<b>Background:</b> Peripheral block techniques for total hip arthroplasty have been used as an analgesic strategy, only a few studies described it as an anesthetic technique, so the perioperative performan...<b>Background:</b> Peripheral block techniques for total hip arthroplasty have been used as an analgesic strategy, only a few studies described it as an anesthetic technique, so the perioperative performance and safety are poorly studied. <b>Methods:</b> 78 total hip arthroplasties were prospectively observed in our hospital. Divided into 2 groups: 1) General anesthesia;and 2) Lumbar sacral plexus block anesthesia. Variables measured in both groups were: demographics, conversion to general anesthesia, total opioid doses, surgical time, blood loss, postoperative pain, use and total dose of vasopressors drugs, transfusion and ICU transfer needs, postoperative ambulation time, and length of hospital stay. T student and chi-square tests were used upon the case. A significant difference was considered when a value of p < 0.05 was obtained. Descriptive statistics were performed in frequency, percentages, variance and standard deviation. <b>Results:</b> 3 patients (7.3%) anesthetized with combined lumbar sacral plexus block were converted to general anesthesia. When comparing peripheral nerve block and general anesthesia, less intraoperative (p = 0.000) and postoperative (p = 0.002) opioid consumption were noted, less postoperative pain in PACU (p = 0.002) and in the first 24 hours (p = 0.005), as well as earlier onset of ambulation (p = 0.008) and shorter hospital stay (p = 0.031). <b>Conclusions:</b> In our study, the lumbar and sacral plexus block anesthesia technique provided anesthetic conditions to perform hip joint arthroplasty and it was proved to be advantageous in comparison to general anesthesia.展开更多
Background: Pneumatic arterial tourniquet is a utilized strategy in limb surgeries to provide bloodless field to facilitate surgical procedure. Be that as it may, arterial tourniquet has numerous injurious impacts inc...Background: Pneumatic arterial tourniquet is a utilized strategy in limb surgeries to provide bloodless field to facilitate surgical procedure. Be that as it may, arterial tourniquet has numerous injurious impacts including hemodynamic changes and tourniquet-induced pain which sometimes can be severe and intolerable. Objectives: Our primary aim was to assess the impact of performing “Lumbar Plexus Block and sciatic nerve block” with General Anesthesia (GA) on the degree of arterial tourniquet-induced hemodynamic effects. On the other hand, our secondary aims were: amount of postoperative analgesic prerequisites, patient satisfactory score and documented side effects. Settings and Design: Ain Shams University, Orthopedic operating theatre;a prospective, randomized, double-blind study. Methods and Material: The physical status of 50 patients (both sexes) including I and II patients from American Society of Anesthesiologists, whose ages are from 20 - 40 years, is not so ideal when they are undergoing elective knee Arthroscopy. The duration lasts no more than ninety minutes under GA with application of tourniquet. Patients were allotted haphazardly to one of two groups. In Group C (Control group): Only GA. In Group B: LPB and sciatic nerve block were performed just before GA administration. Intraoperative hemodynamics was recorded at specific timings. Results: Incidence of tourniquet induced hypertension (TIH) was markedly less with Group B at: forty five, sixty, seventy five mins after tourniquet inflation and just before tourniquet deflation. Also, the total ketorolac consumption during first 24 hours of postoperative period was significantly less with Group B (p Conclusions: Combined Sciatic-Lumbar plexus blocks when combined with general anesthesia were very effective in attenuating TIH.展开更多
Sixty-four cases of protrusion of lumbarintervertebral disc were treated by massotherapy withheavy manipulations plus blocking therapy underanesthesia from August,1997 to July,1998,withsatisfactory therapeutic results...Sixty-four cases of protrusion of lumbarintervertebral disc were treated by massotherapy withheavy manipulations plus blocking therapy underanesthesia from August,1997 to July,1998,withsatisfactory therapeutic results as reported in thefollowing.Clinical DataNinety-four cases in the series were randomlydivided into two groups.All the 94 cases satisfied thecriteria for diagnosis of the disorder,and thediagnosis was confirmed by展开更多
Objective:To study the effects of dexmedetomidine combined with hypobaric lumbar anesthesia on pain mediator secretion as well as inflammatory response and stress response activation in elderly patients with hip repla...Objective:To study the effects of dexmedetomidine combined with hypobaric lumbar anesthesia on pain mediator secretion as well as inflammatory response and stress response activation in elderly patients with hip replacement.Methods: Elderly patients who were>70 years old and underwent hip replacement in Hancheng People's Hospital between March 2015 and June 2017 were chosen and randomly divided into the experimental group who accepted dexmedetomidine combined with hypobaric lumbar anesthesia and the control group who accepted hypobaric lumbar anesthesia alone. The levels of pain mediators and stress mediators in serum as well as the expression of inflammatory molecules in peripheral blood were measured before surgery, the same day after surgery and 3 d after surgery.Results:Compared with those of same group before surgery, CGRP,β-EP, SP, BK, TNF-α, ACTH, F-C, F-Ins, NE and MDA levels in serum as well as NLRP3, Caspase-1, TLR4 and NF-κB mRNA expression in peripheral blood of both groups significantly increased the same day after surgery and 3 d after surgery, and CGRP,β-EP, SP, BK, TNF-α, ACTH, F-C, F-Ins, NE and MDA levels in serum as well as NLRP3, Caspase-1, TLR4 and NF-κB mRNA expression in peripheral blood of experimental group the same day after surgery and 3 d after surgery were significantly lower than those of control group.Conclusion: Dexmedetomidine combined with hypobaric lumbar anesthesia for hip replacement in the elderly can reduce the secretion of pain mediators and relieve the inflammatory response and stress response.展开更多
Objective To summarize the anesthesia techniques performed in the selective posterior rhizotomy(SPR) at lumbar and sacral regions(L&R)on juvenile cerebral palsy(CP) patients. Method 144 CP patients below 10 years ...Objective To summarize the anesthesia techniques performed in the selective posterior rhizotomy(SPR) at lumbar and sacral regions(L&R)on juvenile cerebral palsy(CP) patients. Method 144 CP patients below 10 years were successfully performed SPR at L&R under combined intravenous and inhalation anesthesia (CIIA) in prone position with threshold values of each nerve root being measured by means of nerve root electric stimulus (NRES). Result All patients were performed SPR and NRES successfully although blood pressure and heart rate increased significantly while NRES. Conclusion CIIA is safe and effective for juvenile CP patients to be performed SPR at L&R.展开更多
Regional anesthesia is an integral component of successful orthopedic surgery.Neuraxial anesthesia is commonly used for surgical anesthesia while peripheral nerve blocks are often used for postoperative analgesia.Pati...Regional anesthesia is an integral component of successful orthopedic surgery.Neuraxial anesthesia is commonly used for surgical anesthesia while peripheral nerve blocks are often used for postoperative analgesia.Patient evaluation for regional anesthesia should include neurological,pulmonary,cardiovascular,and hematological assessments.Neuraxial blocks include spinal,epidural,and combined spinal epidural.Upper extremity peripheral nerve blocks include interscalene,supraclavicular,infraclavicular,and axillary.Lower extremity peripheral nerve blocks include femoral nerve block,saphenous nerve block,sciatic nerve block,iPACK block,ankle block and lumbar plexus block.The choice of regional anesthesia is a unanimous decision made by the surgeon,the anesthesiologist,and the patient based on a risk-benefit assessment.The choice of the regional block depends on patient cooperation,patient positing,operative structures,operative manipulation,tourniquet use and the impact of postoperative motor blockade on initiation of physical therapy.Regional anesthesia is safe but has an inherent risk of failure and a relatively low incidence of complications such as local anesthetic systemic toxicity(LAST),nerve injury,falls,hematoma,infection and allergic reactions.Ultrasound should be used for regional anesthesia procedures to improve the efficacy and minimize complications.LAST treatment guidelines and rescue medications(intralipid)should be readily available during the regional anesthesia administration.展开更多
<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">In...<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">In this retrospective observational study, we evaluated patients who underwent elective lumbar stenosis surgery between February 1, 2019, and April 1, 2019. Patients who underwent surgery for lumbar spinal stenosis under general anesthesia alone were compared with those who underwent general anesthesia combined with erector spinae plane block.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Aims:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">We aimed to retrospectively evaluate whether erector spinae plane block reduced opioid consumption following surgery for spinal stenosis.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Study Design:</span></b><span style="font-family:Verdana;"> A retrospective observational study</span><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">We collected data on the pain scores, time for the first requirement for patient-controlled analgesia with tramadol, the cumulative patient-controlled analgesia dose, requirement for rescue analgesia, time to first stand up postoperatively and the incidence of postoperative nausea and vomiting.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">Sixty patients were included in the study. The numerical rating scale</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s pain scores were significantly lower in the erector spinae plane group at 1, 2, 4, 6, 12 and 24 hours than in the general anesthesia group. The cumulative dose of patient-controlled analgesia with tramadol was higher in the general anesthesia group than in the ESP group [212.0 (6.6) mg, vs. 107.3 (36.9 mg), (p <0.001)]. The time to first stand up after surgery was significantly longer in the general anesthesia group (p = 0.011).</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> ESP block appear to be an effective method to relieve pain after lumbar surgery.</span>展开更多
目的:探讨超声引导下髂筋膜间隙阻滞联合腰硬联合麻醉对老年髋关节手术患者的影响。方法:选取2021年1月—2023年4月于南京市浦口区中医院接受髋关节手术的102例老年患者作为研究对象,患者接受髋关节置换或复位内固定术治疗,根据随机数...目的:探讨超声引导下髂筋膜间隙阻滞联合腰硬联合麻醉对老年髋关节手术患者的影响。方法:选取2021年1月—2023年4月于南京市浦口区中医院接受髋关节手术的102例老年患者作为研究对象,患者接受髋关节置换或复位内固定术治疗,根据随机数表法将患者分为对照组和观察组,各51例。对照组行腰硬联合麻醉,观察组在腰硬联合麻醉基础上行超声引导下髂筋膜间隙阻滞麻醉。对比两组平均动脉压、心率、术后镇痛用药情况[术后舒芬太尼用量、经静脉患者自控镇痛(PCIA)开始按压时间及按压次数]、应激反应指标[超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)]、视觉模拟评分法(VAS)评分、简易智力状态检查量表(MMSE)、中枢神经特异蛋白(S100-β)、β-淀粉样蛋白1~40(Aβ_(1~40))水平、不良反应及满意度。结果:两组麻醉前、手术开始时及手术结束时平均动脉压和心率比较,差异无统计学意义(P>0.05);观察组蛛网膜下腔阻滞体位摆放时平均动脉压和心率低于对照组,差异有统计学意义(P<0.05)。观察组术后舒芬太尼用量少于对照组,PCIA开始按压时间晚于对照组,PCIA按压次数少于对照组,差异有统计学意义(P<0.05)。观察组术后5 d SOD、GSH-Px水平高于对照组,AOPP、MDA水平低于对照组,差异有统计学意义(P<0.05)。观察组术后12 h、1 d、3 d VAS评分低于对照组,差异有统计学意义(P<0.05)。观察组术后6 h、1 d、2 d MMSE评分高于对照组,差异有统计学意义(P<0.05)。观察组术后6 h、1 d S100-β、Aβ_(1~40)水平均低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,总满意度高于对照组,差异有统计学意义(P<0.05)。结论:老年髋关节手术患者接受超声引导下髂筋膜间隙阻滞联合腰硬联合麻醉方法,可改善麻醉操作期间平均动脉压和心率指标水平,减少术后镇痛药物使用剂量,减轻机体应激反应,降低术后疼痛感,改善术后认知功能,降低并发症发生率,提高满意率。展开更多
目的:探讨超声引导下腰骶丛神经阻滞联合全麻对行髋关节置换术老年病人术后谵妄(POD)的影响。方法:选取髋关节置换术老年病人80例,随机分为腰骶丛神经阻滞联合全麻组(h组)和全麻组(q组),各40例。2组病人均采用喉罩通气,维持脑电双频指数...目的:探讨超声引导下腰骶丛神经阻滞联合全麻对行髋关节置换术老年病人术后谵妄(POD)的影响。方法:选取髋关节置换术老年病人80例,随机分为腰骶丛神经阻滞联合全麻组(h组)和全麻组(q组),各40例。2组病人均采用喉罩通气,维持脑电双频指数40~60,术后静脉自控镇痛(PCA)。比较2组病人术中麻醉药物用量、手术相关指标;采用视觉模拟量表(VAS)评估病人术后疼痛情况;于术前(D0)、术后第1(D1)、3(D3)、7(D7)天分别测定病人意识模糊评估量表(CAM)评分,并抽取静脉血检测白细胞介素(IL)-1β、IL-6、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)和S100β蛋白水平。结果:与q组相比,h组病人术中麻醉药物用量、术后拔管时间、术后24 h PCA次数、术后各时间点VAS评分、首次下床时间及出院时间均明显减少(P<0.01);h组术后IL-1β、IL-6、TNF-α、CRP、S100β蛋白水平、CAM评分及POD发生率均明显低于q组(P<0.01)。结论:超声引导下腰骶丛神经阻滞联合全麻较单纯全麻,可减少行髋关节置换术的老年病人麻醉药用量,完善镇痛,降低炎性反应和POD发生率,有助于病人术后快速康复。展开更多
文摘<b>Background:</b> Peripheral block techniques for total hip arthroplasty have been used as an analgesic strategy, only a few studies described it as an anesthetic technique, so the perioperative performance and safety are poorly studied. <b>Methods:</b> 78 total hip arthroplasties were prospectively observed in our hospital. Divided into 2 groups: 1) General anesthesia;and 2) Lumbar sacral plexus block anesthesia. Variables measured in both groups were: demographics, conversion to general anesthesia, total opioid doses, surgical time, blood loss, postoperative pain, use and total dose of vasopressors drugs, transfusion and ICU transfer needs, postoperative ambulation time, and length of hospital stay. T student and chi-square tests were used upon the case. A significant difference was considered when a value of p < 0.05 was obtained. Descriptive statistics were performed in frequency, percentages, variance and standard deviation. <b>Results:</b> 3 patients (7.3%) anesthetized with combined lumbar sacral plexus block were converted to general anesthesia. When comparing peripheral nerve block and general anesthesia, less intraoperative (p = 0.000) and postoperative (p = 0.002) opioid consumption were noted, less postoperative pain in PACU (p = 0.002) and in the first 24 hours (p = 0.005), as well as earlier onset of ambulation (p = 0.008) and shorter hospital stay (p = 0.031). <b>Conclusions:</b> In our study, the lumbar and sacral plexus block anesthesia technique provided anesthetic conditions to perform hip joint arthroplasty and it was proved to be advantageous in comparison to general anesthesia.
文摘Background: Pneumatic arterial tourniquet is a utilized strategy in limb surgeries to provide bloodless field to facilitate surgical procedure. Be that as it may, arterial tourniquet has numerous injurious impacts including hemodynamic changes and tourniquet-induced pain which sometimes can be severe and intolerable. Objectives: Our primary aim was to assess the impact of performing “Lumbar Plexus Block and sciatic nerve block” with General Anesthesia (GA) on the degree of arterial tourniquet-induced hemodynamic effects. On the other hand, our secondary aims were: amount of postoperative analgesic prerequisites, patient satisfactory score and documented side effects. Settings and Design: Ain Shams University, Orthopedic operating theatre;a prospective, randomized, double-blind study. Methods and Material: The physical status of 50 patients (both sexes) including I and II patients from American Society of Anesthesiologists, whose ages are from 20 - 40 years, is not so ideal when they are undergoing elective knee Arthroscopy. The duration lasts no more than ninety minutes under GA with application of tourniquet. Patients were allotted haphazardly to one of two groups. In Group C (Control group): Only GA. In Group B: LPB and sciatic nerve block were performed just before GA administration. Intraoperative hemodynamics was recorded at specific timings. Results: Incidence of tourniquet induced hypertension (TIH) was markedly less with Group B at: forty five, sixty, seventy five mins after tourniquet inflation and just before tourniquet deflation. Also, the total ketorolac consumption during first 24 hours of postoperative period was significantly less with Group B (p Conclusions: Combined Sciatic-Lumbar plexus blocks when combined with general anesthesia were very effective in attenuating TIH.
文摘Sixty-four cases of protrusion of lumbarintervertebral disc were treated by massotherapy withheavy manipulations plus blocking therapy underanesthesia from August,1997 to July,1998,withsatisfactory therapeutic results as reported in thefollowing.Clinical DataNinety-four cases in the series were randomlydivided into two groups.All the 94 cases satisfied thecriteria for diagnosis of the disorder,and thediagnosis was confirmed by
文摘Objective:To study the effects of dexmedetomidine combined with hypobaric lumbar anesthesia on pain mediator secretion as well as inflammatory response and stress response activation in elderly patients with hip replacement.Methods: Elderly patients who were>70 years old and underwent hip replacement in Hancheng People's Hospital between March 2015 and June 2017 were chosen and randomly divided into the experimental group who accepted dexmedetomidine combined with hypobaric lumbar anesthesia and the control group who accepted hypobaric lumbar anesthesia alone. The levels of pain mediators and stress mediators in serum as well as the expression of inflammatory molecules in peripheral blood were measured before surgery, the same day after surgery and 3 d after surgery.Results:Compared with those of same group before surgery, CGRP,β-EP, SP, BK, TNF-α, ACTH, F-C, F-Ins, NE and MDA levels in serum as well as NLRP3, Caspase-1, TLR4 and NF-κB mRNA expression in peripheral blood of both groups significantly increased the same day after surgery and 3 d after surgery, and CGRP,β-EP, SP, BK, TNF-α, ACTH, F-C, F-Ins, NE and MDA levels in serum as well as NLRP3, Caspase-1, TLR4 and NF-κB mRNA expression in peripheral blood of experimental group the same day after surgery and 3 d after surgery were significantly lower than those of control group.Conclusion: Dexmedetomidine combined with hypobaric lumbar anesthesia for hip replacement in the elderly can reduce the secretion of pain mediators and relieve the inflammatory response and stress response.
文摘Objective To summarize the anesthesia techniques performed in the selective posterior rhizotomy(SPR) at lumbar and sacral regions(L&R)on juvenile cerebral palsy(CP) patients. Method 144 CP patients below 10 years were successfully performed SPR at L&R under combined intravenous and inhalation anesthesia (CIIA) in prone position with threshold values of each nerve root being measured by means of nerve root electric stimulus (NRES). Result All patients were performed SPR and NRES successfully although blood pressure and heart rate increased significantly while NRES. Conclusion CIIA is safe and effective for juvenile CP patients to be performed SPR at L&R.
文摘Regional anesthesia is an integral component of successful orthopedic surgery.Neuraxial anesthesia is commonly used for surgical anesthesia while peripheral nerve blocks are often used for postoperative analgesia.Patient evaluation for regional anesthesia should include neurological,pulmonary,cardiovascular,and hematological assessments.Neuraxial blocks include spinal,epidural,and combined spinal epidural.Upper extremity peripheral nerve blocks include interscalene,supraclavicular,infraclavicular,and axillary.Lower extremity peripheral nerve blocks include femoral nerve block,saphenous nerve block,sciatic nerve block,iPACK block,ankle block and lumbar plexus block.The choice of regional anesthesia is a unanimous decision made by the surgeon,the anesthesiologist,and the patient based on a risk-benefit assessment.The choice of the regional block depends on patient cooperation,patient positing,operative structures,operative manipulation,tourniquet use and the impact of postoperative motor blockade on initiation of physical therapy.Regional anesthesia is safe but has an inherent risk of failure and a relatively low incidence of complications such as local anesthetic systemic toxicity(LAST),nerve injury,falls,hematoma,infection and allergic reactions.Ultrasound should be used for regional anesthesia procedures to improve the efficacy and minimize complications.LAST treatment guidelines and rescue medications(intralipid)should be readily available during the regional anesthesia administration.
文摘<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">In this retrospective observational study, we evaluated patients who underwent elective lumbar stenosis surgery between February 1, 2019, and April 1, 2019. Patients who underwent surgery for lumbar spinal stenosis under general anesthesia alone were compared with those who underwent general anesthesia combined with erector spinae plane block.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Aims:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">We aimed to retrospectively evaluate whether erector spinae plane block reduced opioid consumption following surgery for spinal stenosis.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Study Design:</span></b><span style="font-family:Verdana;"> A retrospective observational study</span><span style="font-family:Verdana;">. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">We collected data on the pain scores, time for the first requirement for patient-controlled analgesia with tramadol, the cumulative patient-controlled analgesia dose, requirement for rescue analgesia, time to first stand up postoperatively and the incidence of postoperative nausea and vomiting.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">Sixty patients were included in the study. The numerical rating scale</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;">s pain scores were significantly lower in the erector spinae plane group at 1, 2, 4, 6, 12 and 24 hours than in the general anesthesia group. The cumulative dose of patient-controlled analgesia with tramadol was higher in the general anesthesia group than in the ESP group [212.0 (6.6) mg, vs. 107.3 (36.9 mg), (p <0.001)]. The time to first stand up after surgery was significantly longer in the general anesthesia group (p = 0.011).</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> ESP block appear to be an effective method to relieve pain after lumbar surgery.</span>
文摘目的:探讨超声引导下髂筋膜间隙阻滞联合腰硬联合麻醉对老年髋关节手术患者的影响。方法:选取2021年1月—2023年4月于南京市浦口区中医院接受髋关节手术的102例老年患者作为研究对象,患者接受髋关节置换或复位内固定术治疗,根据随机数表法将患者分为对照组和观察组,各51例。对照组行腰硬联合麻醉,观察组在腰硬联合麻醉基础上行超声引导下髂筋膜间隙阻滞麻醉。对比两组平均动脉压、心率、术后镇痛用药情况[术后舒芬太尼用量、经静脉患者自控镇痛(PCIA)开始按压时间及按压次数]、应激反应指标[超氧化物歧化酶(SOD)、晚期氧化蛋白产物(AOPP)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)]、视觉模拟评分法(VAS)评分、简易智力状态检查量表(MMSE)、中枢神经特异蛋白(S100-β)、β-淀粉样蛋白1~40(Aβ_(1~40))水平、不良反应及满意度。结果:两组麻醉前、手术开始时及手术结束时平均动脉压和心率比较,差异无统计学意义(P>0.05);观察组蛛网膜下腔阻滞体位摆放时平均动脉压和心率低于对照组,差异有统计学意义(P<0.05)。观察组术后舒芬太尼用量少于对照组,PCIA开始按压时间晚于对照组,PCIA按压次数少于对照组,差异有统计学意义(P<0.05)。观察组术后5 d SOD、GSH-Px水平高于对照组,AOPP、MDA水平低于对照组,差异有统计学意义(P<0.05)。观察组术后12 h、1 d、3 d VAS评分低于对照组,差异有统计学意义(P<0.05)。观察组术后6 h、1 d、2 d MMSE评分高于对照组,差异有统计学意义(P<0.05)。观察组术后6 h、1 d S100-β、Aβ_(1~40)水平均低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,总满意度高于对照组,差异有统计学意义(P<0.05)。结论:老年髋关节手术患者接受超声引导下髂筋膜间隙阻滞联合腰硬联合麻醉方法,可改善麻醉操作期间平均动脉压和心率指标水平,减少术后镇痛药物使用剂量,减轻机体应激反应,降低术后疼痛感,改善术后认知功能,降低并发症发生率,提高满意率。
文摘目的:探讨超声引导下腰骶丛神经阻滞联合全麻对行髋关节置换术老年病人术后谵妄(POD)的影响。方法:选取髋关节置换术老年病人80例,随机分为腰骶丛神经阻滞联合全麻组(h组)和全麻组(q组),各40例。2组病人均采用喉罩通气,维持脑电双频指数40~60,术后静脉自控镇痛(PCA)。比较2组病人术中麻醉药物用量、手术相关指标;采用视觉模拟量表(VAS)评估病人术后疼痛情况;于术前(D0)、术后第1(D1)、3(D3)、7(D7)天分别测定病人意识模糊评估量表(CAM)评分,并抽取静脉血检测白细胞介素(IL)-1β、IL-6、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)和S100β蛋白水平。结果:与q组相比,h组病人术中麻醉药物用量、术后拔管时间、术后24 h PCA次数、术后各时间点VAS评分、首次下床时间及出院时间均明显减少(P<0.01);h组术后IL-1β、IL-6、TNF-α、CRP、S100β蛋白水平、CAM评分及POD发生率均明显低于q组(P<0.01)。结论:超声引导下腰骶丛神经阻滞联合全麻较单纯全麻,可减少行髋关节置换术的老年病人麻醉药用量,完善镇痛,降低炎性反应和POD发生率,有助于病人术后快速康复。
