Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult Hamsters

Injury to axons close to the neuronal bodies in the mammalian central nervous system causes a large proportion of parenting neurons to degenerate. It is known that optic nerve transection close to the eye in rodents leads to a loss of about half of retinal ganglion cells in 1 week and about 90% in 2 weeks. Using low level laser treatment in the present study, we demonstrated that treatment with helium-neon （660 nm） laser with 15 mW power could delay retinal ganglion cell death after optic nerve axotomy in adult hamsters. The effect was most apparent in the ifrst week with a short period of treatment time （5 minutes） in which 65–66% of retinal ganglion cells survived the optic nerve axotomy whereas 45–47% of retinal ganglion cells did so in optic nerve axotomy controls. We also found that single dose and early commencement of laser irradiation were important in protecting retinal ganglion cells following optic nerve axotomy. These ifndings thus convincingly show that appropriate laser treatment may be neuroprotective to retinal gan-glion cells.

Effect of low level laser therapy on dental pulp during orthodontic movement

AIM: To validate the protocol described here to be used in future clinical trials related to the effect of laser therapy on dental pulp. METHODS: Histologically treated samples from eight human healthy premolar teeth obtained from the middle root level were distributed in four groups: group 1(G1) absolute control; group 2(G2) only laser irradiation; group 3(G3) exposed only to orthodontics; and group 4(G4) treated with orthodontics and laser. Laser treatment was performed at 830 nm wavelength, 100 mW(energy 80 J/cm2, 2.2 J), for 22 s in the vestibular surface and 22 s in the palatal surface, 1 mm away from the dental root mucosa. Three staining methods were performed: hematoxylin-eosin(HE), Masson's Trichrome method and Gomori's method.RESULTS: The pulp histology parameters were evaluated and the results classified in to 3 parts: an inflammatory response, soft tissue response(dental pulp) and hard tissue response(dentin and predentin). There was no inflammation(chronic or acute) in any of the evaluated groups. The zones of pulp necrosis were found in one premolar of G3 and in one of G4; in groups G2 and G4 there was higher angiogenesis than in the other two groups. G4 group presented the highest level of vascularization. A reduced nerve density was observed in G3. A G2 specimen showed increased nerve density. A higher rate of calcification was observed in G1 compared to G2. Denticles, either real or false, were observed in G1, G2 and G3. Sclerosis of dentin and focal dentin loss was observed among all the groups. Secondary dentin was present in one sample in G1 and G2. A necrosis zone was found in one sample of G3 and G4. No differences between groups were observed in the odontoblast irregularity layer but the layer was wider in the group treated with laser only. A notable difference was detected in reduction of the cell-free layer between the groups G1 and G4. The findings in pulp tissue favor its adaptative response against dental movement induced by orthodontics. No definitive conclusions may be derived as this is a pilot study. CONCLUSION: The protocol described here was shown to be an effective method to evaluate changes in dental pulp submitted to low level laser in teeth under orthodontic movement.

Advance in Functional Restoration of Injured Nerve with Low Level Laser and its Utilization in the Dental and Maxillofacial Region

The inferior alveolar nerve and facial nerve are the two most important nerves in the dental and maxillofacial region.The injury to them is one of the major postoperative complications after alveolar surgery and orthognathic surgery.However,recovering the nerve function after injury takes a long time and the recovery effect tends to be unsatisfactory.In recent years,an intensively investigated technique,low level laser which has been applying in assisting the recovery of nerve function,has been gradually proved to be effective in clinically treating postoperative nerve injury.In this article we review in terms of the mechanisms involved in low level laser-assisted functional restoration of nerve injury and its clinical application in the recovery of nerve function in the dental and maxillofacial area as well.

Efficacy of super-pulsed 905 nm Low Level Laser Therapy (LLLT) in the management of Traumatic Brain Injury (TBI): A case study

Traumatic brain injury is a major health concern worldwide with massive financial and social impact. Conventional treatments primarily focus on the prevention of further damage to the brain parenchyma, while failing to address the already existent symptoms. Previous clinical studies have shown that Low Level Laser Therapy (LLLT) can significantly reduce pain and induce temporary vasodilation in capillaries, which the authors hypothesize can be used to improve the quality of life in TBI patients by treating their current symptoms, which are predominately migraine-like headaches. This case report illustrates the use of LLLT in the treatment of a patient with a TBI and the great clinical success achieved in the reduction of pain, as measured by VAS—achievable within five treatments of 10 minutes in duration.

Effect of autologous mesenchymal stem cells induced by low level laser therapy on cardiogenesis in the infarcted area following myocardial infarction in rats

In this study, we investigated the hypothesis that photobiostimulation by low-energy laser therapy (LLLT) applied to the bone marrow (BM) of myocardial infarcted rats may attenuate the scarring processes that follow myocardial infarction (MI). Wistar rats underwent experimental MI. LLLT (Ga-Al-As diode laser) was applied to the BM of the exposed tibia at different time intervals post-MI (4 hrs, 48 hrs and 5 days). Sham-operated infarcted rats served as control. Infarct size was significantly reduced (55%) in the laser-treated rats as compared to the control non-treated rats, at 2 weeks post-MI. A significant 3-fold increase was observed in the density of desmin immunopositive stained cells 14 days post-MI in the infarcted area of the laser-treated rats as compared to the non-laser-treated controls. The electron microscopy from the control infarcted rat hearts revealed a typical interphase area between the intact myocardium and the infarcted area, with conspicuous fibroblasts with collagen deposition dispersed among them. In rats that were laser treated (to BM), the interphase zone demonstrated cells with different intracellular structures. There was also a significant increase in the percentage of c-kit positive cells and macrophages in the circulating blood of the laser treated rats as compared to control non treated ones. In the majority of the cells clusters of myofibrils anchored to well-developed Z-lines and structures resembling the morphological characteristics of mature intact cardiomyocytes were evident. In conclusion, LLLT to the BM of rats post-MI induces cardiogenesis mainly at the borders of the infarcted area in the heart.

Effect of Intrauterine Laser Therapy at the IVF Success Rate on Infertile Patients with a History of IVF Failure: A Pilot Non-Blinded Study

Backgrounds: While there’s developing proof aimed toward improving embryo implantation thru a focal point on great development, restrained studies have been performed on enhancing endometrial receptivity. Intrauterine Laser Therapy (LT) can be powerful in selling endometrial cell proliferation, therefore enhancing the achievement of assisted reproductive techniques (ART). The contemporary look at aimed to research the effectiveness of effective intrauterine lasers in growing endometrial thickness and the achievement of being pregnant rate. Materials and Methods: In the current clinical randomized trial (RTC) study, the infertile women (20 - 42 years old) referred to the infertility clinic in 2023-2024 who were candidates for IVF treatment with recurrent implantation failure (RIF) history were included. The patients were divided into two main groups: the intervention group;low level laser therapy (LLLT) after hormone administration) (n = 52) and the control group (hormone administration without LT) (n = 52). The IVF success rate and change in endometrial thickness before and after the LT were compared in groups. Results: There was a significant difference between groups (p Conclusion: It appears that the incorporation of Intrauterine LT in the realm of infertility could significantly impact as a novel supplementary treatment in improving endometrial receptivity and pregnancy rate.

Effects of wavelength,beam type and size on cerebral low-level laser therapy by a Monte Carlo study on visible Chinese human

Low-level laser therapy(LLLT)has been clinically utilized for many indications in medicine requiring protection from el/issue death,stimulation of healing and repair of injuries,pain reduction,swelling and inflammation.Presently,the use of LLLT to treat stroke,traumnatic brain injury and cognitive dysfunction are attracting growing interest.Near infrared light is capable of penetrating into the cerebral cortex,allowing noninvasive treatments to be caried out with few treatment-related adverse events.Optimization of LLLT treatment flfect is a crucial isse of this field;however,only a few experimental tests on mice for wavelength selection have been reported.We addressed this ssue by low-ost,straightforward and quantitative comparisons on light dosage distribution within visible Chinese human head by Monte Carlo modeling of near infrared light propagation.Optimized selection in wavelength,beam type and size were given based on comparisons among frequently used setups(ie,wavelengths:660,810 and 980 nm;beam type:Gaussian and flat beamn;beam diameter:2,4 and 6 cm).This study provided an fficient way for guiding the optimization of LLLT setup and selection on wavelength,beam type and size for clinical brain LLLT.

Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats

Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions.

Induction of Autologous Bone-Marrow Stem Cells by Low-Level Laser Therapy Has Beneficial Effects on the Kidneys Post-Ischemia-Reperfusion Injury in the Rat

Acute renal failure has a 50% - 80% mortality rate. Currently, treatment options for this life-threatening disease are limited. Low-level laser therapy (LLLT) has been found to modulate biological activity. The aim of the present study was to investigate the possible beneficial effects of laser application to stem cells in the bone marrow, on the kidneys of rats that had undergone ischemia-reperfusion injury (IRI). IRI was induced by occlusion of the renal artery to 3- and 7-month-old rats for 15 or 30 minutes. In an additional experiment IRI was applied to both kidneys for 20 min each in 2-3-month-old rats. Rats were then divided randomly into two groups of control and laser-treated. Laser therapy (Ga-Al-As 810 nm, 200 mW output for 2 min) was applied to the bone marrow 1 and 7 days post-IRI to the kidneys, and rats were sacrificed 2 weeks later. Histomorphometry and immunohistochemistry were performed on kidney sections and blood markers for kidney function. Quantitative histomorphometric analysis revealed a reduction in dilatation of the renal tubules, restored structural integrity of the renal tubules, and reduced necrosis in the laser-treated rats as compared to the control, non-laser-irradiated group. C-kit positive cell density in kidneys post-IRI and laser-treatment was significantly (p = 0.015) 3.2-fold higher compared to the control group. Creatinine and blood urea nitrogen content were significantly lower in the laser-treated rats as compared to control. It is concluded that LLLT application to the bone marrow (BM) causes a significant increase in the density of mesenchymal stem cells in the kidneys post-IRI, probably by induction of stem cells in the BM, which subsequently migrate to the IRI kidney, significantly reducing the pathological features of the kidney and increasing kidney function post IRI.

Low-Level Laser Therapy versus Four Layers Compression Technique in the Treatment of Venous Ulcers

Objective: The aim of the study is to evaluate the effect of low-level laser therapy in comparison to compression bandage therapy in the treatment of venous ulcers. Subjects & Methods: This study was carried out in the period from March 2013 to March 2014. The study included 40 adult patients with a diagnosis of venous ulcer classified as C6 according to the clinical classification of CEAP classification. The patients were divided into 2 groups: the first one included 20 patients treated by low-level laser therapy at the Rheumatology and Rehabilitation department, and the second group included 20 patients in whom we use four layers compression bandaging at the vascular surgery department. Results: 32 ulcers were treated in group I and 35 ulcers were treated in group II. The patients of group I were 7 (35%) females and 13 (65%) males, their age range were (24 - 56) years. The patients of group II were 11 (55%) males and 9 (45%) females;their age ranges were (32 - 50) years. Measurements of the ulcers size by (cm2) were taken at the beginning of therapy, at 1 month, at 2 months and at 3 months later on. The calculation of the area of the ulcer was done by using the graph papers to document the ulcer’s perpendicular linear dimensions. According to the size of the ulcer, some ulcers heal within 1 month (15.6%) ulcers in group I, and (28.5%) in group II. Some ulcers heal within 2 months (28%) in group I, and (37%) in group II. The remaining ulcers heal within 3 months or more which are (56%) ulcers in group I, and (34.2%) ulcers in group II. The recurrence rate of chronic venous leg ulcer in compression bandage technique used in group II was the least one as the total number of recurrent cases were 5 (25%), followed by laser therapy used in group I. Conclusion: There was no significant efficacy of the low-level laser therapy over the four layers compression technique in the management of chronic venous ulcers.

Application of Well-Known Antiviral Drugs in the Field Formed by the Unexplained Properties of Low-Level Laser Radiation in Therapy of Covid-19 and Chronic Viral Hepatitis

Low-level laser therapy (LLLT) or cold laser has been used in medicine for several decades. However, the method utilizes a direct contact of the light beam with a patient. Further research resulted in development of another method that enables remote transmission of the pharmacological properties of a medicament into a human body with the application of low-level laser radiation as the light source. 18 patients with different viral diseases were treated with the antiviral drugs placed into the field formed by the unexplained properties of low-level laser radiation of the “device for transfer of the pharmacological properties of a drug into the patient’s body”. This resulted in improvement of the patient’s condition, the absence of side effects and adverse reactions when using drugs in the proposed device and shortened therapy period for patients with chronic hepatitis C infection and Covid-19 patients. The long-term follow-up of the patients with chronic hepatitis B infection showed that hepatitis B virus remained at low replication levels under the influence of the therapy, which made it possible to avoid such formidable complications of the disease as cirrhosis of the liver and liver cancer.

Photobiomodulation with Super-Pulsed Laser Shows Efficacy for Stroke and Aphasia: Case Studies

Background: Brain disorders have become more and more common today, due to both the aging population and the ever-expanding sports community. However, a new therapeutic technology called photobiomodulation (PBM) is giving hope to thousands of individuals in need. Traumatic brain injury (TBI), dementia, post traumatic stress (PTSD) and attention deficit (ADD) disorders are in many cases quickly and safely improved by PBM. PBM employs red or near-infrared (NIR) light (600 - 1100 nm) to stimulate healing, protect tissue from dying, increase mitochondrial function, improve blood flow, and tissue oxygenation. PBM can also act to reduce edema, increase antioxidants, decrease inflammation, protect against apoptosis, and modulate the microglial activation state. All these effects can occur when light is delivered to the head, and can be beneficial in both acute and chronic brain conditions. Methods: In this case series, we used a high power, FDA-approved superpulsed laser system applied to the head to treat four chronic stroke patients. Patients received as few as three 6 - 9 minute treatments over a one-week period. The follow up time varied, but in one case was two years. Results: Patients showed significant improvement in their speech and verbal skills. Improvements were also noticed in walking ability, limb movement, less numbness, and better vision. Conclusion: The use of PBM in stroke rehabilitation deserves to be tested in controlled clinical trials, because this common condition has no approved pharmaceutical treatment at present.

近红外低能量激光调节血小板活性氧水平对防止冷藏损伤的研究

目的探究近红外低能量激光(Low Level Laser,LLL)照射处理对冷藏血小板保存期间活性氧的调节作用,进而对减少被巨噬细胞和肝细胞识别吞噬的影响。方法将白膜来源的浓缩血小板分为室温保存组(RTP)、冷藏保存组(CSP)和LLL照射组(CSP-L)。LLL照射组为血小板冷藏12 h后,采用1 J、5 J、10 J不同辐照强度的LLL单次照射并继续冷藏保存。各组保存5 d后,流式细胞仪检测血小板ROS生成、活化指标表达、糖基蛋白及其残基的暴露情况并进行比较。佛波酯诱导的THP-1细胞和HepG2肝细胞用于检测对各组血小板的吞噬作用。结果保存5 d后,CSP组血小板胞内ROS(cyto-ROS)水平较RTP组显著升高(RTP vs.CSP,3960±259.6 vs.5846±757.4,P<0.01),而线粒体ROS(mito-ROS)水平则低于RTP组(RTP vs.CSP,595±47.1 vs.416±50.2,P<0.05)。经低强度LLL(1 J)照射后,CSP-L1组血小板较CSP组显著降低了cyto-ROS水平(5846±757.4 vs.3945±459.4,P<0.01),CD62P、PS表达和GPⅠb/ɑ糖蛋白残基的暴露程度均显著减少(P<0.05),且与RTP组均无显著性差异。THP-1和HepG2对CSP-L1组血小板的吞噬率也显著低于CSP组(P<0.05)。同时,LLL照射对冷藏血小板的计数、pH值和MPV均无明显影响。结论低强度LLL照射处理可显著降低冷藏血小板胞内ROS水平并维持线粒体ROS的低水平生成,并能有效的抑制血小板活化和GPⅠb/ɑ去唾液酸化,减轻冷藏损伤,进而减少冷藏血小板被巨噬细胞和肝细胞识别吞噬。

物理因子促进干细胞的成骨分化

背景:针对骨缺损传统修复方法的局限性,干细胞广泛应用于再生医学的研究。化学性因子是当前的研究热点,但是近年来的研究证实,国内外应用物理因素调控干细胞分化的研究不断深入,物理因子联合生物支架在骨组织工程中为解决骨缺损修复难题提供了一种新的思路和方法,具有良好的发展前景。目的:就物理因子如电磁场、超声等对干细胞成骨分化的分子机制以及信号通路的调控、在骨组织工程中应用的可行性等方面做一总结。方法:应用计算机检索中国知网和PubMed数据库中近20年的相关文献,在标题和摘要中以“干细胞,骨缺损,成骨分化,电磁场,超声,冲击波,低强度激光,机械力,骨组织工程”或“stem cell,osteoporosis,osteogenic differentiation,Electromagnetic Fields,Ultrasound,Bone Tissue Engineering”为检索词进行检索,对相关文章94篇进行综述分析。结果与结论:(1)物理因子作为一种无创、非接触的辅助疗法对骨组织工程有着显著影响,在调控干细胞的成骨分化、促进细胞的增殖以及在骨工程支架内的生存能力方面有着积极作用。(2)除了激活信号通路和成骨基因转录外,物理因子还可以改善血管化、增加支架中形成的骨的体积、面积和厚度,可以促进骨整合,提高骨支架再生健康骨组织的成功率。(3)然而,将物理因子用于骨组织工程的研究均采用不同的实验条件,如支架类型、细胞类型及干预条件等,无法直接进行比较以确定最佳参数设置,在临床应用中,这些不同干预对促进骨折愈合的有效性研究结果也缺乏一致性,因此未来还需要进一步确定物理因子用于骨组织工程的最佳参数。(4)总体而言,物理因子作为一种理想的辅助疗法,在与各种生物材料结合并应用于骨组织工程方面具有巨大的潜力。

低能量激光治疗雄激素性秃发中国专家共识

低能量激光治疗雄激素性秃发已在临床使用10余年,疗效确切,安全性高。国内已有多种低能量激光设备获批上市,广泛应用于临床,目前暂无统一使用规范。本共识总结近年来国内外相关指南及临床研究,为在临床实践中正确选择和使用低能量激光治疗雄激素性秃发提供参考。

光生物调节诱导间充质干细胞的成骨分化

背景:间充质干细胞是从多种组织中分离出来的多能基质细胞,能够在特定的条件下分化为成骨细胞,光生物调节作为一种外部刺激能够单独或与其他诱导物联合使用加速间充质干细胞成骨分化的进程,从而为解决系列骨疾病提供新的思路。目的:综述光生物调节诱导间充质干细胞成骨分化的相关研究及机制,旨在为选用间充质干细胞作为种子细胞的骨组织工程奠定理论基础,并提出一些发展方向的建议。方法:检索中国知网、PubMed及Wed of Science数据库近年来发表的相关文献,中文检索词为“光生物调节,低功率激光,低水平激光,发光二极管,间充质干细胞,成骨分化,生物材料”;英文检索词为“Photobiomodulation,low level laser(light),light-emitting diode(LED),mesenchymal stem cell,osteogenic differentiation,Biomaterials”,最终纳入88篇文献进行分析。结果与结论:①以低水平激光和发光二极管为代表的光生物调节对于促进间充质干细胞的增殖与分化有着积极的影响。②光生物调节诱导间充质干细胞成骨分化的可行性已在细胞实验、动物实验中得到验证,一方面,光生物调节能够通过激活相关信号通路、上调成骨标志物的表达促进干细胞在体外扩增与分化;另一方面,光生物调节可以提高系统移植的干细胞体内存活率及归巢效应,缩短骨缺损愈合时间。但是光生物调节存在双相剂量效应,各项研究中激光参数、实验环境及细胞类型等要素参差不齐,使得研究结果缺乏一致性,难以推广。③光生物调节可以与生物材料、其他物理因子及药物联合使用加速干细胞成骨分化的进程。④总之,光生物调节因其无创、高效且无明显副反应等优势在医疗领域的应用逐渐广泛;近年来,其在骨组织工程中的作用也逐渐凸显,为骨缺损等疾病的治疗提供了新策略,后续研究应进一步探索光生物调节的标准化治疗参数。

光生物调节疗法在口腔颌面外科领域的应用研究进展

光生物调节疗法(PBMT)不会引起局部温度升高,不会造成组织不可逆的损伤,而且具有止痛、控制炎症、促进骨再生等多种作用,是一种非创伤性、非侵入性、不良反应少、低成本的治疗方法。该文就PBMT机制及其在口腔颌面外科领域的应用进行了综述。

激光治疗膝骨关节炎多途径生物效应的可能机制

背景:激光疗法是一种无创、无痛的治疗手段,由于它操作简单和非侵入性的特点,被认为是治疗骨关节炎的适用方法。目前,激光疗法对组织的作用机制尚不明确,并且其临床应用的研究结果仍存在争议。目的:回顾总结激光疗法治疗膝骨关节炎在细胞水平、动物实验和临床疗效方面的最新研究进展,探讨激光介导多途径生物效应的可能机制,从而为进一步研究激光治疗膝骨关节炎提供理论基础。方法:在中国知网、万方数据、维普和PubMed数据库对2018-2023年发表的有关激光疗法治疗膝骨关节炎的文献进行检索,以“激光疗法,低强度激光疗法,高强度激光疗法,光生物调节,膝关节骨关节炎,软骨细胞”为中文检索词,以“laser therapy,low level laser therapy,high level laser therapy,photobiomodulation,knee osteoarthritis,chondrocytes”为英文检索词。加上手工检索的14篇文献,最终纳入70篇文献进行综述。结果与结论:(1)激光疗法治疗膝骨关节炎主要分为高强度激光和低强度激光两种类型,激光参数和治疗方案的不同会对激光疗效产生直接影响;在使用适当的参数时,低强度激光在细胞实验、动物模型以及临床疗效方面都显示出积极的作用;高强度激光在膝骨关节炎治疗中的研究较少,但一些初步的临床研究结果显示出积极的效果;(2)细胞实验表明,低强度激光可促进软骨细胞增殖和软骨基质合成,从而降低炎症反应;(3)动物实验表明,低强度激光可以减少促炎症因子的释放,促进软骨基质合成,抑制基质降解,有效改善软骨组织的修复过程;低强度激光还能减轻膝骨关节炎过程中的氧化应激损伤,缓解疼痛;(4)在临床试验中,低强度激光和高强度激光均可以减轻患者疼痛,改善功能活动;激光疗法与运动治疗方式联合使用可能会提高治疗效果;(5)激光可能通过光生物效应或热力学效应影响细胞内的信号传导和细胞功能,为激光促进关节软骨再生提供了直接证据。

光生物疗法影响正畸牙根吸收的研究进展

牙根吸收是正畸治疗中最危险的并发症之一,轻度的牙根吸收可在停止加力后自行修复,而对于严重的牙根吸收尚无行之有效的应对手段。光生物疗法作为一种新的物理治疗手段,与传统方法相比,具有设备体积小、无创性、波长范围广、作用范围局限、生物安全性高等优点,其波长范围覆盖了线粒体吸收波长的范围。组织或细胞接受红光或近红外光照射后生物活性改变,上调抗炎相关因子表达,促进细胞三磷酸腺苷生成、加速局部血液微循环、促进软硬组织的修复,抑制或修复牙根吸收。光生物疗法的疗效取决于其波长、能量密度、功率密度、照射频率四个要素,遵循“Arndlt-Schulz”定律,即“双向剂量效应”,生物疗效具有参数相关性,因而难以确定最佳使用参数。但光生物疗法独特的优势,使其在正畸领域有着巨大的应用潜力。

人工智能辅助的太赫兹成像无标记检测识别方法研究

低强度激光治疗(Low-level Laser Therapy,LLLT)是一种可以提供局部治疗的新型无创光动力疗法。现有不同病症下光配方检测方法复杂而且对专业经验要求高,限制了LLLT的发展。为了检测急性肺损伤(Acute Lung Injury,ALI)的LLLT高效光配方,提出人工智能(Artificial Intelligence,AI)辅助的基于太赫兹(Terahertz,THz)成像的无标记识别方法。AI辅助的无标记THz成像可通过投票分类器自动识别。结果表明,AI辅助的THz成像自动识别方法对于不同光配方的LLLT其ALI的治疗效果识别率高达91.7%,可作为LLLT进一步开发和应用的新工具。