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Community-acquired multidrug-resistant pneumonia,bacteraemia,and infective endocarditis:A case report 被引量:1
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作者 Basavaraj Jatteppanavar Arnab Choudhury +1 位作者 Prasan Kumar Panda Mukesh Bairwa 《World Journal of Critical Care Medicine》 2024年第1期85-91,共7页
BACKGROUND The prevalence of multidrug-resistant(MDR)bacteria has increased globally,with extensive drug-resistant(XDR)bacteria posing a threat to patients.CASE SUMMARY This case report describes a young man admitted ... BACKGROUND The prevalence of multidrug-resistant(MDR)bacteria has increased globally,with extensive drug-resistant(XDR)bacteria posing a threat to patients.CASE SUMMARY This case report describes a young man admitted for suspected tropical fever infections who experienced rapid deterioration in health.Despite negative results for tropical fever infections,he had neutrophilic leucocytosis,acute kidney injury,and chest imaging findings suggestive of bilateral consolidations.On day two,he was diagnosed with infective endocarditis with possible rheumatic heart disease and MDR methicillin-resistant Staphylococcus aureus bacteraemia,and communityacquired pneumonia.Despite treatment with broad-spectrum antibiotics,he did not respond and succumbed to death on day five.CONCLUSION This case highlights that clinicians/public should be aware of MDR communityacquired pneumonia,bacteraemia,and endocarditis which ultimately culminate in high rates of morbidity and mortality.Early identification of pathogenic strain and prompt antibiotic treatment are a mainstay for the management and prevention of early fatalities.Simultaneously,route cause analysis of communityacquired MDR/XDR pathogens is a global need. 展开更多
关键词 Antibiotic resistance Community-acquired infections Infective endocarditis Methicillin-resistant staphylococcus aureus Rheumatic heart disease Case report
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Echocardiographic predictors and associated outcomes of multiple vegetations in infective endocarditis:A pilot study
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作者 Ajay Kumar Mishra Kannu Bansal +6 位作者 Ibragim Al-Seykal Pradnya B Bhattad Anu Anna George Anil Jha Nitish Sharma Jennifer Sargent Mark J Kranis 《World Journal of Cardiology》 2024年第6期318-328,共11页
BACKGROUND Infective endocarditis(IE)is a life-threatening infection with an annual mortality of 40%.Embolic events reported in up to 80%of patients.Vegetations of>10 mm size are associated with increased embolic e... BACKGROUND Infective endocarditis(IE)is a life-threatening infection with an annual mortality of 40%.Embolic events reported in up to 80%of patients.Vegetations of>10 mm size are associated with increased embolic events and poor prognosis.There is a paucity of literature on the association of multiple vegetations with outcome.AIM To study the echocardiographic(ECHO)features and outcomes associated with the presence of multiple vegetations.METHODS In this retrospective,single-center,cohort study patients diagnosed with IE were recruited from June 2017 to June 2019.A total of 84 patients were diagnosed to have IE,of whom 67 with vegetation were identified.Baseline demographic,clinical,laboratory,and ECHO parameters were reviewed.Outcomes that were studied included recurrent admission,embolic phenomenon,and mortality.RESULTS Twenty-three(34%)patients were noted to have multiple vegetations,13(56.5%)were male and 10(43.5%)were female.The mean age of these patients was 50.Eight(35%)had a prior episode of IE.ECHO features of moderate to severe valvular regurgitation[odds ratio(OR)=4],presence of pacemaker lead(OR=4.8),impaired left ventricle(LV)relaxation(OR=4),and elevated pulmonary artery systolic pressure(PASP)(OR=2.2)are associated with higher odds of multiple vegetations.Of these moderate to severe valvular regurgitation(P=0.028),pacemaker lead(P=0.039)and impaired relaxation(P=0.028)were statistically significant.These patients were noted to have an increased association of recurrent admissions(OR=3.6),recurrent bacteremia(OR=2.4),embolic phenomenon(OR=2.5),intensive care unit stay(OR=2.8),hypotension(OR=2.1),surgical intervention(OR=2.8)and device removal(OR=4.8).Of this device removal(P=0.039)and recurrent admissions(P=0.017)were statistically significant.CONCLUSION This study highlights the associations of ECHO predictors and outcomes in patients with IE having multiple vegetations.ECHO features of moderate to severe regurgitation,presence of pacemaker lead,impaired LV relaxation,and elevated PASP and outcomes including recurrent admissions and device removal were found to be associated with multiple vegetations. 展开更多
关键词 endocarditis ECHOCARDIOGRAPHY VEGETATIONS PREDICTORS OUTCOME
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Early Prosthetic Valve Endocarditis with Mycobacterium Tuberculosis after Mitral Valve Replacement: A Case Report
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作者 Papa Amath Diagne Mory Camara +12 位作者 Papa Ousmane Ba Momar Sokhna Diop Moussa Samba Abdou Lahad Mbengue Jean Claude Ndiogou Dione Myriam Bizrane Marième Soda Mbaye Moussa Seck Diop Toudiani Malam Kaka Papa Salmane Ba Papa Adama Dieng Amadou Gabriel Ciss Assane Ndiaye 《World Journal of Cardiovascular Surgery》 2024年第3期33-40,共8页
Background: Tuberculous endocarditis is a rare but serious complication of heart valve replacement surgery. We report the case of a 24-year-old patient, who presented with tuberculous endocarditis after mechanical mit... Background: Tuberculous endocarditis is a rare but serious complication of heart valve replacement surgery. We report the case of a 24-year-old patient, who presented with tuberculous endocarditis after mechanical mitral valve replacement, with a favorable clinical course following anti-tuberculosis treatment. Case Presentation: We report a 24-year-old male patient, admitted to the cardiac surgery department of the Fann Hospital (Dakar, Senegal), for the management of severe mixed (rheumatic and endocarditic) mitral insufficiency with associated tricuspid insufficiency. He had a history of recurrent angina and polyarthralgia in childhood, was hospitalized several times for refractory global cardiac decompensation, and for a suspected infective endocarditis a month before his admission. On admission, the clinical examination revealed signs suggestive of mitral and tricuspid insufficiency. Transthoracic echocardiography revealed severe post-endocarditic mitral insufficiency with A3 amputation, highly mobile 15 mm vegetations on the free edge of the large valve, moderate tricuspid insufficiency, and severe pulmonary artery hypertension. Mechanical mitral valve replacement and tricuspid valve annuloplasty using autologous pericardial strip were performed via median sternotomy. After ten days, the patient presented with global cardiac decompensation associated with a clinico-biological infectious syndrome, and tans-oesophageal echography revealed an abscess at the sinotubular junction, communicating with the aorta. A thoraco-abdomino-pelvic CT scan was done, which revealed a bilateral alveolar-interstitial syndrome with mediastinal lymphadenopathy. Anti-tuberculosis treatment with RHZE was initiated for 06 months. The clinical course was favorable. Conclusion: Tuberculous endocarditis in prostheses is a serious complication of heart valve replacement surgery, which may evolve favorably under medical treatment. 展开更多
关键词 Tuberculous endocarditis Prosthetic Valve endocarditis Mycobacterium Tuberculosis
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A Rare Case of Aortic Valve Endocarditis and Acute Meningitis Due to Haemophilus influenzae
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作者 Zachary M. Visinoni Justin D. Tse Christopher F. Pease 《Case Reports in Clinical Medicine》 2024年第6期207-211,共5页
HACEK organisms represent a rare but important group of causative pathogens in endocarditis. These bacteria have historically been associated with culture-negative endocarditis;however, modern laboratory techniques ha... HACEK organisms represent a rare but important group of causative pathogens in endocarditis. These bacteria have historically been associated with culture-negative endocarditis;however, modern laboratory techniques have made this less common. In this case, we present a 74-year-old man who presented with acute onset altered mentation, fever, and sepsis. He was ultimately found to have Haemophilus influenzae meningitis, cerebral empyema, aortic valve endocarditis, psoas myositis, and L2 - L3 diskitis with osteomyelitis. Although HACEK organisms are commonly found in the oropharynx and upper respiratory tract in humans, our patient did not report recent preceding dental or ENT procedures. H. influenzae is responsible for approximately 0.16% of all cases of bacterial endocarditis, representing a very limited subset. Although generally considered low virulent pathogens, this case demonstrates the unusual extent of infection from a HACEK organism, H. influenzae, causing aortic valve endocarditis as well as atypical non-cardiac sequelae, including acute meningitis. 展开更多
关键词 HACEK Haemophilus influenzae Aortic Valve endocarditis Bacterial Meningitis Cerebral Empyema
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Infective Endocarditis in Chronic Hemodialysis Patients: Specificities and Therapeutic Management
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作者 Imane Saidi Amal Zniber +3 位作者 Mina Agrou Tarik Bouattar Naima Ouzeddoun Loubna Benamar 《Open Journal of Internal Medicine》 2024年第2期247-258,共12页
Infective endocarditis (IE) is a frequent complication in chronic hemodialysis patients (CHD). The repeated placement and manipulation of central venous catheters, underlying valvulopathies, and immunosuppression are ... Infective endocarditis (IE) is a frequent complication in chronic hemodialysis patients (CHD). The repeated placement and manipulation of central venous catheters, underlying valvulopathies, and immunosuppression are the main predisposing factors for these patients to develop IE. We aimed to highlight the clinical and microbiological specificities of IE in CHD patients, detail the therapeutic management in these patients and identify the risk factors for in-hospital mortality. We included 28 CHD patients in whom the diagnosis of IE was established according to modified Duke criteria. The mean age was 47 ± 17 years. Among them, 57% were hypertensive and 39% were diabetic. The average duration of hemodialysis was 3.5 ± 7 years. The vascular access was a tunnelled jugular catheter, arteriovenous fistula, and temporary catheter in 54%, 28%, and 18% of patients, respectively. Half of the patients presented with heart failure at admission. Methicillin-sensitive Staphylococcus is the most commonly implicated pathogen. Transthoracic echocardiography revealed vegetation in all patients. In 60% of cases, the lesion is located on the mitral valve, and in 35% it is on the tricuspid valve. Patients initially received empirical antibiotic therapy, which was adjusted according to bacteriological results. Valve surgery was indicated in 12 patients, with aortic valve replacement being the most performed procedure followed by tricuspid annuloplasty. The in-hospital mortality rate was 32%. Factors associated with mortality were severe mitral insufficiency (p = 0.036), heart failure (p = 0.043), and the presence of Methicillin-resistant Staphylococcus in blood cultures (p = 0.047). IE is a complication with high morbidity and mortality. Its increasing incidence, specificities in chronic CHD patients, and the complexity of its management require a rigorous preventive strategy. A multidisciplinary collaboration between nephrologists, infectious disease specialists, cardiologists, and surgeons is crucial to optimize therapeutic management. 展开更多
关键词 Infective endocarditis Infectious Complications Chronic Hemodialysis Patients
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Granulicatella adiacens: A Rare Cause of Infective Endocarditis: A Case Report
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作者 Manuji Bandara 《Case Reports in Clinical Medicine》 2024年第10期425-431,共7页
Granulicatella adiacens (G. adiacens), formerly classified as a nutritionally variant streptococci (NVS), is a commensal organism in the mouth. It is known to be a rare cause of infective endocarditis (IE). This case ... Granulicatella adiacens (G. adiacens), formerly classified as a nutritionally variant streptococci (NVS), is a commensal organism in the mouth. It is known to be a rare cause of infective endocarditis (IE). This case report presents a case of IE caused by G. adiacens in a 63-year-old man with mitral valve prolapse (MVP), severe mitral regurgitation (MR), and dual vessel disease (DVD). G. adiacens was isolated from two of three blood cultures, and the organism was sensitive to penicillin, vancomycin, cefotaxime, and gentamicin. He was successfully treated with a combination of ceftriaxone and gentamicin. Prompt identification of the organism and determination of antibiotic sensitivity pattern led to successful treatment. This case report showcases the challenges in diagnosis, and treatment, giving insight to healthcare providers on a rare entity. 展开更多
关键词 Granulicatella adiacens Infective endocarditis Nutritionally Variant Streptococci Antibiotic Sensitivity Pattern Mitral Valve Disease
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Obstructive shock secondary to fungal prosthetic aortic valve endocarditis 被引量:3
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作者 Emilio Rodriguez-Ruiz Diego Iglesias-Alvarez Carlos Pena-Gil 《World Journal of Emergency Medicine》 SCIE CAS 2018年第3期227-228,共2页
Dear editor,Fungal endocarditis is a rare disease with a poor prognosis,suboptimal diagnostic tools responsible for long diagnostic delays in most cases,and poorly defined activity of most antifungal agents in endocar... Dear editor,Fungal endocarditis is a rare disease with a poor prognosis,suboptimal diagnostic tools responsible for long diagnostic delays in most cases,and poorly defined activity of most antifungal agents in endocarditis.^([1])The burden of diagnosis still lies with clinicians:they need a 展开更多
关键词 OBSTRUCTIVE shock secondary FUNGAL PROSTHETIC AORTIC VALVE endocarditis
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Infective endocarditis and thoracic aortic disease: A review on forgotten psychological aspects 被引量:3
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作者 Mariana Suárez Bagnasco Iván J Núnez-Gil 《World Journal of Cardiology》 CAS 2017年第7期620-628,共9页
AIM To summarize the current evidence on psychological issues in thoracic aortic disease(TAD) and infective endocarditis(IE) setting. METHODS We performed a narrative review about psychological issues in adults with I... AIM To summarize the current evidence on psychological issues in thoracic aortic disease(TAD) and infective endocarditis(IE) setting. METHODS We performed a narrative review about psychological issues in adults with IE and TAD. Through the electronic databases, Pub Med and Psyc INFO, we searched full manuscripts in English and published until September 1, 2014. RESULTS We found sixteen studies exploring psychological issues in patients with IE(six studies) and in TAD(ten papers). Psychological issues assessed were quality of life, depression, anxiety and posttraumatic stress disorder. Quality of life was explored in IE(four papers) and in TAD(eight papers). Depression and anxiety were analyzed in TAD only(five papers). Post-traumatic stress disorder was assessed in IE(one study). Quality of life was found impaired in three of four studies about IE and in three of eight studies about TAD. Posttraumatic stress disorder was present in 11% and was associated with lower levels of quality of life in IE patients. In TAD patients, anxiety and depression levels after different invasive interventions did not differ. CONCLUSION Sixteen studies report about psychological issues in IE and TAD. Most of them explore quality of life and to a less extent anxiety and depression. 展开更多
关键词 Infective endocarditis Thoracic aortic disease PSYCHOLOGY DEPRESSION ANXIETY Quality of life Posttraumatic stress disorder
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Acquired aortocameral fistula occurring late after infective endocarditis: An emblematic case and review of 38 reported cases 被引量:2
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作者 Salah AM Said Massimo A Mariani 《World Journal of Cardiology》 CAS 2016年第8期488-495,共8页
AIM To delineate the features and current therapeutic option of congenital and acquired aortocameral fistulas(ACF) secondary to iatrogenic or infectious disorders.METHODS From a Pub Med search using the term "aor... AIM To delineate the features and current therapeutic option of congenital and acquired aortocameral fistulas(ACF) secondary to iatrogenic or infectious disorders.METHODS From a Pub Med search using the term "aortocameral fistula", 30 suitable papers for the current review were retrieved. Reviews, case series and case reports published in English were considered. Abstracts and reports from scientific meetings were not included. A total of 38 reviewed subjects were collected and analyzed. In addition, another case- an adult male who presented with ACF between commissures of the right and noncoronary sinuses and right atrium as a late complication of Staphylococcus aureus infective endocarditis of the AV- is added, the world literature is briefly reviewed.RESULTS A total of thirty-eight subjects producing 39 fistulas were reviewed, analyzed and stratified into either congenital(47%) or acquired(53%) according to their etiology. Of all subjects, 11% were asymptomatic and 89% were symptomatic with dyspnea(21 ×) as the most common presentation. Diagnosis was established by a multidiagnostic approach in 23(60%), single method in 14(37%)(echocardiography in 12 and catheterization in 2), and at autopsy in 2(3%) of the subjects. Treatment options included percutaneous transcatheter closure in 12(30%) with the deployment of the Amplatzer duct or septal occluder and Gianturco coil and surgical correction in 24(63%). CONCLUSION Acquired ACF is an infrequent entity which may occur late after an episode of endocarditis of the native AV. The management of ACF is generally by surgical correction but non-surgical device intervention has recently been introduced as a safe alternative. 展开更多
关键词 Aortic-atrial shunt Aortic-atrial FISTULAS INFECTIVE endocarditis LATE complication Surgical correction
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Candida tropicalis infection in a term neonate with gall bladder masses and infective endocarditis 被引量:1
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作者 Mamta Jajoo Vishal Kumar +1 位作者 Vishnu K.Goyal Amit Garg 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2012年第5期410-412,共3页
Candida endocarditis is extremely rare in term neonates,and gall bladder involvement due to candidemia has never been reported amongst neonates and infants.A term,appropriate for gestational age neonate developed Cand... Candida endocarditis is extremely rare in term neonates,and gall bladder involvement due to candidemia has never been reported amongst neonates and infants.A term,appropriate for gestational age neonate developed Candida tropicalis blood stream infection in second week of life.He was started on conventional amphotericin B.However,he failed to show any clinical improvement,and candidemia keep on persisting.Repeat sanctuary sites screening revealed multiple echogenic masses in heart(vegetations) and gall bladder.On changing the treatment to liposomal amphotericin B and fluconazole,he recovered clinically,echogenic masses in gall bladder disappeared,and intracardiac vegetations decreased in size. 展开更多
关键词 CANDIDA TROPICALIS endocarditis GALL BLADDER
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Late endocarditis of Amplatzer atrial septal occluder device in a child 被引量:1
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作者 Neerod K Jha Laszlo Kiraly +9 位作者 John SK Murala Csaba Tamas Haitham Talo Hazem El Badaoui Magdi Tofeig Malaika Mendonca Sameer Sajwani Mary A Thomas Sura Ahmed Al Doory Mohammad D Khan 《World Journal of Cardiology》 CAS 2015年第10期703-706,共4页
Bacterial endocarditis following atrial septal defect closure using Amplatzer device in a child is extremely rare. We report a 10-year-old girl who developed late bacterial endocarditis, 6 years after placement of an ... Bacterial endocarditis following atrial septal defect closure using Amplatzer device in a child is extremely rare. We report a 10-year-old girl who developed late bacterial endocarditis, 6 years after placement of an Amplatzer atrial septal occluder device. Successful explantation of the device and repair of the resultant septal defect was carried out using a homograft patch. The rare occurrence of this entity prompted us to highlight the importance of a closed long-term follow up, review the management and explore preventive strategies for similar patients who have multiple co-morbidities and a cardiac device. A high index of suspicion is warranted particularly in pediatric patients. 展开更多
关键词 endocarditis ATRIAL SEPTAL Device
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More to the picture of the psychological impact of endocarditis and thoracic aortic pathology 被引量:1
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作者 Meridith Ginesi Michael S Firstenberg 《World Journal of Cardiology》 CAS 2018年第6期38-40,共3页
Over the years there has been substantial advanced in the diagnosis and surgical management of complex thoracic aortic disease and complex endocarditis.As these therapies are being offered to a growing segment of pati... Over the years there has been substantial advanced in the diagnosis and surgical management of complex thoracic aortic disease and complex endocarditis.As these therapies are being offered to a growing segment of patients-and more and more patients are felt to potentially benefit from such therapies,the longterm consequences of these interventions is sometimes poorly understood.While traditional medical complications,such as stroke,renal failure,respiratory failure,and even death are often the focus of outcomes studies,little is known on the impact of these diseases and therapies on mental health.This commentary emphasizes the importance of better understanding the psychologic impact of endocarditis and thoracic aortic pathology as reviewed by Dr.Bagnasco. 展开更多
关键词 endocarditis THORACIC AORTA MENTAL health ANXIETY Depression
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Implantable cardioverter defibrillator lead-related methicillin resistant Staphylococcus aureus endocarditis:Importance of heightened awareness 被引量:1
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作者 Obiora F Anusionwu Cheri Smith Alan Cheng 《World Journal of Cardiology》 CAS 2012年第7期231-233,共3页
Methicillin resistant Staphylococcus aureus(MRSA) septicemia is associated with high morbidity and mortality especially in patients with immunosuppression,diabetes,renal disease and endocarditis.There has been an incr... Methicillin resistant Staphylococcus aureus(MRSA) septicemia is associated with high morbidity and mortality especially in patients with immunosuppression,diabetes,renal disease and endocarditis.There has been an increase in implantation of cardiac implantable electronic devices(CIED) with more cases of devicelead associated endocarditis been seen.A high index of suspicion is required to ensure patient outcomes are optimized.The excimer laser has been very efficient in helping to ensure successful lead extractions in patients with CIED infections.We present an unusual case report and literature review of MRSA septicemia from device-lead endocarditis and the importance of early recognition and prompt treatment. 展开更多
关键词 endocarditis METHICILLIN resistant STAPHYLOCOCCUS AUREUS Sepsis PACEMAKERS Implantable CARDIOVERTER-DEFIBRILLATOR
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Diagnosis and Treatment of Infective Endocarditis in Chronic Hemodialysis Patients 被引量:3
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作者 Jian-ling Tao Jie Ma +8 位作者 Guang-li Ge Li-meng Chen Hang Li Bao-tong Zhou Yang Sun Wen-ling Ye Qi Miao Xue-mei Li Xue-wang Li 《Chinese Medical Sciences Journal》 CAS CSCD 2010年第3期135-139,共5页
Objective To analyze the clinical features of hemodialysis patients complicated by infective endo carditis. Methods The clinical features of six such patients admitted to Peking Union Medical College Hospital during ... Objective To analyze the clinical features of hemodialysis patients complicated by infective endo carditis. Methods The clinical features of six such patients admitted to Peking Union Medical College Hospital during the year 1990 to 2009 were analyzed. All of them were diagnosed based on Chinese Children Diagnostic Criteria for Infective Endocarditis. Results The average age of the six patients was 52.3±19.3 years old. Four were males. Vascular accesses at the onset of infective endocarditis were as follows: permanent catheters in three, temporary catheters in two, and arteriovenous fistula in one. Three were fbund with mitral valve involvement, two with aor tic valve involvement, and one with both. Five vegetations were found by transthoracic echocardiography, and one by transesophageal echocardiography. Four had positive blood culture results. The catheters were all removed. Four of the patients were improved by antibiotics treatment, in which two were still on hemodialy sis in the following 14-24 months and the other two were lost to follow-up. One patient received surgery, but died of heart failure alter further hemodialysis for three months. One was well on maintenance hemodi alvsis for three months after surgery. Conclusions Infective endocarditis should be suspected when hemodialysis patients suffer from long-term fever, for which prompt blood culture and transthoracic echocardiography confirmation could be performed. Transesophageal echocardiography could be considered even when transthoracic echocardiography produces negative findings. With catheters removed, lull course of appropriate sensitive antibiotics and surgery if indicated could improve the outcome of chronic hemodialysis patients complicated by infective cndocarditis. 展开更多
关键词 HEMODIALYSIS infective endocarditis clinical feature
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An Early Diagnosis of Endocarditis Facilitated by the Electronic Stethoscope 被引量:1
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作者 Walid Barake Amer M. Johri 《Open Journal of Clinical Diagnostics》 2014年第2期101-104,共4页
The practice of cardiac auscultation is a critical tool used by physicians to detect alterations in the cardiovascular system. A case of both left and right sided endocarditis initially detected by electronic ausculta... The practice of cardiac auscultation is a critical tool used by physicians to detect alterations in the cardiovascular system. A case of both left and right sided endocarditis initially detected by electronic auscultation in a woman with a history of injection drug use is described. The electronic stethoscope, with the ability to amplify heart sounds, established the presence of both a systolic and diastolic murmur when standard auscultation failed to detect the diastolic component. Urgent standard echocardiography confirmed concurrent tricuspid and aortic valves endocarditis, and the patient was referred for surgical evaluation urgently. The present case demonstrates the value of the electronic stethoscope to amplify murmurs in the early detection of endocarditis. The case presented also serves as a useful reminder that right-sided endocarditis can have important leftsided complications. 展开更多
关键词 Electronic STETHOSCOPE CONVENTIONAL STETHOSCOPE endocarditis MURMURS
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Isolation,identification,and antifungal susceptibility test for Kodamaea ohmeri:a case report on endocarditis 被引量:2
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作者 Qin Yanghua Wang Weiwei +2 位作者 Liu Yang Xiao Jian Shen Qian 《Journal of Medical Colleges of PLA(China)》 CAS 2010年第4期252-256,共5页
A 43-year-old man with a history of rheumatoid heart disease developed endocarditis.Blood culture showed endocarditis was caused by Kodamaea ohmeri and the susceptibility test showed the yeast species were susceptible... A 43-year-old man with a history of rheumatoid heart disease developed endocarditis.Blood culture showed endocarditis was caused by Kodamaea ohmeri and the susceptibility test showed the yeast species were susceptible to itraconazole,amphotericin B,and voriconazole,but susceptible-dose dependent to fluconazole,and resistant to 5-flucytosine.Treated with surgery and anti-fungi agents,the patient recovered from endocarditis.This is the first case of K.ohmeri fungemia found in Chinese from mainland.More and more evidence indicate that K.ohmeri is an important opportunistic pathogen for human beings. 展开更多
关键词 endocarditis Kodamaea Ohmeri FUNGEMIA
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Vancomycin-induced thrombocytopenia in endocarditis:A case report and review of literature 被引量:2
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作者 Si-Ri Guleng Ri-Han Wu Xiao-Bin Guo 《World Journal of Clinical Cases》 SCIE 2021年第7期1696-1704,共9页
BACKGROUND Thrombocytopenia is a serious complication in the medical practice of numerous drugs.Vancomycin is frequently used for the prophylaxis and treatment of suspected or identified methicillin-resistant positive... BACKGROUND Thrombocytopenia is a serious complication in the medical practice of numerous drugs.Vancomycin is frequently used for the prophylaxis and treatment of suspected or identified methicillin-resistant positive infections.Several cases with vancomycin-induced thrombocytopenia(VIT)have been reported.However,these have rarely been extensively reviewed.The present report describes a case of VIT in endocarditis,and reviews all VIT cases reported in the literature.CASE SUMMARY A 26-year-old male diagnosed with infective endocarditis was admitted.The patient was treated with multiple drugs,including vancomycin,which was initially intravenously given at 1000 mg every 12 h and subsequently at 500 mg every 8 h on day 3.On day 11,the platelet count decreased to 51×10^(9)/L,vancomycin was switched to 500 mg every 12 h,and platelet transfusion was given.On day 17,the platelet count dropped to 27×10^(9)/L,and platelet transfusion was administered again.On day 23,vancomycin was adjusted to 500 mg every 8 h as the trough concentration dropped to the minimum effective concentration.On day 33,the platelet count declined to approximately 40×10^(9)/L.After platelet transfusion,the platelet count rebounded to 90×10^(9)/L on day 35 but dropped again to 42×10^(9)/L on day 43.Based on the time-to-platelet count curve and Naranjo’s Adverse Drug Reaction Probability Scale score,VIT was suspected.After vancomycin discontinuation and platelet transfusion,the platelet count gradually normalized.CONCLUSION The diagnosis of VIT can be achieved through the time-to-platelet count curve and Naranjo’s Adverse Drug Reaction Probability Scale score.The platelet count cannot be normalized simply by platelet transfusion alone,and vancomycin discontinuation is essential. 展开更多
关键词 Case report VANCOMYCIN THROMBOCYTOPENIA endocarditis Platelet transfusion Literature review
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Global and Regional Trends and Projections of Infective Endocarditis-Associated Disease Burden and Attributable Risk Factors from 1990 to 2030 被引量:1
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作者 Lijin Lin Yemao Liu +10 位作者 Juanjuan Qin Fang Lei Wenxin Wang Xuewei Huang Weifang Liu Xingyuan Zhang Zhigang She Peng Zhang Xiaojing Zhang Zhaoxia Jin Hongliang Li 《Chinese Medical Sciences Journal》 CAS CSCD 2022年第3期181-194,I0003,共15页
Objective To forecast the future burden and its attributable risk factors of infective endocarditis(IE).Methods We analyzed the disease burden of IE and its risk factors from 1990 to 2019 using the Global Burden of Di... Objective To forecast the future burden and its attributable risk factors of infective endocarditis(IE).Methods We analyzed the disease burden of IE and its risk factors from 1990 to 2019 using the Global Burden of Disease 2019 database and projected the disease burden from 2020 to 2030 using a Bayesian age-period-cohort model.Results By 2030,the incidence of IE will increase uncontrollably on a global scale,with developed countries having the largest number of cases and developing countries experiencing the fastest growth.The affected population will be predominantly males,but the gender gap will narrow.The elderly in high-income countries will bear the greatest burden,with a gradual shift to middle-income countries.The incidence of IE in countries with middle/high-middle social-demographic indicators(SDI) will surpass that of high SDI countries.In China,the incidence rate and the number of IE will reach 18.07 per 100,000 and 451,596 in 2030,respectively.IEassociated deaths and heart failure will continue to impose a significant burden on society,the burden on women will increase and surpass that on men,and the elderly in high-SDI countries will bear the heaviest burden.High systolic blood pressure has become the primary risk factor for IE-related death.Conclusions This study provides comprehensive analyses of the disease burden and risk factors of IE worldwide over the next decade.The IE-associated incidence will increase in the future and the death and heart failure burden will not be appropriately controlled.Gender,age,regional,and country heterogeneity should be taken seriously to facilitate in making effective strategies for lowering the IE disease burden. 展开更多
关键词 infective endocarditis disease burden risk factors Bayesian age-period-cohort model PROJECTION
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Calcific left atrium:A rare consequence of endocarditis 被引量:1
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作者 Giuseppe Dattilo Carmelo Anfuso +4 位作者 Matteo Casale Vincenza Giugno Lorenzo Camarda Natascia Laganà Gianluca Di Bella 《World Journal of Cardiology》 CAS 2014年第9期1038-1040,共3页
Usually, cardiac calcifications are observed in aortic and mitral valves, atrio-ventricular plane, mitral annulus, coronary arteries, pericaridium(usually causing constrictive pericarditis) and cardiac masses. Calcifi... Usually, cardiac calcifications are observed in aortic and mitral valves, atrio-ventricular plane, mitral annulus, coronary arteries, pericaridium(usually causing constrictive pericarditis) and cardiac masses. Calcifications of atrial walls are unusual findings that can be identified only using imaging with high spatial resolution, such as cardiac magnetic resonance and computed tomography. We report a case of a 43-year-old patient with no history of heart disease that underwent cardiac evaluation for mild dyspnoea. The echocardiogram showed a calcific aortic valve and a hyper-echogenic lesion located in atrio-ventricular plane. The patient was submitted to cardiac magnetic resonance and to computed tomography imaging to better characterize the localization of mass. The clinical features and location of calcified lesion suggest an infective aetiology causing an endocarditis involving the aortic valve, atrioventricular plane and left atrium. Although we haven't data to support a definite and clear diagnosis, the clinical features and location of the calcified lesion suggest an infective aetiology causing an endocarditis involving the aortic valve, atrio-ventricular plane and left atrium. The patient was followed for 12 mo both clinically and by electrocardiogram and echocardiography without worsening of clinical, electrocardiographic and echocardiographic data. Cardiac magnetic resonance imaging and computed tomography are ideal methods for identifying and following over time patients with calcific degeneration in the heart. 展开更多
关键词 endocarditis complications Left atrium calcification Cardiac magnetic resonance Computed tomography
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Tricuspid valve endocarditis:Cardiovascular imaging evaluation and management 被引量:1
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作者 Agostina M Fava Bo Xu 《World Journal of Clinical Cases》 SCIE 2021年第30期8974-8984,共11页
Right-sided infective endocarditis is an increasingly recognized disease entity,with tricuspid valve being most frequently involved.Risk factors for tricuspid valve endocarditis(TVIE)include intravenous drug use,cardi... Right-sided infective endocarditis is an increasingly recognized disease entity,with tricuspid valve being most frequently involved.Risk factors for tricuspid valve endocarditis(TVIE)include intravenous drug use,cardiac implantable electronic devices and indwelling catheters.Staphylococcus aureus is the predominant causative organism in TVIE.The diagnosis of infective endocarditis(IE)is based on clinical manifestations,blood cultures,and the presence of valvular vegetations detected by echocardiography.Complementary imaging is helpful when there is ongoing clinical suspicion for IE following initially negative echocardiography.Multislice computed tomography allows for assessment of extra-cardiac complications in TVIE,including pulmonary septic emboli.18F-fluorodeoxyglucose positron emission tomography/computed tomography and radiolabelled white blood cell,single-photon emission computed tomography provide important clinical information concerning the presence of IE in right-sided prosthetic valves or cardiac implantable electronic devices.The aim of this review is to provide an update on TVIE,discussing the role of multimodality imaging in TVIE and the management of these patients. 展开更多
关键词 Tricuspid valve endocarditis Multimodality imaging ECHOCARDIOGRAPHY Computed tomography Positron emission tomography/computed tomography
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