MYH7 mutation in a pedigree with familial dilated hypertrophic cardiomyopathy:A case report and review of literature

BACKGROUND Hypertrophic cardiomyopathy(HCM)is one of the most prevalent inherited myocardial disorders and is charac-terized by considerable genetic and phenotypic heterogeneity.A subset of patients with HCM progress to a dilated phase of HCM(DPHCM),which is associated with a poor prognosis;however,the underlying pathogenesis remains inadequately understood.CASE SUMMARY In this study,we present a case involving a pedigree with familial DPHCM and conduct a retrospective review of patients with DPHCM with identified gene mutations.Through panel sequencing targeting the coding regions of 312 genes associated with inherited cardiomyopathy,a heterozygous missense mutation(c.746G>A,p.Arg249Glu)in the MYH7 gene was identified in the proband(III-5).Sanger sequencing subsequently confirmed this pathogenic mutation in three additional family members(II-4,III-4,and IV-3).A total of 26 well-documented patients with DPHCM were identified in the literature.Patients with DPHCM are commonly middle-aged and male.The mean age of patients with DPHCM was 53.43±12.79 years.Heart failure,dyspnoea,and atrial fibrillation were the most prevalent symptoms observed,accompanied by an average left ventricular end-diastolic size of 58.62 mm.CONCLUSION Our findings corroborate the pathogenicity of the MYH7(c.746G>A,p.Arg249Glu)mutation for DPHCM and suggest that the Arg249Gln mutation may be responsible for high mortality.

AVAPS通气模式联合TCM监测在慢性阻塞性肺疾病急性加重期患者脱机中的应用价值

目的探讨AVAPS通气模式联合经皮氧/二氧化碳检测仪(TCM)监测在慢性阻塞性肺疾病急性加重(AECOPD)患者有创-无创序贯通气中的应用价值。方法选取行有创通气的老年慢阻肺患者120例,根据无创呼吸机的不同通气模式,将患者脱机后随机分为S/T组及AVAPS组,每组患者60例。所有患者在“出窗”时记录呼吸频率(RR)、心率(HR)、血氧饱和度(SpO_(2))、吸氧浓度(FiO_(2))、序贯性器官功能衰竭评分(SOFA)、白细胞总数、降钙素原、血小板、白蛋白及肌酐等指标,并记录无创机械通气6h后呼吸频率(RR)、心率(HR)、血氧饱和度(SpO_(2))及吸氧浓度(FiO_(2))等指标。同时记录二氧化碳分压(PaCO_(2)),行经皮二氧化碳分压(PtcCO_(2))监测,比较PtcCO_(2)与PaCO_(2)的相关性及治疗前后各生理参数的差异。比较两组患者48h再插管率、距插管时间、ICU住院时间。分析撤机后行无创机械通气6h后PtcCO_(2)变异度对48h再插管的预测效能。结果两组患者“出窗”时各生理参数及PtcCO_(2)值,均无统计学差异(P>0.05)。与S/T组比较,无创通气6h后,AVAPS组的生理参数RR、HR、PtcCO_(2)变异度及ROX指数均有所改善,差异有统计学意义(P<0.05),且AVAPS组的48h再插管率优于S/T组,且距插管时间更长(P<0.05)。ROC曲线分析显示,通气6h后的PtcCO_(2)变异度对AVAPS组患者48h再插管具有一定的诊断效能,其敏感度为92.30%,特异度为82.60%,AUC为0.898。结论AVAPS通气模式联合PtcCO_(2)在重症慢阻肺有创-无创“序贯”治疗的运用,能有更好的生理参数,更低的再插管率,以及更为优势的“人机协调性”。

基于TCM模式的护理干预对胃癌手术患者负性情绪及生活质量的影响

分析胃癌手术患者在倡导TCM的理念下所实施的护理,对其心态和生活健康情况的影响。方法 将2021年3月至2022年3月本院接诊的胃癌手术患者共计92例全部作为研究对象,进行研究分析,利用红蓝球法分为对照组、观察组,每个小组46例患者。对照组实施传统护理,观察组在TCM的理念下进行护理。对比两组护理后的心态、睡眠和生活健康情况。结果 观察组总体心态好转情况均好于对照组,差异表现显著(P<0.05);观察组睡眠好转情况强于对照组,差异表现显著(P<0.05);观察组生活健康评分比对照组更好,差异显著(P<0.05)。结论 对于胃癌手术患者,可采取TCM的理念下的康复护理,能够显著改善患者的心理状态,提高其睡眠情况,同时生活更加健康。

中医药团体标准评价体系(SCORE-TCM)解读

本文全面解读了中医药团体标准评价体系(System of Consortium Standards Rating and Evaluation of Traditional Chinese Medicine,SCORE-TCM)。SCORE-TCM是结合定性与定量评价,全面评估中医药团体标准在制定主体、文本编写、技术内容、推广应用和实施效益等几方面特征的综合评价工具。文中详述了SCORE-TCM的构建目的、定义和构建过程,解释了评价指标体系中的各项指标,并对每项指标的评价材料进行介绍。本文旨在帮助中医药团体标准的制定者、第三方评价机构和其他相关方更好地理解SCORE-TCM各评价条目的含义,更有效地运用于中医药团体标准的自评价或第三方评价,SCORE-TCM将为《中医药团体标准管理办法》的贯彻实施,以及中医药团体标准的高质量发展提供技术支持。

TCM抗阻训练在肥胖型阻塞性睡眠呼吸暂停低通气综合征患者中的应用

目的:探讨过渡期护理(TCM)抗阻训练在肥胖型阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者中的应用效果。方法:选取2022年1月1日~2023年1月1日接受治疗的102例肥胖型OSAHS患者作为研究对象,根据随机数字表法将其分为对照组和研究组各51例。对照组行常规抗阻训练,研究组行TCM抗阻训练;对比两组入院次日、出院1个月时体质指标[包括体质量指数(BMI)、颈围、腹围]、嗜睡程度[采用中文版Epworth嗜睡量表(ESS)]及生活质量[采用睡眠呼吸暂停低通气综合征生命质量评估表(QOL-OSAHS)]。结果:共有102例患者参与研究,其中对照组有1例在中途失访剔除,最后101例患者完整参与研究。出院1个月时,两组BMI、颈围、腹围及均ESS评分均低于入院次日(P<0.05),且研究组低于对照组(P<0.05);出院1个月时,两组QOL-OSAHS评分高于入院次日(P<0.05),且研究组高于对照组(P<0.05)。结论:TCM抗阻训练可有效改善肥胖型OSAHS患者体质指标,提升睡眠质量和生活质量。

Study on TCM Syndrome Types and Syndromes of Knee Osteoarthritis Based on Modern Literature

Objective: To explore the patterns of TCM syndromes and syndrome distribution of knee osteoarthritis through modern literature research. Methods: All journal articles from China Knowledge Network, Wanfang, and China Biomedical Database from January to August 1, 2019 were searched, and documents that met the criteria for inclusion and exclusion were screened out. Knee joints were extracted on the premise of data standardization. Inflammatory syndrome types, syndromes, regional distribution of literature, and commonly cited literature of syndrome reference standards are used to establish a database using an Excel table for analysis using frequency analysis. Results: A total of 2027 articles were included. The geographical distribution of the included articles was mainly East China (23.53%), Central China (19.93%), and South China (19.24%). The commonly cited reference for the knee osteoarthritis syndrome reference standard is "Chinese medicine" Guiding Principles for Clinical Research of New Drugs (47.09%),"Traditional Chinese Medicine Diagnosis and Efficacy Standards" (40.27%), "Traditional Chinese Medicine Diagnosis and Treatment Plan for 95 Major Diseases in 22 Specialties" (4.58%), "Diagnosis and Treatment Plan for Knee Paralysis", " KOA TCM Experts' Consensus (2015 Edition) "," Traditional Chinese Medicine ", the common types of knee osteoarthritis are liver and kidney deficiency (17.65%), blood stasis (12.40%), wind cold and dampness (11.76%) , Cold dampness obstruction, yang deficiency and cold coagulation, liver and kidney deficiency, tendon and blood stasis, qi stagnation and blood stasis syndrome;common disease site syndromes are liver and kidney, and disease syndrome syndromes are dampness, cold, blood stasis, and yin Deficiency, wind, yang deficiency, heat, qi stagnation, fine deficiency, sputum, qi deficiency, and blood deficiency;the most common form of syndrome combination is the combination of two and three syndromes. Conclusion: TCM syndrome types and the distribution of syndrome elements are in line with the current mainstream understanding of the pathogenesis of knee osteoarthritis. The syndrome differentiation of knee osteoarthritis can summarize the main pathogenesis of the disease. Helps to classify TCM syndromes of knee osteoarthritis.

基于SCORE-TCM的中医药团体标准抽样评价方案设计

目前,各社会团体积极参与中医药标准的制定和发布,特别是“十四五”以来,中医药团体标准化工作更是迎来了提质增效的关键阶段。深入评估社会团体发布的中医药标准质量,是推进中医药团体标准工作的关键环节和重点任务。前期已研制并形成了中医药团体标准评价体系(System of Consortium Standards Rating and Evaluation of Traditional Chinese Medicine, SCORETCM)。在上述背景下,本研究通过专家共识法,设计了一套基于SCORE-TCM的中医药团体标准抽样评价方案,应用场景为对于特定社会团体发布的标准,或各团体发布的特定技术类别的标准进行快速评估。该方案涵盖了标准抽样、材料收集、标准评价、结果解读的完整流程,为中医药团体标准的抽样评价工作提供了参考方案。

Chen Shigong,Founder of“TCM Orthodox School of External Medicine”

Chen Shigong,styled name Yuren,was also known by the literary name Ruoxu.Coming from Donghaichongchuan(present Nantong City,Jiangsu Province)he was a famous traditional Chinese medicine(TCM)specialist of external medicine of the Ming Dynasty(1368-1644).The Orthodox Lineage of External Medicine(Wai Ke Zheng Zong)written by him has been valued as the founder of the TCM Orthodox School of External Medicine.

From Research on TCM Images to Historiography of TCM Images——Comments on History of Chinese Image Culture:Medical Image Volume

1 Introduction.Chinese medicine has a long and rich history,dating back to the classics of the Qin and Han dynasties and extending to the integration of Chinese and Western medicine in the modern era.The vast amount of literature and scholarly works in this field makes it essential to thoroughly study the history of traditional Chinese medicine(TCM)in order to understand its development path throughout the ages and boost innovation based on tradition.This is why the sages emphasized the importance of“classifying the works into different schools and tracing back to their origins”(辨章学术,考镜源流).

A Conversation with Professor Ted Kaptchuk,a Key Architect of Modern TCM in the West

The interview was conducted on November 20th,2022 by Ioannis Solos and Charles Buck.Ted Kaptchuk(泰开阳)is a Professor of Medicine and a Professor of Global Health&Social Medicine at Harvard Medical School.In 1975,he graduated from the Macao Institute of Chinese Medicine,Macao,China.After returning to the West,Ted taught Chinese medicine throughout the States,Europe,Latin America,and Australia.Ted’s book,The Web that Has No Weaver:Understanding Chinese Medicine is a groundbreaking explanation of East Asian medicine that continues to shape the discourse of the Chinese medicine profession in the West and has been translated into 13 languages.In 1990,Ted was recruited in Harvard Medical School to help research Chinese medicine.After encountering high placebo responses in multiple acupuncture clinical trials,Ted decided to switch his career to primarily studying placebo.He has published over 300 peer-reviewed articles.He has been awarded the Lifetime Achievement Award from the Society of Acupuncture Research(2015),the Lifetime Achievement Award from the Society for Interdisciplinary Placebo Studies(2021),and the William Silen Lifetime Achievement Award in Mentoring from Harvard Medical School(2022).

The Applicability and Productiveness of a Systematic Literature Review Methodology in Volcanology Research: Case of the Magma Pathway at the Mount Cameroon Volcano

The presented research illustrates the applicability and productiveness of the systematic literature review methodology, a non-empirical methodology in the geological sciences, particularly volcanology. The systematic literature review methodology is a replicable, rigorous, and transparent methodology for synthesizing existing literature to answer questions on a specific topic. The synthesis allows for knowledge consolidation, such as identifying knowledge gaps. In our illustration of this methodology, we focused on the expanding knowledge about the magma pathway at Mount Cameroon, one of Africa’s active volcanoes. Our synthesis of the relevant international geoscience research literature is based on the framework of knowledge about the magma pathway beneath a typical basaltic volcano. The framework has three primary components: magma supply, storage, and transport to erupting vents. Across these components is a total of twelve secondary components. The result is a previously non-existent and fragmented overall understanding of the magma pathway at Mount Cameroon. The gaps in the understanding (such as in the magma supply rates, timescales of chamber processes, and magma ascent rates) may be addressed in future research. Another key implication of the presented research lies in the proof of concept of the systematic literature review methodology as an applicable qualitative research methodology in the study of volcanoes.

Analysis of standardization development of TCM in Sichuan

Sichuan province is home to rich traditional Chinese medicine(TCM)resources.Recent years have seen unremitting efforts of TCM standardization in the province.By analyzing the measures and existing problems,this paper provides recommendations to boost TCM development through standardization.

My Relationship with TCM

A Spanish businessman becomes a dedicated advocate of traditional Chinese medicine after witnessing its effects in treating his terminally ill young son.MY relationship with traditional Chinese medicine(TCM)-and with China-began in 1988,when I traveled to Beijing with my two-year-old son Joan.He was suffering from an extremely rare disease called leukoencephalopathy,in which the brain is affected,and we wanted to explore treatment possibilities.

Classification research of TCM pulse conditions based on multi-label voice analysis

Objective:To explore the feasibility of remotely obtaining complex information on traditional Chinese medicine(TCM)pulse conditions through voice signals.Methods: We used multi-label pulse conditions as the entry point and modeled and analyzed TCM pulse diagnosis by combining voice analysis and machine learning.Audio features were extracted from voice recordings in the TCM pulse condition dataset.The obtained features were combined with information from tongue and facial diagnoses.A multi-label pulse condition voice classification DNN model was built using 10-fold cross-validation,and the modeling methods were validated using publicly available datasets.Results: The analysis showed that the proposed method achieved an accuracy of 92.59%on the public dataset.The accuracies of the three single-label pulse manifestation models in the test set were 94.27%,96.35%,and 95.39%.The absolute accuracy of the multi-label model was 92.74%.Conclusion: Voice data analysis may serve as a remote adjunct to the TCM diagnostic method for pulse condition assessment.

Relation and Relationships Between Folk Literature and Classical Literature:Taking Autochthony as a Case Study

According to current discipline classification,folk literature is usually categorized as an individual research field,distinguished from classical literature or classical canon,which leads to the fact that in current research,the study of folk literature is often separated from the study of classical texts,or even opposed to it.This paper intends to review the relations and relationships between the two and argues that,at least,in ancient Greek world of culture,there is a considerable intersection between folk literature and classical literature.In many cases,a myth appeared both in the two literary fields,and thus these two fields were often intertwined and in conversation.Taking Athenian autochthony as a case study,this paper shows that this myth not only appeared as a folk story in daily occasions such as symposium,architecture,and vase painting,but also entered classic texts such as the tragic works of the three great tragedians and even Plato’s philosophical works,becoming one part of“classical literature”.By examining the application of the myth in folk literature and classical literature,it can be seen that in ancient Greece,folk and classical literature not only communicated and borrowed from each other,but also formed a dialogue between the two,thus constructing a lively and living literary world.

Therapeutic Communication Methods Targeting Families and Family Members: A Literature Review

Background and Purpose: Therapeutic communication is a new term in family health care nursing, defined by Hohashi (2019) as a method of family intervention, and characterized by inclusion of not only verbal conversation but also nonverbal interaction. However, specific therapeutic communication methods have not been systematized. The purpose of this study was to clarify therapeutic communication methods for families/family members from the perspectives of verbal communication and non-verbal communication through a review of existing literature. Methods: We conducted a search using the medical literature databases PubMed and Ichushi-Web using the keywords “therapeutic communication”. Analysis was performed on seven articles from PubMed and 14 articles from Ichushi-Web that described therapeutic communication methods performed by healthcare professionals for families/family members. Through directed content analysis, therapeutic communication methods were subcategorized, and classified into three categories: verbal communication, non-verbal communication, and verbal/non-verbal communication. Results: A total of 23 subcategories were extracted. Verbal communication included 11 subcategories, such as “asking questions using the communicatee’s words as they are”. Non-verbal communication included five subcategories, such as “noticing changes in the content of the communicatee’s story”. And verbal/non-verbal communication featured seven subcategories, such as “making the communicatee aware of one’s own beliefs”. Conclusion: Therapeutic communication methods included basic care/caring in family interviews/meetings, as well as verbal communication and non-verbal communication that act on family/family members’ beliefs. It is believed that changes in family/family members’ beliefs can be used to eliminate, reduce, or improve problematic conditions in the family. .

Research Status of TCM Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD)

This paper mainly analyzes the application status of TCM rehabilitation in chronic obstructive pulmonary disease(COPD),hoping to provide support and help for clinical staff through this study,and promote the further development of COPD rehabilitation program.

Unexpected right-sided sigmoid colon in laparoscopy: A case report and review of literature

BACKGROUND The presence of a right-sided sigmoid colon is a rare anatomical variation usually discovered incidentally during surgical interventions.This case report details an unexpected right-sided sigmoid colon identified during a laparoscopic appendectomy and examines the pertinent literature to explore its clinical importance.CASE SUMMARY A 71-year-old woman presented with acute appendicitis.A preoperative computed tomography(CT)scan showed peri-appendiceal inflammation but no significant anatomical abnormalities.During laparoscopic surgery,an unexpected finding was encountered:The sigmoid colon was situated on the right side and exhibited an abnormal relationship with the cecum and ascending colon.Postoperative pathological examination confirmed appendicitis with no additional pathological findings.The right-sided sigmoid colon anomaly was verified through intraoperative assessment and later re-evaluation with CT and colonographic imaging.The patient underwent a laparoscopic appendectomy and experienced a smooth postoperative recovery.CONCLUSION This case highlights the necessity of being attentive to anatomical variations during laparoscopic surgery,particularly when managing appendicitis.A review of the literature indicated that the occurrence of a right-sided sigmoid colon is infrequent and may be associated with anomalies in midgut rotation during embryonic development.Awareness of this variation can help prevent surgical complications and inform future clinical practice.

Exploring the Future Of TCM Cooperation--2024 China-ASEAN Traditional Chinese Medicine Industry Exchange and Promotion Conference in Taiyuan

“Traditional Chinese medicine(TCM)is very popular in Cambodia because it can treat a variety of diseases,”said Nhek Soparama,ministercounselor of the Embassy of Cambodia in China,at the 2024 China-ASEAN Traditional Chinese Medicine Industry Exchange and Promotion Conference in Taiyuan,Shanxi Province,on July 26.“Over the past two years,more than 20,000 Cambodians have received TCM treatment.”

“十七年”时期《中国文学》(Chinese Literature)“计划翻译模式”研究

“十七年”时期以《中国文学》(Chinese Literature)和外文出版社为代表的国家翻译机构翻译实践形成了一种特殊的翻译模式,即“计划翻译模式”。首先,作为中国文学对外翻译的组织者与业务负责人,叶君健经过“下乡”完成知识分子身份认同和思想认识的改造。其次,作为冷战时期中国国家对外文化交流的窗口,《中国文学》精心设计翻译策略,开展国家文学翻译实践。再次,作为国家翻译机构和国家文化单位,外文出版社服务于国家对外宣传的翻译目的。最后,翻译界经过组织化、计划化的整合,成为社会主义文化建设的工具,中国文学对外翻译是冷战时期重要的国家文化工程。