Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were stud...Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were studied before,during,and just on bed rest conditions at -6°head-down-tilt(HDT) bed rest and bed rest position(BD) for 10 days.We measured the salivary and serum oxidative markers such as Malonaldehyde,8-hydroxydeoxyguanosine, vitamin C and E just before HDT & BD.during HDT & BD experiment,and in course time of recovery with curcumin and without curcumin groups.Results:The values of serum and salivary vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to those of the conditions before and during the recovery stage.However,these levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin (P】0.05).MDA and 8-OHdG levels showed significant increase in simulating microgravity and zero gravity conditions as compared to those before and in the recovery stage.However,these levels were lower in curcumin groups in contrast to the groups without curcumin(P【0.05).Serum and salivary correlation analysis revealed a strong and highly significant correlation for MDA. vitamin C & E and 8 dihydro-2 deoxyguanosine(8-OHdG) in the conditions before,during and in the recovery periods in both bed rest conditions.Since saliva collection is easy and noninvasive, measurements of salivary marker levels may prove to be useful in the space research. Conclusions:Curcumin prevents peroxidative damage in both bed rest conditions.Further study is required on antioxidation actions of curcumin in space microgravity conditions.展开更多
Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant live...Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant liver tumors,who met the enrollment criteria,were randomly divided into experimental and control groups.During HAIC treatment,the patients in the experimental group,who were not confined to bed and could get out of bed,used electronic injection pumps to infuse chemotherapy drugs.The patients in the control group,who were strictly confined to bed and prohibited from getting out of bed,used infusion pumps to infuse chemotherapy drugs.The complications of the two groups were observed.The Christenson standard improved method was used to evaluate the bleeding and hematoma of limbs on the operation side.The Kolcaba General Comfort Questionnaire(GCQ)and Barthel Index(BI)were used to evaluate the two groups.Results:Ninety patients with malignant liver tumors were enrolled,including 53 with primary liver cancer and 37 with colorectal liver metastasis.There were 70 males and 20 females,aged 41-81 years old,with an average age of 61.6±9.248 years old.There were 60 patients in the experimental group and 30 patients in the control group.All patients underwent HAIC.The study showed that,during the treatment period,there were 3 cases of postoperative puncture point hematoma formation in the two groups,including 2 cases in the experimental group(2/60,3.3%)and 1 case in the control group(1/30,3.3%).The difference was not statistically significant(p>0.05).There were 5 cases of postoperative puncture point bleeding,including 4 cases in the experimental group(4/60,6.7%)and 1 case in the control group(1/30,3.3%),and the difference was not statistically significant(p>0.05).A total of 23 cases,with 6 cases in the experimental group(6/60,10%)and 17 cases in the control group(17/30,56.7%),complained of back pain after the operation,and the difference was statistically significant(p<0.05).Twenty-one cases complained of poor defecation after the operation,including 10 cases in the experimental group(10/60,16.7%)and 11 cases in the control group(11/30,36.7%).The difference was statistically significant(p<0.05).During the period of infusion chemotherapy,the two groups of patients had there was a significant difference between the two groups in terms of comfort status(GCQ)(88.78±6.705,78.47±9.519,p<0.001)and self-care ability(BI)(74.25±9.152,66.83±6.628,p<0.001).Conclusion:During HAIC treatment,getting out of bed is safe and reliable and can increase the patients’comfort and self-care ability.Hence,it merits clinical application.展开更多
Considering the maternal risk for both short- and long-term disability imposed by activity restriction, it is of great concern that the antepartum symptoms of bed rest are still evident in the postpartum period. The b...Considering the maternal risk for both short- and long-term disability imposed by activity restriction, it is of great concern that the antepartum symptoms of bed rest are still evident in the postpartum period. The benefits of bed-rest-exercise may alleviate or even prevent physiological distresses or deconditioning associated with activity restriction, thus, eliminating or stabilizing, factors that may augment existing complications. This is the first study to investigate the feasibility of incorporating a bed-rest exercise program in a specific hospitalized twin pregnancy case. The maternal physiological responses of heart rate, blood pressure and uterine contractions to a four week bed-rest resistance program were measured in a woman hospitalized due to complications during her twin pregnancy. A second participant (same diagnoses) was included as a control. The bed-rest-exercise reduced the degree of swelling in the lower extremities, promoted more energy during the day and a better night’s sleep. There were no significant differences in uterine contractions pre vs. post protocol and all babies were born healthy.展开更多
<strong>Objective:</strong> Against a background of the two-child policy in China, the objective is to explore the effects of lower limb strengthening exercises on hospitalized pregnant women put on bed re...<strong>Objective:</strong> Against a background of the two-child policy in China, the objective is to explore the effects of lower limb strengthening exercises on hospitalized pregnant women put on bed rest for prevention of miscarriage. <strong>Method:</strong> Sixty cases of pregnant women admitted to the Department of Obstetrics in one of the highest ranking hospitals in Guangzhou, China, during the period from November 2018 to December 2019 for the purpose of preventing miscarriage were selected. They were divided into an experimental group and a control group of 30 cases each. The control group was put under routine care while the intervention group conducted lower limb muscle strengthening exercise on top of the routine care. After the intervention, the conditions of lower limbs, the psychological states and the results of pregnancy for the two groups were compared. <strong>Results: </strong>After the intervention, the scores of the experimental group in anxiety, depression and postpartum depression were lower and leg circumferences were smaller compared to the control group. The difference is statistically significant (<em>P</em> < 0.05). The experimental group had longer gestation than the control group and was able to get out of bed earlier than the control group after delivery, with statistically significant difference (<em>P</em> < 0.05). <strong>Conclusion:</strong> Lower limb muscle strengthening exercises can effectively improve the physiological and psychological states of pregnant women hospitalized for prevention of miscarriage and promote their postpartum recovery.展开更多
Shake table testing was performed to investigate the dynamic stability of a mid-dip bedding rock slope under frequent earthquakes. Then, numerical modelling was established to further study the slope dynamic stability...Shake table testing was performed to investigate the dynamic stability of a mid-dip bedding rock slope under frequent earthquakes. Then, numerical modelling was established to further study the slope dynamic stability under purely microseisms and the influence of five factors, including seismic amplitude, slope height, slope angle, strata inclination and strata thickness, were considered. The experimental results show that the natural frequency of the slope decreases and damping ratio increases as the earthquake loading times increase. The dynamic strength reduction method is adopted for the stability evaluation of the bedding rock slope in numerical simulation, and the slope stability decreases with the increase of seismic amplitude, increase of slope height, reduction of strata thickness and increase of slope angle. The failure mode of a mid-dip bedding rock slope in the shaking table test is integral slipping along the bedding surface with dipping tensile cracks at the slope rear edge going through the bedding surfaces. In the numerical simulation, the long-term stability of a mid-dip bedding slope is worst under frequent microseisms and the slope is at risk of integral sliding instability, whereas the slope rock mass is more broken than shown in the shaking table test. The research results are of practical significance to better understand the formation mechanism of reservoir landslides and prevent future landslide disasters.展开更多
AIM: To investigate the long term(≥5 y) efficacy, predictability, and safety of laser in situ keratomileusis(LASIK) in eyes with thin corneas [central corneal thickness(CCT) 〈500 μm]. METHODS: A total of 33...AIM: To investigate the long term(≥5 y) efficacy, predictability, and safety of laser in situ keratomileusis(LASIK) in eyes with thin corneas [central corneal thickness(CCT) 〈500 μm]. METHODS: A total of 339 patients met the criteria of this study. Finally, 175 eyes of 89 patients who had thin corneas and underwent LASIK≥5 y ago returned to our clinic and included in this study. Preoperative parameters recorded included uncorrected visual acuity(UCVA), corrected distance visual acuity(CDVA), manifest refraction, CCT and corneal topography. At returning visits, in addition to visual acuity and manifest refraction, ultrasound CCT and corneal topography were performed. Optical coherence tomography was used to measure the CCT, LASIK flap thickness, and residual stromal bed thickness(RSBT). Safety index, efficacy index, percentage of eyes within ±0.5 D and ±1.0 D of refraction, percent tissue altered(PTA), and percentage stromal bed thickness(PSBT) were calculated. RESULTS: The safety index was 1.09 and efficacy index was 0.99. The percentages of eyes within ±0.5 D and ±1.0 D were 71.2% and 87.7%, respectively. The mean PTA was 40%±6%(range 20% to 55%); 76 eyes(43.4%) had PTA 〈40% and 99 eyes(56.6%) had PTA≥40%. The mean RSBT was 303±27 μm(range 240 to 390 μm), and 2 eyes had RSBT〈250 μm. The mean PSBT was 61%±9%(range 51% to 85%). No eyes developed ectasia. CONCLUSION: In this cohort with the PSBT of 50% or more, LASIK is safe with follow-up for at least 5 y.展开更多
Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019(COVID-19)exhibit anxiety,depression,and altered brain microstructure,their long-term physical problems,ne...Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019(COVID-19)exhibit anxiety,depression,and altered brain microstructure,their long-term physical problems,neuropsychiatric sequelae,and changes in brain function remain unknown.This observational cohort study collected 1-year follow-up data from 22 patients who had been hospitalized with COVID-19(8 males and 11 females,aged 54.2±8.7 years).Fatigue and myalgia were persistent symptoms at the 1-year follow-up.The resting state functional magnetic resonance imaging revealed that compared with 29 healthy controls(7 males and 18 females,aged 50.5±11.6 years),COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation(ALFF)values in the left precentral gyrus,middle frontal gyrus,inferior frontal gyrus of operculum,inferior frontal gyrus of triangle,insula,hippocampus,parahippocampal gyrus,fusiform gyrus,postcentral gyrus,inferior parietal angular gyrus,supramarginal gyrus,angular gyrus,thalamus,middle temporal gyrus,inferior temporal gyrus,caudate,and putamen.ALFF values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores,and those in the left precentral gyrus were positively correlated with neutrophil count during hospitalization.The long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 survivors.This can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric sequelae.This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University(approval No.2020 S004)on March 19,2020.展开更多
文摘Objective:To determine the preventive effects of curcumin on peroxidative damage under two bed rest conditions.Methods:20 healthy male(10 with curcumin and 10 without curcumin ) volunteers were selected.They were studied before,during,and just on bed rest conditions at -6°head-down-tilt(HDT) bed rest and bed rest position(BD) for 10 days.We measured the salivary and serum oxidative markers such as Malonaldehyde,8-hydroxydeoxyguanosine, vitamin C and E just before HDT & BD.during HDT & BD experiment,and in course time of recovery with curcumin and without curcumin groups.Results:The values of serum and salivary vitamin C & E showed statistically significant decrease in both bed rest conditions as compared to those of the conditions before and during the recovery stage.However,these levels were not significantly lowered in curcumin groups in contrast to the groups without curcumin (P】0.05).MDA and 8-OHdG levels showed significant increase in simulating microgravity and zero gravity conditions as compared to those before and in the recovery stage.However,these levels were lower in curcumin groups in contrast to the groups without curcumin(P【0.05).Serum and salivary correlation analysis revealed a strong and highly significant correlation for MDA. vitamin C & E and 8 dihydro-2 deoxyguanosine(8-OHdG) in the conditions before,during and in the recovery periods in both bed rest conditions.Since saliva collection is easy and noninvasive, measurements of salivary marker levels may prove to be useful in the space research. Conclusions:Curcumin prevents peroxidative damage in both bed rest conditions.Further study is required on antioxidation actions of curcumin in space microgravity conditions.
文摘Objective:To investigate the safety of relieving bed restriction in hepatic arterial infusion chemotherapy(HAIC)and its effects on patient comfort.Methods:A prospective study was conducted.Patients with malignant liver tumors,who met the enrollment criteria,were randomly divided into experimental and control groups.During HAIC treatment,the patients in the experimental group,who were not confined to bed and could get out of bed,used electronic injection pumps to infuse chemotherapy drugs.The patients in the control group,who were strictly confined to bed and prohibited from getting out of bed,used infusion pumps to infuse chemotherapy drugs.The complications of the two groups were observed.The Christenson standard improved method was used to evaluate the bleeding and hematoma of limbs on the operation side.The Kolcaba General Comfort Questionnaire(GCQ)and Barthel Index(BI)were used to evaluate the two groups.Results:Ninety patients with malignant liver tumors were enrolled,including 53 with primary liver cancer and 37 with colorectal liver metastasis.There were 70 males and 20 females,aged 41-81 years old,with an average age of 61.6±9.248 years old.There were 60 patients in the experimental group and 30 patients in the control group.All patients underwent HAIC.The study showed that,during the treatment period,there were 3 cases of postoperative puncture point hematoma formation in the two groups,including 2 cases in the experimental group(2/60,3.3%)and 1 case in the control group(1/30,3.3%).The difference was not statistically significant(p>0.05).There were 5 cases of postoperative puncture point bleeding,including 4 cases in the experimental group(4/60,6.7%)and 1 case in the control group(1/30,3.3%),and the difference was not statistically significant(p>0.05).A total of 23 cases,with 6 cases in the experimental group(6/60,10%)and 17 cases in the control group(17/30,56.7%),complained of back pain after the operation,and the difference was statistically significant(p<0.05).Twenty-one cases complained of poor defecation after the operation,including 10 cases in the experimental group(10/60,16.7%)and 11 cases in the control group(11/30,36.7%).The difference was statistically significant(p<0.05).During the period of infusion chemotherapy,the two groups of patients had there was a significant difference between the two groups in terms of comfort status(GCQ)(88.78±6.705,78.47±9.519,p<0.001)and self-care ability(BI)(74.25±9.152,66.83±6.628,p<0.001).Conclusion:During HAIC treatment,getting out of bed is safe and reliable and can increase the patients’comfort and self-care ability.Hence,it merits clinical application.
文摘Considering the maternal risk for both short- and long-term disability imposed by activity restriction, it is of great concern that the antepartum symptoms of bed rest are still evident in the postpartum period. The benefits of bed-rest-exercise may alleviate or even prevent physiological distresses or deconditioning associated with activity restriction, thus, eliminating or stabilizing, factors that may augment existing complications. This is the first study to investigate the feasibility of incorporating a bed-rest exercise program in a specific hospitalized twin pregnancy case. The maternal physiological responses of heart rate, blood pressure and uterine contractions to a four week bed-rest resistance program were measured in a woman hospitalized due to complications during her twin pregnancy. A second participant (same diagnoses) was included as a control. The bed-rest-exercise reduced the degree of swelling in the lower extremities, promoted more energy during the day and a better night’s sleep. There were no significant differences in uterine contractions pre vs. post protocol and all babies were born healthy.
文摘<strong>Objective:</strong> Against a background of the two-child policy in China, the objective is to explore the effects of lower limb strengthening exercises on hospitalized pregnant women put on bed rest for prevention of miscarriage. <strong>Method:</strong> Sixty cases of pregnant women admitted to the Department of Obstetrics in one of the highest ranking hospitals in Guangzhou, China, during the period from November 2018 to December 2019 for the purpose of preventing miscarriage were selected. They were divided into an experimental group and a control group of 30 cases each. The control group was put under routine care while the intervention group conducted lower limb muscle strengthening exercise on top of the routine care. After the intervention, the conditions of lower limbs, the psychological states and the results of pregnancy for the two groups were compared. <strong>Results: </strong>After the intervention, the scores of the experimental group in anxiety, depression and postpartum depression were lower and leg circumferences were smaller compared to the control group. The difference is statistically significant (<em>P</em> < 0.05). The experimental group had longer gestation than the control group and was able to get out of bed earlier than the control group after delivery, with statistically significant difference (<em>P</em> < 0.05). <strong>Conclusion:</strong> Lower limb muscle strengthening exercises can effectively improve the physiological and psychological states of pregnant women hospitalized for prevention of miscarriage and promote their postpartum recovery.
基金National Natural Science Foundation of China under Grant No. 41372356the College Cultivation Project of the National Natural Science Foundation of China under Grant No. 2018PY30+1 种基金the Basic Research and Frontier Exploration Project of Chongqing,China under Grant No. cstc2018jcyj A1597the Graduate Scientific Research and Innovation Foundation of Chongqing,China under Grant No. CYS18026。
文摘Shake table testing was performed to investigate the dynamic stability of a mid-dip bedding rock slope under frequent earthquakes. Then, numerical modelling was established to further study the slope dynamic stability under purely microseisms and the influence of five factors, including seismic amplitude, slope height, slope angle, strata inclination and strata thickness, were considered. The experimental results show that the natural frequency of the slope decreases and damping ratio increases as the earthquake loading times increase. The dynamic strength reduction method is adopted for the stability evaluation of the bedding rock slope in numerical simulation, and the slope stability decreases with the increase of seismic amplitude, increase of slope height, reduction of strata thickness and increase of slope angle. The failure mode of a mid-dip bedding rock slope in the shaking table test is integral slipping along the bedding surface with dipping tensile cracks at the slope rear edge going through the bedding surfaces. In the numerical simulation, the long-term stability of a mid-dip bedding slope is worst under frequent microseisms and the slope is at risk of integral sliding instability, whereas the slope rock mass is more broken than shown in the shaking table test. The research results are of practical significance to better understand the formation mechanism of reservoir landslides and prevent future landslide disasters.
基金Supported in part by the National Natural Science Foundation of China(No.11402161)the Programs for Science and Technique Development of Shanxi Province,China(No.20120313025-3)+1 种基金the Science and Technology Research Projects of the Shanxi Provincial Health Department,China(No.201201018)an unrestricted grant from Research to Prevent Blindness,New York,NY,USA
文摘AIM: To investigate the long term(≥5 y) efficacy, predictability, and safety of laser in situ keratomileusis(LASIK) in eyes with thin corneas [central corneal thickness(CCT) 〈500 μm]. METHODS: A total of 339 patients met the criteria of this study. Finally, 175 eyes of 89 patients who had thin corneas and underwent LASIK≥5 y ago returned to our clinic and included in this study. Preoperative parameters recorded included uncorrected visual acuity(UCVA), corrected distance visual acuity(CDVA), manifest refraction, CCT and corneal topography. At returning visits, in addition to visual acuity and manifest refraction, ultrasound CCT and corneal topography were performed. Optical coherence tomography was used to measure the CCT, LASIK flap thickness, and residual stromal bed thickness(RSBT). Safety index, efficacy index, percentage of eyes within ±0.5 D and ±1.0 D of refraction, percent tissue altered(PTA), and percentage stromal bed thickness(PSBT) were calculated. RESULTS: The safety index was 1.09 and efficacy index was 0.99. The percentages of eyes within ±0.5 D and ±1.0 D were 71.2% and 87.7%, respectively. The mean PTA was 40%±6%(range 20% to 55%); 76 eyes(43.4%) had PTA 〈40% and 99 eyes(56.6%) had PTA≥40%. The mean RSBT was 303±27 μm(range 240 to 390 μm), and 2 eyes had RSBT〈250 μm. The mean PSBT was 61%±9%(range 51% to 85%). No eyes developed ectasia. CONCLUSION: In this cohort with the PSBT of 50% or more, LASIK is safe with follow-up for at least 5 y.
基金supported by Key Emergency Project of Pneumonia Epidemic of Novel Coronavirus Infection of China,No.2020SK3006(to JL)Clinical Research Center for Medical Imaging in Hunan Province of China,No.2020SK4001(to JL)the Innovative Major Emergency Project Funding against the New Coronavirus Pneumonia in Hunan Province of China,No.2020SK3014(to JYL)。
文摘Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019(COVID-19)exhibit anxiety,depression,and altered brain microstructure,their long-term physical problems,neuropsychiatric sequelae,and changes in brain function remain unknown.This observational cohort study collected 1-year follow-up data from 22 patients who had been hospitalized with COVID-19(8 males and 11 females,aged 54.2±8.7 years).Fatigue and myalgia were persistent symptoms at the 1-year follow-up.The resting state functional magnetic resonance imaging revealed that compared with 29 healthy controls(7 males and 18 females,aged 50.5±11.6 years),COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation(ALFF)values in the left precentral gyrus,middle frontal gyrus,inferior frontal gyrus of operculum,inferior frontal gyrus of triangle,insula,hippocampus,parahippocampal gyrus,fusiform gyrus,postcentral gyrus,inferior parietal angular gyrus,supramarginal gyrus,angular gyrus,thalamus,middle temporal gyrus,inferior temporal gyrus,caudate,and putamen.ALFF values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores,and those in the left precentral gyrus were positively correlated with neutrophil count during hospitalization.The long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 survivors.This can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric sequelae.This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University(approval No.2020 S004)on March 19,2020.