An Exploration of Organizational Development in the Process of Innovation and Transformation of Pharmaceutical Enterprises-Taking X Pharmaceutical Enterprise as an Example

Objective To study how to promote the smooth innovation and transformation of enterprises and enhance the market competitiveness of enterprises from the perspective of human resources organization development.In the wave of pharmaceutical industry reform,some entrepreneurs realize the importance of innovation and technology in the future.However,domestic pharmaceutical enterprises are still in the production-oriented stage.In the process of transformative innovation,pharmaceutical enterprises should not only rely on the support of scientific and technological and economic forces,but also need a suitable organizational change and many excellent talents as the source of development.Methods Through retrieving relevant literature and combined with the organizational development practice of X pharmaceutical enterprise,the organizational development model was explored in this paper.Results and Conclusion By forming a system of strategy,organization,talent,culture and mechanism,and building an organizational development model,we can improve the organizational atmosphere and organizational efficiency in the process of enterprise innovation and transformation,so as to enhance the competitiveness of enterprises in the market.

Impact of taxes on the 2030 Agenda for Sustainable Development:Evidence from Organization for Economic Cooperation and Development(OECD)countries

Multiple ecological and socioeconomic problems have occurred worldwide,raising the awareness of sustainability.This study aims to examine the impact of taxes on Sustainable Development Goals(SDGs)in the context of Organization for Economic Co-operation and Development(OECD)countries.This research used effective average tax(EAT),tax on personal income(TPI),tax on corporate profits(TCP),and tax on goods and services(TGS)as the variables of taxes,and employed secondary data from 38 OECD countries covering 2000–2021.The study also used Breusch-Pagan Lagrange Multiplier(LM),Pesaran Scaled LM,Bias-Corrected Scaled LM,and Pesaran Cross-sectional dependence(CSD)tests to analyze the existence of crosssectional dependency.Then,we established the stationarity of variables through second-generation panel unit root tests(Cross-sectional Augmented Dickey-Fuller(CADF)and Cross-sectional Im,Pesaran,and Shin(CIPS)),and confirmed the long-run cointegration of the variables by using secondgeneration panel cointegration test(Westerlund cointegration test).The results showed that EAT,TPI,TCP,and TGS are positively associated with SDGs.However,the change in TPI has a smaller effect on SDGs than the change in EAT or TCP or TGS.The result of panel causality indicated that EAT,TPI,and TGS have a unidirectional causal relationship with SDGs.The study also found that TCP has a bi-directional causal relationship with SDGs.Moreover,the finding indicated that the OECD countries need to focus on tax policies to achieve the 2030 Agenda for Sustainable Development.This study is based on the theory of optimal taxation(TOT),which suggests that tax systems should be designed to maximize social welfare.Finally,we suggests the importance of taking a comprehensive approach for the managers and policy-makers when analyzing the impact of taxes on SDGs.

Entrepreneurship and Organizations' Development

In modern society,the competition has become increasingly fierce.Organizations pay close attention to their manage ment in order to gain the priority.Under this context,entrepreneurship has been attached great importance to.Entrepreneurship has played an indispensable role in organizations.Compare to those short-lived companies,powerful organizations,such as Google,IBM and P&G has gain great progress in the last decades.Therefore,it is essential to study how the powerful organiza tion could always be innovative.This paper aims to study the role that entrepreneurship plays in the organizations and take Google as an example.It provides some previous lessons that Chinese organizations could draw from.

Development of business capacity and organization of commercial business of farmer based organizations in the northern intervention zone in Ghana: A case study of nine-farmer based organizations

The Agricultural Component of the Millennium Challenge Account Ghana Compact was to alleviate poverty and improve livelihoods of farmers through commercial development of farmer organizations in the intervention zones in Ghana. In Ghana, there were three intervention zones as Southern Horticultural Zone, Afram Basin Zone and Northern Horticultural Zone. Nine Farmer Based Organizations (FBO’s) of 450 farmers consisting of 65.1% males and 34.9% females in the West Mamprusi district of the Northern Horticultural Zone were trained by authors under the Millennium Development Authority (MiDA) Agricultural Project. Farmers of the FBO’s were trained on nine modules on Business Capacity Building and five modules on Organization of Commercial Business over a period of six weeks. Age range of trainee farmers was 30-39 years for males representing 37.54% and 40-49 years for females representing 29.94%. Educational level of trainee farmers was 9.90% males and 1.91% females who completed primary school. Trainee farmers who completed senior high school were 2.73% and 0.64% for males and females, respectively. There were no university graduates among the trainees of the nine farmer groups trained. Among the educated trainee farmers was 81.91% male illiterate and 91.72% illiterate. Trainees’ farm size was 0.4-2.0 hectares representing 57.43% males and 66.45% females. Attendance of male trainees over the period of six weeks was 89.76% and 10.24% absentees, whereas attendance of females over the same period was 88.96% and 11.04% absentees. Nine Action Business Plans were developed for the nine FBO’s to access financial support from the MiDA participating financial institutions in the horticultural zone for the commercial development of farmers’ organizations. This paper presents a case study analysis of Business Capacity Building and Organization of Commercial Business modules provided in the Northern Horticultural Zone to nine Farmer Based Organizations (FBO’s).

Training and Development Strategies for Senior and Middle Level Managers with the Purpose of Learning Organizations

In the presence of dynamic organizational environment and a growing supply of‘knowledgeable employees’which require more professional managers to address their fast changing and increasing needs,senior and middle level managers are now required to keep up with the dynamic and learning environment more than ever.In order to train senior and middle level managers,the article has recommended four perspectives to encourage the development of learning manager.The first aspect for senior and middle level mangers is to integrate learning talents into their practices.The second point is to encourage managers to provide strong support for individuals and teams to develop a learning organization.The third point encourages learning managers and organizations to be composed into the culture of the organization.The last point advocates for more open and free dissemination of information and knowledge to be allowed within an organization.

Present Situation and Development Mode of Chinese Farmers' Cooperative Organizations

In developed countries,the typical modes of farmers' cooperative organizations are " German mode", " Japan and South Korea mode" and " American mode". The development of farmers' cooperative organizations in China is the product of need and being needed,with low level of specialization,systematism and industrialization. However,Chinese farmers' cooperative organizations have the advantages of diversification,full supporting and great opportunities of Internet economy and e-commerce environment. Based on that,this paper puts forward the " Chinese mode" for the development of farmers' cooperative organizations in China in the future,that is,the main body of innovation and entrepreneurship will unite,and the other entities of production and industry will follow them.

Review of History and Recent Development of Organic Farming Worldwide

The history of the organic farming worldwide was reviewed in this paper. The development of the organic farming worldwide had gone through three stages, emergence, expansion, and growth. The contributors and their thoughts during the different development stages of the organic farming were briefly introduced. And the development status of the organic farming worldwide was reviewed from the aspects of land area under organic management, land area under organic management in percentage of total agricultural area, and world markets for organic products. Besides, the main existing problems for the further development of the world＇s organic farming, as well as the development status, problems and strategies of the Chinese organic farming were discussed.

Impact of chilling accumulation and hydrogen cyanamide on floral organ development of sweet cherry in a warm region

The microscopic investigation of the floral development of sweet cherry（Prunus avium L. cv. Hongdeng） from a warm winter climate（Shanghai） and cold winter climate（Tai＇an, Shandong Province, China） was conducted to explore the reason of low fruit set. The effect of hydrogen cyanamide（HCN） on floral development under warm winter conditions was also investigated. Trees grown in Shanghai with insufficient chilling accumulation exhibited little difference in the progression of microspore development compared to trees in Tai＇an that accumulated adequate chilling, but showed substantial delays in ovule and embryo sac development. The growth of nucelli did not proceed beyond the macrospore mother cell and macrospore stages with abortion rates of 13, 15 and 45% by 6, 3 and 0 d before full bloom, respectively. These abnormalities in the ovule and embryo sac in the Shanghai-grown trees were eliminated by HCN application. These results suggest that chilling regulates the development of female floral organs in winter dormancy; therefore, insufficient chilling accumulation, causing abnormality of the female floral organs, restricts the cultivation of sweet cherry in warm winter regions. Interestingly, HCN application, which decreased the chilling requirements for Hongdeng, may be a potential strategy for sweet cherry cultivation in warm winter regions.

UNITED INTERNATIONAL CENTRAL CITY: A NEW SPATIAL ORGANIZATION MODEL IN TUMEN RIVER ECONOMY DEVELOPMENT ZONE

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Non-Fullerene-Based Inverted Organic Photovoltaic Device with Long-Term Stability

In this work,we developed the PM6:Y6-based inverted structure organic photovoltaic(i-OPV)with improved power conversion efficiency(PCE)and long-term stability by resolving the origins of the performance deterioration.The deep defects between the metal oxide-based electron transport layer and bulk-heterojunction photoactive layer interface were responsible for suboptimal PCE and facilitated degradation of devices.While the density of deep traps is increased during the storage of i-OPV,the penetrative oxygen-containing defects additionally generated shallow traps below the band-edge of Y6,causing an additional loss in the open-circuit voltage.The suppression of interfacial defects by chemical modification effectively improved the PCE and long-term stability of i-OPV.The modified i-OPV(mi-OPV)achieved a PCE of 17.42%,which is the highest value among the reported PM6:Y6-based i-OPV devices.Moreover,long-term stability was significantly improved:~90%and~80%retention of its initial PCE after 1200 h of air storage and illumination,respectively.

Development of Acidification-resistant Organic Fertilizer for Improvement of Acid Red Soil in Guangxi

The soil in Guangxi has been severely acidified,restricting sustainable development of agriculture.In this paper,based on the screening of organic fertilizer additives,a method for the production of acidification-resistant organic fertilizer specific for acid red soil improvement was proposed,and the developed acidification-resistant organic fertilizer was used in sugarcane experiment.The results showed that in the treatment that the specific acidification-resistant organic fertilizer was applied,the yield of sugarcane significantly increased,the p H value of soil effectively increased,the physical and chemical properties of soil improved,and the contents of microorganisms and available nutrients in soil increased.

Organic carbon isotope and pollen evidence for mangrove development and response to human activity in Guangxi(Southwest China) over the last 140 years

Mangrove degradation must reduce carbon sequestration in recent years, thereby aggravating global warming.Thus, short-term impacts of human activity on mangrove ecosystems are cause for concern from local governments and scientists. Mangroves sediments can provide detailed records of mangrove species variation in the last one hundred years, based on detailed 210 Pb data. The study traced the history of mangrove development and its response to environmental change over the last 140 years in two mangrove swamps of Guangxi, Southwest China. Average sedimentation rates were calculated to be 0.48 cm/a and 0.56 cm/a in the Yingluo Bay and the Maowei Sea, respectively. Chemical indicators（δ13Corg and C：N） were utilized to trace the contribution of mangrove-derived organic matter（MOM） using a ternary mixing model. Simultaneous use of mangrove pollen can help to supplement some of these limitations in diagenetic/overlap of isotopic signatures. We found that vertical distribution of MOM was consistent with mangrove pollen, which could provide similar information for tracing mangrove ecosystems. Therefore, mangrove development was reconstructed and divided into three stages： flourishing, degradation and re-flourishing/re-degradation period. The significant degradation, found in the period of 1968–1998 and 1907–2007 in the Yingluo Bay and the Maowei Sea, respectively, corresponding to a rapid increase of reclamation area and seawall length, rather than climate change as recorded in the region.

The role of lysyl oxidase-like 1 and fibulin-5 in the development of atherosclerosis and pelvic organ prolapse

Dear Editor： I would like to congratulate Zhou et al.[1] on their study of the correlation between expression of lysyl oxidase-like 1 （LOX-1） and fibulin-5 （F5） in the car- dinal ligament tissue and pelvic organ prolapse （POP）. In their elegant work, they evaluated the levels of LOX-1 and F5 in connective tissue of the cardinal ligament in order to demonstrate signs of elastinopa- thy in women with POP. They stress the concept that several environmental risk factors could cause qualitative and quantitative changes in the connective tissue promoting POP. The above authors conclude that the specific mechanism of LOXL1 and F5 involved in the development of POP is unclear.

3D genome organization and its study in livestock breeding

Eukaryotic genomes are hierarchically packaged into cell nucleus,affecting gene regulation.The genome is organized into multiscale structural units,including chromosome territories,compartments,topologically associating domains(TADs),and DNA loops.The identification of these hierarchical structures has benefited from the development of experimental approaches,such as 3C-based methods(Hi-C,ChIA-PET,etc.),imaging tools(2D-FISH,3D-FISH,Cryo-FISH,etc.)and ligation-free methods(GAM,SPRITE,etc.).In recent two decades,numerous studies have shown that the 3D organization of genome plays essential roles in multiple cellular processes via various mechanisms,such as regulating enhancer activity and promoter-enhancer interactions.However,there are relatively few studies about the 3D genome in livestock species.Therefore,studies for exploring the function of 3D genomes in livestock are urgently needed to provide a more comprehensive understanding of potential relationships between the genome and production traits.In this review,we summarize the recent advances of 3D genomics and its biological functions in human and mouse studies,drawing inspiration to explore the 3D genomics of livestock species.We then mainly focus on the biological functions of 3D genome organization in muscle development and its implications in animal breeding.

Ontogeny of immune organs during early development stage of P. crocea

A histological and ultrastructural study was performed on the development of the head kidney, thymus, and spleen in Pseudosciaena crocea aging in range from just hatching to the 60th day after hatching （DAH）. Head kidney was first present on the 3rd DAH. Primordial haemopoietic stem cells were first observed in the head kidney which rapidly differentiate into different cellular types. Progenitor spleen was present on the 4th DAH, located close to the gut, which soon became rich in blood capillaries, red blood cells and thrombocytes. The thymus was obvious on the 4th DAH, and was located on either side of the upper comer of the opercular cavity, closely under the membrance of the opercuhr cavity. The thymus was the last lymphoid organ to appear but showed a quick development. This organ seemed to originate from haemopoietic stem cells migrating from the head region of the kidney. The thymus consisted of outer thymocytic and inner epithelioid zones. There was no obvious demarcation between them, but both zones were visible. Small lymphocytes appeared, or lymphoid organs become lymphoid, in the sequence thymus, head kidney and spleen. Only a small number of lymphocytes appeared in the later stages. Non-specific systems may play an important role in the immunocompetence mechanisms of P. crocea during its early development stage.

Organic Agriculture: The Inevitable Choice for the Sustainable Development of Agriculture

The current situation of farmland utilization in China was analyzed firstly, and then cost of fertilizer misuse leading to decrease of cultivat- ed land in quality was discussed. Finally, it is concluded that organic agriculture is the inevitable choice for the sustainable development of agricul- ture from the meaning, advantages and countermeasures of developing organic agriculture in China.

Researches on Agricultural Cooperative Economic Organization Promoting Agricultural Insurance Development

The advantages of cooperative economic organization being the effective carrier of agricultural insurance development are analyzed. Firstly, cooperative economic organization promotes scale management and solves the problem of decentralized operation of small households. Secondly, cooperative economic organization can settle the problem of peasants' low systematization. Thirdly, cooperative economic organization can largely reduce the costs of agricultural insurance operation. Fourthly, cooperative organization decreases moral risks as well as adverse selection to some extent. Lastly, cooperative organization, to a certain degree, reduces the risks of agricultural production and increases the insurability of agricultural risks. Meanwhile, limitations of agricultural cooperative economic organization being the carrier of agricultural insurance operation are pointed out. Firstly, cooperative economic organization has limited coverage and small size of organization, which is harmful to the diversification of agricultural risks. Secondly, cooperative economic organization lacks capital funds and its development is not standard, which is not perfect for the function exertion as a carrier. Lastly, members of professional cooperative organization have low cultural qualities, which restrict the implementation of agricultural insurance. The modes of farmers' cooperative economic organization promoting agricultural insurance development are proposed, including mode of agricultural insurance cooperative ( mutual corporation), mode of "leading enterprises (companies) + professional cooperative organization (planting majors) + insurance" and mode of professional cooperatives serving as agricultural insurance agent. Last of all, the promoting role of agricultural insurance in agricultural cooperative economic organization is briefly illustrated.

Developing Universities into Learning Organizations

A number of companies and organizations consider that it is necessary todevelop into learning organizations in order to meet the challenges of rapidly changing world. Aftera review on the literature on the learning organization, there is no question that the concept isboth attractive and complex. There appears to be more consensus about that becoming a learningorganization is more of a journey than a destination. Senge identifies five key disciplines thatKelp organization to become a learning organization, and the disciplines mean commitment, focus,and practice. In recent years the concept of the learning organization is translated into theeducation sector. Today, more than ever, more and more people see education as the highest form ofleverage to improve society. As the highest form of the education sector, universities must try todevelop into learning organizations. But the process will be neither easy nor swift, and we shouldview the process not as a task to be completed, but as the ongoing work. Effective change andimprovement can only happen by conducting long-term practice involving teachers, administrators,parents, and students who have a common vision and work and live with a learning culture.

The potential of contribution of mangrove-derived organic matter in intertidal sediments as a proxy of mangrove development in the northern Beibu Gulf

Located between terrestrial and marine ecosystems,mangrove forests are sensitive to changes in climate.The responses of mangrove ecosystems to climate change in the future can be understood by reconstructing past mangrove dynamics using proxies preserved in the intertidal sediments.Considering the complexity of the proxies commonly used,it is necessary to develop a relatively simple,inexpensive proxy.In this study,available chemical tracers(δ13Corg and C:N)of the four cores(YLW02,YLW03,O18,and Q37)from the intertidal zone of the northern Beibu Gulf(NBG)and a three-end-member(mangrove,sea grass,and suspended particulate matter)model was utilized to determine the contribution of mangrove-derived organic matter(CMOM)in carbonate-free sediments.Compared with the summed concentration of mangrove pollen(SCMP),a significant positive correlation between CMOM and SCMP is displayed.The calculated CMOM for an additional 210Pb-dated sediment core from the Yingluo Bay,NBG(YLW01)clearly indicates a mangrove development going through degradation,flourishing,relative degradation,and relative flourishing,which are separately in correspondence with the lowest,highest,lower,and higher air temperature and rainfall in the time intervals of 1890–1918 AD,1919–1956 AD,1957–1990 AD,and 1991–2010 AD.This suggests that CMOM preserved in intertidal sediments has a potential to reconstruct historical mangrove development in high resolution,at the very least,along the coasts of the NBG.