Dissimilar survival and clinicopathological characteristics of mucinous adenocarcinoma located in pancreatic head and body/tail

BACKGROUND Growing evidence shows that pancreatic tumors in different anatomical locations have different characteristics,which have a significant impact on prognosis.However,no study has reported the differences between pancreatic mucinous adenocarcinoma(PMAC)in the head vs the body/tail of the pancreas.AIM To investigate the differences in survival and clinicopathological characteristics between PMAC in the head and body/tail of pancreas.METHODS A total of 2058 PMAC patients from the Surveillance,Epidemiology,and End Results database diagnosed between 1992 and 2017 were retrospectively reviewed.We divided the patients who met the inclusion criteria into pancreatic head group(PHG)and pancreatic body/tail group(PBTG).The relationship between two groups and risk of invasive factors was identified using logistic regression analysis.Kaplan-Meier analysis and Cox regression analysis were conducted to compare the overall survival(OS)and cancer-specific survival(CSS)of two patient groups.RESULTS In total,271 PMAC patients were included in the study.The 1-year,3-year,and 5-year OS rates of these patients were 51.6%,23.5%,and 13.6%,respectively.The 1-year,3-year,and 5-year CSS rates were 53.2%,26.2%,and 17.4%,respectively.The median OS of PHG patients was longer than that of PBTG patients(18 vs 7.5 mo,P<0.001).Compared to PHG patients,PBTG patients had a greater risk of metastases[odds ratio(OR)=2.747,95%confidence interval(CI):1.628-4.636,P<0.001]and higher staging(OR=3.204,95%CI:1.895-5.415,P<0.001).Survival analysis revealed that age<65 years,male sex,low grade(G1-G2),low stage,systemic therapy,and PMAC located at the pancreatic head led to longer OS and CSS(all P<0.05).The location of PMAC was an independent prognostic factor for CSS[hazard ratio(HR)=0.7,95%CI:0.52-0.94,P=0.017].Further analysis demonstrated that OS and CSS of PHG were significantly better than PBTG in advanced stage(stage III-IV).CONCLUSION Compared to the pancreatic body/tail,PMAC located in the pancreatic head has better survival and favorable clinicopathological characteristics.

Linux文件搜索命令解析以及locate命令查询优化

随着linux系统逐渐被广泛使用，系统使用者一般使用命令行的方式操作系统包括文件查找，特别是将linux系统作为服务器时，在数量众多的文件中找到需要的文件需要消耗很多时间，为了更快找到所需要的文件，针对现有的两种linux文件搜索命令的实现原理以及实现过程进行剖析，以及对著名的Boyer-Moore串匹配算法进行分析后，使用改进的BM算法对其中一种搜索命令即locate命令中字符串匹配算法进行优化，对改进算法的复杂度进行分析发现，在文件名的字符串匹配过程中与原来KMP算法相比较具有更高的效率，查找的速度更快。

Three-dimensional morphometric analysis for hepatectomy of centrally located hepatocellular carcinoma:A pilot study

AIM: To describe a three-dimensional model(3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas(HCCs).METHODS: From March 2013 to July 2014, reconstructions and visual simulations of centrally located HCCs were performed in 39 patients using a 3D subject-based computed tomography(CT) model with customdeveloped software. CT images were used for the 3D reconstruction of Couinaud's pedicles and hepatic veins, and the calculation of corresponding tumor territories and hepatic segments was performed using Yorktal DMIT software. The respective volume, surgical margin, and simulated virtual resection of tumors were also estimated by this model preoperatively. All patients were treated surgically and the results were retrospectively assessed. Clinical characteristics, imaging data, procedure variables, pathologic features, and postoperative data were recorded and compared to determine the reliability of the model.RESULTS: 3D reconstruction allowed stereoscopic identification of the spatial relationships between physiologic and pathologic structures, and offered quantifiable liver resection proposals based on individualized liver anatomy. The predicted values were consistent with the actual values for tumor mass volume(82.4 ± 109.1 m L vs 84.1 ± 108.9 m L, P = 0.910), surgical margin(10.1 ± 6.2 mm vs 9.1 ± 5.9 mm, P = 0.488), and maximum tumor diameter(4.61 ± 2.16 cm vs 4.53 ± 2.14 cm, P = 0.871). In addition,the number and extent of portal venous ramifications, as well as their relation to hepatic veins, were visualized. Preoperative planning based on simulated resection facilitated complete resection of large tumors located in the confluence of major vessels. And most of the predicted data were correlated with intraoperative findings.CONCLUSION: This 3DM provides quantitative morphometry of tumor masses and a stereo-relationship with adjacent structures, thus providing a promising technique for the management of centrally located HCCs.

Management of centrally located hepatocellular carcinoma:Update 2016

Centrally located hepatocellular carcinoma(HCC)is sited in the central part of the liver and adjacent to main hepatic vascular structures.This special location is associated with an increase in the difficulty of surgery,aggregation of the recurrence disease,and greater challenge in disease management.This review summarizes the evolution of our understanding for centrally located HCC and discusses the development of treatment strategies,surgical approaches and recurrence prevention methods.To improve patient survival,a multi-disciplinary modality is greatly needed throughout the whole treatment period.

Earthquake detection in the Jiangsu region, China using graphics-processing-unit-based Match & Locate and rapid earthquake association and location

Earthquake detection and location are essential in earthquake studies,which generally consists of two main classes:waveform-based and pick-based methods.To evaluate the ability of two different methods,a graphicsprocessing-unit-based Match&Locate(GPU-M&L)method and a rapid earthquake association and location(REAL)method are applied to continuous seismic data recorded by 24 digital seismic stations from Jiangsu Seismic Network during 2013 for comparison.GPU-M&L is one of waveform-based methods by waveform cross-correlations while REAL is one of pick-based method to associate arrivals of different seismic phases and locate events through counting the number of P and S picks and travel time residuals.Twenty-six templates are selected from the Jiangsu Seismic Network local catalog by using the GPU-M&L.The number of newly detected and located events is about 2.8 times more than those listed in the local catalog.We both utilize a deep-neural-network-based arrival-time picking method called PhaseNet and a shortterm/long-term average(STA/LTA)trigger algorithm for seismic phase detection and picking by applying the REAL.We then refine seismic locations using a least-squares location method(VELEST)and a high-precision relative location method(hypoDD).By applying STA/LTA and PhaseNet,1006 and 1893 events are associated and located,respectively.The newly detected events are mainly clustered and show steeply dipping fault planes.By analyzing the performance of these methods based on long-term continuous seismic data,the detected catalogs by the GPU-M&L and REAL show that the magnitudes of completeness are 1.4 and 0.8,respectively,which are smaller than 2.6 given by the local catalog.Although REAL provides improvement compared with GPU-M&L,REAL is highly dependent on phase detection and picking which is strongly affected by signal-noise ratio(SNR).Stations at southeast of the study region with low SNR may lead to few detections in the same area.

Serous macular detachment due to nasally located optic disc pit-coloboma

Dear Editor,We present the first reported case of nasal optic disc pit resulting in serous detachment of the macula. Optic disc pit is a rare congenital anomaly occurring in one out of 11 000 people. The appearance is a localized round or oval depression in that is grey, yellow or black in colour depending on the amount of glial tissue present.

Acute airway emergency caused by an organic foreign body located in the laryngeal mucosa

INTRODUCTION Organic material(e.g.nuts in children and bones or food in adults)is the most common foreign body inhaled by patients.Just one tenth of all foreign bodies in the airway are located in the larynx.^([1])Laryngeal foreign bodies among adults are rarely seen but can be a life threatening

Effects of Long-term Located Fertilization on Evolution of Available Phosphorus and Phosphorus Pool in Shandong Fluvo-aquic Soil

This study was conducted to investigate the effects of long-term located fertilization on soil phosphorus,the changes of soil available phosphorus（ OlsenP）,the evolution of soil total phosphorus（ TP） and the ratio change of Olsen-P to TP（ PAC） by 33-year fertilization experiments in winter wheat-summer maize rotation system in Shandong fluvo-aquic soil. Eight treatments were designed as no fertilization（ CK）,nitrogen fertilizer（ N）,nitrogen and phosphate fertilizer（ NP）,nitrogen and potassium fertilizer（ NK）,phosphate and potassium fertilizer（ PK）,nitrogen-phosphate-potassium fertilizer（ NPK）,reduced NPK fertilizer（ N（15） PK）,and increased NPK fertilizer（ N（25） PK）. Meanwhile,eight organic fertilizer-added treatments were designed based on the application of inorganic fertilizer the same as the above ones. The results showed that TP,Olsen-P and PAC of treatments added with organic fertilizer were higher than those without organic fertilizer,and those of the treatments applied with phosphate fertilizer were higher than those of no phosphate fertilizer. With the increase of years,soil P pool decreased due to crop absorption,nutrient loss and morphological transformation and other causes under the treatments of without and only phosphate fertilizer,while remained stable under the treatments added with organic fertilizer. The PAC values were generally lower in fluvo-aquic soil,and it could be improved by the application of organic fertilizer. On the whole,the application of chemical phosphate fertilizer combined with organic fertilizer could improve the phosphorus content in soil and ensure the supply of phosphorus nutrition. This study would provide scientific basis for fertilization management and soil fertility in fluvo-aquic soil.

Effects of Long-term Located Fertilization on the Physico-chemical Property of Soil Humus

A systematic study concerning the effects of a long-term stationary fertilization on content and property of soil humus in fluvo-aquic soil sampled from Malan Farm, Xinji City, Hebei, and arid red soil and paddy red soil sampled from the Institute of Red Soil, Jinxian County, Jiangxi was conducted. The results showed that long-term fertilization had effects not only on the content and composition of soil humus, but also on the physico-chemical property of humus. With applying organic manure or combined application of organic manure and chemical fertilizer, E4 and E6 values of humic acid decreased in fluvo-aquic soil and arid red soil, but increased in paddy red soil. In paddy red soil, E4 and E6 values of humic acid increased also with a single application of chemical fertilizer, but E4 and E6 values had less change of humic acid in fluvo-aquic soil and arid red soil. The effects on the visible spectroscopic property of f ulvic acid were different from that of humic acid. Long-term application of organic manure or combined application of organic manure and chemical fertilizer could increase E4 and E6 values of f ulvic acid in three types of soil. Single application of chemical fertilizer had less effect on the E4 and E6. Long-term fertilization could also influence the ultraviolet spectroscopic property of humus. With a single application of organic manure or combined application of organic manure and chemical fertilizer, the ultraviolet absorbance of humic acid and f ulvic acid increased in the three types of soil. But this effect was obvious only in short wave length, and the effect could decrease if the wave length increased. With a single application of chemical fertilizer the ultraviolet absorbance of fulvic acid could increase, but it of humic acid increased only in fluvo-aquic soil. Long-term application of organic manure or combined application of organic manure and chemical fertilizer could increase the content of total acidic groups, carboxy groups and phenolic hydroxy groups of humic acid and fuvic acid in the three types of soil. Single application of chemical fertilizer had less effect on the content of total acidic groups, carboxy groups and phenolic hydroxy groups of humic acid and fuvic acid in the three types of soil.

Field experiment using transient energy method to locate a single-phase to ground fault

Distribution networks in China and several other countries are predominantly neutral inefficiently grounding systems(NIGSs),and more than 80%of the faults in distribution networks are single-phase-to-ground(SPG)faults.Because of the weak fault current and imperfect monitoring equipment configurations,methods used to determine the faulty line secti ons with SPG faults in NIGSs are in effective.The developme nt and application of distributi on-level phasor measurement units(PMUs)provide further comprehensive fault information for fault diagnosis in a distribution network.When an SPG fault occurs,the transient energy of the faulted line section tends to be higher than the sum of the transient energies of other line sections.In this regard,transient energy-based fault location algorithms appear to be a promising resolution.In this study,a field test plan was designed and implemented for a 10 kV distribution network.The test results dem on strate the effective ness of the transient en ergy-based SPG locati on method in practical distributi on networks.

ANALYSIS OF EFFECT OF APOPLECTIC HEMIPLEGIA TREATED BY NEEDLING AROUND THE PROJECTIVE AREA ON THE SCALP OF FOCUS LOCATED WITH NUCLEAR MAGNETIC RESONANCE(NMR)

Sixty-one patients of ischemic apoplectic hemiplegia were randomly divided into group ofneedling around the ipsilateral projective area on the scalp of the fOcus (group A) and group of scalpacupuncture (group B). After 30 treatments, there is a significant difference between the therapeuticeffects of two groups (P < 0. 05 ), the former is better than the latter. It suggests that the method ofneedling around the projective area on the scalp of the focus is an effective and a feasible

Clinical significance of distally located periurethral calcification in patients with lower urinary tract symptoms of benign prostate hyperplasia

This study evaluated the association of periurethral calcification(PUC)with uroflowmetric parameters and symptom severity in male patients with lower urinary tract symptoms(LUTS)of benign prostatic hyperplasia(BPH).The data were collected from a prospectively maintained database of 1321 men with LUTS of BPH who visited Chonnam National University Hospital(Gwang-ju,Korea)from January 2015 to December 2019.PUC severity and location were evaluated on the midsagittal plane during transrectal ultrasonography.Relationships among age,prostate-related parameters,International Prostate Symptom Score(IPSS),and uroflowmetric parameters were assessed.Among the 1321 patients in this study,530(40.1%)had PUC.Patients with PUC had significantly higher IPSS(mean±standard deviation[s.d.]:15.1±8.7 vs 13.1±7.9;P<0.001)and lower peak flow rate(Qmax;mean±s.d.:12.4±6.6 ml s^(-1) vs 14.7±13.3 ml s^(-1);P<0.001),compared with patients who did not have PUC.Analyses according to PUC severity revealed that patients with severe PUC had higher prostate-specific antigen(PSA)level(P=0.009),higher total IPSS(P<0.001),lower Qmax(P=0.002),and smaller prostate volume(P<0.001),compared with patients who had non-severe(mild or moderate)PUC.Multivariate analysis showed that distal PUC was independently associated with high total IPSS(P=0.02),voiding symptom score(P=0.04),and storage symptom score(P=0.023),and low Qmax(P=0.015).In conclusion,PUC was significantly associated with worse LUTS parameters in terms of IPSS and Qmax.Furthermore,distally located PUC was independently associated with worse LUTS of BPH in men.

Reviewer Locator模块在科技期刊中的应用实践与发展前景——以《中国肺癌杂志》为例

科技期刊作为科技传播的重要力量,其对重要科研成果的发布速度影响着科学技术的传播效力,而编辑工作效率直接决定稿件发表周期,提高编辑工作效率是科技期刊发展的推进器。为此,从同行评议审稿人储备和遴选方面入手,重点阐述如何准确高效地多维度遴选优质审稿人,归纳并探析Reviewer Locator模块在科技期刊办刊工作中的实际应用经验,助力出版业实现质量更好、效率更高的发展。

The MW5.5 earthquake on August 6,2023,in Pingyuan,Shandong,China:A rupture on a buried fault

On August 6,2023,a magnitude MW5.5 earthquake struck Pingyuan County,Dezhou City,Shandong Province,China.This event was significant as no large earthquakes had been recorded in the region for over a century,and no active fault had been previously identified.This study collects 1309 P-wave arrival times and 866 S-wave arrival times from 74 seismic stations less than 200 km to the epicenter to constrain the spatial distribution of the mainshock and its 125 early aftershocks by the double difference earthquake relocation method,and selects 864 P-waveforms from 288 stations located within 800 km of the epicenter to constrain the focal mechanism solution of the mainshock through centroid moment tensor inversion.The relocation and the inversion indicate,the Pingyuan MW5.5 earthquake was caused by a rupture on a buried fault,likely an extensive segment of the Gaotang fault.This buried fault exhibited a dip of approximately 75°to the northwest,with a strike of 222°,similar to the Gaotang fault.The rupture initiated at the depth of 18.6 km and propagated upward and northeastward.However,the ground surface was not broken.The total duration of the rupture was~6.0 s,releasing the scalar moment of 2.5895×1017 N·m,equivalent to MW5.54.The moment rate reached the maximum only 1.4 seconds after the rupture initiation,and the 90%scalar moment was released in the first 4.6 s.In the first 1.4 seconds of the rupture process,the rupture velocity was estimated to be 2.6 km/s,slower than the local S-wave velocity.As the rupture neared its end,the rupture velocity decreased significantly.This study provides valuable insights into the seismic characteristics of the Pingyuan MW5.5 earthquake,shedding light on the previously unidentified buried fault responsible for the seismic activity in the region.Understanding the behavior of such faults is crucial for assessing seismic hazards and enhancing earthquake preparedness in the future.

Industrial Carbon Emission Distribution and Regional Joint Emission Reduction:A Case Study of Cities in the Pearl River Basin,China

China’s low-carbon development path will make significant contributions to achieving global sustainable development goals.Due to the diverse natural and economic conditions across different regions in China,there exists an imbalance in the distribution of car-bon emissions.Therefore,regional cooperation serves as an effective means to attain low-carbon development.This study examined the pattern of carbon emissions and proposed a potential joint emission reduction strategy by utilizing the industrial carbon emission intens-ity(ICEI)as a crucial factor.We utilized social network analysis and Local Indicators of Spatial Association(LISA)space-time trans-ition matrix to investigate the spatiotemporal connections and discrepancies of ICEI in the cities of the Pearl River Basin(PRB),China from 2010 to 2020.The primary drivers of the ICEI were determined through geographical detectors and multi-scale geographically weighted regression.The results were as follows:1)the overall ICEI in the Pearl River Basin is showing a downward trend,and there is a significant spatial imbalance.2)There are numerous network connections between cities regarding the ICEI,but the network structure is relatively fragile and unstable.3)Economically developed cities such as Guangzhou,Foshan,and Dongguan are in the center of the network while playing an intermediary role.4)Energy consumption,industrialization,per capita GDP,urbanization,science and techno-logy,and productivity are found to be the most influential variables in the spatial differentiation of ICEI,and their combination in-creased the explanatory power of the geographic variation of ICEI.Finally,through the analysis of differences and connections in urban carbon emissions under different economic levels and ICEI,the study suggests joint carbon reduction strategies,which are centered on carbon transfer,financial support,and technological assistance among cities.

Spatial-temporal differentiation and influencing factors of rural settlements in mountainous areas: an example of Liangshan Yi Autonomous Prefecture, Southwestern China

Rural settlement is the basic spatial unit for compact communities in rural area. Scientific exploration of spatial-temporal differentiation and its influencing factors is the premise of spatial layout rationalization. Based on land use data of Liangshan Yi Autonomous Prefecture(hereinafter referred to as Liangshan Prefecture) in Sichuan Province, China from 1980 to 2020, compactness index, fractal dimension, imbalance index, location entropy and the optimal parameters-based geographical detector(OPGD) model are used to analyze the spatial-temporal evolution of the morphological characteristics of rural settlements, and to explore the influence of natural geographical factors, socioeconomic factors, and policy factors on the spatial differentiation of rural settlements. The results show that:(1) From 1980 to 2020, the rural settlements area in Liangshan Prefecture increased by 15.96 km^(2). In space, the rural settlements are generally distributed in a local aggregation, dense in the middle and sparse around the periphery. In 2015, the spatial density and expansion index of rural settlements reached the peak.(2) From 1980 to 2020, the compactness index decreased from 0.7636 to 0.7496, the fractal dimension increased from 1.0283 to 1.0314, and the fragmentation index decreased from 0.1183 to 0.1047. The spatial morphological structure of rural settlements tended to be loose, the shape contour tended to be complex, the degree of fragmentation decreased, and the spatial distribution was significantly imbalanced.(3) The results of OPGD detection in 2015 show that the influence of each factor is slope(0.2371) > traffic accessibility(0.2098) > population(0.1403) > regional GDP(0.1325) > elevation(0.0987) > poverty alleviation(0). The results of OPGD detection in 2020 show that the influence of each factor is slope(0.2339) > traffic accessibility(0.2198) > population(0.1432) > regional GDP(0.1219) > poverty alleviation(0.0992) > elevation(0.093). Natural geographical factors(slope and elevation) are the basic factors affecting the spatial distribution of rural settlements, and rural settlements are widely distributed in the river valley plain and the second half mountain area. Socioeconomic factors(traffic accessibility, population, and regional GDP) have a greater impact on the spatial distribution of rural settlements, which is an important factor affecting the spatial distribution of rural settlements. Policy factors such as poverty alleviation relocation have an indispensable impact on the spatial distribution of rural settlements. The research results can provide decisionmaking basis for the spatial arrangement of rural settlements in Liangshan Prefecture, and optimize the implementation of rural revitalization policies.

A Hybrid and Lightweight Device-to-Server Authentication Technique for the Internet of Things

The Internet of Things(IoT)is a smart networking infrastructure of physical devices,i.e.,things,that are embedded with sensors,actuators,software,and other technologies,to connect and share data with the respective server module.Although IoTs are cornerstones in different application domains,the device’s authenticity,i.e.,of server(s)and ordinary devices,is the most crucial issue and must be resolved on a priority basis.Therefore,various field-proven methodologies were presented to streamline the verification process of the communicating devices;however,location-aware authentication has not been reported as per our knowledge,which is a crucial metric,especially in scenarios where devices are mobile.This paper presents a lightweight and location-aware device-to-server authentication technique where the device’s membership with the nearest server is subjected to its location information along with other measures.Initially,Media Access Control(MAC)address and Advance Encryption Scheme(AES)along with a secret shared key,i.e.,λ_(i) of 128 bits,have been utilized by Trusted Authority(TA)to generate MaskIDs,which are used instead of the original ID,for every device,i.e.,server and member,and are shared in the offline phase.Secondly,TA shares a list of authentic devices,i.e.,server S_(j) and members C_(i),with every device in the IoT for the onward verification process,which is required to be executed before the initialization of the actual communication process.Additionally,every device should be located such that it lies within the coverage area of a server,and this location information is used in the authentication process.A thorough analytical analysis was carried out to check the susceptibility of the proposed and existing authentication approaches against well-known intruder attacks,i.e.,man-in-the-middle,masquerading,device,and server impersonations,etc.,especially in the IoT domain.Moreover,proposed authentication and existing state-of-the-art approaches have been simulated in the real environment of IoT to verify their performance,particularly in terms of various evaluation metrics,i.e.,processing,communication,and storage overheads.These results have verified the superiority of the proposed scheme against existing state-of-the-art approaches,preferably in terms of communication,storage,and processing costs.

Efficient Ship:A Hybrid Deep Learning Framework for Ship Detection in the River

Optical image-based ship detection can ensure the safety of ships and promote the orderly management of ships in offshore waters.Current deep learning researches on optical image-based ship detection mainly focus on improving one-stage detectors for real-time ship detection but sacrifices the accuracy of detection.To solve this problem,we present a hybrid ship detection framework which is named EfficientShip in this paper.The core parts of the EfficientShip are DLA-backboned object location(DBOL)and CascadeRCNN-guided object classification(CROC).The DBOL is responsible for finding potential ship objects,and the CROC is used to categorize the potential ship objects.We also design a pixel-spatial-level data augmentation(PSDA)to reduce the risk of detection model overfitting.We compare the proposed EfficientShip with state-of-the-art(SOTA)literature on a ship detection dataset called Seaships.Experiments show our ship detection framework achieves a result of 99.63%(mAP)at 45 fps,which is much better than 8 SOTA approaches on detection accuracy and can also meet the requirements of real-time application scenarios.

Using Improved Particle Swarm Optimization Algorithm for Location Problem of Drone Logistics Hub

Drone logistics is a novel method of distribution that will become prevalent.The advantageous location of the logistics hub enables quicker customer deliveries and lower fuel consumption,resulting in cost savings for the company’s transportation operations.Logistics firms must discern the ideal location for establishing a logistics hub,which is challenging due to the simplicity of existing models and the intricate delivery factors.To simulate the drone logistics environment,this study presents a new mathematical model.The model not only retains the aspects of the current models,but also considers the degree of transportation difficulty from the logistics hub to the village,the capacity of drones for transportation,and the distribution of logistics hub locations.Moreover,this paper proposes an improved particle swarm optimization(PSO)algorithm which is a diversity-based hybrid PSO(DHPSO)algorithm to solve this model.In DHPSO,the Gaussian random walk can enhance global search in the model space,while the bubble-net attacking strategy can speed convergence.Besides,Archimedes spiral strategy is employed to overcome the local optima trap in the model and improve the exploitation of the algorithm.DHPSO maintains a balance between exploration and exploitation while better defining the distribution of logistics hub locations Numerical experiments show that the newly proposed model always achieves better locations than the current model.Comparing DHPSO with other state-of-the-art intelligent algorithms,the efficiency of the scheme can be improved by 42.58%.This means that logistics companies can reduce distribution costs and consumers can enjoy a more enjoyable shopping experience by using DHPSO’s location selection.All the results show the location of the drone logistics hub is solved by DHPSO effectively.