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长链非编码RNA AC023794.4-201在喉鳞状细胞癌中的表达及临床意义 被引量:2
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作者 童巧玲 沈志森 +2 位作者 李群 郝文娟 周重昌 《中国耳鼻咽喉头颈外科》 CSCD 2018年第10期564-566,共3页
喉癌是头颈部最常见的恶性肿瘤之一,其中85%~95%为鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)[1]。据报道早期LSCC患者的生存率远高于晚期患者[2]。研究发现,长链非编码RNA(long non-coding RNA,lncRNA)参与调控头颈部... 喉癌是头颈部最常见的恶性肿瘤之一,其中85%~95%为鳞状细胞癌(laryngeal squamous cell carcinoma,LSCC)[1]。据报道早期LSCC患者的生存率远高于晚期患者[2]。研究发现,长链非编码RNA(long non-coding RNA,lncRNA)参与调控头颈部肿瘤细胞的增殖、分化、迁移和侵袭等,发挥抑癌基因或癌基因的功能[3~5]。 展开更多
关键词 喉肿瘤(Laryngeal Neoplasms) 鳞状细胞(Carcinoma Squamous Cell) 逆转录聚合酶链反应(Reverse Transcriptase POLYMERASE chain Reaction) 预后(Prognosis) 长链非编码rna(long non-coding rna)
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Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer 被引量:11
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作者 Ganepola AP Ganepola Joel Nizin +1 位作者 John R Rutledge David H Chang 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2014年第4期83-97,共15页
Early screening for colorectal cancer(CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate b... Early screening for colorectal cancer(CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate because of their high cost and cumbersome preparatory procedures that ultimately lead to a low participation rate. People simply do not like to have colonoscopies. It would be ideal, therefore, to develop an alternative modality based on blood biomarkers as the first line screening test. This will allow for the differentiation of the general population from high risk individuals. Colonoscopy would then become the secondary test, to further screen the high risk segment of the population. This will encourage participation and therefore help to reach the goal of early detection and thereby reduce the anticipated increasing global CRC incidence rate. A blood-based screening test is anappealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher participation rate. This review surveys various blood-based test strategies currently under investigation, discusses the potency of what is available, and assesses how new technology may contribute to future test design. 展开更多
关键词 Colorectal neoplasms Early detection of cancer Colonoscopy Biological markers BLOOD Messenger rna Microrna long non-coding rna DNA methylation Microsatellite instability Loss of HETEROZYGOSITY High-throughput NUCLEOTIDE sequencing Mass spectrometry Real-time polymerase chain reaction Microarray analysis
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