Lipoprotein（a） [Lp（a）] is composed of a low density lipoprotein（LDL）-like particle to which apolipoprotein（a）[apo（a）] is linked by a single disulfide bridge. Lp（a） is considered a causal risk factor for is...Lipoprotein（a） [Lp（a）] is composed of a low density lipoprotein（LDL）-like particle to which apolipoprotein（a）[apo（a）] is linked by a single disulfide bridge. Lp（a） is considered a causal risk factor for ischemic cardiovascular disease（CVD） and calcific aortic valve stenosis（CAVS）. The evidence for a causal role of Lp（a） in CVD and CAVS is based on data from large epidemiological databases, mendelian randomization studies, and genome-wide association studies. Despite the well-established role of Lp（a） as a causal risk factor for CVD and CAVS, the underlying mechanisms are not well understood. A key role in the Lp（a） functionality may be played by its oxidized phospholipids（OxPL） content. Importantly, most of circulating OxPL are associated with Lp（a）; however, the underlying mechanisms leading to this preferential sequestration of OxPL on Lp（a） over the other lipoproteins,are mostly unknown. Several studies support the hypothesis that the risk of Lp（a） is primarily driven by its OxPL content.An important role in Lp（a） functionality may be played by the lipoprotein-associated phospholipase A_2（Lp-PLA_2）,an enzyme that catalyzes the degradation of OxPL and is bound to plasma lipoproteins including Lp（a）. The present review article discusses new data on the pathophysiological role of Lp（a） and particularly focuses on the functional role of OxPL and Lp-PLA_2 associated with Lp（a）.展开更多
目的:探讨脂蛋白相关磷脂酶A2(Lp-PLA2)与冠心病(CHD)和2型糖尿病(T2DM)的关系。方法:入选患者200例,分为4组,CHD组80例,T2DM组20例,CHD+T2DM组60例,对照组(非CHD非T2DM组)40例。检测Lp-PLA2及C反应蛋白(CRP)。采用析因设计方差分析研究...目的:探讨脂蛋白相关磷脂酶A2(Lp-PLA2)与冠心病(CHD)和2型糖尿病(T2DM)的关系。方法:入选患者200例,分为4组,CHD组80例,T2DM组20例,CHD+T2DM组60例,对照组(非CHD非T2DM组)40例。检测Lp-PLA2及C反应蛋白(CRP)。采用析因设计方差分析研究Lp-PLA2及CRP与CHD和T2DM的相关性。同时分析CHD合并T2DM患者Lp-PLA2水平与冠脉病变程度的相关性。结果:CHD组、T2DM组、CHD+T2DM组Lp-PLA2及CRP均高于对照组(均P<0.05),且经析因设计方差分析显示CHD和T2DM在CRP及Lp-PLA2升高方面有交互作用(F=7.62,P<0.05;F=9.68,P<0.05)。CHD+T2DM组冠脉Gensini积分大于CHD组(44.15±36.28 vs 60.51±42.58,P=0.020)。CHD组Lp-PLA2水平与Gensini积分呈正相关(r=0.181,P=0.016),CHD+T2DM组Lp-PLA2水平与Gensini积分也呈正相关(r=0.224,P=0.011),且后者相关性更好。结论:CHD和T2DM在CRP及Lp-PLA2升高方面有交互作用;与单纯CHD患者相比,CHD合并T2DM患者Lp-PLA2水平更高,冠脉病变更重。展开更多
文摘Lipoprotein（a） [Lp（a）] is composed of a low density lipoprotein（LDL）-like particle to which apolipoprotein（a）[apo（a）] is linked by a single disulfide bridge. Lp（a） is considered a causal risk factor for ischemic cardiovascular disease（CVD） and calcific aortic valve stenosis（CAVS）. The evidence for a causal role of Lp（a） in CVD and CAVS is based on data from large epidemiological databases, mendelian randomization studies, and genome-wide association studies. Despite the well-established role of Lp（a） as a causal risk factor for CVD and CAVS, the underlying mechanisms are not well understood. A key role in the Lp（a） functionality may be played by its oxidized phospholipids（OxPL） content. Importantly, most of circulating OxPL are associated with Lp（a）; however, the underlying mechanisms leading to this preferential sequestration of OxPL on Lp（a） over the other lipoproteins,are mostly unknown. Several studies support the hypothesis that the risk of Lp（a） is primarily driven by its OxPL content.An important role in Lp（a） functionality may be played by the lipoprotein-associated phospholipase A_2（Lp-PLA_2）,an enzyme that catalyzes the degradation of OxPL and is bound to plasma lipoproteins including Lp（a）. The present review article discusses new data on the pathophysiological role of Lp（a） and particularly focuses on the functional role of OxPL and Lp-PLA_2 associated with Lp（a）.
文摘目的:探讨脂蛋白相关磷脂酶A2(Lp-PLA2)与冠心病(CHD)和2型糖尿病(T2DM)的关系。方法:入选患者200例,分为4组,CHD组80例,T2DM组20例,CHD+T2DM组60例,对照组(非CHD非T2DM组)40例。检测Lp-PLA2及C反应蛋白(CRP)。采用析因设计方差分析研究Lp-PLA2及CRP与CHD和T2DM的相关性。同时分析CHD合并T2DM患者Lp-PLA2水平与冠脉病变程度的相关性。结果:CHD组、T2DM组、CHD+T2DM组Lp-PLA2及CRP均高于对照组(均P<0.05),且经析因设计方差分析显示CHD和T2DM在CRP及Lp-PLA2升高方面有交互作用(F=7.62,P<0.05;F=9.68,P<0.05)。CHD+T2DM组冠脉Gensini积分大于CHD组(44.15±36.28 vs 60.51±42.58,P=0.020)。CHD组Lp-PLA2水平与Gensini积分呈正相关(r=0.181,P=0.016),CHD+T2DM组Lp-PLA2水平与Gensini积分也呈正相关(r=0.224,P=0.011),且后者相关性更好。结论:CHD和T2DM在CRP及Lp-PLA2升高方面有交互作用;与单纯CHD患者相比,CHD合并T2DM患者Lp-PLA2水平更高,冠脉病变更重。
