BACKGROUND In contrast to many Western countries,China has maintained its large psychiatric hospitals.The prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in inpatients with schizophrenia(S...BACKGROUND In contrast to many Western countries,China has maintained its large psychiatric hospitals.The prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in inpatients with schizophrenia(SCZ)are unclear.AIM To assess the prevalence of COVID-19 among inpatients with SCZ and compare the infected to uninfected SCZ patients in a Wuhan psychiatric hospital.METHODS We retrospectively collected demographic characteristics and clinical profiles of all SCZ patients with COVID-19 at Wuhan’s Youfu Hospital.RESULTS Among the 504 SCZ patients,84 had COVID-19,and we randomly sampled 174 who were uninfected as a comparison group.The overall prevalence of COVID-19 in SCZ patients was 16.7%.Among the 84 SCZ patients with confirmed COVID-19,the median age was 54 years and 76.2%were male.The most common symptom was fever(82%),and less common symptoms were cough(31%),poor appetite(20%),and fatigue(16%).Compared with SCZ patients without COVID-19,those with COVID-19 were older(P=0.006)and significantly lighter(P=0.002),and had more comorbid physical diseases(P=0.001).Surprisingly,those infected were less likely to be smokers(<0.001)or to be treated with dozapine(P=0.03).Further logistic regression showed that smoking[odds ratio(OR)=5.61],clozapine treated(OR=2.95),and male(OR=3.48)patients with relatively fewer comorbid physical diseases(OR=0.098)were at a lower risk for COVID-19.SCZ patients with COVID-19 presented primarily with fever,but only one-third had a cough,which might otherwise be the most common mode of transmission between individuals.CONCLUSION Two unexpected protective factors for COVID-19 among SCZ inpatients are smoking and dozapine treatment.展开更多
Objective: The aim of the present study is to explore clinical factors associated with basic ability of social life in schizophrenia inpatients. Methods: The subjects were 50 inpatients with schizophrenia (DSM-IV). Th...Objective: The aim of the present study is to explore clinical factors associated with basic ability of social life in schizophrenia inpatients. Methods: The subjects were 50 inpatients with schizophrenia (DSM-IV). Their mean age was 53.08 (SD = 12.08) years. Social life functioning was evaluated using the Rehabilitation Evaluation of Hall and Baker (REHAB). Cognitive function was assessed with the Brief Assessment of Cognition in Schizophrenia (BACS) and clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia and the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). Results: The REHAB deviant behavior score showed a significant correlation with the PANSS positive syndrome score (r = 0.55, p < 0.01) and the REHAB general behavior score had significant correlations with the PANSS positive syndrome score (r = 0.28, p < 0.05), the PANSS negative syndrome score (r = 0.53, p < 0.01), and the DIEPSS score (r = 0.43, p < 0.01). However, there was no significant correlation between the scores of the REHAB and the BACS. Conclusion: These results suggest that negative and drug-induced extrapyramidal symptoms are much more important factors related to lowered basic ability of social life of schizophrenia inpatients than cognitive function.展开更多
An experimental model of schizophrenia was established using dizocilpine （MK-801）. Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results ...An experimental model of schizophrenia was established using dizocilpine （MK-801）. Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment.展开更多
Discontinuation of antipsychotic therapy has been a significant clinical issue among patients with schizophrenia, since the patients who discontinued antipsychotic treatment showed worse clinical and functional outcom...Discontinuation of antipsychotic therapy has been a significant clinical issue among patients with schizophrenia, since the patients who discontinued antipsychotic treatment showed worse clinical and functional outcomes, and higher risks of relapse of schizophrenia symptoms and hospitalization. We conducted a post-hoc analysis of a post-marketing research with a 12-month follow-up period to identify the predictors for discontinuation of antipsychotic monotherapy in Japan. This is a prospective, naturalistic multicenter observational study, designed to evaluate the discontinuation rates of olanzapine monotherapy and non-olanzapine antipsychotic monotherapy in Japanese adult patients with acute schizophrenia. Patients were treatment-naive, or had switched from other antipsychotics or from poly-pharmacotherapy to oral antipsychotic monotherapy. We analyzed the correlation of discontinuation of antipsychotic monotherapy with baseline characteristics of patients. A total of 1089 patients (578 patients treated with olanzapine and 511 with non-olanzapine antipsychotics) were eligible for analysis. By the end of the 12-month study period, 614 patients (56.4%) discontinued antipsychotic therapy. Multivariate logistic regression analyses indicated significantly lower discontinuation rates in all patients treated with antipsychotics: older age (Odds ratio [OR], 0.871;95% confidence interval [CI], 0.797 to 0.953;p = 0.003), outpatient status (OR, 0.508;95% CI, 0.383 to 0.675;p < 0.001), prior use of antipsychotics (OR, 0.693;95% CI, 0.516 to 0.930;p = 0.015), and olanzapine group showed lower discontinuation rate than that of non-olanzapine group (OR, 1.416;95% CI, 1.086 to 1.846;p = 0.010). The present study indicated that the outpatient status, older age, and prior use of antipsychotics have better adherence to antipsychotic treatment. In addition to these factors, use of anti-parkinson agents showed lower discontinuation rates in the olanzapine monotherapy group.展开更多
目的探讨团体绘画治疗对恢复期精神分裂症住院患者阴性和阳性症状、社会功能和认知功能的影响,为患者提供非药物治疗方法。方法将2022年1月至9月45例本院住院恢复期精神分裂症患者设为对照组,并予以常规药物及康复训练;2022年10月至2023...目的探讨团体绘画治疗对恢复期精神分裂症住院患者阴性和阳性症状、社会功能和认知功能的影响,为患者提供非药物治疗方法。方法将2022年1月至9月45例本院住院恢复期精神分裂症患者设为对照组,并予以常规药物及康复训练;2022年10月至2023年6月45例恢复期精神分裂症住院患者设为观察组,在对照组基础上团体绘画治疗干预。干预时间8w。干预前后分别采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)、住院精神患者社会功能量表(scale of social function in psychosis inpatients,SSPI)、重复性成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS)比较两组患者阳性与阴性症状、社会功能和认知功能。结果两组各45例患者完成研究。观察组患者阳性阴性症状量表评分干预前后差值高于对照组;观察组患者SSPI评分干预前后差值高于对照组;观察组RBANS评分干预前后差值高于对照组,差异具有统计学意义(均P<0.001)。结论团体绘画治疗可改善患者临床症状,提高患者认知功能,促进社会功能恢复。展开更多
目的:评估精神分裂症住院患者社交技能训练的效果。方法:应用自行编制的社交技能训练手册,对32位符合国际疾病和相关健康问题第10版(International Classification of Diseases and Related Health Problems.Tenth Revision,ICD-10)精...目的:评估精神分裂症住院患者社交技能训练的效果。方法:应用自行编制的社交技能训练手册,对32位符合国际疾病和相关健康问题第10版(International Classification of Diseases and Related Health Problems.Tenth Revision,ICD-10)精神分裂症诊断标准的稳定期住院患者实施12次训练,为期4周,随访6个月。分别于训练前、训练结束时、训练后3个月和6个月评定社交技能量表(Social Skills Checklist,SSC)和社会适应能力评定量表(Social Adaptive Functioning Evaluation,SAFE)。结果:与训练前比较,SSC和SAFE总分在训练结束时、训练后3个月和6个月均有显著下降;在以上3个评定时点上,SSC12个条目中分别有8个、11个和10个条目得分显著下降,SAFE的19个条目中分别有7个、14个和16个条目得分显著下降,差异均具有统计学意义(P<0.01)。结论:应用自行编制的社交技能训练手册对精神分裂症住院患者进行社交技能训练,可提高患者的社交技能和社会适应能力,效果延续至训练后6个月。展开更多
文摘BACKGROUND In contrast to many Western countries,China has maintained its large psychiatric hospitals.The prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in inpatients with schizophrenia(SCZ)are unclear.AIM To assess the prevalence of COVID-19 among inpatients with SCZ and compare the infected to uninfected SCZ patients in a Wuhan psychiatric hospital.METHODS We retrospectively collected demographic characteristics and clinical profiles of all SCZ patients with COVID-19 at Wuhan’s Youfu Hospital.RESULTS Among the 504 SCZ patients,84 had COVID-19,and we randomly sampled 174 who were uninfected as a comparison group.The overall prevalence of COVID-19 in SCZ patients was 16.7%.Among the 84 SCZ patients with confirmed COVID-19,the median age was 54 years and 76.2%were male.The most common symptom was fever(82%),and less common symptoms were cough(31%),poor appetite(20%),and fatigue(16%).Compared with SCZ patients without COVID-19,those with COVID-19 were older(P=0.006)and significantly lighter(P=0.002),and had more comorbid physical diseases(P=0.001).Surprisingly,those infected were less likely to be smokers(<0.001)or to be treated with dozapine(P=0.03).Further logistic regression showed that smoking[odds ratio(OR)=5.61],clozapine treated(OR=2.95),and male(OR=3.48)patients with relatively fewer comorbid physical diseases(OR=0.098)were at a lower risk for COVID-19.SCZ patients with COVID-19 presented primarily with fever,but only one-third had a cough,which might otherwise be the most common mode of transmission between individuals.CONCLUSION Two unexpected protective factors for COVID-19 among SCZ inpatients are smoking and dozapine treatment.
文摘Objective: The aim of the present study is to explore clinical factors associated with basic ability of social life in schizophrenia inpatients. Methods: The subjects were 50 inpatients with schizophrenia (DSM-IV). Their mean age was 53.08 (SD = 12.08) years. Social life functioning was evaluated using the Rehabilitation Evaluation of Hall and Baker (REHAB). Cognitive function was assessed with the Brief Assessment of Cognition in Schizophrenia (BACS) and clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), the Calgary Depression Scale for Schizophrenia and the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS). Results: The REHAB deviant behavior score showed a significant correlation with the PANSS positive syndrome score (r = 0.55, p < 0.01) and the REHAB general behavior score had significant correlations with the PANSS positive syndrome score (r = 0.28, p < 0.05), the PANSS negative syndrome score (r = 0.53, p < 0.01), and the DIEPSS score (r = 0.43, p < 0.01). However, there was no significant correlation between the scores of the REHAB and the BACS. Conclusion: These results suggest that negative and drug-induced extrapyramidal symptoms are much more important factors related to lowered basic ability of social life of schizophrenia inpatients than cognitive function.
基金sponsored by the Natural Science Foundation of China (No. 81160423)Research Plan of Traditional Chinese Medicine of Jiangxi Province Department of Public Health (No. 2009A054)Jiangxi Provincial Youth Science Fund Project (No. GJJ11190)
文摘An experimental model of schizophrenia was established using dizocilpine （MK-801）. Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment.
文摘Discontinuation of antipsychotic therapy has been a significant clinical issue among patients with schizophrenia, since the patients who discontinued antipsychotic treatment showed worse clinical and functional outcomes, and higher risks of relapse of schizophrenia symptoms and hospitalization. We conducted a post-hoc analysis of a post-marketing research with a 12-month follow-up period to identify the predictors for discontinuation of antipsychotic monotherapy in Japan. This is a prospective, naturalistic multicenter observational study, designed to evaluate the discontinuation rates of olanzapine monotherapy and non-olanzapine antipsychotic monotherapy in Japanese adult patients with acute schizophrenia. Patients were treatment-naive, or had switched from other antipsychotics or from poly-pharmacotherapy to oral antipsychotic monotherapy. We analyzed the correlation of discontinuation of antipsychotic monotherapy with baseline characteristics of patients. A total of 1089 patients (578 patients treated with olanzapine and 511 with non-olanzapine antipsychotics) were eligible for analysis. By the end of the 12-month study period, 614 patients (56.4%) discontinued antipsychotic therapy. Multivariate logistic regression analyses indicated significantly lower discontinuation rates in all patients treated with antipsychotics: older age (Odds ratio [OR], 0.871;95% confidence interval [CI], 0.797 to 0.953;p = 0.003), outpatient status (OR, 0.508;95% CI, 0.383 to 0.675;p < 0.001), prior use of antipsychotics (OR, 0.693;95% CI, 0.516 to 0.930;p = 0.015), and olanzapine group showed lower discontinuation rate than that of non-olanzapine group (OR, 1.416;95% CI, 1.086 to 1.846;p = 0.010). The present study indicated that the outpatient status, older age, and prior use of antipsychotics have better adherence to antipsychotic treatment. In addition to these factors, use of anti-parkinson agents showed lower discontinuation rates in the olanzapine monotherapy group.
文摘目的探讨团体绘画治疗对恢复期精神分裂症住院患者阴性和阳性症状、社会功能和认知功能的影响,为患者提供非药物治疗方法。方法将2022年1月至9月45例本院住院恢复期精神分裂症患者设为对照组,并予以常规药物及康复训练;2022年10月至2023年6月45例恢复期精神分裂症住院患者设为观察组,在对照组基础上团体绘画治疗干预。干预时间8w。干预前后分别采用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)、住院精神患者社会功能量表(scale of social function in psychosis inpatients,SSPI)、重复性成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS)比较两组患者阳性与阴性症状、社会功能和认知功能。结果两组各45例患者完成研究。观察组患者阳性阴性症状量表评分干预前后差值高于对照组;观察组患者SSPI评分干预前后差值高于对照组;观察组RBANS评分干预前后差值高于对照组,差异具有统计学意义(均P<0.001)。结论团体绘画治疗可改善患者临床症状,提高患者认知功能,促进社会功能恢复。
文摘目的:评估精神分裂症住院患者社交技能训练的效果。方法:应用自行编制的社交技能训练手册,对32位符合国际疾病和相关健康问题第10版(International Classification of Diseases and Related Health Problems.Tenth Revision,ICD-10)精神分裂症诊断标准的稳定期住院患者实施12次训练,为期4周,随访6个月。分别于训练前、训练结束时、训练后3个月和6个月评定社交技能量表(Social Skills Checklist,SSC)和社会适应能力评定量表(Social Adaptive Functioning Evaluation,SAFE)。结果:与训练前比较,SSC和SAFE总分在训练结束时、训练后3个月和6个月均有显著下降;在以上3个评定时点上,SSC12个条目中分别有8个、11个和10个条目得分显著下降,SAFE的19个条目中分别有7个、14个和16个条目得分显著下降,差异均具有统计学意义(P<0.01)。结论:应用自行编制的社交技能训练手册对精神分裂症住院患者进行社交技能训练,可提高患者的社交技能和社会适应能力,效果延续至训练后6个月。
