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CfDNA-based liquid biopsy of cerebrospinal fluid in medulloblastoma
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作者 FU Bing-biao ZHAO Ze-yu +2 位作者 AN Si-long CHEN Hua-shuai ZHAO Jian-nong 《Journal of Hainan Medical University》 CAS 2023年第18期70-74,共5页
Medulloblastoma(MB)is the most common childhood embryonal malignant tumour in the central nervous system.The diagnosis,prognosis and therapeutic targets of MB depend on the molecular characteristics of the tumor,and i... Medulloblastoma(MB)is the most common childhood embryonal malignant tumour in the central nervous system.The diagnosis,prognosis and therapeutic targets of MB depend on the molecular characteristics of the tumor,and it is a great challenge to obtain the tissue samples from the patients with brain tumor.Genomic changes found in cell-free DNA(cfDNA)of cerebrospinal fluid(CSF)can predict genomic changes present in tumor tissue,fluid biopsy of CSF can detect the genomic profile of tumor-associated cfDNA and evaluate cfDNA as a marker of measurable residual disease(MRD)in a relatively noninvasive manner,which provides the evidence of"individualized precision therapy"for MB patients.In this paper,we reviewed the recent studies in medulloblastoma based on cfDNA Liquid Biopsy of CSF. 展开更多
关键词 MEDULLOBLASTOMA liquid biopsy of cerebrospinal fluid cfDNA
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