As is known, the Great Red Spot (GRS) is one of the most mysterious sights in the solar system and is a strong storm that is quite large. According to the laws of hydrodynamics and gas dynamics, it should have disappe...As is known, the Great Red Spot (GRS) is one of the most mysterious sights in the solar system and is a strong storm that is quite large. According to the laws of hydrodynamics and gas dynamics, it should have disappeared several centuries ago, but scientists still observe it and cannot accurately explain this phenomenon. Since turbulence and atmospheric waves in the GRS region absorb the energy of its winds, the vortex loses energy by radiating heat. In the work, it is proved with a mathematical and non-classical approach that the GRS and anticyclones will live for a long time;otherwise, we had to first of all prove that the vortex threads (loops) and ovals could not exist. Based on these supports, mathematical methods prove their existence forever by observing a large vortex (GRS);moreover, they are sources of heat. When proofs are obtained, the results are consistent with the previous hypotheses of the researcher. The introduction of the work gives a comparison of various hypotheses;for example, one of them states that the decrease in the size of the GRS is only an illusory observation. Next, we first consider the applicability conditions for the mathematical justification of the hypothesis of the longevity of the Great Red Spot. The wind equation and the GRS are energized by absorbing smaller eddies and ovals, and this total energy is constant. With the help of the KH mechanism in the case of Brunt Vaisala, the frequencies (which can be calculated by a program with given formulas) are determined using very strictly mathematical evidence to substantiate the validity of the hypothesis about the longevity of Jupiter’s Great Red Spot.展开更多
Traditional Chinese medicine(TCM)has rich theories and techniques for health maintenance.Its cultural tradition of emphasizing health maintenance is not only related to its medical function of treating injuries and di...Traditional Chinese medicine(TCM)has rich theories and techniques for health maintenance.Its cultural tradition of emphasizing health maintenance is not only related to its medical function of treating injuries and diseases and prolonging life span but also closely related to Daoism,which is the fundamental religious tenet of pursuing immortality in Chinese culture.As this paper reviews,the fanatical Daoist religious culture of pursuing immortality has influenced the formation of a medical culture in TCM that cares about longevity and values health and wellness.However,this health and wellness culture is more practical–it replaces immortality with longevity as the goal.The Daoist religious concept of longevity is preserved in the basic principles and ethical values of health care:it emphasizes the harmony and consistency of the spirit and the body.It turns a lifestyle of maintaining physical and spiritual health into the pursuit of an ideal state of life.As for the specific Daoist health techniques,there are various cases of inheritance,change or abandonment:TCM inherited most of the drugs and prescriptions from the Daoist longevity techniques based on natural medicines taking and formed a popular health culture of medicinal and dietary supplements;TCM also developed internal health techniques such as internal elixir and breathing practice from Daoist internal health maintenance techniques for physical health care and disease treatment;TCM did not completely accept recipe techniques such as inedia and sex manual from Daoism because they contradicted with its secularization concept,but their general value orientation of lightness and low desire also influenced its concept of health care.展开更多
Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals ...Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals relative to their size,particularly the Myotis bats,which can live up to 40 years.However,the mechanisms underlying these distinctive traits remain incompletely understood.In our prior research,we demonstrated that bats exhibit dampened STING-interferon activation,potentially conferring upon them the capacity to mitigate virus-or aging-induced inflammation.To substantiate this hypothesis,we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING(MdSTING)into the mouse genome.We monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on MdSTING and wild-type mice over a 3-year aging process.Blood transcriptomic analysis indicated a reduction in aging-related inflammation in female MdSTING mice,as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines,immunopathology,and neutrophil recruitment in aged female MdSTING mice compared to aged wild-type mice in vivo.These results indicated that MdSTING knock-in attenuates the aging-related inflammatory response and may also improve the healthspan in mice in a sex-dependent manner.Although the underlying mechanism awaits further study,this research has critical implications for bat longevity research,potentially contributing to our comprehension of healthy aging in humans.展开更多
To investigate the effects of drinking the soaking of Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China.It has been reported that longevity...To investigate the effects of drinking the soaking of Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China.It has been reported that longevity is closely related to metabolism and the gut microbiota.The 16S rRNA sequencing and liquid chromatography-mass spectrometry(LC-MS)were used to analysis fecal samples and explore the factors affecting longevity in the region.Interestingly,we discovered,that elderly individuals who had been drinking the soaking of M.domeri(Bois)Chev.leaves for a long time exhibited higher diversity of the gut microbiota than without drinking the soaking,notably.The proportions of Ruminococcaceae and Prevotella were decreased in those who did not drink this soaking.In addition,a total of 106 metabolites were characterized,and the people of long-lived people(>90 years old)and elderly people(<90 years old)who drinking soaking of M.domeri(Bois)Chev.leaves significantly altered the gut microbiota and upregulated levels of haplopine,farnesol,genipic acid,momordicinin,2-hydroxyestrone,hydroxyphenyllactic acid,caffeic acid,sophoraflavanone B,and soyasaponin I.We preliminarily determined that M.domeri(Bois)Chev.leaves consumption may be an important factor affecting longevity in this area.展开更多
This editorial commentary critically examines the systematic review by Miotti et al,which discusses the evolving trends in upper lid blepharoplasty towards a conservative,volume-preserving approach.The review emphasiz...This editorial commentary critically examines the systematic review by Miotti et al,which discusses the evolving trends in upper lid blepharoplasty towards a conservative,volume-preserving approach.The review emphasizes the shift from traditional tissue resection to techniques that maintain anatomical integrity,paralleling broader trends in panfacial rejuvenation.Miotti et al delve into the nuances of fat pad management,advocating for conservation over reduction to sustain natural contours and improve long-term aesthetic outcomes.This perspective is supported by comparative studies and empirical data,such as those from Massry and Alghoul et al,highlighting the benefits of conservative approaches in terms of patient satisfaction and aesthetic longevity.The review also stresses the importance of surgeon discretion in adapting procedures to diverse patient demographics,particularly in addressing distinct features such as the Asian upper eyelid.However,it identifies a significant gap in long-term comparative research,underscoring the need for future studies to substantiate the safety and efficacy of these minimalist techniques.Overall,Miotti et al.'s work contributes profoundly to the discourse on personalized,conservative cosmetic surgery,urging ongoing research to refine and validate surgical best practices in upper eyelid blepharoplasty.展开更多
This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the...This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the MCNPX code for analysing neutron behavior and the PARET/ANL code for understanding power variations, to get a clearer picture of the reactor’s performance. The analysis covers the initial six years of GHARR-1’s operation and includes projections for its whole 60-year lifespan. We closely observed the patterns of both the highest and average PPFs at 21 axial nodes, with measurements taken every ten years. The findings of this study reveal important patterns in power distribution within the core, which are essential for improving the safety regulations and fuel management techniques of the reactor. We provide a meticulous approach, extensive data, and an analysis of the findings, highlighting the significance of continuous monitoring and analysis for proactive management of nuclear reactors. The findings of this study not only enhance our comprehension of nuclear reactor safety but also carry significant ramifications for sustainable energy progress in Ghana and the wider global context. Nuclear engineering is essential in tackling global concerns, such as the demand for clean and dependable energy sources. Research on optimising nuclear reactors, particularly in terms of safety and efficiency, is crucial for the ongoing advancement and acceptance of nuclear energy.展开更多
文摘As is known, the Great Red Spot (GRS) is one of the most mysterious sights in the solar system and is a strong storm that is quite large. According to the laws of hydrodynamics and gas dynamics, it should have disappeared several centuries ago, but scientists still observe it and cannot accurately explain this phenomenon. Since turbulence and atmospheric waves in the GRS region absorb the energy of its winds, the vortex loses energy by radiating heat. In the work, it is proved with a mathematical and non-classical approach that the GRS and anticyclones will live for a long time;otherwise, we had to first of all prove that the vortex threads (loops) and ovals could not exist. Based on these supports, mathematical methods prove their existence forever by observing a large vortex (GRS);moreover, they are sources of heat. When proofs are obtained, the results are consistent with the previous hypotheses of the researcher. The introduction of the work gives a comparison of various hypotheses;for example, one of them states that the decrease in the size of the GRS is only an illusory observation. Next, we first consider the applicability conditions for the mathematical justification of the hypothesis of the longevity of the Great Red Spot. The wind equation and the GRS are energized by absorbing smaller eddies and ovals, and this total energy is constant. With the help of the KH mechanism in the case of Brunt Vaisala, the frequencies (which can be calculated by a program with given formulas) are determined using very strictly mathematical evidence to substantiate the validity of the hypothesis about the longevity of Jupiter’s Great Red Spot.
基金supported by the Fundamental Research Funds for the Central Universities(No.21lzujbkydx036).
文摘Traditional Chinese medicine(TCM)has rich theories and techniques for health maintenance.Its cultural tradition of emphasizing health maintenance is not only related to its medical function of treating injuries and diseases and prolonging life span but also closely related to Daoism,which is the fundamental religious tenet of pursuing immortality in Chinese culture.As this paper reviews,the fanatical Daoist religious culture of pursuing immortality has influenced the formation of a medical culture in TCM that cares about longevity and values health and wellness.However,this health and wellness culture is more practical–it replaces immortality with longevity as the goal.The Daoist religious concept of longevity is preserved in the basic principles and ethical values of health care:it emphasizes the harmony and consistency of the spirit and the body.It turns a lifestyle of maintaining physical and spiritual health into the pursuit of an ideal state of life.As for the specific Daoist health techniques,there are various cases of inheritance,change or abandonment:TCM inherited most of the drugs and prescriptions from the Daoist longevity techniques based on natural medicines taking and formed a popular health culture of medicinal and dietary supplements;TCM also developed internal health techniques such as internal elixir and breathing practice from Daoist internal health maintenance techniques for physical health care and disease treatment;TCM did not completely accept recipe techniques such as inedia and sex manual from Daoism because they contradicted with its secularization concept,but their general value orientation of lightness and low desire also influenced its concept of health care.
基金supported by the China Natural Science Foundation for Outstanding Scholars(82325032)Self-Supporting Program of Guangzhou Laboratory(SRPG22-001)。
文摘Bats,notable as the only flying mammals,serve as natural reservoir hosts for various highly pathogenic viruses in humans(e.g.,SARS-CoV and Ebola virus).Furthermore,bats exhibit an unparalleled longevity among mammals relative to their size,particularly the Myotis bats,which can live up to 40 years.However,the mechanisms underlying these distinctive traits remain incompletely understood.In our prior research,we demonstrated that bats exhibit dampened STING-interferon activation,potentially conferring upon them the capacity to mitigate virus-or aging-induced inflammation.To substantiate this hypothesis,we established the first in vivo bat-mouse model for aging studies by integrating Myotis davidii bat STING(MdSTING)into the mouse genome.We monitored the genotypes of these mice and performed a longitudinal comparative transcriptomic analysis on MdSTING and wild-type mice over a 3-year aging process.Blood transcriptomic analysis indicated a reduction in aging-related inflammation in female MdSTING mice,as evidenced by significantly lower levels of pro-inflammatory cytokines and chemokines,immunopathology,and neutrophil recruitment in aged female MdSTING mice compared to aged wild-type mice in vivo.These results indicated that MdSTING knock-in attenuates the aging-related inflammatory response and may also improve the healthspan in mice in a sex-dependent manner.Although the underlying mechanism awaits further study,this research has critical implications for bat longevity research,potentially contributing to our comprehension of healthy aging in humans.
基金supported by the National Natural Science Foundation of China (32072193)the Natural Science Foundation of Guangxi,China (2020GXNSFBA297083)。
文摘To investigate the effects of drinking the soaking of Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China.It has been reported that longevity is closely related to metabolism and the gut microbiota.The 16S rRNA sequencing and liquid chromatography-mass spectrometry(LC-MS)were used to analysis fecal samples and explore the factors affecting longevity in the region.Interestingly,we discovered,that elderly individuals who had been drinking the soaking of M.domeri(Bois)Chev.leaves for a long time exhibited higher diversity of the gut microbiota than without drinking the soaking,notably.The proportions of Ruminococcaceae and Prevotella were decreased in those who did not drink this soaking.In addition,a total of 106 metabolites were characterized,and the people of long-lived people(>90 years old)and elderly people(<90 years old)who drinking soaking of M.domeri(Bois)Chev.leaves significantly altered the gut microbiota and upregulated levels of haplopine,farnesol,genipic acid,momordicinin,2-hydroxyestrone,hydroxyphenyllactic acid,caffeic acid,sophoraflavanone B,and soyasaponin I.We preliminarily determined that M.domeri(Bois)Chev.leaves consumption may be an important factor affecting longevity in this area.
文摘This editorial commentary critically examines the systematic review by Miotti et al,which discusses the evolving trends in upper lid blepharoplasty towards a conservative,volume-preserving approach.The review emphasizes the shift from traditional tissue resection to techniques that maintain anatomical integrity,paralleling broader trends in panfacial rejuvenation.Miotti et al delve into the nuances of fat pad management,advocating for conservation over reduction to sustain natural contours and improve long-term aesthetic outcomes.This perspective is supported by comparative studies and empirical data,such as those from Massry and Alghoul et al,highlighting the benefits of conservative approaches in terms of patient satisfaction and aesthetic longevity.The review also stresses the importance of surgeon discretion in adapting procedures to diverse patient demographics,particularly in addressing distinct features such as the Asian upper eyelid.However,it identifies a significant gap in long-term comparative research,underscoring the need for future studies to substantiate the safety and efficacy of these minimalist techniques.Overall,Miotti et al.'s work contributes profoundly to the discourse on personalized,conservative cosmetic surgery,urging ongoing research to refine and validate surgical best practices in upper eyelid blepharoplasty.
文摘This study aims to thoroughly investigate the axial power peaking factors (PPF) within the low-enriched uranium (LEU) core of the Ghana Research Reactor-1 (GHARR-1). This study uses advanced simulation tools, like the MCNPX code for analysing neutron behavior and the PARET/ANL code for understanding power variations, to get a clearer picture of the reactor’s performance. The analysis covers the initial six years of GHARR-1’s operation and includes projections for its whole 60-year lifespan. We closely observed the patterns of both the highest and average PPFs at 21 axial nodes, with measurements taken every ten years. The findings of this study reveal important patterns in power distribution within the core, which are essential for improving the safety regulations and fuel management techniques of the reactor. We provide a meticulous approach, extensive data, and an analysis of the findings, highlighting the significance of continuous monitoring and analysis for proactive management of nuclear reactors. The findings of this study not only enhance our comprehension of nuclear reactor safety but also carry significant ramifications for sustainable energy progress in Ghana and the wider global context. Nuclear engineering is essential in tackling global concerns, such as the demand for clean and dependable energy sources. Research on optimising nuclear reactors, particularly in terms of safety and efficiency, is crucial for the ongoing advancement and acceptance of nuclear energy.