Simon Kahn:多屏移动营销大趋势

在亚洲,包括中国,消费者现在都生活在移动连接的世界里,日复一日地使用移动终端购买商品,移动互联网趋势越来越明显。例如,两年前的中国,桌面终端和移动终端使用数字的差距还没有显现出来;现在,无论是欧美还是包括中国在内的亚洲国家,消费者通过移动终端购买的比例已超过桌面终端。从消费者的角度看,购物行为的最大变化就是通过移动终端购买;从商家的角度看,他们要考虑消费者使用移动终端对他们的业务产生什么影响,对消费者的购买决策有什么影响。Google的数据表明,91%的中国消费者通过各种移动终端搜索要买的东西,至少超过一半的消费者通过移动终端购买。由此可见,移动终端蕴含着巨大的商机。

Prevalence and the Risk Factors of Renal Insufficiency in the City of Saint Louis in Senegal

Background: The true scale of renal insufficiency (RI) in Sub-Saharan Africa remains unknown due to the lack of national registries. The aim of this study is to describe the epidemiological characteristics of renal insufficiency in urban areas in Saint Louis of Senegal. Materials and Methods: It is an observational, cross-sectional and descriptive study. The study was conducted during 27 days starting from 3 to 30 May 2010. All senegalese residents of Saint Louis (older than 15 years at the time of the study) in whom creatinine clearance was performed were included in the study. The sampling method used was a systematic random sampling, stratified cluster. The survey was designed by an expert comitee based on STEPS survey of the World Health Organization. RI was defined as a glomerular filtration rate (GFR) 2. Results: Among 1424 people initially selected a final selection of 1416 was made. The sex ratio was 0.45. The mean age was 43.4 ± 17.8 years. The overall prevalence of renal insufficiency according to MDRD (Modification of diet in renal disease) formula was 181 cases or 12.7%. The mean age of the people with renal insufficiency was 47.6 ± 17.4 years. Renal insufficiency was correlated to height blood pressure (p = 0.01) and Physical inactivity (p = 0.0001). The prevalence of renal insufficiency was higher in diabetics (71.4%) and obese people (66.6%) than in non-diabetics (64.9%) and non-obese people (56.5%), although the difference was not statistically significant. Dyslipidemia and smoking were not correlated to the risk of occurrence of IR. Conclusions: This study reports the increasing magnitude of RI and its risk factors in the city of Saint Louis in Senegal. It is imperative to establish à national prevention strategies to avoid the dizzying growth of this scourge.

Ned Kahn：以景观设计展现自然的力量

Ned Kahn是一位景观设计师，他的设计灵感源自各种自然现象，如风、水、火、雾、沙等，他运用大胆而细致的设计手法，将这些元素，通过雕塑和大型的装置艺术，带到公众面前。他的景观设计作品非常直观，有时亦很平实，相信读者看过之后，都能从中感受到自然的力量。正如Ned Kahn本人所说，“我希望我的艺术品，能让人们记起大自然的美丽与神秘，希望人们在看到这些自然现象发生时，能产生一种对自然的敬畏之感，同时也点燃他们对大自然的热爱之情。”

Reinforced concrete in Louis Kahn＇s National Assembly, Dhaka： Modernity and modernism in Bangladeshi architecture

Louis Kahn is often credited with having in his introduced modern architecture to Bangladesh. In construction as any he employed was already in National Assembly in Dhaka （1962-1983） fact at least as technologically advanced use there. Nor was he the first to use a sophisticated abstract esthetic in what was from 1947 to 1971 East Pakistan. The importance and originality of the National Assembly instead resides in the care with which he built in reinforced concrete and the forms into which he required that it be cast. These were esthetic decisions rooted in a particular theoretical position; they were located outside established modernist practice of the time in both South Asia and the United States. Indeed operating at such a great remove from home may have heightened Kahn＇s authority to implement these forms even as it substantially complicated their execution.

解读LOUIS I.KAHN的孟加拉首都政府建筑群

通过分析孟加拉首都政府建筑群来诠释路易斯·康的设计哲学理念及他将物质要素的功能性与精神性完美结合的设计手法。

COVID-19/Tuberculosis Co-Infection at the Epidemic Treatment Center (ETC) of Saint-Louis (Senegal): About 9 Cases

Introduction: COVID-19 is a global public health emergency that can cause acute respiratory distress syndrome. In countries where tuberculosis (TB) is endemic, coinfection of COVID-19 and TB is often encountered, which increases the risk of developing severe forms of COVID-19. Objectives: The aim of this study was to determine the prevalence of COVID-19/TB coinfection at the Epidemic treatment center (ETC) in Saint-Louis (Senegal) and to describe the epidemiological, clinical, paraclinical, and outcome profile of co-infected patients. Patients and Methods: This is a retrospective, cross-sectional, descriptive cohort study based on the records of COVID-19/ TB co-infected patients who were hospitalized at the ETC in Saint-Louis (Senegal) over an 18-month period from March 2020 to September 2021. Results: Out of a total of 454 hospitalizations, we collected records of 9 patients co-infected with COVID-19/TB, resulting in a prevalence of 2%. The study included patients with a median age of 34 years (range: 10-86 years), with a male predominance (7 cases) and a sex ratio of 3.5. The majority of patients (88.9%) had severe forms of COVID-19. Dyspnea and cough were reported in all patients (100%). Pulmonary TB was the most frequent localization, with 9 cases. The diagnosis of COVID-19 was confirmed by nasopharyngeal PCR in all patients (100%). Bacilloscopy was positive in 3 out of 5 cases. One patient tested positive for GeneXpert? MTB/RIF without rifampicin resistance. All patients were prescribed the hydroxychloroquine-azithromycin combination and anti-tuberculosis treatment. Out of the nine patients, four recovered (44.4%) and five died (55.5%). Conclusion: COVID-19/TB coinfection had a low prevalence in our cohort, but was associated with a high mortality due to the frequent occurrence of severe forms of the disease.

Profile of SARS-CoV-2 Infected Patients Hospitalized at the Epidemic Treatment Center (ETC) in Saint-Louis, Senegal during the First Two Waves

Introduction: The SARS-CoV-2 infection is a major public health emergency. Several risk factors are involved in the occurrence of respiratory distress that can lead to death despite resuscitation measures. Objectives: The aim of this study was to describe the epidemiological, clinical, paraclinical, therapeutic, and evolution profile of patients infected with SARS-CoV-2 hospitalized at the CTE of Saint-Louis (Senegal) during the first two waves. Patients and Methods: We conducted a retrospective, cross-sectional, descriptive, and analytical study that included all patients hospitalized at the ETC of Saint-Louis (Senegal) with SARS-CoV-2 infection from March 2020 to April 2021. Results: A total of 358 cases were collected, 256 (71.5%) during the first wave and 102 (28.5%) during the second wave. The mean age was 49.5 years (19.5). There was a male predominance (58.4%), with a sex ratio of 1.4. Hypertension was the main comorbidity, with 87 cases (24.3%). The most common functional signs were cough in 194 cases (54.2%), dyspnea in 143 cases (40%) and ageusia in 134 cases (37.4%). Thoracic CT scans were performed on 20 patients (5.6%), with severe involvement (50% - 75%) observed in 50% of cases. Hydroxychloroquine-azithromycin was prescribed to 351 patients (98%). Overall, 338 (94.4%) recovered and 17 (4.7%) died. In multivariate analysis, factors associated with death were male sex [OR = 2.645;95% CI: 1.530 - 4.785;p = 0.011], age 60 years [OR = 1.039;95% CI: 0.564 - 1.914;p = 0.002], the presence of comorbidities [OR = 2.171;95% CI: 0.564 - 3.429;p = 0.033], SpO2 (ambient air) 95% [OR = 2.061;95% CI: 0.616 - 3.827;p = 0.03], acute respiratory distress syndrome (ARDS) [OR = 0.635;95% CI: 0.316 - 1.275;p = 0.001], severe form [OR = 1.664;95% CI: 0.298 - 2.478;p = 0.016], occurrence of complications [OR = 0.521;95% CI: 0.287 - 0.944;p = 0.032], high creatinine levels [OR = 2.061;95% CI: 1.616 - 3.827;p = 0.026], and lymphopenia [OR = 0.485;95% CI: 0.370 - 0.636;p = 0.001]. Conclusion: In our series, infection with SARS-CoV-2 was associated with low lethality. Several risk factors were identified that need to be considered for successful management of patients.

解读Louis Vuitton打造顶级品牌形象之谜

品牌形象是企业竞争力的核心。本文从树立品牌最为重要的部分--品牌形象入手,对国际顶级箱包品牌Louis Vuitton进行剖析,企图找到对民族企业有所启迪的东西。

Test of the Louis scheme and COARE algorithm for friction velocity in different wind-sea/swell regimes

The Louis scheme and the COARE algorithm （version 3.0） are tested against eddy covariance and inertial dissipation methods for friction velocity estimates in different wind-sea/swell regimes. Atmospheric forcing data, tabulated by Donelan et al. （1997.J Phys Oceanog, 27：2087-2099）, were collected from a mast on the foredeck of a SWATH （small water-plane area, twin hull） ship in deep sea off the State of Virginia during the surface wave dynamics experiment. These data are representative of low to moderate wind regimes. The aerodynamic roughness length is determined by using the Charnock relationship. The intercomparison shows that the Louis scheme and the COARE algorithm underestimate the friction velocity by 6% and 3% respectively under pure wind sea conditions, 15% and 13% respectively under cross swell conditions, and 21% and 17% respectively under counter swell conditions. The analysis shows that these underestimations were caused by the method chosen to determine the aerodynamic roughness length because it significantly underestimates the aerodynamic roughness length. It is especially true under the cross swell and counter swell conditions.

Evaluation of Access to Care for Patients with Chronic Kidney Disease Not on Dialysis in Saint-Louis Region (SENEGAL)

Introduction: Patients with chronic diseases, especially kidney diseases, frequently use the health care system and free dialysis policies are being implemented in many countries in Africa. This study aimed to evaluate access to care for patients with chronic kidney disease (CKD) in northern region of Saint-Louis. Methodology: In a cross-sectional survey, we included non-dialyzed CKD patients aged ≥20 years who attended outpatient nephrology clinic at University Hospital of Saint-Louis between January 1st and January 31st 2018. Access to care was measured using a questionnaire that integrated dimensions such as availability, geographic and financial accessibility, convenience, acceptability, effectiveness of care and quality of information. Socio-demographic and clinical data were also collected and analyzed with Epi Info 7. Results: Among 97 surveyed patients, 90 were included (response rate of 92.8%). Patients’ mean age was 35.2 years (20 - 89 years) and 55% were male. Only 30% of patients had health coverage either by the government, or private insurance or community health insurance. Access to care was rated as globally low by 73% of participants. However, we noticed some variations according to dimensions of access. Geographical accessibility and convenience of delivered care were good for the majority of patients, while financial access and acceptability of care were considered as very limited. Bivariate analysis showed that acceptability and effectiveness of care were linked to CKD stage while the quality of patients’ information was correlated with their educational level. Furthermore, health coverage was also associated with financial accessibility of care but not with its availability. Conclusion: This study showed that access to care is poor for majority of patients with CKD in Saint-Louis. Identification of the main barriers will help define appropriate strategies to achieve universal access to quality renal care.

Review on Infections of the Central Nervous System by St. Louis Encephalitis, Rocio and West Nile Flaviviruses in Brazil, 2004-2014

Rocio (ROCV), Saint Louis encephalitis (SLEV) and West Nile (WNV) are Flavivirus (Flaviviridae) probably carried by birds and transmitted by Culex mosquitoes. We show here a review on infections of the central nervous system by St. Louis Encephalitis, Rocio and West Nile Flaviviruses in Brazil, 2004-2014. In the last 10 years, serologic surveys in horses showed high proportions of seropositive animals which point out that SLEV and ROCV have circulated infecting horses in west-central, southeast and other regions of Brazil and that WNV has been introduced into Brazil and circulates mostly in Pantanal region. However humans infected by WNV have not been reported. In the State of Sao Paulo: SLEV was isolated from a case clinically diagnosed as dengue in 2004;in 2006, 6 SLEV patients including 3 cases of menigoencephalitis were reported in the middle of a large epidemic of dengue type 3;and in 2008, 1 patient with acute febrile illness that was IgM-positive for dengue was found infected by SLEV by detection of the virus genome. In 2010, ROCV genome was detected in the cerebrospinal fluids of 2 patients from the northern region with meningoenchephalitis and also AIDS. This was the first report of infections by ROCV in the last 34 years and curiously, it occured more than 2000 km from where the virus was firstly found. It is necessary to improve the surveillance of SLEV, ROCV and WNV in Brazil.

The Search for the Lost American Indian Identity in Louis Owens’s Wolfsong

The problem of identity is a hot issue frequently talked about in many literary works.Especially,the identity problem or the search for identity can be seen as one of the major themes in the literary works written by ethnic writers.Louis Owens is a distinguished American Indian writer who has Choctaw,Cherokee,and Irish descent.In his debut work Wolfsong which was published in 1995,Louis Owens depicts the story about the protagonist Tom Joseph’s search for his lost American Indian identity.With deep knowledge and notion about American Indian culture and tradition,Owens reveals his worry about their own identity and precious culture and tradition which are disappearing gradually.This paper tries to analyze Tom Joseph’s search for his identity,and discusses how the American Indian tradition and culture influence his endeavor to find the lost American Indian identity.

Total Spending Equation of St. Louis Model： A Causality Analysis for Turkish Economy

Andersen and Jordan （1968） aimed to measure efficiency of monetary and fiscal actions on real GDP by employing a time-series model which was called as St. Louis Model afterwards. Although the model is performed in many countries similarly, the results differ from each other in accordance with the economic structure of relevant country In this regard, the aim of this paper is to investigate the effectiveness of monetary and fiscal policies on real activity and to find out causal relationship among questioned variables using OLS and causality methodologies in Turkish economy over the period 1998：1-2010： IV. Empirical findings indicate that only monetary policy has a significant positive effect on economic activity in the short run, Nonetheless, neither monetary nor fiscal policy has significant impact on real output in the long run. Causality analysis shows that there exists a unidirectional causality running from real output and money stock to government expenditures. Moreover, not surprisingly, it is also found that crisis experiences of Turkey in sample period have highly adverse impact on real activity. Causality analysis suggests us considering government expenditures as explained variable instead of real output. Hence, it can be concluded that St. Louis Model total spending equation is not applicable for Turkish economy during 1998-2010 periods

不同功率的氩离子(Ar^+)激光对小鼠Louis肺癌细胞生长的影响

目的 :探讨氩离子 (Ar+)激光对体外小鼠 Louis肺癌细胞生长的影响。方法 :在相同时间内 ,采用不同功率的激光照射小鼠 Louis肺癌细胞 ,通过脱落细胞 -时间曲线来研究。结果 :不同功率的激光对细胞生长的影响不同 ,当功率大于 50 m W时 ,具有明显的抑制作用 ,而低于 50 m W则波动较大 ,甚至有负性生长作用。结论 :采用激光治疗肿瘤 。

Chinatown's Community Organizations Reflected in Louis Chu's Eat a Bowl of Tea

Louis Chu's novel Eat a Bowl of Tea(1961) is widely recognized as a pioneer masterpiece in Chinese American litera-ture. It pictures the bachelor society of Chinatown in New York City after the Second World War. Several characteristics of China-town's community organizations are reflected in this novel: kinship-based; responsible for protecting and caring for the members;led by commercial elites; rule of man, rather than rule of law. It offers us a precious chance to take a glimpse of the Chinese-Ameri-can society in post-World War II era.

Prevalence and Associated Factors of Diabetic Kidney Disease in Senegalese Patients: A Cross-Sectional Study in Saint-Louis

Introduction: Diabetes is a leading cause of chronic kidney disease in the world. During the next decade, its burden is expected to increase in Africa with potential complications such as chronic kidney disease. However, epidemiology and risk factors of diabetic kidney disease are poorly described at population level. This study aimed to determine prevalence of diabetic kidney disease (DKD) in adult diabetics living in Saint-Louis, northern Senegal. Methods: A cross-sectional study including diabetic patients followed-up aged ≥18 years during a five-year period (2013-2018) in Saint-Louis. Clinical and biological parameters were collected during annual community-based mass screening. Diabetes was defined as fasting blood glucose ≥ 1.26 g/L confirmed by a second lab dosage. DKD was defined as persistence of albuminuria ≥ 30 mg/24h and/or estimated glomerular filtration rate (eGFR) 2. Data were analyzed with Stata 12.0. Results: We included a total of 1310 diabetic patients among whom 3.7% (95% CI = 1.4% - 9.8%) presented DKD. Their mean age was 46.2 ± 11.8 years and sex-ratio was 0.7. Micro-albuminuria and macro-albuminuria were present respectively in 59.2% and 18.4% of patients with DKD and half of them had a normal eGFR. Before the survey 89.8% of patients with DKD were not aware of their renal disease and only four of them had seen a nephrologist. After multivariate analysis, age (OR = 1.5;95% CI = 1.1 - 3.4), duration of diabetes (OR = 1.2;95% CI = 1.6 - 4.4) and hypertension (OR = 2.5;95% CI = 1.4 - 4.6) were associated with the presence of DKD in diabetic patients while no significant association was not found with gender, blood glucose level, smoking and familial history. Conclusion: DKD is a frequent complication in diabetic adult population living in Saint-Louis. Early detection and management should be promoted in order to prevent progression to end-stage renal disease.

Compressive Pericardial Teratoma about a Case at Regional Hospital of Saint Louis/Senegal

Introduction: Cardiac tumors in children are rare. Most are discovered in children under one year of age. Echocardiography is the basic examination for the screening, it allows their detection from the fetal stage. Observation: She was a 14-year-old patient with no known history of pathology. She was admitted to our department for the exploration of dyspnea and chest pain. At her admission, she had stable hemodynamics. At cardiac auscultation, heart sounds were muffled. The EKG recorded a sinus rhythm, and negative T-waves from V1 to V4. The chest X-ray showed cardiomegaly and a dense, rounded, heterogeneous left hilar opacity, well limited. Echocardiography objected to a great intrapericardial mass in front of the left cardiac cavities compressing part of the left atrium and left ventricle associated with an important pericardial effusion. The CT scan found a heterogeneous pericardial suspected myxoma mass. The pathological examination confirmed pericardial teratoma. The patient had an excision of the pericardial mass. The evolution after surgery was favorable. Conclusion: Intra-pericardial teratomas are benign tumor. Complete removal of the tumor is curative and without recurrence.

Epidemiological Aspect of ST-Segment Elevation Myocardial Infarction (STEMI) in Saint-Louis of Senegal

Background: Cardiovascular Disease (CVD) has become the largest and most common cause of Non-Communicable Diseases (NCD) related deaths worldwide, accounting for more than 50%. In Senegal, a few studies done on the topic showed a low prevalence of acute coronary syndrome in hospital settings. In the city of Saint-Louis in Northern Senegal, there is little epidemiological data on Acute Coronary Syndrome (ACS) and no study specifically concerned with ST-segment Elevation Myocardial Infarction (STEMI) has been carried out to date. With this in mind, we conducted a study that focused on the analysis of STEMI patients hospitalized in the Cardiology Department of the Regional Hospital of Saint-Louis. The aim of our study was to collect and analyze the epidemiological aspect of STEMI. Results: There were 39 cases of STEMI, (i.e. 82.29% of ACS), giving a hospital prevalence of 8.21%. There was a slight male predominance with a male to female ratio of 1.05. The average age of our patients was 62.93 years ranging from 38 to 90 years. The average time between the onset of pain and arrival at the hospital was 50 hours, ranging from 1 hour to 720 hours. Patients received within the first 12 hours made up 66% (n = 26) of our population, among them, 80.76% (n = 21) (i.e. 53.84% of STEMIs) were able to benefit from thrombolysis. All thrombolysis was performed with Streptokinase. The mean time to thrombolysis was 6 hours ranging from 1 hour and 45 minutes to 11 hours. Arterial hypertension was the most frequent cardiovascular risk factor in our popular with a 43.6% prevalence, followed by diabetes (33.33%), then active smoking (23%). Chest pain was the most frequent symptom, reported in 34 patients (87.17%). The lesions on the Electrocardiogram (EKG) were located in the anterior territory in 64% of the cases (n = 25), in the inferior territory in 28% of the cases (n = 11), in the circumferential territory in 5% of the cases (n = 2), and lateral territory in 5% of the cases (n = 2). Twenty-five patients had a transthoracic echocardiogram, the left ventricular ejection fraction was preserved in 36% of the patients, 40% had moderate ventricular dysfunction and 24% had severe dysfunction. Segmental kinetic disorders of the left ventricle were noted in 18 patients (72%), akinesia in 7 patients (28%) and dyskinesia in 4 patients (16%). The average length of hospitalization was 8.43 days. Seven deaths (17.9%) were recorded during the study. Coronary angiography was performed in six patients (15.38%), and was abnormal in five cases. Conclusion: ST-segment Elevation Myocardial Infarctions remain a major public health issue in Senegal due to their increasing prevalence and poor prognosis due to delayed diagnosis and management.

私有化并购下商业判断规则的创新适用——以Kahn v.M&F Worldwide Corp案为例

案件源于2011年的一起公司收购案,收购方为MacAndrews&Forbes Holdings公司(以下简称M&F公司),其拥有被收购方M&F Worldwide公司(以下简称MFW公司)43%的普通股份。2011年6月,Schwartz(Schwartz同时为MFW公司的总裁和首席执行官和M&F公司的副总裁和首席行政官)向MFW发出了收购要约.

Prevalence and Association of Criteria of Metabolic Syndrome in a Cohort of Diabetes Type 2 in Saint-Louis

Introduction: The metabolic syndrome is characterized by an aggregate of metabolic disorders whose coexistence in the same individual can correspond on the one hand to a common pathophysiological mechanism and on the other hand to expose the subject to an increased risk of cardiovascular diseases. The prevalence of the metabolic syndrome is increasing rapidly in both developed and developing countries, but has been poorly described in sub-Saharan Africa. Most of them reported the components of the metabolic syndrome only in isolation. Methods: This cross-sectional study carried out on a cohort of 76 patients followed at the Sait-louis regional hospital used the definition criteria of the International Diabetes Federation. Results: The average age of our patients is 56.92 with extremes ranging from 32 to 80 years old. The sex ratio is 0.49. The average duration of diabetes progression is 68 months. The prevalence of the metabolic syndrome in this population is 67.1%. Abdominal obesity and high blood pressure are the most commonly found criteria. Abdominal obesity was the most associated component of MS in both sexes followed by high blood pressure. We found relatively weak data for dyslipidemia, especially hypertriglyceridemia. HypoHD is dyslipidemia more found in our cohort: in 45% of women and 21% of men. Conclusion: The management of the metabolic syndrome therefore requires fighting against all the factors that compose it, the first of which is the accumulation of visceral fat. Lifestyle modification is the first priority for these patients facing a society where the reduction of physical activity and the enrichment of the fat diet are becoming more and more important.