The aim of this study is to illustrate the complexity of pain management in chronic pancreatitis(CP).In this context,pain represents the most common and debilitating symptom,and it deeply affects patient’s quality of...The aim of this study is to illustrate the complexity of pain management in chronic pancreatitis(CP).In this context,pain represents the most common and debilitating symptom,and it deeply affects patient’s quality of life.Multiple rating scales(unidimensional,bidimensional and multidimensional)have been proposed to quantify CP pain.However,it represents the result of complex mechanisms,involving genetic,neuropathic and neurogenic factors.Considering all these aspects,the treatment should be discussed in a multidisciplinary setting and it should be approached in a stepwise manner.First,a lifestyle change is recommended and nonsteroidal anti-inflammatory drugs represent the gold standard among medical treatments for CP patients.The second step,after medical approach,is endoscopic therapy,especially for complicated CP.In case of failure,tailored surgery represents the third step and decompressive or resection procedures can be chosen.In conclusion,CP pain’s management is challenging considering all these complex aspects and the lack of international protocols.展开更多
BACKGROUND Abdominal pain in chronic pancreatitis(CP)may require invasive interventions.Surgical procedures are rare,and little is known about the long-term results.AIM To study the nationwide frequency of pancreatic ...BACKGROUND Abdominal pain in chronic pancreatitis(CP)may require invasive interventions.Surgical procedures are rare,and little is known about the long-term results.AIM To study the nationwide frequency of pancreatic surgery for CP in Finland,and postoperative symptoms and quality of life(QoL).METHODS All patients in Finland with a diagnosis of CP who had undergone pancreatic surgery during 2000-2008 were selected from a national register.Only patients with CP as an indication for pancreatic surgery were included.Medical records were studied and questionnaires QLQ-C30,PAN26 and AUDIT,and symptom questionnaires were sent out.RESULTS During the 9-year period,pancreatic surgery for CP was performed on 30 patients[77%men,median age 45(21-62)years].Eighty-three percent underwent endoscopic procedures before surgery.Surgery was performed a median 2(0-10)years after the original CP diagnosis,and 17%developed postoperative complications.Primary pain relief after surgery was reported in 70%of cases.Need for strong pain medication was lower after surgery.Eight of 21(38%)returned the questionnaires and 88%reported that surgery had reduced their pain and 63%were almost or entirely pain-free at a median 14(10-18)years after surgery.QoL results did not differ from those in our control Finnish CP group.CONCLUSION Surgery for CP is rare in Finland and most patients had prior endoscopic procedures.Patients who returned the questionnaires reported less pain and good QoL during the 14-year follow-up.展开更多
Chronic pancreatitis(CP)is a condition characterized by persistent and often severe pain resulting from the inflammatory disease of the pancreas.While pharmacological treatments play a significant role in palliative p...Chronic pancreatitis(CP)is a condition characterized by persistent and often severe pain resulting from the inflammatory disease of the pancreas.While pharmacological treatments play a significant role in palliative pain management,some patients require non-pharmacological methods.This review article focuses on non-pharmacological approaches used to alleviate pain in CP.The article examines non-pharmacological palliation options,including surgery,endoscopic approaches,neurostimulation techniques,acupuncture,and other alternative medicine methods.The effectiveness of each method is evaluated,taking into consideration patient compliance and side effects.Additionally,this article emphasizes the importance of personalized pain management in CP and underscores the need for a multidisciplinary approach.It aims to summarize the existing knowledge on the use of non-pharmacological palliation methods to improve the quality of life for patients with CP.展开更多
Background: The long-term outcomes of patients with chronic pain treated in a multidisciplinary pain management center remain variable. Objective: This study aims to evaluate the changes in outcomes of patient’s self...Background: The long-term outcomes of patients with chronic pain treated in a multidisciplinary pain management center remain variable. Objective: This study aims to evaluate the changes in outcomes of patient’s self-reported pain, psychosocial status, health related quality of life and gender differences following treatment in amultidisciplinary pain management centre. Design: A prospective longitudinal cross-sectional study uses questionnaires. Treatment Setting: A pragmatic and individualized patient centered approach in a tertiary level multidisciplinary pain management center. Subjects: Patients with chronic pain referred to the centre from 2004-2010. Outcome Measures: Pain Numerical Rating Scale (NRS), Pain Temporal Description (1 - 6), Pain Self- Efficacy Questionnaire (PSEQ), Depression Anxiety Stress Scales (DASS-21) and Short Form-36 (SF- 36). Follow-up questionnaires were sent at 6 and 12 months after initial assessment. Results: Mean duration of baseline chronic pain was 8.1 years and 61% of chronic pains were involving the musculoskeletal system. At 6 and 12 month follow-ups, 273 and 180 participants had been surveyed respectively. At 6-month follow-up, there were significant improvements on pain intensity (Cohen’s d = 0.8), pain self-efficacy (Cohen’s d = 0.47), depression and stress scores (Cohen’s d = 0.16) and six out of eight domains of SF-36 (Cohen’s d = 0.2 - 0.4). At 12-month follow-up, improvements were maintained on pain intensity, self-efficacy and three out of eight domains of SF-36. There were distinctive pre- and post-treatment gender differences in these outcomes and overall females showed better short- and long-term outcomes than males. Conclusion: Multidisciplinary pain management using an individualized patient centered approach remains an effective treatment for chronic pain in both the short- (6 month) and long-term (12 month). The distinctive pre- and post-treatment gender differences particularly in the psychological outcomes, suggest that it may be beneficial to further delineate and better manage vulnerable patient subgroups.展开更多
Breast cancer is the most prevalent cancer in women worldwide, and pain following mastectomy is a major post-surgical complication. This paper highlights the risk factors for chronic pain in breast surgery and evaluat...Breast cancer is the most prevalent cancer in women worldwide, and pain following mastectomy is a major post-surgical complication. This paper highlights the risk factors for chronic pain in breast surgery and evaluates various regional block techniques used to reduce post-operative pain, and minimize hospital stays in high-risk patients. Further research is needed to evaluate the effectiveness of novel regional anaesthesia techniques in an enhanced recovery context, and to assess their role in preventing or reducing chronic pain.展开更多
BACKGROUND: Treatment of chronic pancreatitis (CP) is a challenging condition for surgeons. During the last decades, increasing knowledge about pathophysiology of CP, improved results of major pancreatic resections, a...BACKGROUND: Treatment of chronic pancreatitis (CP) is a challenging condition for surgeons. During the last decades, increasing knowledge about pathophysiology of CP, improved results of major pancreatic resections, and integration of sophisticated diagnostic methods in clinical practice have resulted in significant changes in surgery for CP. DATA SOURCES: To detail the indications for CP surgery, the surgical procedures, and outcome, a Pubmed database search was performed. The abstracts of searched articles about surgical management of CP were reviewed. The articles could be identified and further scrutinized. Further references were extracted by cross-referencing. RESULTS: Main indications of CP for surgery are intractable pain, suspicion of malignancy, and involvement of adjacent organs. The goal of surgical treatment is to improve the quality of life of patients. The surgical approach to CP should be individualized according to pancreatic anatomy, pain characteristics, baseline exocrine and endocrine function, and medical co-morbidity. The approach usually involves pancreatic duct drainage and resection including longitudinal pancreatojejunostomy, pancreatoduodenectomy (Whipple’s procedure), pylorus-preserving pancreatoduodenectomy, distal pancreatectomy, total pancreatectomy, duodenum- preserving pancreatic head resection (Beger’s procedure), and local resection of the pancreatic head with longitudinal pancreatojejunostomy (Frey’s procedure). Non-pancreatic and endoscopic management of pain has also been advocated. CONCLUSIONS: Surgical procedures provide long-term pain relief, a good postoperative quality of life withpreservation of endocrine and exocrine pancreatic function, and are associated with low early and late mortality and morbidity. In addition to available results from randomized controlled trials, new studies are needed to determine which procedure is the most effective for the management of patients with CP.展开更多
目的:观察精油穴位按压对慢性鼻窦炎伴鼻息肉患者鼻内窥镜术后疼痛及舒适度的影响。方法:选取120例在全麻下行鼻内窥镜手术的慢性鼻窦炎伴鼻息肉患者,按便利抽样法分为对照组及观察组各60例。对照组予常规术后护理,观察组在常规术后护...目的:观察精油穴位按压对慢性鼻窦炎伴鼻息肉患者鼻内窥镜术后疼痛及舒适度的影响。方法:选取120例在全麻下行鼻内窥镜手术的慢性鼻窦炎伴鼻息肉患者,按便利抽样法分为对照组及观察组各60例。对照组予常规术后护理,观察组在常规术后护理基础上给予精油穴位按压干预。比较2组术后各时间段视觉模拟评分法(VAS)、Kokaba舒适状况量表(GCQ)、匹兹堡睡眠质量指数评定量表(PSQI)评分的变化。结果:观察组术后6 h、术后24 h、术后48 h 3个时间段的VAS评分均低于对照组,差异均有统计学意义(P<0.05)。术后,2组GCQ评分均较术前下降,观察组GCQ评分高于对照组,差异均有统计学意义(P<0.05)。术后,2组PSQI评分均较术前增加,观察组PSQI评分低于对照组,差异均有统计学意义(P<0.05)。治疗期间,2组均未发生明显不良反应。结论:精油穴位按压能够缓解慢性鼻窦炎伴鼻息肉患者鼻内窥镜术后的疼痛程度,提高舒适度,提升睡眠质量。展开更多
文摘The aim of this study is to illustrate the complexity of pain management in chronic pancreatitis(CP).In this context,pain represents the most common and debilitating symptom,and it deeply affects patient’s quality of life.Multiple rating scales(unidimensional,bidimensional and multidimensional)have been proposed to quantify CP pain.However,it represents the result of complex mechanisms,involving genetic,neuropathic and neurogenic factors.Considering all these aspects,the treatment should be discussed in a multidisciplinary setting and it should be approached in a stepwise manner.First,a lifestyle change is recommended and nonsteroidal anti-inflammatory drugs represent the gold standard among medical treatments for CP patients.The second step,after medical approach,is endoscopic therapy,especially for complicated CP.In case of failure,tailored surgery represents the third step and decompressive or resection procedures can be chosen.In conclusion,CP pain’s management is challenging considering all these complex aspects and the lack of international protocols.
基金Medical Research Fund of Pirkanmaa Hospital District,No.9X024and Sigrid Jusélius Foundation,No.MS424.
文摘BACKGROUND Abdominal pain in chronic pancreatitis(CP)may require invasive interventions.Surgical procedures are rare,and little is known about the long-term results.AIM To study the nationwide frequency of pancreatic surgery for CP in Finland,and postoperative symptoms and quality of life(QoL).METHODS All patients in Finland with a diagnosis of CP who had undergone pancreatic surgery during 2000-2008 were selected from a national register.Only patients with CP as an indication for pancreatic surgery were included.Medical records were studied and questionnaires QLQ-C30,PAN26 and AUDIT,and symptom questionnaires were sent out.RESULTS During the 9-year period,pancreatic surgery for CP was performed on 30 patients[77%men,median age 45(21-62)years].Eighty-three percent underwent endoscopic procedures before surgery.Surgery was performed a median 2(0-10)years after the original CP diagnosis,and 17%developed postoperative complications.Primary pain relief after surgery was reported in 70%of cases.Need for strong pain medication was lower after surgery.Eight of 21(38%)returned the questionnaires and 88%reported that surgery had reduced their pain and 63%were almost or entirely pain-free at a median 14(10-18)years after surgery.QoL results did not differ from those in our control Finnish CP group.CONCLUSION Surgery for CP is rare in Finland and most patients had prior endoscopic procedures.Patients who returned the questionnaires reported less pain and good QoL during the 14-year follow-up.
文摘Chronic pancreatitis(CP)is a condition characterized by persistent and often severe pain resulting from the inflammatory disease of the pancreas.While pharmacological treatments play a significant role in palliative pain management,some patients require non-pharmacological methods.This review article focuses on non-pharmacological approaches used to alleviate pain in CP.The article examines non-pharmacological palliation options,including surgery,endoscopic approaches,neurostimulation techniques,acupuncture,and other alternative medicine methods.The effectiveness of each method is evaluated,taking into consideration patient compliance and side effects.Additionally,this article emphasizes the importance of personalized pain management in CP and underscores the need for a multidisciplinary approach.It aims to summarize the existing knowledge on the use of non-pharmacological palliation methods to improve the quality of life for patients with CP.
文摘Background: The long-term outcomes of patients with chronic pain treated in a multidisciplinary pain management center remain variable. Objective: This study aims to evaluate the changes in outcomes of patient’s self-reported pain, psychosocial status, health related quality of life and gender differences following treatment in amultidisciplinary pain management centre. Design: A prospective longitudinal cross-sectional study uses questionnaires. Treatment Setting: A pragmatic and individualized patient centered approach in a tertiary level multidisciplinary pain management center. Subjects: Patients with chronic pain referred to the centre from 2004-2010. Outcome Measures: Pain Numerical Rating Scale (NRS), Pain Temporal Description (1 - 6), Pain Self- Efficacy Questionnaire (PSEQ), Depression Anxiety Stress Scales (DASS-21) and Short Form-36 (SF- 36). Follow-up questionnaires were sent at 6 and 12 months after initial assessment. Results: Mean duration of baseline chronic pain was 8.1 years and 61% of chronic pains were involving the musculoskeletal system. At 6 and 12 month follow-ups, 273 and 180 participants had been surveyed respectively. At 6-month follow-up, there were significant improvements on pain intensity (Cohen’s d = 0.8), pain self-efficacy (Cohen’s d = 0.47), depression and stress scores (Cohen’s d = 0.16) and six out of eight domains of SF-36 (Cohen’s d = 0.2 - 0.4). At 12-month follow-up, improvements were maintained on pain intensity, self-efficacy and three out of eight domains of SF-36. There were distinctive pre- and post-treatment gender differences in these outcomes and overall females showed better short- and long-term outcomes than males. Conclusion: Multidisciplinary pain management using an individualized patient centered approach remains an effective treatment for chronic pain in both the short- (6 month) and long-term (12 month). The distinctive pre- and post-treatment gender differences particularly in the psychological outcomes, suggest that it may be beneficial to further delineate and better manage vulnerable patient subgroups.
文摘Breast cancer is the most prevalent cancer in women worldwide, and pain following mastectomy is a major post-surgical complication. This paper highlights the risk factors for chronic pain in breast surgery and evaluates various regional block techniques used to reduce post-operative pain, and minimize hospital stays in high-risk patients. Further research is needed to evaluate the effectiveness of novel regional anaesthesia techniques in an enhanced recovery context, and to assess their role in preventing or reducing chronic pain.
文摘BACKGROUND: Treatment of chronic pancreatitis (CP) is a challenging condition for surgeons. During the last decades, increasing knowledge about pathophysiology of CP, improved results of major pancreatic resections, and integration of sophisticated diagnostic methods in clinical practice have resulted in significant changes in surgery for CP. DATA SOURCES: To detail the indications for CP surgery, the surgical procedures, and outcome, a Pubmed database search was performed. The abstracts of searched articles about surgical management of CP were reviewed. The articles could be identified and further scrutinized. Further references were extracted by cross-referencing. RESULTS: Main indications of CP for surgery are intractable pain, suspicion of malignancy, and involvement of adjacent organs. The goal of surgical treatment is to improve the quality of life of patients. The surgical approach to CP should be individualized according to pancreatic anatomy, pain characteristics, baseline exocrine and endocrine function, and medical co-morbidity. The approach usually involves pancreatic duct drainage and resection including longitudinal pancreatojejunostomy, pancreatoduodenectomy (Whipple’s procedure), pylorus-preserving pancreatoduodenectomy, distal pancreatectomy, total pancreatectomy, duodenum- preserving pancreatic head resection (Beger’s procedure), and local resection of the pancreatic head with longitudinal pancreatojejunostomy (Frey’s procedure). Non-pancreatic and endoscopic management of pain has also been advocated. CONCLUSIONS: Surgical procedures provide long-term pain relief, a good postoperative quality of life withpreservation of endocrine and exocrine pancreatic function, and are associated with low early and late mortality and morbidity. In addition to available results from randomized controlled trials, new studies are needed to determine which procedure is the most effective for the management of patients with CP.
文摘目的:观察精油穴位按压对慢性鼻窦炎伴鼻息肉患者鼻内窥镜术后疼痛及舒适度的影响。方法:选取120例在全麻下行鼻内窥镜手术的慢性鼻窦炎伴鼻息肉患者,按便利抽样法分为对照组及观察组各60例。对照组予常规术后护理,观察组在常规术后护理基础上给予精油穴位按压干预。比较2组术后各时间段视觉模拟评分法(VAS)、Kokaba舒适状况量表(GCQ)、匹兹堡睡眠质量指数评定量表(PSQI)评分的变化。结果:观察组术后6 h、术后24 h、术后48 h 3个时间段的VAS评分均低于对照组,差异均有统计学意义(P<0.05)。术后,2组GCQ评分均较术前下降,观察组GCQ评分高于对照组,差异均有统计学意义(P<0.05)。术后,2组PSQI评分均较术前增加,观察组PSQI评分低于对照组,差异均有统计学意义(P<0.05)。治疗期间,2组均未发生明显不良反应。结论:精油穴位按压能够缓解慢性鼻窦炎伴鼻息肉患者鼻内窥镜术后的疼痛程度,提高舒适度,提升睡眠质量。
