased activity of superoxide dismutase observed in rats remained unaltered in mice. Conclusion: HCH induces oxidative stress in the testis of both rats and mice. However, the pattern of response of testicular oxidative stress parameters seems to be species specific.展开更多
目的观察以智能化6分钟步行试验为指导制定的个体化运动方案对老年糖尿病患者的影响。方法选取2022年6月-12月于某市三甲医院就诊的老年糖尿病患者95例,将其随机分为观察组49例与对照组46例。对照组每周进行中等强度的运动150 min以上,...目的观察以智能化6分钟步行试验为指导制定的个体化运动方案对老年糖尿病患者的影响。方法选取2022年6月-12月于某市三甲医院就诊的老年糖尿病患者95例,将其随机分为观察组49例与对照组46例。对照组每周进行中等强度的运动150 min以上,观察组基于智能化6分钟步行试验结果制定个体化的运动处方指导运动。比较干预前及干预12周后2组空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平,糖化血红蛋白和体质指数(body mass index,BMI)。结果干预12周后,观察组BMI、总胆固醇、三酰甘油、空腹血糖、糖化血红蛋白均低于对照组(t=2.327,P=0.022;t=2.134,P=0.035;t=2.480,P=0.015;t=2.295,P=0.024;t=2.050,P=0.043)。结论以智能化6分钟步行试验为指导制定的个体化运动方案,能有效降低老年糖尿病患者的糖脂代谢指标和BMI。展开更多
Oxidative stress has been identified as one of the factors that affects fertility status. Therefore, this study sought to investigate the inhibitory effect of aqueous extract of Moringa oleifera and Newbuoldia laevis ...Oxidative stress has been identified as one of the factors that affects fertility status. Therefore, this study sought to investigate the inhibitory effect of aqueous extract of Moringa oleifera and Newbuoldia laevis leaves on FeSO4 and Sodium Nitroprusside (SNP) induced lipid peroxidation in rat testes in vitro. Incubation of the testes tissue homogenate in the presence of FeSO4 and SNP caused a significant increase in the malondialdehyde (MDA) contents of the testes. The aqueous extract from both Moringa oleifera and Newbuoldia laevis leaves caused a significant decrease in the MDA contents of the testes in a dose-dependent manner. However, aqueous extract from Moringa oleifera leaf (EC50 = 0.29 mg/ml) had a significant (P2+ induced lipid peroxidation in the rat testes homogenate than that of Newbuoldia laevis leaf extract (EC50 = 0.58 mg/ml);while there was no significant (P2+ chelating and reducing power. Therefore, these plants have potential to prevent oxidative stress in testes and improve fertility outcomes.展开更多
Usage of lipid lowering drugs is a common therapeutic steps in preventing or treating diseases. With the advent of Pharmacogenetics and Pharmacogenomics, it is now important to understand the implication of pharmacoge...Usage of lipid lowering drugs is a common therapeutic steps in preventing or treating diseases. With the advent of Pharmacogenetics and Pharmacogenomics, it is now important to understand the implication of pharmacogenetic testing in patient care. Ethical and economic concerns are wide considered to be an issue in a pharmacy setting and it is important that the health care professionals in the pharmacy setting need to be aware. This article encompasses current pharmacogenomic information that is relevant to lipid homeostasis and addressed the concerns of patient that may be a factor in ultimate decision making process.展开更多
文摘Aim: To find out whether the response of testicular oxidative stress parameters to hexachlorocyclohexane (HCH) is species specific. Methods: In rats and mice (n=5 in each group), HCH was administered at a dose of 20 mg/kg/day intraperitoneally for 30 days in 0.1 ml of refined groundnut oil. The control groups received equal volume of the vehicle. Animals were sacrificed 24 hours after the last injection and various oxidative stress parameters were measured immediately. Results: The level of both endogenous as well as FeSO_4 and ascorbic acid-stimulated lipid peroxidation was increased significantly in the HCH-treated rats, whereas the pattern was just the reverse in case of mice. Although the level of H_2O_2 content increased in response to HCH in both groups, a totally different trend was observed for the activity of the principal H_2O_2-metabolising enzyme, catalase. In case of rats, a significant decline in the activity of catalase was recorded in response to HCH whereas a sharp augmentation in the enzyme activity was noticed in mice. Similarly, the decreased activity of superoxide dismutase observed in rats remained unaltered in mice. Conclusion: HCH induces oxidative stress in the testis of both rats and mice. However, the pattern of response of testicular oxidative stress parameters seems to be species specific.
文摘目的观察以智能化6分钟步行试验为指导制定的个体化运动方案对老年糖尿病患者的影响。方法选取2022年6月-12月于某市三甲医院就诊的老年糖尿病患者95例,将其随机分为观察组49例与对照组46例。对照组每周进行中等强度的运动150 min以上,观察组基于智能化6分钟步行试验结果制定个体化的运动处方指导运动。比较干预前及干预12周后2组空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平,糖化血红蛋白和体质指数(body mass index,BMI)。结果干预12周后,观察组BMI、总胆固醇、三酰甘油、空腹血糖、糖化血红蛋白均低于对照组(t=2.327,P=0.022;t=2.134,P=0.035;t=2.480,P=0.015;t=2.295,P=0.024;t=2.050,P=0.043)。结论以智能化6分钟步行试验为指导制定的个体化运动方案,能有效降低老年糖尿病患者的糖脂代谢指标和BMI。
文摘Oxidative stress has been identified as one of the factors that affects fertility status. Therefore, this study sought to investigate the inhibitory effect of aqueous extract of Moringa oleifera and Newbuoldia laevis leaves on FeSO4 and Sodium Nitroprusside (SNP) induced lipid peroxidation in rat testes in vitro. Incubation of the testes tissue homogenate in the presence of FeSO4 and SNP caused a significant increase in the malondialdehyde (MDA) contents of the testes. The aqueous extract from both Moringa oleifera and Newbuoldia laevis leaves caused a significant decrease in the MDA contents of the testes in a dose-dependent manner. However, aqueous extract from Moringa oleifera leaf (EC50 = 0.29 mg/ml) had a significant (P2+ induced lipid peroxidation in the rat testes homogenate than that of Newbuoldia laevis leaf extract (EC50 = 0.58 mg/ml);while there was no significant (P2+ chelating and reducing power. Therefore, these plants have potential to prevent oxidative stress in testes and improve fertility outcomes.
文摘Usage of lipid lowering drugs is a common therapeutic steps in preventing or treating diseases. With the advent of Pharmacogenetics and Pharmacogenomics, it is now important to understand the implication of pharmacogenetic testing in patient care. Ethical and economic concerns are wide considered to be an issue in a pharmacy setting and it is important that the health care professionals in the pharmacy setting need to be aware. This article encompasses current pharmacogenomic information that is relevant to lipid homeostasis and addressed the concerns of patient that may be a factor in ultimate decision making process.