Spinal nerve roots have a peculiar structure, different from the arrangements in the peripheral nerve. The nerve roots are devoid of lymphatic vessels but are immersed in the cerebrospinal fluid(CSF) within the subara...Spinal nerve roots have a peculiar structure, different from the arrangements in the peripheral nerve. The nerve roots are devoid of lymphatic vessels but are immersed in the cerebrospinal fluid(CSF) within the subarachnoid space. The blood supply of nerve roots depends on the blood flow from both and peripheral direction(ascending) and the spinal cord direction(descending). There is no hypovascular region in the nerve root, although there exists a so-called water-shed of the bloodstream in the radicular artery itself. Increased mechanical compression promotes the disturbance of CSF flow, circulatory disturbance starting from the venous congestion and intraradicular edema formation resulting from the breakdown of the blood-nerve barrier. Although this edema may diffuse into CSF when the subarachnoid space is preserved, the endoneurial fluid pressure may increase when the area is closed by increased compression. On the other hand, the nerve root tissue has already degenerated under the compression and the numerous macrophages releasing various chemical mediators, aggravating radicular symptomsthat appear in the area of Wallerian degeneration. Prostaglandin E1(PGE1) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis. However, investigations in the clinical setting have shown that PGE1 is effective in some patients but not in others, although the reason for this is unclear.展开更多
目的分析硬膜外造影后多排螺旋CT扫描(epidurography and multispiral CT scanning,MSCTE)的影像学特点和对腰神经根管狭窄的诊断作用。方法自2007年12月至2008年10月共完成了MSCTE检查29例,26例完善了CT、MRI和MSCTE三项检查,26例中23...目的分析硬膜外造影后多排螺旋CT扫描(epidurography and multispiral CT scanning,MSCTE)的影像学特点和对腰神经根管狭窄的诊断作用。方法自2007年12月至2008年10月共完成了MSCTE检查29例,26例完善了CT、MRI和MSCTE三项检查,26例中23例进行了手术探查。分析MSCTE的影像学特点,并与CT和MRI影像进行对比研究,对CT、MRI和MSCTE三种影像诊断试验评价的灵敏度、特异度和总符合率进行统计学分析。结果MSCTE能很好地兼顾腰神经根管的骨与软组织界限。CT、MRI和MSCTE诊断神经根管狭窄的灵敏度依次为76.5%、88.2%和94.1%;特异度依次为60.0%、60.0%和80.0%;总的符合率依次为72.7%、81.0%和90.9%。MSCTE对腰神经根管狭窄诊断灵敏度、特异度和总符合率高于CT和MRI。结论MSCTE有其独特的影像学特点,在诊断腰神经根管狭窄方面优于CT和MRI。展开更多
基金Supported by Grant-in Aid from the Ministry of Education,Science and Culture of Japan,No,25460719
文摘Spinal nerve roots have a peculiar structure, different from the arrangements in the peripheral nerve. The nerve roots are devoid of lymphatic vessels but are immersed in the cerebrospinal fluid(CSF) within the subarachnoid space. The blood supply of nerve roots depends on the blood flow from both and peripheral direction(ascending) and the spinal cord direction(descending). There is no hypovascular region in the nerve root, although there exists a so-called water-shed of the bloodstream in the radicular artery itself. Increased mechanical compression promotes the disturbance of CSF flow, circulatory disturbance starting from the venous congestion and intraradicular edema formation resulting from the breakdown of the blood-nerve barrier. Although this edema may diffuse into CSF when the subarachnoid space is preserved, the endoneurial fluid pressure may increase when the area is closed by increased compression. On the other hand, the nerve root tissue has already degenerated under the compression and the numerous macrophages releasing various chemical mediators, aggravating radicular symptomsthat appear in the area of Wallerian degeneration. Prostaglandin E1(PGE1) is a potent vasodilator as well as an inhibitor of platelet aggregation and has therefore attracted interest as a therapeutic drug for lumbar canal stenosis. However, investigations in the clinical setting have shown that PGE1 is effective in some patients but not in others, although the reason for this is unclear.
文摘目的分析硬膜外造影后多排螺旋CT扫描(epidurography and multispiral CT scanning,MSCTE)的影像学特点和对腰神经根管狭窄的诊断作用。方法自2007年12月至2008年10月共完成了MSCTE检查29例,26例完善了CT、MRI和MSCTE三项检查,26例中23例进行了手术探查。分析MSCTE的影像学特点,并与CT和MRI影像进行对比研究,对CT、MRI和MSCTE三种影像诊断试验评价的灵敏度、特异度和总符合率进行统计学分析。结果MSCTE能很好地兼顾腰神经根管的骨与软组织界限。CT、MRI和MSCTE诊断神经根管狭窄的灵敏度依次为76.5%、88.2%和94.1%;特异度依次为60.0%、60.0%和80.0%;总的符合率依次为72.7%、81.0%和90.9%。MSCTE对腰神经根管狭窄诊断灵敏度、特异度和总符合率高于CT和MRI。结论MSCTE有其独特的影像学特点,在诊断腰神经根管狭窄方面优于CT和MRI。
