A number of previous papers have studied the problem of recovering low-rank matrices with noise, further combining the noisy and perturbed cases, we propose a nonconvex Schatten p-norm minimization method to deal with...A number of previous papers have studied the problem of recovering low-rank matrices with noise, further combining the noisy and perturbed cases, we propose a nonconvex Schatten p-norm minimization method to deal with the recovery of fully perturbed low-rank matrices. By utilizing the p-null space property (p-NSP) and the p-restricted isometry property (p-RIP) of the matrix, sufficient conditions to ensure that the stable and accurate reconstruction for low-rank matrix in the case of full perturbation are derived, and two upper bound recovery error estimation ns are given. These estimations are characterized by two vital aspects, one involving the best r-approximation error and the other concerning the overall noise. Specifically, this paper obtains two new error upper bounds based on the fact that p-RIP and p-NSP are able to recover accurately and stably low-rank matrix, and to some extent improve the conditions corresponding to RIP.展开更多
The method of recovering a low-rank matrix with an unknown fraction whose entries are arbitrarily corrupted is known as the robust principal component analysis (RPCA). This RPCA problem, under some conditions, can b...The method of recovering a low-rank matrix with an unknown fraction whose entries are arbitrarily corrupted is known as the robust principal component analysis (RPCA). This RPCA problem, under some conditions, can be exactly solved via convex optimization by minimizing a combination of the nuclear norm and the 11 norm. In this paper, an algorithm based on the Douglas-Rachford splitting method is proposed for solving the RPCA problem. First, the convex optimization problem is solved by canceling the constraint of the variables, and ~hen the proximity operators of the objective function are computed alternately. The new algorithm can exactly recover the low-rank and sparse components simultaneously, and it is proved to be convergent. Numerical simulations demonstrate the practical utility of the proposed algorithm.展开更多
Low-rank matrix recovery is an important problem extensively studied in machine learning, data mining and computer vision communities. A novel method is proposed for low-rank matrix recovery, targeting at higher recov...Low-rank matrix recovery is an important problem extensively studied in machine learning, data mining and computer vision communities. A novel method is proposed for low-rank matrix recovery, targeting at higher recovery accuracy and stronger theoretical guarantee. Specifically, the proposed method is based on a nonconvex optimization model, by solving the low-rank matrix which can be recovered from the noisy observation. To solve the model, an effective algorithm is derived by minimizing over the variables alternately. It is proved theoretically that this algorithm has stronger theoretical guarantee than the existing work. In natural image denoising experiments, the proposed method achieves lower recovery error than the two compared methods. The proposed low-rank matrix recovery method is also applied to solve two real-world problems, i.e., removing noise from verification code and removing watermark from images, in which the images recovered by the proposed method are less noisy than those of the two compared methods.展开更多
In this paper,we study the low-rank matrix completion problem with Poisson observations,where only partial entries are available and the observations are in the presence of Poisson noise.We propose a novel model compo...In this paper,we study the low-rank matrix completion problem with Poisson observations,where only partial entries are available and the observations are in the presence of Poisson noise.We propose a novel model composed of the Kullback-Leibler(KL)divergence by using the maximum likelihood estimation of Poisson noise,and total variation(TV)and nuclear norm constraints.Here the nuclear norm and TV constraints are utilized to explore the approximate low-rankness and piecewise smoothness of the underlying matrix,respectively.The advantage of these two constraints in the proposed model is that the low-rankness and piecewise smoothness of the underlying matrix can be exploited simultaneously,and they can be regularized for many real-world image data.An upper error bound of the estimator of the proposed model is established with high probability,which is not larger than that of only TV or nuclear norm constraint.To the best of our knowledge,this is the first work to utilize both low-rank and TV constraints with theoretical error bounds for matrix completion under Poisson observations.Extensive numerical examples on both synthetic data and real-world images are reported to corroborate the superiority of the proposed approach.展开更多
Low-rank matrix decomposition with first-order total variation(TV)regularization exhibits excellent performance in exploration of image structure.Taking advantage of its excellent performance in image denoising,we app...Low-rank matrix decomposition with first-order total variation(TV)regularization exhibits excellent performance in exploration of image structure.Taking advantage of its excellent performance in image denoising,we apply it to improve the robustness of deep neural networks.However,although TV regularization can improve the robustness of the model,it reduces the accuracy of normal samples due to its over-smoothing.In our work,we develop a new low-rank matrix recovery model,called LRTGV,which incorporates total generalized variation(TGV)regularization into the reweighted low-rank matrix recovery model.In the proposed model,TGV is used to better reconstruct texture information without over-smoothing.The reweighted nuclear norm and Li-norm can enhance the global structure information.Thus,the proposed LRTGV can destroy the structure of adversarial noise while re-enhancing the global structure and local texture of the image.To solve the challenging optimal model issue,we propose an algorithm based on the alternating direction method of multipliers.Experimental results show that the proposed algorithm has a certain defense capability against black-box attacks,and outperforms state-of-the-art low-rank matrix recovery methods in image restoration.展开更多
The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functio...The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.展开更多
Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to p...Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.展开更多
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv...Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.展开更多
In this paper, a sufficient condition is obtained to ensure the stable recovery(ε≠ 0) or exact recovery(ε = 0) of all r-rank matrices X ∈ Rm×nfrom b = A(X) + z via nonconvex Schatten p-minimization for anyδ4...In this paper, a sufficient condition is obtained to ensure the stable recovery(ε≠ 0) or exact recovery(ε = 0) of all r-rank matrices X ∈ Rm×nfrom b = A(X) + z via nonconvex Schatten p-minimization for anyδ4r∈ [3~(1/2))2, 1). Moreover, we determine the range of parameter p with any given δ4r∈ [(3~(1/2))/22, 1). In fact, for any given δ4r∈ [3~(1/2))2, 1), p ∈(0, 2(1- δ4r)] suffices for the stable recovery or exact recovery of all r-rank matrices.展开更多
As a kind of weaker supervisory information, pairwise constraints can be exploited to guide the data analysis process, such as data clustering. This paper formulates pairwise constraint propagation, which aims to pred...As a kind of weaker supervisory information, pairwise constraints can be exploited to guide the data analysis process, such as data clustering. This paper formulates pairwise constraint propagation, which aims to predict the large quantity of unknown constraints from scarce known constraints, as a low-rank matrix recovery(LMR) problem. Although recent advances in transductive learning based on matrix completion can be directly adopted to solve this problem, our work intends to develop a more general low-rank matrix recovery solution for pairwise constraint propagation, which not only completes the unknown entries in the constraint matrix but also removes the noise from the data matrix. The problem can be effectively solved using an augmented Lagrange multiplier method. Experimental results on constrained clustering tasks based on the propagated pairwise constraints have shown that our method can obtain more stable results than state-of-the-art algorithms,and outperform them.展开更多
Principal Component Analysis (PCA) is a widely used technique for data analysis and dimensionality reduction, but its sensitivity to feature scale and outliers limits its applicability. Robust Principal Component Anal...Principal Component Analysis (PCA) is a widely used technique for data analysis and dimensionality reduction, but its sensitivity to feature scale and outliers limits its applicability. Robust Principal Component Analysis (RPCA) addresses these limitations by decomposing data into a low-rank matrix capturing the underlying structure and a sparse matrix identifying outliers, enhancing robustness against noise and outliers. This paper introduces a novel RPCA variant, Robust PCA Integrating Sparse and Low-rank Priors (RPCA-SL). Each prior targets a specific aspect of the data’s underlying structure and their combination allows for a more nuanced and accurate separation of the main data components from outliers and noise. Then RPCA-SL is solved by employing a proximal gradient algorithm for improved anomaly detection and data decomposition. Experimental results on simulation and real data demonstrate significant advancements.展开更多
In this paper,we propose a decentralized algorithm to solve the low-rank matrix completion problem and analyze its privacy-preserving property.Suppose that we want to recover a low-rank matrix D=[D1,D2,・・・,DL]from a s...In this paper,we propose a decentralized algorithm to solve the low-rank matrix completion problem and analyze its privacy-preserving property.Suppose that we want to recover a low-rank matrix D=[D1,D2,・・・,DL]from a subset of its entries.In a network composed of L agents,each agent i observes some entries of Di.We factorize the unknown matrix D as the product of a public matrix X which is common to all agents and a private matrix Y=[Y1,Y2,・・・,YL]of which Yi is held by agent i only.Each agent i updates Yi and its local estimate of X,denoted by X(i),in an alternating manner.Through exchanging information with neighbors,all the agents move toward a consensus on the estimates X(i).Once the consensus is(nearly)reached throughout the network,each agent i recovers Di=X(i)Yi,thus D is recovered.In this progress,communication through the network may disclose sensitive information about the data matrices Di to a malicious agent.We prove that in the proposed algorithm,D-LMaFit,if the network topology is well designed,the malicious agent is unable to reconstruct the sensitive information from others.展开更多
As a high-resulotion biological imaging technology, photoacoustic microscopy(PAM) is difficult to use in realtime imaging due to the long data acquisition time. Herein, a fast data acquisition and image recovery met...As a high-resulotion biological imaging technology, photoacoustic microscopy(PAM) is difficult to use in realtime imaging due to the long data acquisition time. Herein, a fast data acquisition and image recovery method named sparse PAM based on a low-rank matrix approximation is proposed. Specifically, the process to recover the final image from incomplete data is formulated into a low-rank matrix completion framework, and the "Go Decomposition" algorithm is utilized to solve the problem. Finally, both simulated and real PAM experiments are conducted to verify the performance of the proposed method and demonstrate clinical potential for many biological diseases.展开更多
BACKGROUND Frey syndrome,also known as ototemporal nerve syndrome or gustatory sweating syndrome,is one of the most common complications of parotid gland surgery.This condition is characterized by abnormal sensations ...BACKGROUND Frey syndrome,also known as ototemporal nerve syndrome or gustatory sweating syndrome,is one of the most common complications of parotid gland surgery.This condition is characterized by abnormal sensations in the facial skin accompanied by episodes of flushing and sweating triggered by cognitive processes,visual stimuli,or eating.AIM To investigate the preventive effect of acellular dermal matrix(ADM)on Frey syndrome after parotid tumor resection and analyzed the effects of Frey syndrome across various surgical methods and other factors involved in parotid tumor resection.METHODS Retrospective data from 82 patients were analyzed to assess the correlation between sex,age,resection sample size,operation time,operation mode,ADM usage,and occurrence of postoperative Frey syndrome.RESULTS Among the 82 patients,the incidence of Frey syndrome was 56.1%.There were no significant differences in sex,age,or operation time between the two groups(P>0.05).However,there was a significant difference between ADM implantation and occurrence of Frey syndrome(P<0.05).ADM application could reduce the variation in the incidence of Frey syndrome across different operation modes.CONCLUSION ADM can effectively prevent Frey syndrome and delay its onset.展开更多
For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then ...For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then adding amino-functionalized UiO-66-NH_(2)(Am-UiO-66-NH_(2)).Aminofunctionalization of UiO-66 was accomplished by melamine,followed by an amidation reaction to immobilize Am-UiO-66-NH_(2),which was immobilized on the surface of the membrane as well as in the pore channels,which enhanced the hydrophilicity of the membrane surface while increasing the negative potential of the membrane surface.This nanoparticle-loaded ultrafiltration membrane has good permeation performance,with a pure water flux of up to 482.3 L·m^(-2)·h^(-1) for C-SPAEKS/AmUiO-66-NH_(2) and a retention rate of up to 98.7%for bovine serum albumin(BSA)-contaminated solutions.Meanwhile,after several hydrophilic modifications,the flux recovery of BSA contaminants by this series of membranes increased from 56.2%to 80.55%of pure membranes.The results of ultra-filtration flux time tests performed at room temperature showed that the series of ultrafiltration membranes remained relatively stable over a test time of 300 min.Thus,the newly developed mixed matrix membrane showed potential for high efficiency and stability in wastewater treatment containing bovine serum proteins.展开更多
Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousfillers,making them an effective alternative to conventional polymer membranes.However,interfacial incompatibility issues,s...Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousfillers,making them an effective alternative to conventional polymer membranes.However,interfacial incompatibility issues,such as the presence of interfacial voids,hardening of polymer chains,and blockage of micropores by polymers between common MMMsfillers and the polymer matrix,currently limit the gas sep-aration performance of MMMs.Ternary phase MMMs(consisting of afiller,an additive,and a matrix)made by adding a third compound,usually functionalized additives,can overcome the structural problems of binary phase MMMs and positively impact membrane separation performance.This review introduces the structure and fabrication processes for ternary MMMs,categorizes various nanofillers and the third component,and summarizes and analyzes in detail the CO_(2) separation performance of newly developed ternary MMMs based on both rubbery and glassy polymers.Based on this separation data,the challenges of ternary MMMs are also discussed.Finally,future directions for ternary MMMs are proposed.展开更多
BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown...BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown that decellularized extracellular matrix(ECM)derived from autologous,allogenic,or xenogeneic mesenchymal stromal cells(MSCs)can effectively restore osteochondral integrity.AIM To determine whether the decellularized ECM of antler reserve mesenchymal cells(RMCs),a xenogeneic material from antler stem cells,is superior to the currently available treatments for osteochondral defects.METHODS We isolated the RMCs from a 60-d-old sika deer antler and cultured them in vitro to 70%confluence;50 mg/mL L-ascorbic acid was then added to the medium to stimulate ECM deposition.Decellularized sheets of adipocyte-derived MSCs(aMSCs)and antlerogenic periosteal cells(another type of antler stem cells)were used as the controls.Three weeks after ascorbic acid stimulation,the ECM sheets were harvested and applied to the osteochondral defects in rat knee joints.RESULTS The defects were successfully repaired by applying the ECM-sheets.The highest quality of repair was achieved in the RMC-ECM group both in vitro(including cell attachment and proliferation),and in vivo(including the simultaneous regeneration of well-vascularized subchondral bone and avascular articular hyaline cartilage integrated with surrounding native tissues).Notably,the antler-stem-cell-derived ECM(xenogeneic)performed better than the aMSC-ECM(allogenic),while the ECM of the active antler stem cells was superior to that of the quiescent antler stem cells.CONCLUSION Decellularized xenogeneic ECM derived from the antler stem cell,particularly the active form(RMC-ECM),can achieve high quality repair/reconstruction of osteochondral defects,suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship.展开更多
Functional brain networks (FBNs) provide a potential way for understanding the brain organizational patterns and diagnosing neurological diseases. Due to its importance, many FBN construction methods have been propose...Functional brain networks (FBNs) provide a potential way for understanding the brain organizational patterns and diagnosing neurological diseases. Due to its importance, many FBN construction methods have been proposed currently, including the low-order Pearson’s correlation (PC) and sparse representation (SR), as well as the high-order functional connection (HoFC). However, most existing methods usually ignore the information of topological structures of FBN, such as low-rank structure which can reduce the noise and improve modularity to enhance the stability of networks. In this paper, we propose a novel method for improving the estimated FBNs utilizing matrix factorization (MF). More specifically, we firstly construct FBNs based on three traditional methods, including PC, SR, and HoFC. Then, we reduce the rank of these FBNs via MF model for estimating FBN with low-rank structure. Finally, to evaluate the effectiveness of the proposed method, experiments have been conducted to identify the subjects with mild cognitive impairment (MCI) and autism spectrum disorder (ASD) from norm controls (NCs) using the estimated FBNs. The results on Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset and Autism Brain Imaging Data Exchange (ABIDE) dataset demonstrate that the classification performances achieved by our proposed method are better than the selected baseline methods.展开更多
文摘A number of previous papers have studied the problem of recovering low-rank matrices with noise, further combining the noisy and perturbed cases, we propose a nonconvex Schatten p-norm minimization method to deal with the recovery of fully perturbed low-rank matrices. By utilizing the p-null space property (p-NSP) and the p-restricted isometry property (p-RIP) of the matrix, sufficient conditions to ensure that the stable and accurate reconstruction for low-rank matrix in the case of full perturbation are derived, and two upper bound recovery error estimation ns are given. These estimations are characterized by two vital aspects, one involving the best r-approximation error and the other concerning the overall noise. Specifically, this paper obtains two new error upper bounds based on the fact that p-RIP and p-NSP are able to recover accurately and stably low-rank matrix, and to some extent improve the conditions corresponding to RIP.
基金supported by the National Natural Science Foundation of China(No.61271014)the Specialized Research Fund for the Doctoral Program of Higher Education(No.20124301110003)the Graduated Students Innovation Fund of Hunan Province(No.CX2012B238)
文摘The method of recovering a low-rank matrix with an unknown fraction whose entries are arbitrarily corrupted is known as the robust principal component analysis (RPCA). This RPCA problem, under some conditions, can be exactly solved via convex optimization by minimizing a combination of the nuclear norm and the 11 norm. In this paper, an algorithm based on the Douglas-Rachford splitting method is proposed for solving the RPCA problem. First, the convex optimization problem is solved by canceling the constraint of the variables, and ~hen the proximity operators of the objective function are computed alternately. The new algorithm can exactly recover the low-rank and sparse components simultaneously, and it is proved to be convergent. Numerical simulations demonstrate the practical utility of the proposed algorithm.
基金supported by the National Natural Science Foundation of China (No. 91320201 and No. 61471262)the International (Regional) Collaborative Key Research Projects (No. 61520106002)
基金Projects(61173122,61262032) supported by the National Natural Science Foundation of ChinaProjects(11JJ3067,12JJ2038) supported by the Natural Science Foundation of Hunan Province,China
文摘Low-rank matrix recovery is an important problem extensively studied in machine learning, data mining and computer vision communities. A novel method is proposed for low-rank matrix recovery, targeting at higher recovery accuracy and stronger theoretical guarantee. Specifically, the proposed method is based on a nonconvex optimization model, by solving the low-rank matrix which can be recovered from the noisy observation. To solve the model, an effective algorithm is derived by minimizing over the variables alternately. It is proved theoretically that this algorithm has stronger theoretical guarantee than the existing work. In natural image denoising experiments, the proposed method achieves lower recovery error than the two compared methods. The proposed low-rank matrix recovery method is also applied to solve two real-world problems, i.e., removing noise from verification code and removing watermark from images, in which the images recovered by the proposed method are less noisy than those of the two compared methods.
基金supported in part by the National Natural Science Foundation of China(Grant No.12201473)by the Science Foundation of Wuhan Institute of Technology(Grant No.K202256)+3 种基金The research of M.K.Ng was supported in part by the HKRGC GRF(Grant Nos.12300218,12300519,17201020,17300021)The research of X.Zhang was supported in part by the National Natural Science Foundation of China(Grant No.12171189)by the Knowledge Innovation Project of Wuhan(Grant No.2022010801020279)by the Fundamental Research Funds for the Central Universities(Grant No.CCNU22JC023).
文摘In this paper,we study the low-rank matrix completion problem with Poisson observations,where only partial entries are available and the observations are in the presence of Poisson noise.We propose a novel model composed of the Kullback-Leibler(KL)divergence by using the maximum likelihood estimation of Poisson noise,and total variation(TV)and nuclear norm constraints.Here the nuclear norm and TV constraints are utilized to explore the approximate low-rankness and piecewise smoothness of the underlying matrix,respectively.The advantage of these two constraints in the proposed model is that the low-rankness and piecewise smoothness of the underlying matrix can be exploited simultaneously,and they can be regularized for many real-world image data.An upper error bound of the estimator of the proposed model is established with high probability,which is not larger than that of only TV or nuclear norm constraint.To the best of our knowledge,this is the first work to utilize both low-rank and TV constraints with theoretical error bounds for matrix completion under Poisson observations.Extensive numerical examples on both synthetic data and real-world images are reported to corroborate the superiority of the proposed approach.
基金Project supported by the National Natural Science Foundation of China(No.62072024)the Outstanding Youth Program of Beijing University of Civil Engineering and Architecture,China(No.JDJQ20220805)the Shenzhen Stability Support General Project(Type A),China(No.20200826104014001)。
文摘Low-rank matrix decomposition with first-order total variation(TV)regularization exhibits excellent performance in exploration of image structure.Taking advantage of its excellent performance in image denoising,we apply it to improve the robustness of deep neural networks.However,although TV regularization can improve the robustness of the model,it reduces the accuracy of normal samples due to its over-smoothing.In our work,we develop a new low-rank matrix recovery model,called LRTGV,which incorporates total generalized variation(TGV)regularization into the reweighted low-rank matrix recovery model.In the proposed model,TGV is used to better reconstruct texture information without over-smoothing.The reweighted nuclear norm and Li-norm can enhance the global structure information.Thus,the proposed LRTGV can destroy the structure of adversarial noise while re-enhancing the global structure and local texture of the image.To solve the challenging optimal model issue,we propose an algorithm based on the alternating direction method of multipliers.Experimental results show that the proposed algorithm has a certain defense capability against black-box attacks,and outperforms state-of-the-art low-rank matrix recovery methods in image restoration.
基金supported by National Institute on Aging(NIH-NIA)R21 AG074152(to KMA)National Institute of Allergy and Infectious Diseases(NIAID)grant DP2 AI171150(to KMA)Department of Defense(DoD)grant AZ210089(to KMA)。
文摘The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.
基金supported by the Natio`nal Natural Science Foundation of China,No. 81801241a grant from Sichuan Science and Technology Program,No. 2023NSFSC1578Scientific Research Projects of Southwest Medical University,No. 2022ZD002 (all to JX)。
文摘Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.
基金supported by the Natural Science Foundation of Shandong Province,No.ZR2023MC168the National Natural Science Foundation of China,No.31670989the Key R&D Program of Shandong Province,No.2019GSF107037(all to CS).
文摘Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.
基金supported by National Natural Science Foundation of China(Grant Nos.11271050 and 11371183)Beijing Center for Mathematics and Information Interdisciplinary Sciences
文摘In this paper, a sufficient condition is obtained to ensure the stable recovery(ε≠ 0) or exact recovery(ε = 0) of all r-rank matrices X ∈ Rm×nfrom b = A(X) + z via nonconvex Schatten p-minimization for anyδ4r∈ [3~(1/2))2, 1). Moreover, we determine the range of parameter p with any given δ4r∈ [(3~(1/2))/22, 1). In fact, for any given δ4r∈ [3~(1/2))2, 1), p ∈(0, 2(1- δ4r)] suffices for the stable recovery or exact recovery of all r-rank matrices.
基金supported by the National Natural Science Foundation of China (No. 61300164)
文摘As a kind of weaker supervisory information, pairwise constraints can be exploited to guide the data analysis process, such as data clustering. This paper formulates pairwise constraint propagation, which aims to predict the large quantity of unknown constraints from scarce known constraints, as a low-rank matrix recovery(LMR) problem. Although recent advances in transductive learning based on matrix completion can be directly adopted to solve this problem, our work intends to develop a more general low-rank matrix recovery solution for pairwise constraint propagation, which not only completes the unknown entries in the constraint matrix but also removes the noise from the data matrix. The problem can be effectively solved using an augmented Lagrange multiplier method. Experimental results on constrained clustering tasks based on the propagated pairwise constraints have shown that our method can obtain more stable results than state-of-the-art algorithms,and outperform them.
文摘Principal Component Analysis (PCA) is a widely used technique for data analysis and dimensionality reduction, but its sensitivity to feature scale and outliers limits its applicability. Robust Principal Component Analysis (RPCA) addresses these limitations by decomposing data into a low-rank matrix capturing the underlying structure and a sparse matrix identifying outliers, enhancing robustness against noise and outliers. This paper introduces a novel RPCA variant, Robust PCA Integrating Sparse and Low-rank Priors (RPCA-SL). Each prior targets a specific aspect of the data’s underlying structure and their combination allows for a more nuanced and accurate separation of the main data components from outliers and noise. Then RPCA-SL is solved by employing a proximal gradient algorithm for improved anomaly detection and data decomposition. Experimental results on simulation and real data demonstrate significant advancements.
文摘In this paper,we propose a decentralized algorithm to solve the low-rank matrix completion problem and analyze its privacy-preserving property.Suppose that we want to recover a low-rank matrix D=[D1,D2,・・・,DL]from a subset of its entries.In a network composed of L agents,each agent i observes some entries of Di.We factorize the unknown matrix D as the product of a public matrix X which is common to all agents and a private matrix Y=[Y1,Y2,・・・,YL]of which Yi is held by agent i only.Each agent i updates Yi and its local estimate of X,denoted by X(i),in an alternating manner.Through exchanging information with neighbors,all the agents move toward a consensus on the estimates X(i).Once the consensus is(nearly)reached throughout the network,each agent i recovers Di=X(i)Yi,thus D is recovered.In this progress,communication through the network may disclose sensitive information about the data matrices Di to a malicious agent.We prove that in the proposed algorithm,D-LMaFit,if the network topology is well designed,the malicious agent is unable to reconstruct the sensitive information from others.
基金supported by the National Natural Science Foundation of China (Nos.61371045 and 61308116)the Science and Technology Development Plan Project of Shandong Province (No.2015GGX103016)the China Postdoctoral Science Foundation (No.2015M571413)
文摘As a high-resulotion biological imaging technology, photoacoustic microscopy(PAM) is difficult to use in realtime imaging due to the long data acquisition time. Herein, a fast data acquisition and image recovery method named sparse PAM based on a low-rank matrix approximation is proposed. Specifically, the process to recover the final image from incomplete data is formulated into a low-rank matrix completion framework, and the "Go Decomposition" algorithm is utilized to solve the problem. Finally, both simulated and real PAM experiments are conducted to verify the performance of the proposed method and demonstrate clinical potential for many biological diseases.
文摘BACKGROUND Frey syndrome,also known as ototemporal nerve syndrome or gustatory sweating syndrome,is one of the most common complications of parotid gland surgery.This condition is characterized by abnormal sensations in the facial skin accompanied by episodes of flushing and sweating triggered by cognitive processes,visual stimuli,or eating.AIM To investigate the preventive effect of acellular dermal matrix(ADM)on Frey syndrome after parotid tumor resection and analyzed the effects of Frey syndrome across various surgical methods and other factors involved in parotid tumor resection.METHODS Retrospective data from 82 patients were analyzed to assess the correlation between sex,age,resection sample size,operation time,operation mode,ADM usage,and occurrence of postoperative Frey syndrome.RESULTS Among the 82 patients,the incidence of Frey syndrome was 56.1%.There were no significant differences in sex,age,or operation time between the two groups(P>0.05).However,there was a significant difference between ADM implantation and occurrence of Frey syndrome(P<0.05).ADM application could reduce the variation in the incidence of Frey syndrome across different operation modes.CONCLUSION ADM can effectively prevent Frey syndrome and delay its onset.
基金financial support of this work by Natural Science Foundation of China(22075031,51673030,51603017 and 51803011)Jilin Provincial Science&Technology Department(20220201105GX)Chang Bai Mountain Scholars Program of Jilin Province.
文摘For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then adding amino-functionalized UiO-66-NH_(2)(Am-UiO-66-NH_(2)).Aminofunctionalization of UiO-66 was accomplished by melamine,followed by an amidation reaction to immobilize Am-UiO-66-NH_(2),which was immobilized on the surface of the membrane as well as in the pore channels,which enhanced the hydrophilicity of the membrane surface while increasing the negative potential of the membrane surface.This nanoparticle-loaded ultrafiltration membrane has good permeation performance,with a pure water flux of up to 482.3 L·m^(-2)·h^(-1) for C-SPAEKS/AmUiO-66-NH_(2) and a retention rate of up to 98.7%for bovine serum albumin(BSA)-contaminated solutions.Meanwhile,after several hydrophilic modifications,the flux recovery of BSA contaminants by this series of membranes increased from 56.2%to 80.55%of pure membranes.The results of ultra-filtration flux time tests performed at room temperature showed that the series of ultrafiltration membranes remained relatively stable over a test time of 300 min.Thus,the newly developed mixed matrix membrane showed potential for high efficiency and stability in wastewater treatment containing bovine serum proteins.
基金support from Sichuan Science and Technology Program(2021YFH0116)National Natural Science Foundation of China(No.52170112)DongFang Boiler Co.,Ltd.(3522015).
文摘Mixed matrix membranes(MMMs)could combine the advantages of both polymeric membranes and porousfillers,making them an effective alternative to conventional polymer membranes.However,interfacial incompatibility issues,such as the presence of interfacial voids,hardening of polymer chains,and blockage of micropores by polymers between common MMMsfillers and the polymer matrix,currently limit the gas sep-aration performance of MMMs.Ternary phase MMMs(consisting of afiller,an additive,and a matrix)made by adding a third compound,usually functionalized additives,can overcome the structural problems of binary phase MMMs and positively impact membrane separation performance.This review introduces the structure and fabrication processes for ternary MMMs,categorizes various nanofillers and the third component,and summarizes and analyzes in detail the CO_(2) separation performance of newly developed ternary MMMs based on both rubbery and glassy polymers.Based on this separation data,the challenges of ternary MMMs are also discussed.Finally,future directions for ternary MMMs are proposed.
基金National Natural Science Foundation of China,No.U20A20403This study was conducted in accordance with the Animal Ethics Committee of the Institute of Antler Science and Product Technology,Changchun Sci-Tech University(AEC No:CKARI202309).
文摘BACKGROUND Cartilage defects are some of the most common causes of arthritis.Cartilage lesions caused by inflammation,trauma or degenerative disease normally result in osteochondral defects.Previous studies have shown that decellularized extracellular matrix(ECM)derived from autologous,allogenic,or xenogeneic mesenchymal stromal cells(MSCs)can effectively restore osteochondral integrity.AIM To determine whether the decellularized ECM of antler reserve mesenchymal cells(RMCs),a xenogeneic material from antler stem cells,is superior to the currently available treatments for osteochondral defects.METHODS We isolated the RMCs from a 60-d-old sika deer antler and cultured them in vitro to 70%confluence;50 mg/mL L-ascorbic acid was then added to the medium to stimulate ECM deposition.Decellularized sheets of adipocyte-derived MSCs(aMSCs)and antlerogenic periosteal cells(another type of antler stem cells)were used as the controls.Three weeks after ascorbic acid stimulation,the ECM sheets were harvested and applied to the osteochondral defects in rat knee joints.RESULTS The defects were successfully repaired by applying the ECM-sheets.The highest quality of repair was achieved in the RMC-ECM group both in vitro(including cell attachment and proliferation),and in vivo(including the simultaneous regeneration of well-vascularized subchondral bone and avascular articular hyaline cartilage integrated with surrounding native tissues).Notably,the antler-stem-cell-derived ECM(xenogeneic)performed better than the aMSC-ECM(allogenic),while the ECM of the active antler stem cells was superior to that of the quiescent antler stem cells.CONCLUSION Decellularized xenogeneic ECM derived from the antler stem cell,particularly the active form(RMC-ECM),can achieve high quality repair/reconstruction of osteochondral defects,suggesting that selection of decellularized ECM for such repair should be focused more on bioactivity rather than kinship.
文摘Functional brain networks (FBNs) provide a potential way for understanding the brain organizational patterns and diagnosing neurological diseases. Due to its importance, many FBN construction methods have been proposed currently, including the low-order Pearson’s correlation (PC) and sparse representation (SR), as well as the high-order functional connection (HoFC). However, most existing methods usually ignore the information of topological structures of FBN, such as low-rank structure which can reduce the noise and improve modularity to enhance the stability of networks. In this paper, we propose a novel method for improving the estimated FBNs utilizing matrix factorization (MF). More specifically, we firstly construct FBNs based on three traditional methods, including PC, SR, and HoFC. Then, we reduce the rank of these FBNs via MF model for estimating FBN with low-rank structure. Finally, to evaluate the effectiveness of the proposed method, experiments have been conducted to identify the subjects with mild cognitive impairment (MCI) and autism spectrum disorder (ASD) from norm controls (NCs) using the estimated FBNs. The results on Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset and Autism Brain Imaging Data Exchange (ABIDE) dataset demonstrate that the classification performances achieved by our proposed method are better than the selected baseline methods.