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心脏磁共振T1 mapping评价缺血性心肌病心肌纤维化与LVEF及NT-proBNP的关系 被引量:12
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作者 李亮 罗艺 +5 位作者 沈磊 丁超 汪家财 卫军 吕鹏 邓克学 《中国医学计算机成像杂志》 CSCD 北大核心 2021年第1期10-15,共6页
目的:探讨心脏磁共振纵向驰豫时间定量(T1mapping)评价缺血性心肌病(ICM)心肌纤维化与左室射血分数(LVEF)及N端脑钠肽前体(NT-proBNP)的关系。方法:回顾性分析2018年10月至2020年6月在我院诊治的29例ICM患者资料,将其设为ICM组;采集同... 目的:探讨心脏磁共振纵向驰豫时间定量(T1mapping)评价缺血性心肌病(ICM)心肌纤维化与左室射血分数(LVEF)及N端脑钠肽前体(NT-proBNP)的关系。方法:回顾性分析2018年10月至2020年6月在我院诊治的29例ICM患者资料,将其设为ICM组;采集同期在我院进行体检的30名健康志愿者资料作为对照组。所有受试者均给予T1 mapping扫描及延迟增强扫描,并检测血清NT-proBNP水平;增强前后,比较2组左心功能参数、左心室平均T1值及NT-proBNP水平,并采用Pearson相关性分析考察ICM心肌纤维化指标与LVEF及NT-proBNP水平的关系。结果:ICM组左室收缩末期容积(LVESV)、左室舒张末期容积(LVEDV)、左室心肌质量(LVMM)、NT-proBNP、细胞外容积(ECV)、T1_(Native)等指标均高于或长于对照组,而LVEF、T1_(Post)则明显小于或短于对照组(均P<0.05);且LVESV、LVEDV、LVMM、NT-proBNP、ECV、T1_(Native)等值在ICM患者中均呈纽约心脏病协会(NYHA)Ⅱ级<NYHA Ⅲ级<NYHA Ⅳ级的趋势(均P<0.05);而LVEF、T1_(Post)在患者中均呈NYHA Ⅱ级>NYHA Ⅲ级>NYHA Ⅳ级(均P<0.05);Pearson相关性分析结果显示:ECV、T1_(Native)与NT-proBNP呈正相关,与LVEF呈负相关(P<0.01);T1_(Post)则与NT-proBNP呈负相关,与LVEF呈正相关(P<0.01)。结论:T1 mapping通过ECV可评估心肌纤维化水平,随着ICM患者心功能受损程度加深,ECV、T1_(Native)也随之升高,T1_(Post)则逐渐下降,且上述指标均与NT-proBNP和LVEF相关。 展开更多
关键词 缺血性心肌病 磁共振成像 纵向驰豫时间定量(t1 mapping) 左室射血分数 N端脑钠肽前体 细胞外容积
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Numerical simulation of(T_2,T_1) 2D NMR and fluid responses 被引量:1
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作者 谭茂金 邹友龙 +1 位作者 张晋言 赵昕 《Applied Geophysics》 SCIE CSCD 2012年第4期401-413,495,共14页
One-dimensional nuclear magnetic resonance (1D NMR) logging technology is limited for fluid typing, while two-dimensional nuclear magnetic resonance (2D NMR) logging can provide more parameters including longitudi... One-dimensional nuclear magnetic resonance (1D NMR) logging technology is limited for fluid typing, while two-dimensional nuclear magnetic resonance (2D NMR) logging can provide more parameters including longitudinal relaxation time (71) and transverse relaxation time (T2) relative to fluid types in porous media. Based on the 2D NMR relaxation mechanism in a gradient magnetic field, echo train simulation and 2D NMR inversion are discussed in detail. For 2D NMR inversion, a hybrid inversion method is proposed based on the damping least squares method (LSQR) and an improved truncated singular value decomposition (TSVD) algorithm. A series of spin echoes are first simulated with multiple waiting times (Tws) in a gradient magnetic field for given fluid models and these synthesized echo trains are inverted by the hybrid method. The inversion results are consistent with given models. Moreover, the numerical simulation of various fluid models such as the gas-water, light oil-water, and vicious oil-water models were carried out with different echo spacings (TEs) and Tws by this hybrid method. Finally, the influences of different signal-to-noise ratios (SNRs) on inversion results in various fluid models are studied. The numerical simulations show that the hybrid method and optimized observation parameters are applicable to fluid typing of gas-water and oil-water models. 展开更多
关键词 Two-dimensional NMR (2D-NMR) logging hybrid inversion method transverserelaxation time (T2) longitudinal relaxation time t1 fluid typing
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