Casais et al have reported an inverse correlation between serum phosphate and body weight after administration of sodium phosphate at a dose of 60 g.Our group has already described the relationship between body weight...Casais et al have reported an inverse correlation between serum phosphate and body weight after administration of sodium phosphate at a dose of 60 g.Our group has already described the relationship between body weight and hyperphosphatemia with these preparations,although our study was not quoted by Casais.We performed a pharmacokinetic study involving 13 volunteers who were divided into two groups on the basis of body weight:group Ⅰconsisting of seven women with a median weight of 60 kg and group Ⅱconsisting of five men and one woman with a median weight of 119.2 kg.Group Ⅰdeveloped higher peak phosphate levels and maintained these levels above the subjects in Group Ⅱ for a prolonged time period despite adequate hydration being ensured with frequent monitoring of weight,fluid intake and total body weight.Our study demonstrated that adequate hydration does not protect against the secondary effects of hyperphosphatemia.In the study by Casais et al,66% of the study subjects were women,the correlation between serum phosphate and gender in their data also appears to be important.Women are at higher risk of acute phosphate nephropathy due to a diminished volume of distribution of the high dose of ingested phosphate.Decreased volume of distribution in women is due to diminished body weight.This is further compounded by decreased creatinine clearance in females.展开更多
OBJECTIVE: To investigate the combined effect of Traditional Chinese Medicine(TCM) decoction and low-molecular-weight heparin calcium on deep vein thrombosis(DVT) induced by surgery in patients with lower limb fractur...OBJECTIVE: To investigate the combined effect of Traditional Chinese Medicine(TCM) decoction and low-molecular-weight heparin calcium on deep vein thrombosis(DVT) induced by surgery in patients with lower limb fracture.METHODS: Totally 86 hospitalized patients with DVT after surgery of lower limb fracture between September 2012 and January 2015 were recruited and randomly divided into control group and observation group, 43 cases in each group. The patients in the control group were treated with subcutaneous injection of low-molecular-weight heparin calcium, and those in the observation group were additionally given Danshen Injection and TCM decoction. The differences between two groups in occurrence rate, medication time, therapeutic effects,recurrence rate of thrombosis, activated partial thromboplastin time(APTT), and prothrombin time(PT) were compared.RESULTS: The occurrence rate of DVT in observation group(4.65%, 2/43) was lower than that in control group(27.91%,12/43)(P<0.05). The medication time of observation group was(6.15±2.94) d, shorter than(9.76±3.12) d in the control group(P<0.05). In observation group, 2 cases of DVT were cured(2/2); in the control group, 9 cases presented therapeutic effects and the total effective rate was 75.00%(9/12). The improvement of APTT and PT in the observation group was better than that in the control group(P<0.05).CONCLUSION: Integrative TCM decoction plus low-molecularweight heparin calcium is superior to applicaton of low-molecularweight heparin calcium alone in reducing and treating DVT in the postoperative patients with lower limb fracture.展开更多
The traditional HB-weighted time-delay estimation （TDE） method degenerates under the impulsive noise environment. Two new time-delay estimation methods are proposed based on fractional lower order statistics （FLOS...The traditional HB-weighted time-delay estimation （TDE） method degenerates under the impulsive noise environment. Two new time-delay estimation methods are proposed based on fractional lower order statistics （FLOS） according to the impulsive characteristics of fractional lower order α-stable noises. Theoretic analysis and computer simulations indicate that the proposed covariation based HB weighted （COV-HB） algorithm can suppress impulsive noises in one received signal for 1 ≤α≤ 2, whereas the other proposed fractional lower order eovariancebased HB weighted （FLOC-HB） algorithm has robust performance under arbitrary impulsive noise conditions for the whole range of 0 〈α≤ 2.展开更多
文摘Casais et al have reported an inverse correlation between serum phosphate and body weight after administration of sodium phosphate at a dose of 60 g.Our group has already described the relationship between body weight and hyperphosphatemia with these preparations,although our study was not quoted by Casais.We performed a pharmacokinetic study involving 13 volunteers who were divided into two groups on the basis of body weight:group Ⅰconsisting of seven women with a median weight of 60 kg and group Ⅱconsisting of five men and one woman with a median weight of 119.2 kg.Group Ⅰdeveloped higher peak phosphate levels and maintained these levels above the subjects in Group Ⅱ for a prolonged time period despite adequate hydration being ensured with frequent monitoring of weight,fluid intake and total body weight.Our study demonstrated that adequate hydration does not protect against the secondary effects of hyperphosphatemia.In the study by Casais et al,66% of the study subjects were women,the correlation between serum phosphate and gender in their data also appears to be important.Women are at higher risk of acute phosphate nephropathy due to a diminished volume of distribution of the high dose of ingested phosphate.Decreased volume of distribution in women is due to diminished body weight.This is further compounded by decreased creatinine clearance in females.
基金2012 Science and Technology Program of Shenzhen(Grant No.:201203283)
文摘OBJECTIVE: To investigate the combined effect of Traditional Chinese Medicine(TCM) decoction and low-molecular-weight heparin calcium on deep vein thrombosis(DVT) induced by surgery in patients with lower limb fracture.METHODS: Totally 86 hospitalized patients with DVT after surgery of lower limb fracture between September 2012 and January 2015 were recruited and randomly divided into control group and observation group, 43 cases in each group. The patients in the control group were treated with subcutaneous injection of low-molecular-weight heparin calcium, and those in the observation group were additionally given Danshen Injection and TCM decoction. The differences between two groups in occurrence rate, medication time, therapeutic effects,recurrence rate of thrombosis, activated partial thromboplastin time(APTT), and prothrombin time(PT) were compared.RESULTS: The occurrence rate of DVT in observation group(4.65%, 2/43) was lower than that in control group(27.91%,12/43)(P<0.05). The medication time of observation group was(6.15±2.94) d, shorter than(9.76±3.12) d in the control group(P<0.05). In observation group, 2 cases of DVT were cured(2/2); in the control group, 9 cases presented therapeutic effects and the total effective rate was 75.00%(9/12). The improvement of APTT and PT in the observation group was better than that in the control group(P<0.05).CONCLUSION: Integrative TCM decoction plus low-molecularweight heparin calcium is superior to applicaton of low-molecularweight heparin calcium alone in reducing and treating DVT in the postoperative patients with lower limb fracture.
基金supported by the National Natural Science Foundation of China (60372081)China Postdoctoral Science Foundation (20070410347)the Doctor Startup Fund of Liaoning Province (20071076)
文摘The traditional HB-weighted time-delay estimation （TDE） method degenerates under the impulsive noise environment. Two new time-delay estimation methods are proposed based on fractional lower order statistics （FLOS） according to the impulsive characteristics of fractional lower order α-stable noises. Theoretic analysis and computer simulations indicate that the proposed covariation based HB weighted （COV-HB） algorithm can suppress impulsive noises in one received signal for 1 ≤α≤ 2, whereas the other proposed fractional lower order eovariancebased HB weighted （FLOC-HB） algorithm has robust performance under arbitrary impulsive noise conditions for the whole range of 0 〈α≤ 2.
