1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee o...1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.展开更多
he effects of porous hydroxyapatite blocks（PHABs） and an adjunct low-intensity pulsed ultrasound stimulation（LIPUS） on the fusion rate in a rabbit spinal posterolateral fusion（PLF） model were evaluated.Twenty ra...he effects of porous hydroxyapatite blocks（PHABs） and an adjunct low-intensity pulsed ultrasound stimulation（LIPUS） on the fusion rate in a rabbit spinal posterolateral fusion（PLF） model were evaluated.Twenty rabbits underwent PLF with autograft and PHABs were randomly assigned to two groups：treated group with 20 min LIPUS daily and untreated control group for 4 weeks until euthanasia.The fused motion segments were subjected to manual palpation,gross observation,and radiographic investigation before histomorphologic and scanning electron microscopic analyses.Statistical differences between the LIPUS group and the control group are found in the fusion rate,bone density gray scale,trabecular bone formation,osteoblast-like cells,chondrocytes and positive expression of BMP-2 and TGF-β1 in the junction zone（significance level p〈0.05）.The results suggest that LIPUS can increase fusion rates and accelerate bone in-growth into PHAB.Hence,PHAB and LIPUS may be used together to increase fusion rates in a rabbit spinal fusion model with a promising extension to human application.展开更多
[目的]比较不同方式引导下股神经连续阻滞(PCNA)在全膝关节置换术后镇痛效果和并发症及对康复功能的影响。[方法]全身麻醉下行单侧膝关节置换术患者60例,随机分为三组(n=20):超声引导组(U组)、神经刺激仪组(S组)、超声联合神经刺激仪双...[目的]比较不同方式引导下股神经连续阻滞(PCNA)在全膝关节置换术后镇痛效果和并发症及对康复功能的影响。[方法]全身麻醉下行单侧膝关节置换术患者60例,随机分为三组(n=20):超声引导组(U组)、神经刺激仪组(S组)、超声联合神经刺激仪双重引导组(D组),观察3组患者术后的镇痛效果、穿刺成功时间与次数及并发症,术后6、12、24 h及48 h不同时间点VAS评分。[结果]D组和U组成功完成操作的穿刺次数明显少于S组(P<0.05),D组和U组比较差异无统计学意义(P>0.05);从准备穿刺到完成操作所需的时间三组间比较差异无统计学意义(P>0.05)。术后6 h VAS评分,D组优于S组和U组(P<0.05),其余各时间点比较三组间差异无统计学意义(P>0.05)。术后镇痛泵的按压次数,D组少于U组和S组(P<0.05),U组和S组比较差异无统计学意义(P>0.05)。术后S组有5例出现穿刺部位皮下淤血,U组和D组无并发症发生。[结论]超声联合神经刺激器技术引导股神经阻滞,其穿刺的安全性和准确性优于单独一项技术的使用,且两种技术的联合操作未见穿刺时间的延长,应用于全膝关节置换术后镇痛有其优越性。展开更多
文摘1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.
文摘he effects of porous hydroxyapatite blocks（PHABs） and an adjunct low-intensity pulsed ultrasound stimulation（LIPUS） on the fusion rate in a rabbit spinal posterolateral fusion（PLF） model were evaluated.Twenty rabbits underwent PLF with autograft and PHABs were randomly assigned to two groups：treated group with 20 min LIPUS daily and untreated control group for 4 weeks until euthanasia.The fused motion segments were subjected to manual palpation,gross observation,and radiographic investigation before histomorphologic and scanning electron microscopic analyses.Statistical differences between the LIPUS group and the control group are found in the fusion rate,bone density gray scale,trabecular bone formation,osteoblast-like cells,chondrocytes and positive expression of BMP-2 and TGF-β1 in the junction zone（significance level p〈0.05）.The results suggest that LIPUS can increase fusion rates and accelerate bone in-growth into PHAB.Hence,PHAB and LIPUS may be used together to increase fusion rates in a rabbit spinal fusion model with a promising extension to human application.
文摘[目的]比较不同方式引导下股神经连续阻滞(PCNA)在全膝关节置换术后镇痛效果和并发症及对康复功能的影响。[方法]全身麻醉下行单侧膝关节置换术患者60例,随机分为三组(n=20):超声引导组(U组)、神经刺激仪组(S组)、超声联合神经刺激仪双重引导组(D组),观察3组患者术后的镇痛效果、穿刺成功时间与次数及并发症,术后6、12、24 h及48 h不同时间点VAS评分。[结果]D组和U组成功完成操作的穿刺次数明显少于S组(P<0.05),D组和U组比较差异无统计学意义(P>0.05);从准备穿刺到完成操作所需的时间三组间比较差异无统计学意义(P>0.05)。术后6 h VAS评分,D组优于S组和U组(P<0.05),其余各时间点比较三组间差异无统计学意义(P>0.05)。术后镇痛泵的按压次数,D组少于U组和S组(P<0.05),U组和S组比较差异无统计学意义(P>0.05)。术后S组有5例出现穿刺部位皮下淤血,U组和D组无并发症发生。[结论]超声联合神经刺激器技术引导股神经阻滞,其穿刺的安全性和准确性优于单独一项技术的使用,且两种技术的联合操作未见穿刺时间的延长,应用于全膝关节置换术后镇痛有其优越性。
