Early postsurgical lethal outcome due to splenic littoral cell angioma:A case report

BACKGROUND Littoral cell angioma(LCA)is a rare benign vascular tumor of the spleen.Given its rarity,standard diagnostic and therapeutic recommendations have yet to be developed for reported cases.Splenectomy is the only method of obtaining a pathological diagnosis and providing treatment to obtain a favorable prognosis.CASE SUMMARY A 33-year-old female presented with abdominal pain for one month.Computed tomography and ultrasound revealed splenomegaly with multiple lesions and two accessory spleens.The patient underwent laparoscopic total splenectomy and accessory splenectomy,and splenic LCA was confirmed by pathology.Four months after surgery,the patient presented with acute liver failure,was readmitted,rapidly progressed to multiple organ dysfunction syndrome and died.CONCLUSION Preoperative diagnosis of LCA is challenging.We systematically reviewed online databases to identify the relevant literature and found a close relationship between malignancy and immunodysregulation.When a patient suffers from both splenic tumors and malignancy or immune-related disease,LCA is possible.Due to potential malignancy,total splenectomy(including accessory spleen)and regular follow-up after surgery are recommended.If LCA is diagnosed after surgery,a comprehensive postoperative examination is needed.

Multiple disciplinary team management of rare primary splenic malignancy:Two case reports

BACKGROUND Malignant splenic tumors are rare but fatal,presenting a challenge in diagnosis and management involving hematology,oncology,and general surgery.By contrast,diagnosing and treating other common malignant tumors(such as lung and gastrointestinal cancer)offers multiple strategies for chemotherapy,radiotherapy,targeted therapy,and immunotherapy with the prospect of a cure.With various specialists involved in clinical multiple disciplinary team(MDT)discussion,personal bias can be minimized.It can also ignite important discussion which can benefit not only one patient but many patients.CASE SUMMARY Here,we report on the MDT diagnosis and management of the malignant splenic tumors littoral cell angiosarcoma and histiocytic sarcoma.Although only two cases of rare primary splenic malignancy are presented,MDT is a novel means of rare disease treatment.CONCLUSION To benefit patients,imaging analysis,safe operation,precise pathology examination,and individualized therapeutic treatment strategies are required.The involvement of various specialists in a clinical MDT discussion minimizes personal bias and can create important ideas to benefit all patients.

Sea-level rise impact on the evolution of a microtidal Mediterranean coastline without human-made structures——a case of the Port aux Princes-Sidi Daoued coastline,Gulf of Tunis,NE-Tunisia

The evolution of the natural and pristine Mediterranean coastline Port aux Princes-Sidi Daoued(Gulf of Tunis,NE-Tunisia) is studied during the period of 1887–2010 on the basis of an ancient minute of bathymetry(1887) and aerial photographs treated by numerical photogrammetric methods. Morphological changes of the coastline shows a general retreat despite the absence of the various anthropogenic actions. Adding to the drift currents and the currents of high energy that are generated by the N-W dominant waves along steeply sub-marine funds, the erosion is mainly due to the sea level rise which increased since the beginning of the 2000 s. The Port aux PrincesSidi Daoued coastline works as a single littoral cell limited by Jbel Korbous to the SW and the fishing harbor of Sidi Daoued to the N-E.

Littoral cell angioma of the spleen： report of three cases and a review of the literature

Littoral cell angioma is a recently described rare vascular tumor of the spleen. The clinical course of this benign tumor is asymptomatic in most patients. Herein, we described three patients with littoral cell angioma detected during physical examination. A brief discussion and review of a handful of cases of splenic littoral cell angioma, which have been previously reported in the English language literature, are performed in this PaPer.