BACKGROUND Primary ciliary dyskinesia(PCD)is an inherited autosomal-recessive disorder of impaired mucociliary clearance characterized by chronic respiratory diseases,otolaryngological diseases,central nervous system ...BACKGROUND Primary ciliary dyskinesia(PCD)is an inherited autosomal-recessive disorder of impaired mucociliary clearance characterized by chronic respiratory diseases,otolaryngological diseases,central nervous system abnormalities,reproductive system abnormalities,and cardiac function abnormalities.General anesthesia in these patients is associated with a higher incidence of respiratory complications than in patients without the disease.CASE SUMMARY A 16-year-old male patient was referred to the emergency room complaining of right ankle pain due to distal tibiofibular fracture.Three years prior,he had been diagnosed with PCD.At that time,he had experienced several episodes of pneumonia,sinusitis,and chronic middle ear infections,for which he underwent surgical interventions.At the current admission,he presented with cough and sputum but no other respiratory symptoms.A chest computed tomography scan revealed centrilobular ground-glass opacities in both lower lobes and a calcified nodule in the left lower lobe.For the surgical procedure and postoperative pain management,combined spinal-epidural anesthesia was employed.The patient’s postoperative pain score was measured by the numerical rating scale(NRS).On the day of surgery,his NRS was 5 points.By the second postoperative day,the NRS score had decreased to 2–3 points.The epidural catheter was removed on the fourth day following the operation.The patient was subsequently discharged no respiratory complications.CONCLUSION We performed combined spinal-epidural anesthesia in a patient with PCD.The patient experienced no additional respiratory complications and was discharged with a low NRS score for pain.展开更多
目的探讨下腹部手术后硬膜外自控镇痛(PCA)对血清补体C3、C4和C-反应蛋白(CRP)的影响。方法选择择期施行下腹部手术的患者60例,其中30例于术后行PCA(A组),另30例于术后肌内注射镇痛药止痛(B组),比较2组镇痛效果,并分别测定术前12 h及术...目的探讨下腹部手术后硬膜外自控镇痛(PCA)对血清补体C3、C4和C-反应蛋白(CRP)的影响。方法选择择期施行下腹部手术的患者60例,其中30例于术后行PCA(A组),另30例于术后肌内注射镇痛药止痛(B组),比较2组镇痛效果,并分别测定术前12 h及术后12 h、24 h、48 h时补体C3、C4和CRP含量。结果A组患者术后伤口疼痛明显减轻;术后12h 2组患者补体C3、C4含量均下降,术后48 h A组补体C3、C4含量回升,而B组仍处于低水平。术后12 h 2组患者CRP含量均升高,术后48 h A组CRP含量下降,而B组仍处于高水平。结论下腹部手术后施行PCA能有效地减轻术后伤口的疼痛,并能减轻应激反应所致的免疫抑制,从而保护机体的免疫功能,有利于机体的康复。展开更多
文摘BACKGROUND Primary ciliary dyskinesia(PCD)is an inherited autosomal-recessive disorder of impaired mucociliary clearance characterized by chronic respiratory diseases,otolaryngological diseases,central nervous system abnormalities,reproductive system abnormalities,and cardiac function abnormalities.General anesthesia in these patients is associated with a higher incidence of respiratory complications than in patients without the disease.CASE SUMMARY A 16-year-old male patient was referred to the emergency room complaining of right ankle pain due to distal tibiofibular fracture.Three years prior,he had been diagnosed with PCD.At that time,he had experienced several episodes of pneumonia,sinusitis,and chronic middle ear infections,for which he underwent surgical interventions.At the current admission,he presented with cough and sputum but no other respiratory symptoms.A chest computed tomography scan revealed centrilobular ground-glass opacities in both lower lobes and a calcified nodule in the left lower lobe.For the surgical procedure and postoperative pain management,combined spinal-epidural anesthesia was employed.The patient’s postoperative pain score was measured by the numerical rating scale(NRS).On the day of surgery,his NRS was 5 points.By the second postoperative day,the NRS score had decreased to 2–3 points.The epidural catheter was removed on the fourth day following the operation.The patient was subsequently discharged no respiratory complications.CONCLUSION We performed combined spinal-epidural anesthesia in a patient with PCD.The patient experienced no additional respiratory complications and was discharged with a low NRS score for pain.
文摘目的探讨下腹部手术后硬膜外自控镇痛(PCA)对血清补体C3、C4和C-反应蛋白(CRP)的影响。方法选择择期施行下腹部手术的患者60例,其中30例于术后行PCA(A组),另30例于术后肌内注射镇痛药止痛(B组),比较2组镇痛效果,并分别测定术前12 h及术后12 h、24 h、48 h时补体C3、C4和CRP含量。结果A组患者术后伤口疼痛明显减轻;术后12h 2组患者补体C3、C4含量均下降,术后48 h A组补体C3、C4含量回升,而B组仍处于低水平。术后12 h 2组患者CRP含量均升高,术后48 h A组CRP含量下降,而B组仍处于高水平。结论下腹部手术后施行PCA能有效地减轻术后伤口的疼痛,并能减轻应激反应所致的免疫抑制,从而保护机体的免疫功能,有利于机体的康复。
