Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also ch...Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also challenging.Besides,sluggish reaction kinetics at low temperatures restrict the operation of SIBs in cold climates.Herein,cross-linking nanoarchitectonics of WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,featuring built-in electric field(BIEF),have been developed,employing as a model to reveal the positive effect of heterojunction design and BIEF for modifying the reaction kinetics and electrochemical activity.Particularly,the theoretical analysis manifests the discrepancy in work functions leads to the electronic flow from the electron-rich Ti_(3)C_(2)T_(x) to layered WS_(2),spontaneously forming the BIEF and“ion reservoir”at the heterogeneous interface.Besides,the generation of cross-linking pathways further promotes the transportation of electrons/ions,which guarantees rapid diffusion kinetics and excellent structure coupling.Consequently,superior sodium storage performance is obtained for the WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,with only 0.2%decay per cycle at 5.0 A g^(-1)(25℃)up to 1000 cycles and a high capacity of 293.5 mA h g^(-1)(0.1A g^(-1)after 100 cycles)even at-20℃.Importantly,the spontaneously formed BIEF,accompanied by“ion reservoir”,in heterojunction provides deep understandings of the correlation between structure fabricated and performance obtained.展开更多
BACKGROUND Both phases of euthyroid sick syndrome(ESS)are associated with worse prognosis in septic shock patients.Although there are still no indications for supplementation therapy,there is no evidence that both pha...BACKGROUND Both phases of euthyroid sick syndrome(ESS)are associated with worse prognosis in septic shock patients.Although there are still no indications for supplementation therapy,there is no evidence that both phases(initial and prolonged)are adaptive or that only prolonged is maladaptive and requires supplementation.AIM To analyze clinical,hemodynamic and laboratory differences in two groups of septic shock patients with ESS.METHODS A total of 47 septic shock patients with ESS were divided according to values of their thyroid hormones into low T3 and low T3T4 groups.The analysis included demographic data,mortality scores,intensive care unit stay,mechanical ventilation length and 28-day survival and laboratory with hemodynamics.RESULTS The Simplified Acute Physiology Score II score(P=0.029),dobutamine(P=0.003)and epinephrine requirement(P=0.000)and the incidence of renal failure and multiple organ failure(MOF)(P=0.000)were significantly higher for the low T3T4.Hypoalbuminemia(P=0.047),neutrophilia(P=0.038),lymphopenia(P=0.013)and lactatemia(P=0.013)were more pronounced on T2 for the low T3T4 group compared to the low T3 group.Diastolic blood pressure at T0(P=0.017)and T1(P=0.007),as well as mean arterial pressure at T0(P=0.037)and T2(P=0.033)was higher for the low T3 group.CONCLUSION The low T3T4 population is associated with higher frequency of renal insufficiency and MOF,with worse laboratory and hemodynamic parameters.These findings suggest potentially maladaptive changes in the chronic phase of septic shock.展开更多
AIM： To investigate the predictive value of low freeT3 for long-term mortality in chronic hemodialysis （HD） patients and explore a possible causative role of chronic infammation.METHODS： One hundred fourteen HD pa...AIM： To investigate the predictive value of low freeT3 for long-term mortality in chronic hemodialysis （HD） patients and explore a possible causative role of chronic infammation.METHODS： One hundred fourteen HD patients （84 males） consecutively entered the study and were assessed for thyroid function and two established markers of inflammation, high sensitivity C-reactive protein （hsCRP） and interleukin-6 （IL-6）. Monthly blood samples were obtained from all patients for three consecutive months during the observation period for evaluation of thyroid function and measurement of infammatory markers. The patients were then divided in two groups based on the cut-off value of 1.8 pg/mL for mean plasma freeT3, and were prospectively studied for a mean of 50.3 ± 30.8 mo regarding cumulative survival. The prognostic power of low serum fT3 levels for mortality was assessed using the Kaplan-Meier method and univariate and multivariate regression analysis.RESULTS： Kaplan-Meier survival curve showed a negative predictive power for low freeT3. In Cox regression analysis low freeT3 remained a significant predictor of mortality after adjustment for age, diabetes mellitus, hypertension, hsCRP, serum creatinine and albumin. Regarding the possible association with inflammation, freeT3 was correlated with hsCRP, but not IL-6, and only at the frst month of the study.CONCLUSION： In chronic hemodialysis patients, low plasma freeT3 is a significant predictor of all-cause mortality. Further studies are required to identify the underlying mechanisms of this association.展开更多
It is highly important to develop ultrastable electrode materials for Li-ion batteries(LIBs),especially in the low temperature.Herein,we report Fe^(3+)-stabilized Ti_(3)C_(2)T_(x) MXene(donated as T/F-4:1)as the anode...It is highly important to develop ultrastable electrode materials for Li-ion batteries(LIBs),especially in the low temperature.Herein,we report Fe^(3+)-stabilized Ti_(3)C_(2)T_(x) MXene(donated as T/F-4:1)as the anode material,which exhibits an ultrastable low-temperature Li-ion storage property(135.2 m A h g^(-1)after300 cycles under the current density of 200 m A g^(-1)at-10℃),compared with the negligible capacity for the pure Ti_(3)C_(2)T_(x) MXene(26 m A h g^(-1)at 200 m A g^(-1)).We characterized as-made T/F samples via the Xray photoelectron spectroscopy(XPS),Fourier transformed infrared(FT-IR)and Raman spectroscopy,and found that the terminated functional groups(-O and-OH)in T/F are Li^(+) storage sites.Fe^(3+)-stabilization makes-O/-OH groups in MXene interlayers become active towards Li^(+),leading to much more active sites and thus an enhanced capacity and well cyclic stability.In contrast,only-O/-OH groups on the top and bottom surfaces of pure Ti_(3)C_(2)T_(x) MXene can be used to adsorb Li^(+),resulting in a low capacity.Transmission electron microscopy(TEM)and XPS data confirm that T/F-4:1 holds the highly stable solid electrolyte interphase(SEI)layer during the cycling at-10℃.Density functional theory(DFT)calculations further uncover that T/F has fast diffusion of Li^(+) and consequent better electrochemical performances than pure Ti_(3)C_(2)T_(x) MXene.It is believed that the new strategy used here will help to fabricate advanced MXene-based electrode materials in the energy storage application.展开更多
Objective：To observe the clinical efficacy of triple needling plus moxibustion and Tanbo-plucking tender points in treating the third lumbar vertebra transverse process syndrome. Methods： Totally 108 patients with t...Objective：To observe the clinical efficacy of triple needling plus moxibustion and Tanbo-plucking tender points in treating the third lumbar vertebra transverse process syndrome. Methods： Totally 108 patients with the third lumbar vertebra transverse process syndrome were randomized into two groups, 56 cases in the observation group were intervened by triple needling method plus moxibustion and Tanbo-plucking tender points; 52 cases in the control group were by acupuncture plus moxibustion. The pain rating index（PRI）, visual analogue scale （VAS）, and present pain intensity （PPI） from the short-form McGill pain questionnaire （SF-MPQ） were observed before and after intervention for comparing the therapeutic efficacy. Results： The total effective rate was 96.4% in the observation group versus 76.9% in the control group, and the difference was statistically significant （P〈0.05）. After intervention, the sensory-PRI, affective-PRI, totaI-PRI, VAS, and PPI scores were markedly changed in both groups （P〈0.05）. The difference in comparing the change of clinical sign score was statistically significant between the two groups （P〈0.05）. The follow-ups performed 4 weeks and 8 weeks after treatment showed that there were significant differences in comparing the relapse rate between the two groups （P〈0.05）. Conclusion： Triple needling plus moxibustion and Tanbo-plucking tender points can produce a better efficacy in treating the third lumbar vertebra transverse process syndrome than acupuncture plus moxibustion alone, and the relapse rate is relatively low.展开更多
基金supported by the faculty startup funds from the Yangzhou Universitythe Natural Science Foundation of Jiangsu Province(BK20210821)+1 种基金the National Natural Science Foundation of China(22102141)the Lvyangjinfeng Talent Program of Yangzhou。
文摘Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also challenging.Besides,sluggish reaction kinetics at low temperatures restrict the operation of SIBs in cold climates.Herein,cross-linking nanoarchitectonics of WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,featuring built-in electric field(BIEF),have been developed,employing as a model to reveal the positive effect of heterojunction design and BIEF for modifying the reaction kinetics and electrochemical activity.Particularly,the theoretical analysis manifests the discrepancy in work functions leads to the electronic flow from the electron-rich Ti_(3)C_(2)T_(x) to layered WS_(2),spontaneously forming the BIEF and“ion reservoir”at the heterogeneous interface.Besides,the generation of cross-linking pathways further promotes the transportation of electrons/ions,which guarantees rapid diffusion kinetics and excellent structure coupling.Consequently,superior sodium storage performance is obtained for the WS_(2)/Ti_(3)C_(2)T_(x) heterojunction,with only 0.2%decay per cycle at 5.0 A g^(-1)(25℃)up to 1000 cycles and a high capacity of 293.5 mA h g^(-1)(0.1A g^(-1)after 100 cycles)even at-20℃.Importantly,the spontaneously formed BIEF,accompanied by“ion reservoir”,in heterojunction provides deep understandings of the correlation between structure fabricated and performance obtained.
基金approved by the Institutional Review Board(IRB)of Cantonal Hospital Zenica,and the protocols used in the study were approved by the Ethical Committee of Cantonal Hospital Zenica(00-03-35-38-14/22).
文摘BACKGROUND Both phases of euthyroid sick syndrome(ESS)are associated with worse prognosis in septic shock patients.Although there are still no indications for supplementation therapy,there is no evidence that both phases(initial and prolonged)are adaptive or that only prolonged is maladaptive and requires supplementation.AIM To analyze clinical,hemodynamic and laboratory differences in two groups of septic shock patients with ESS.METHODS A total of 47 septic shock patients with ESS were divided according to values of their thyroid hormones into low T3 and low T3T4 groups.The analysis included demographic data,mortality scores,intensive care unit stay,mechanical ventilation length and 28-day survival and laboratory with hemodynamics.RESULTS The Simplified Acute Physiology Score II score(P=0.029),dobutamine(P=0.003)and epinephrine requirement(P=0.000)and the incidence of renal failure and multiple organ failure(MOF)(P=0.000)were significantly higher for the low T3T4.Hypoalbuminemia(P=0.047),neutrophilia(P=0.038),lymphopenia(P=0.013)and lactatemia(P=0.013)were more pronounced on T2 for the low T3T4 group compared to the low T3 group.Diastolic blood pressure at T0(P=0.017)and T1(P=0.007),as well as mean arterial pressure at T0(P=0.037)and T2(P=0.033)was higher for the low T3 group.CONCLUSION The low T3T4 population is associated with higher frequency of renal insufficiency and MOF,with worse laboratory and hemodynamic parameters.These findings suggest potentially maladaptive changes in the chronic phase of septic shock.
文摘AIM： To investigate the predictive value of low freeT3 for long-term mortality in chronic hemodialysis （HD） patients and explore a possible causative role of chronic infammation.METHODS： One hundred fourteen HD patients （84 males） consecutively entered the study and were assessed for thyroid function and two established markers of inflammation, high sensitivity C-reactive protein （hsCRP） and interleukin-6 （IL-6）. Monthly blood samples were obtained from all patients for three consecutive months during the observation period for evaluation of thyroid function and measurement of infammatory markers. The patients were then divided in two groups based on the cut-off value of 1.8 pg/mL for mean plasma freeT3, and were prospectively studied for a mean of 50.3 ± 30.8 mo regarding cumulative survival. The prognostic power of low serum fT3 levels for mortality was assessed using the Kaplan-Meier method and univariate and multivariate regression analysis.RESULTS： Kaplan-Meier survival curve showed a negative predictive power for low freeT3. In Cox regression analysis low freeT3 remained a significant predictor of mortality after adjustment for age, diabetes mellitus, hypertension, hsCRP, serum creatinine and albumin. Regarding the possible association with inflammation, freeT3 was correlated with hsCRP, but not IL-6, and only at the frst month of the study.CONCLUSION： In chronic hemodialysis patients, low plasma freeT3 is a significant predictor of all-cause mortality. Further studies are required to identify the underlying mechanisms of this association.
基金supported financially by the Fundamental Research Funds for the Central Universities(Nos.2019RC021,2018JBZ107,2019RC035)the National Natural Science Foundation of China(Nos.51971056,91961125,51802013,21905019)+3 种基金the Key Program for International S&T Cooperation Projects of China from the Ministry of Science and Technology of China(No.2018YFE0124600)the Chemistry and Chemical Engineering Guangdong Laboratory(Nos.1932004 and 1911021)the financial support from Natural Science Foundation of Liaoning Province(No.20180510003)support from the“Excellent One Hundred”Project of Beijing Jiaotong University。
文摘It is highly important to develop ultrastable electrode materials for Li-ion batteries(LIBs),especially in the low temperature.Herein,we report Fe^(3+)-stabilized Ti_(3)C_(2)T_(x) MXene(donated as T/F-4:1)as the anode material,which exhibits an ultrastable low-temperature Li-ion storage property(135.2 m A h g^(-1)after300 cycles under the current density of 200 m A g^(-1)at-10℃),compared with the negligible capacity for the pure Ti_(3)C_(2)T_(x) MXene(26 m A h g^(-1)at 200 m A g^(-1)).We characterized as-made T/F samples via the Xray photoelectron spectroscopy(XPS),Fourier transformed infrared(FT-IR)and Raman spectroscopy,and found that the terminated functional groups(-O and-OH)in T/F are Li^(+) storage sites.Fe^(3+)-stabilization makes-O/-OH groups in MXene interlayers become active towards Li^(+),leading to much more active sites and thus an enhanced capacity and well cyclic stability.In contrast,only-O/-OH groups on the top and bottom surfaces of pure Ti_(3)C_(2)T_(x) MXene can be used to adsorb Li^(+),resulting in a low capacity.Transmission electron microscopy(TEM)and XPS data confirm that T/F-4:1 holds the highly stable solid electrolyte interphase(SEI)layer during the cycling at-10℃.Density functional theory(DFT)calculations further uncover that T/F has fast diffusion of Li^(+) and consequent better electrochemical performances than pure Ti_(3)C_(2)T_(x) MXene.It is believed that the new strategy used here will help to fabricate advanced MXene-based electrode materials in the energy storage application.
基金supported by Shanghai Community Project of Traditional Chinese Medicine,No:SHJCZYYNLTS-SQZYYTS-21~~
文摘Objective：To observe the clinical efficacy of triple needling plus moxibustion and Tanbo-plucking tender points in treating the third lumbar vertebra transverse process syndrome. Methods： Totally 108 patients with the third lumbar vertebra transverse process syndrome were randomized into two groups, 56 cases in the observation group were intervened by triple needling method plus moxibustion and Tanbo-plucking tender points; 52 cases in the control group were by acupuncture plus moxibustion. The pain rating index（PRI）, visual analogue scale （VAS）, and present pain intensity （PPI） from the short-form McGill pain questionnaire （SF-MPQ） were observed before and after intervention for comparing the therapeutic efficacy. Results： The total effective rate was 96.4% in the observation group versus 76.9% in the control group, and the difference was statistically significant （P〈0.05）. After intervention, the sensory-PRI, affective-PRI, totaI-PRI, VAS, and PPI scores were markedly changed in both groups （P〈0.05）. The difference in comparing the change of clinical sign score was statistically significant between the two groups （P〈0.05）. The follow-ups performed 4 weeks and 8 weeks after treatment showed that there were significant differences in comparing the relapse rate between the two groups （P〈0.05）. Conclusion： Triple needling plus moxibustion and Tanbo-plucking tender points can produce a better efficacy in treating the third lumbar vertebra transverse process syndrome than acupuncture plus moxibustion alone, and the relapse rate is relatively low.
