Future directions:combination of acupuncture with mesenchymal stem cells for Parkinson’s disease

Parkinson’s disease(PD)is a progressive chronic disease currently with no radical cure drugs and means due to the complex pathological mechanisms and limited regenerative capacity of neurons.Acupuncture aids in neuronal regeneration via various signaling routes like ROCK,Wnt,and Notch,safeguarding dopaminergic neurons against inflammation,oxidative stress,and cell death,which in turn enhances the progression of PD progression.Numerous research findings indicate that integrating acupuncture with mesenchymal stem cells(MSCs)transplantation is more effective than using either acupuncture or MSCs infusion alone.The combined treatment improves the survival rate of MSCs,promotes the generation of functional neural networks by stimulating the secretion of neurotrophic factors,and ultimately improves the disease microenvironment.In this review,we state the neuroprotective effects of acupuncture or MSCs treament alone in PD,then summarize the application of acupuncture combined with MSCs therapy in other diseases.Consequently,we anticipate that integrating acupuncture with MSCs transplantation may emerge as a novel and efficient approach for managing PD.This possibility needs to be verified through further basic and clinical research.

IMPACTS OF PENETRATION THERAPY WITH HEAD ELECTRICAL ACUPUNCTURE ON PROLIFERATION OF NEURAL STEM CELLS IN SUBSTANTIA NIGRA OF RAT MODEL OF PARKINSON'S DISEASE

Objective To probe into the function mechanism of penetration therapy with head electrical acupuncture on Parkinson＇s disease. Methods Microinjection of 6-hydroxydopamin （6-OHDA） on the left cor- pus striatum was adopted to prepare rotation model of Parkinson^s disease in rat. Penetration therapy with head electrical acupuncture was administered in treatment. Normal group, sham-operation group, model group and penetration therapy group were set up. （1）lmmunohistochemical （IHC） method was used to test the morphology and count of positive cell of tyrosine hydroxylase （TH）. （2）RT-PCR technology was used to detect the expression of nestin mRNA of neural stem cell （NSC）. Results （1）Compared with model group, in pene- tration therapy group, the expressions of TH-positive neurons in immune response were increased in areal density （AD）, numerical density （ND） and integrating optic density （P〈0.05）. （2）Compared with model group, in penetration therapy group, the expression of nestin mRNA was increased （P〈0. 05）. Conclusion Penetration therapy with head electrical acupuncture promotes the proliferation of endogenous neural stem cells in substantia nigra of rat model of Parkinson＇s disease.

EFFECTS OF ELECTRO ACUPUNCTURE AND TWIRLING REINFORCING-REDUCING MANIPULATIONS ON VOLUME OF MICROCIRCULATORY BLOOD FLOW IN CEREBRAL PIA MATER

Effects of electroacupuncture (EA) and routine acupuncture with twirling reinforcing and reducing manipulation of the needle (RA) both at Zusanli point (St 36) on volume of microcirculatory blood flow in the cerebral pia mater were observed by fenestration of the cranial bone and laser Doppler microcirculatory blood flow analyser. Results showed that both RA and EA could increase the volume of microcirculatory blood flow in the cerebral pia mater; and that the increase in the EA group was superior to that in RA group. This suggests that a moderate and effective stimulation is a key to the production of a regulative effect on the organism.

Acupuncture and vitamin B_(12) injection for Bell's palsy:no high-quality evidence exists

OBJECTIVE： To assess the efficacy of acupuncture combined with vitamin B12 acupoint injection versus acupuncture alone to reduce incomplete recovery in patients with Bell＇s palsy. DATA RETRIEVAL： A computer-based online retrieval of Medline, Web of Science, CNKI, CBM databases until April 2014 was performed for relevant trials, using the key words ＂Bell＇s palsy or idiopathic facial palsy or facial palsy＂ and＂acupuncture or vitamin B12 or methylcobalamin＂. STUDY SELECTION： All randomized controlled trials that compared acupuncture with acupuncture combined with vitamin B12 in patients with Bell＇s palsy were included in the me- ta-analysis. The initial treatment lasted for at least 4 weeks. The outcomes of incomplete facial recovery were monitored. The scoring index varied and the definition of healing was consistent. The combined effect size was calculated by using relative risk （RR） with 95% confidence interval （C/） using the fixed effect model of Review Manager. MAIN OUTCOME MEASURES： Incomplete recovery rates were chosen as the primary outcome. RESULTS： Five studies involving 344 patients were included in the final analysis. Results showed that the incomplete recovery rate of Bell＇s palsy patients was 44.50% in the acupuncture combined with vitamin B12 group but 62.57% in the acupuncture alone group. The major acupoints were Taiyang （EX-HN5）, Jiache （ST6）, Dicang （ST4） and Sibai （ST2）. The combined effect size showed that acupuncture combined with vitamin B12 was better than acupuncture alone for the treatment of Belrs palsy （RR = 0.71, 95%CI： 0.58-0.87; P = 0.001）, this result held true when 8 patients lost to follow up in one study were included into the analyses （RR = 0.70, 95%CI： 0.58-0.86; P = 0.0005）. In the subgroup analyses, the therapeutic effect in patients of the electroacupuncture subgroup was better than in the non-electroacupuncture subgroup （P = 0.024）. There was no significant dif- ference in the incomplete recovery rate by subgroup analysis on drug types and treatment period. Most of the included studies were moderate or low quality, and bias existed. CONCLUSION： In patients with Bell＇s palsy, acupuncture combined with vitamin 812 can reduce the risk of incomplete recovery compared with acupuncture alone in our meta-analysis. Because of study bias and methodological limitations, this conclusion is uncertain and the clinical appli- cation of acupuncture combined with vitamin B12 requires further exploration.

40 CASES OF PARKINSON'S DISEASE TREATED WITH ACUPUNCTURE

40 cases of Parkinson’s disease were treated with acupuncture at Baihui(GV 20), Taichong(LR 3), Shaohai(HT 3), Hegu(LI 4), Waigaun(TE 5) and Juegu(GB 39) points. As a result,the total effective rate was 95 %. The therapy has the action of regulating Qi and blood, and balancingYin and Yang.

Clinical observation of body acupuncture combined with FANG’s scalp acupuncture for limb dysfunction in the remission stage of stroke

Objective:To observe the clinical efficacy of body acupuncture combined with FANG’s scalp acupuncture in treating limb dysfunction in the remission stage of stroke and explore the mechanism.Methods:Sixty patients in the remission stage of stroke with limb dysfunction were divided into a control group and a treatment group using the random number table method,with 30 cases in each group.The control group was treated with ordinary acupuncture based on the conventional rehabilitation treatment,and the treatment group was additionally offered FANG’s scalp acupuncture.The interventions were conducted once daily with 10 sessions as 1 course.The Fugl-Meyer assessment(FMA)and Barthel index(BI)scores and serum malondialdehyde(MDA)and superoxide dismutase(SOD)levels were compared after 2 treatment courses,and the clinical efficacy was evaluated.Results:After treatment,the FMA and BI scores increased in both groups(P<0.05)and were higher in the treatment group than in the control group(P<0.05).Both groups showed a decreased MDA level and an increased SOD level after the intervention,all showing statistical significance(P<0.05);there were significant differences between the two groups(P<0.05).Conclusion:Based on the conventional rehabilitation treatment,ordinary acupuncture used alone or in combination with FANG’s scalp acupuncture can lower the oxidative stress level and improve limb function in treating limb dysfunction in the remission stage of stroke;body acupuncture plus FANG’s scalp acupuncture can produce better results.

Metaphysical Energy Therapy in the Treatment of Cranial Nerve Palsies with Special Reference to Bell’s Palsy

Neuropathy, or nerve injury, is a severe and common impediment of diabetes. Studies evaluate that 50% of people with diabetes will develop neuropathy. Diabetic nerve injury is impairment of a single solitary nerve (also named mononeuropathy). Com- monly 2 cranial nerves Viz., cranial nerve VII and cranial nerve VI are involved in facial nerve palsies. The former one is called Bell’s palsy and is acute Lower Motor Neuron facial nerve paralysis (>80%) causing an inability to control facial muscles on the affected side. The later one is sixth nerve palsy, (the abducens nerve), which is responsible for triggering contraction of the lateral rectus muscle to abduct (i.e., turn out) the eye resulting in double vision on the affected side. In recent times, we have found to our amazement, rapid restoration of normalcy within a few hours to a few days, of Cranial Nerve palsies in diabetic subjects at our centre. We are presenting a group of cases having Type2DM over different time periods from 6 to 20 years and those who suddenly suffered facial nerve palsy and they came to VHSDRC for treatment. They were started on the new modality called the Dynamic Acupuncture Mediated Meta-physical Energy Therapy (DAMM Therapy), to recover from the facial palsy. The DAMM therapy is a unique novel way of infusing and transferring healing energy from the therapist to the patient. Within 2 - 7 sittings of DAMM therapy patients showed 75% - 100% improvement in their clinical condition.

陆氏健脾和胃针刺法治疗代谢综合征的随机对照研究

目的:观察陆氏健脾和胃针刺法治疗代谢综合征(MetS)的临床疗效。方法:选取2020年3月至2022年3月于上海市第七人民医院就诊的MetS患者90例作为研究对象,按照随机数字表法分为观察组和对照组,每组45例。对照组采用健康宣教及常规药物治疗,观察组在此基础上加用陆氏健脾和胃针刺法。比较2组患者治疗前后体质量、腰围、体质量指数(BMI)、血脂、血糖、血压的变化。结果:意向性治疗(ITT)分析结果显示,2组患者各时间点体质量、腰围及BMI均较治疗前显著降低(P<0.05),且观察组各时间点体质量、腰围及BMI显著低于对照组(P<0.05);2组患者治疗后血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均较治疗前下降(P<0.05),高密度脂蛋白胆固醇(HDL-C)明显上升(P<0.05),治疗后观察组TC、TG、HDL-C变化幅度较对照组更显著(P<0.05);2组患者治疗后空腹血糖(FBG)、糖化血红蛋白(HbA1c)及胰岛素抵抗指数(HOMA-IR)均比治疗前降低(P<0.05),治疗后观察组FPG、HbA1c及HOMA-IR值均比对照组降低明显(P<0.05)。2组患者治疗前后血压指标无明显变化(P>0.05),针刺期待值与临床疗效无明显相关性(P>0.05)。结论:陆氏健脾和胃法针刺法能有效降低MetS患者的体质量、腰围、BMI,改善血脂、血糖水平,并且具有良好的远期疗效。

针刺“管氏益脑十六穴”对痰瘀阻络证痉挛型脑瘫患儿脑血管动力学的影响

目的观察并分析针刺管氏益脑十六穴对痰瘀阻络证痉挛型脑瘫患儿脑血管动力学的影响。方法选取痰瘀阻络证痉挛型脑瘫患儿80例,选取的患儿年龄区间在9个月—5周岁之间,课题选用随机方法将80例患儿分为2组,对照组为单纯康复训练组,观察组为针刺管氏益脑十六穴组,每组的患儿数量为40例,在课题研究治疗开始前及1个治疗疗程结束后分别对比2组患儿脑血管血液流速指标水平,评价指标包括大脑前动脉(ACA)、大脑中动脉(MCA)、椎动脉(VA)、基底动脉(BA)。结果治疗前,2组患者大脑前动脉(ACA)、大脑中动脉(MCA)、椎动脉(VA)、基底动脉(BA),差异均无统计学意义(P>0.05);治疗后,2组患者大脑前动脉(ACA)、大脑中动脉(MCA)、椎动脉(VA)、基底动脉(BA)收缩期峰值流速(Vsmax)和平均血流速度(Vdmin)均明显增加,且观察组改善情况明显优于对照组,差异具有统计学意义(P<0.05)。结论管氏益脑十六穴针刺治疗痰瘀阻络证痉挛型脑瘫能有效促进脑血管血液流速,改善脑组织供血情况,引起一系列脑组织能量代谢改变。

Discussion on the mechanisms of BO's abdominal acupuncture therapy

This article discussed the mechanisms and precautions of abdominal acupuncture from three different perspectives. First, the relationship between Shénquè （神阙 CV 8） and zang-fu and eight extra meridians stated in the ancient literature explained that the theory of CV 8 as the theoretical core of abdominal acupuncture therapy had literature support and theoretical evidence; second, with emphasis on the diagnosis and treatment based on differentiation of syndromes, four methods for selecting the points, including the ones according to hologram, meridians and collaterals, the Ba-kuo （八 廓） and three energizer, meanwhile, the origin of method selecting the points according to Three Energizer and clinical experience was also addressed; third, some problems about the manipulation of abdominal acupuncture therapy were put forward, such as selection of depth, direction, needle tool, as well as personal ideas and precautions, in order to ensure the clinical effect.

穴位注射胞二磷胆碱对创伤性脑损伤大鼠血清神经元烯醇化酶、S100-β蛋白的影响

目的观察足三里穴位注射胞二磷胆碱疗法对创伤性脑损伤大鼠血清神经元烯醇化酶(NSE)、S100-β蛋白含量的影响。方法成年健康雄性SD大鼠30只,采用改进的Feeney法建立大鼠脑损伤模型,设假手术组大鼠6只(A组),造模成功大鼠24只随机分为穴位注药组(B组)、穴位注水组(C组)、腹腔给药组(D组)和腹腔注水组(E组)各6只。造模后1 h,B、C、D、E组分别单次给予足三里穴位注射胞二磷胆碱或生理盐水,腹腔注射胞二磷胆碱或生理盐水处理。造模后24 h检测各组大鼠血清NSE和S100-β含量。结果 B、C、D、E各造模组与A组比较,S-100β和NES含量均显著升高(P均<0.05)。在造模各组中,B组S-100β和NES含量明显低于C、D、E组(P均<0.05)。结论穴位注射胞二磷胆碱疗法可减少创伤性脑损伤大鼠S-100β和NES的产生,对创伤性脑损伤有一定的神经保护作用。

旴江谢氏刺营疗法配合丹参黏膜下注射治疗口腔 黏膜下纤维化的临床研究

目的探讨口腔黏膜下纤维化(OSF)患者采用旴江谢氏刺营疗法配合丹参黏膜下注射治疗的效果。方法将2020年1月至2022年6月该院收治的80例OSF患者随机分为观察组和对照组,每组各40例。对照组予以丹参黏膜下注射治疗,观察组予以旴江谢氏刺营疗法配合丹参黏膜下注射治疗,两组均治疗3个月。比较两组治疗效果、症状体征、血清指标水平。结果观察组治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05);两组治疗后视觉模拟评分法评分、张口度和口腔黏膜病损面积均较治疗前改善,并且观察组较对照组改善情况更明显,差异均有统计学意义(P<0.05);两组治疗后血清转化生长因子-β1(TGF-β1)及白细胞介素-6(IL-6)水平均低于治疗前,并且观察组低于对照组,差异均有统计学意义(P<0.05)。结论OSF患者采用旴江谢氏刺营疗法配合丹参黏膜下注射治疗效果满意,可有效改善患者临床症状,调节血清TGF-β1、IL-6水平。

平衡针灸疗法对颅脑损伤急性期S-100B蛋白的影响

【目的】观察平衡针灸疗法对急性颅脑损伤模型大鼠血清S-100B蛋白水平的影响。【方法】选用SD大鼠随机分为假手术组、模型组、平衡针灸治疗组。采用大鼠液压冲击模型,台式钻在左顶骨部钻孔,保持硬膜完整,用氰基丙烯酸酯粘合剂将不锈钢螺丝帽粘接于钻孔处;使用中等压力(0.2 mPa)冲击,复制急性颅脑损伤模型。假手术组只进行手术,但不进行冲击。从造模成功当日起,平衡针灸疗法组选用偏瘫穴、腰痛穴、头痛穴、降压穴进行平衡针灸疗法治疗,连续3 d。采用酶联免疫吸咐(ELISA)法检测各组动物血清S-100B蛋白水平。【结果】模型组血清S-100B蛋白水平显著性升高(P<0.01),平衡针灸治疗可显著性降低S-100B蛋白水平(P<0.01),但未恢复至正常水平。【结论】平衡针灸疗法在颅脑损伤急性期能降低血清中S-100B蛋白水平,可能具有一定的脑保护作用。

Observation on the therapeutic efficacy of acupuncture plus tuina for cervical vertigo

Objective： To observe the clinical efficacy and action mechanism of Jin＇s three-needle acupuncture plus Long＇s chiropractic tuina manipulations in treating cervical vertigo. Methods： By adopting a randomized controlled method, 80 eligible patients were randomized into an observation group of 41 cases and a control group of 39 cases. The control group was intervened by Jin＇s cervical three-needle acupuncture plus acupuncture at the vertigo-pain points and Fengchi （GB 20）; the observation group was by Long＇s chiropractic tuina manipulations in addition to the treatment given to the control. For both groups, the intervention was given once a day, 7 sessions as a treatment course, with a 1-day interval after a course, for 2 courses in total. The therapeutic efficacy was evaluated after the first session and the second treatment course, at the 3-month and 6-month follow-ups. Results： After the first session, the recovery plus markedly effective rate of the observation group was significantly higher than that of the control group （P〈0.01）; the rate was markedly higher in the observation group than that in the control group after 2 treatment courses （P〈0.01）; at the 3-month follow-up, the relapse rate was 2.5% in the observation group versus 23.5% in the control, and the between-group difference was statistically insignificant （P〉0.05）; the 6-month follow-up study showed that the relapse rate was 5.0% in the observation group versus 21.6% in the control group, and the between-group difference was statistically significant （P〈0.05）; at the 6-month follow-up, the total relapse rate was 7.5% in the observation group versus 35.1% in the control group, and the inter-group difference was statistically significant （P〈O.01）. Conclusion： The two treatment protocols are both effective in treating cervical vertigo. However, due to its more significant efficacy, more efficient action and lower relapse rate compared to acupuncture alone, acupuncture plus tuina can be regarded as a verified protocol for cervical vertigo.

Effects of electroacupuncture at Chize(LU 5) versus Shangjuxu(ST 37) in rats with ulcerative colitis

Objective： To compare the effects between electroacupuncture （EA） at Chize （LU 5, the He-Sea point of the Lung Meridian） and Shangjuxu （ST 37, the lower He-Sea point of the large intestine） in rats with ulcerative colitis （UC） on the variations of mesenteric microcirculation and vasoactive intestinal peptide （VIP） in the colon, lung, and hypothalamus. The relative specificity of acupoints was also explored. Methods： A total of 28 male Wistar rats were randomized into a normal group, a model group, a Chize （LU 5） group and a Shangjuxu （ST 37） group, 7 rats in each group. The UC model was established by enema with acetic acid. Since the third day after modeling, rats in the Chize （LU 5） group and Shangjuxu （ST 37） group respectively received EA at Chize （LU 5） and Shangjuxu （ST 37）, 1S min each time for successive 7 d. The variations of mesenteric microvascular calibers and blood flow status were observed by a microcirculation microscopic tester; VIP in the colon, lung and hypothalamus was measured by radioimmunoassay. Results： Compared with the normal group, the mesenteric microvascular calibers were significantly expanded in the model group （P〈0.05）; there was no significant difference between the model group and Chize （LU 5） group （P〉0.05）; compared with the model group and Chize （LU 5） group, the calibers were obviously shrunk in Shangjuxu （ST 37） group （P〈0.05）. The four groups showed no significant inter-group differences in comparing blood flow status （P〉0.05）. The colonic VIP levels in the model group and Chize （LU 5） group were significantly higher than that in the normal group （P〈0.01, P〈0.05）; the VIP level in Shangjuxu （ST 37） group was markedly lower than that in the model group （P〈0.01）. There were no significant differences among the four groups in comparing VIP level in lung and hypothalamus （P〉0.05）. Conclusion： The effects of Chize （LU 5） and Shangjuxu （ST 37） were different in treating UC. Shangjuxu （ST 37） showed a more significant efficacy in down-regulating VIP in the colon and regulating mesenteric microcirculation, while the effects of Chize （LU 5） were not obvious.

Effect of acupuncture at Bǎihuì (百会GV 20) and Zúsānlǐ (足三里ST 36) on the level of serum inflammatory cytokines in patients with depression

Objective To investigate the immunologic mechanism of acupuncture at Bǎihuì（百 会 GV 20） and Zúsānlǐ（足三里 ST 36） for treatment of depression. Methods Eighty-four cases of depression patients were randomly divided into an electroacupuncture observation group（group A）, an electroacupuncture control group（group B） and a medication control group（group C）, 28 cases in each group. Bǎihuì（百会 GV 20） and Zúsānlǐ（足三里 ST 36） were used in the group A; Tàichōng （太冲 LR 3）, Sānyīnjiāo （三阴交 SP 6）, Nèiguān （内关 PC 6） and Shénmén （神门 HT 7） were used in the group B; and the group C was treated with oral administration of Fluoxetine. The scores of Hamilton Depression Scale （HAMD） were tested and the level of serum interleukin 1（IL-1β）, interleukin 6 （IL-6）, and tumor necrosis factor α （TNF-α） were measured by Enzyme Linked Immunosorbent Assay （ELISA）before and after treatment. Results Their scores of HAMD were obviously decreased after treatment in three groups（all P0.01）. In the group A, 2 cases were cured, 19 cases were markedly effective, 5 cases were effective and 2 cases were failed. In the group B, 16 cases were markedly effective, 12 cases were effective. While in the group C, 1 case was cured, 17 cases were markedly effective, 7 cases were effective and 3 cases were failed. The grade distribution of clinical effect showed that the effect of group A was better （P0.05）. The levels of serum IL-1β and IL-6 in the three groups were obviously decreased after treatment （P0.05, P0.01）, while there was no significant difference between the level of serum TNF-α before and after treatment. Conclusion The effect of electroacupuncture observation group is superior to those of electroacupuncture control group and medication control group.All of these three methods can clear the inflammatory cytokines such as IL-1β and IL-6 away and improve the symptoms of depression.

Clinical observation on effect of cranial suture acupuncture combined with donepezil hydrochloride tablets for Alzheimer's disease

Objective To investigate the clinical efficacy of acupuncture combined with medicine for AIzheimer＇s disease. Methods Fifty-five patients of Alzheimer＇s disease were randomly divided into two groups in accordance with random number table： the drug group （n=28） was treated with oral donepezil hydrochloride tablets, once a day for 5-10 mg with 10 days as a course of treatment; the combined acupuncture and drug group （n=27） was treated with cranial suture acupuncture combined with donepezil hydrochloride tablets in the above-mentioned way. The cranial suture acupuncture was given once a day for 30 min with 10 days as a course of treatment. Both groups were given treatment for two courses. Mini-mental state examination （MMSE）, Alzheimer＇s disease assessment scale （ADAS-Cog）, activities of daily living scale （Barthel） and electroencephalogram （EEG） were checked before and after treatment, to evaluate the efficacy of each group via integral changes of Barthel. Results MMSE score increased, Barthel index score increased, and ADAS-Cog score decreased in the two groups after treatment （P〈0.05, P〈0.01）, and the efficacy of the combined acupuncture and drug group was more significant （P〈0.01）. The α wave frequency and amplitude and θ wave frequency of EEG increased after treatment in both groups （P〈0.05）, θ wave amplitude decreased （P〈0.01）, and the efficacy of the combined acupuncture and drug group was superior to that of the drug group in terms of EEG improvement （P〈0.05）. The total effective rate of the combined acupuncture and drug group （88.9%, 24/27） was superior to that of drug group （67.9%, 18/28, P〈0.05）. Conclusion The effect of cranial suture acupuncture combined with donepezil hydrochloride tablets for Alzheimer＇s disease is more significant than only medicine therapy.

韦氏三联九针治疗糖尿病性眼肌麻痹的疗效及对血液流变学的影响

目的探讨韦氏三联九针治疗糖尿病性眼肌麻痹的疗效和血液流变学的影响。方法纳入2021年1月—2022年3月枣庄市中医医院眼科收治的糖尿病性眼肌麻痹患者100例,以随机数表法分为治疗组和对照组,每组各50例(50只眼)。对照组患者行降糖、控制饮食、营养神经等常规治疗,治疗组在对照组的基础上给予韦氏三联九针治疗,2组均治疗15 d。分别于治疗前、后检测患者的平均斜视角、血液流变学[血浆纤维蛋白原(FIB)、红细胞聚集指数(RBCAI)、全血黏度(BV)、红细胞沉降(ESR)及血浆黏度(PV)]、血清同型半胱氨酸(Hcy)、胱抑素C(CysC)及缺氧诱导因子-1α(HIF-1α)水平及临床疗效。结果2组治疗前平均斜视角、血液流变学水平及Hcy、CysC及HIF-1α水平比较,差异均无统计学意义(P>0.05)。(1)平均斜视角:2组治疗后平均斜视角均较治疗前降低,差异均有统计学意义(t_(治疗组)=14.943,t_(对照组)=9.013,均P=0.000)。治疗后2组间比较,治疗组较对照组降低,差异有统计学意义(t=5.712,P=0.000)。(2)血液流变学:2组治疗后FIB(t_(治疗组)=17.239,t_(对照组)=11.205,均P=0.000)、RBCAI(t_(治疗组)=5.828,P=0.000;t_(对照组)=3.545,P=0.001)、BV(t_(治疗组)=6.029,P=0.000;t_(对照组)=3.354,P=0.001)、ESR(t_(治疗组)=19.640,t_(对照组)=10.874,均P=0.000)及PV(t_(治疗组)=8.122,t_(对照组)=4.608,均P=0.000)均较治疗前降低,差异均有统计学意义。治疗后2组间比较,治疗组均较对照组降低(t_(FIB)=6.476,P=0.000;t_(RBCAI)=2.932,P=0.004;t_(BV)=2.952,P=0.003;t_(ESR)=12.817,P=0.000;t_(PV)=3.667,P=0.000),差异均有统计学意义。(3)Hcy、CysC及HIF-1α水平:2组治疗后Hcy(t_(治疗组)=11.495,P=0.000;t_(对照组)=2.702,P=0.009)、CysC(t_(治疗组)=8.120,P=0.000;t_(对照组)=2.941,P=0.005)及HIF-1α(t_(治疗组)=7.174,P=0.000;t_(对照组)=3.376,P=0.001)水平均较治疗前降低,差异有统计学意义。治疗后2组间比较,治疗组均较对照组降低(t_(Hcy)=8.737,t_(CysC)=5.521,t_(HIF-1α)=5.206,均P=0.000),差异均有统计学意义。(4)临床疗效:治疗组显效率(36%)优于对照组(20%),差异有统计学意义(χ^(2)=6.353,P=0.011)。结论韦氏三联九针在治疗糖尿病性眼肌麻痹患者中能有效提高患者的临床疗效,改善患者的眼外肌功能及血液流变学,其作用机制可能与血清Hcy、CysC及HIF-1α水平有关。

黄甡辨治小儿湿疹

黄甡教授认为,小儿湿疹病位在心、肝、脾、肺,外因为风、湿、热三邪蕴于皮肤,将小儿湿疹分为风热蕴肤证、湿热内蕴证、脾虚湿盛证、血虚风燥证4个证型。风热蕴肤证疏风散热,方用消风散加减治疗;湿热内蕴证清热利湿,选用甘草泻心汤加减治疗;脾虚湿盛证健脾化湿,方用小儿化湿汤加味治疗;血虚风燥证养血祛风,方用土苓二术汤治疗;血瘀明显者,方用土苓二术汤加乌蛇荣皮汤加减治疗。自拟湿疹散、湿疹膏、五倍子油膏外用,常配合针灸、推拿治疗。

Efficacy observation on Governor Vessel-unblocking and mind-calming acupuncture for insomnia

Objective：To observe the effect of Governor Vessel-unblocking and mind-calming acupuncture on insomnia and further develop the academic idea on Gao＇s lineage acupuncture.Methods：A total of 68 insomnia cases were randomly allocated into an acupuncture group（n=34） and a medication group（n=34） according to their sequences of consultation.Patients in the acupuncture group received acupuncture treatment once a day,5 d a week,for 4 weeks.Patients in the medication group took 1 mg of Estazolam before sleep for each dose,one dose a day,for 4 weeks.Before and after treatment,the sleep quality was evaluated using the Pittsburgh sleep quality index（PSQI）,and the efficacy was assessed using the PSQI reductive rate.Results：After treatment,the global PSQI score and scores of each component in the acupuncture group were significantly decreased（all P〈0.01）.The global PSQI score in the medication group was significantly decreased（P〈0.01）.Except for sleep disturbance,scores of the rest of components were significantly decreased（P〈0.01 or P〈0.05）.The between-group difference was statistically significant in global PSQI score（P〈0.01）.Except for sleep latency and duration,scores of the sleep quality,efficiency,disturbance and daytime dysfunction in the acupuncture group were significantly lower than those in the medication group（all P〈0.05）.In addition,the recovery and marked effect rate in the acupuncture group was significantly higher than that in the medication group（P〈0.05）.Conclusion：The Governor Vessel-unblocking and mind-calming acupuncture is safe,reliable for insomnia and has better efficacy than Estazolam.